Dermatological and cosmetic compositions

Abstract

Dermatological and cosmetic compositions having high endermicity and antiageing activity and high stability are herein described consisting of: 1) emulsifying and self-emulsifying agents, having o/w activity formed by a mixture containing (as % w/w); 1') polyethylene glycol mono- or distearate 0.5-5.0%; 2') polyglycol esters of saturated or unsaturated C.sub.14 -C.sub.20 fatty acids 1.0-10.0%; 3') cetyl alcohol and optionally other higher alcohols, comprising free or esterified sterols 1.0'16.0%; 2) sodium versenate and antioxidant agents 0.1-5.0%; 3) anti-mould and bacteriostatic agents 0.05-0.1%; 4) active ingredients 1-30%; 5) purified water F.U. q.s. to 100%.

Description

This application is a 371 of PCT/EP92/02597 filed Nov. 12, 1992.

The present invention relates to dermatological and cosmetic compositions and particularly to compositions having antiageing activity; said compositions are also useful in the treatment of burns, wounds and are characterized by a high stability such as to make them also suitable for the stabilization of active ingredients.

Skin is formed by cells the state of which affects the external appearance of epidermis. Skin ageing derives from a slowing of the derm functions, particularly nutrition, respiration, hydration, regeneration and cutaneous tissues protection. Skin ageing is a natural phenomenon the causes of which are of different origin and can be more or less fast for each person. Generally, the function slowing of certain cells, the role of which is very important in maintaining the integrity of derm structure, begins around one's thirties. This phenomenon may begin at a more or less early age, due to many factors, such as genetic set, general health state, each individual's peculiar way of life.

The object of the present invention is to provide dermatological and cosmetic compositions having antiageing activity and having high stability, also in the presence of active ingredients of various kind.

The compositions according to the invention consist of:

______________________________________1) emulsifying and self-emulsifying agents, having o/w activity formed by a mixture containing (as % w/w)1') polyethylene glycol mono- or distearate 0.5-5.0%2') polyglycol esters of saturated or 1.0-10.0% unsaturated C.sub.14 -C.sub.20 fatty acids3') cetyl alcohol and optionally other 1.0-16.0% higher alcohols, comprising free or esterified sterols2) sodium versenate and antioxidant agents 0.1-5.0%3) anti-mould and bacteriostatic agents 0.05-0.1%4) active ingredients having derm reconstituting 1-30% activity5) purified water F.U. q.s. to 100%______________________________________

Polyethylene glycols, having various molecular weight, weight, for example ranging from 200 to 10,000, preferably from 400 to 2,000, more preferably 1,000, can be used. Polyethylene glycol 1,000 monostearate is particularly preferred.

The antioxidant agents are selected from the group consisting of:

a) polyunsaturated fatty acids, preferably belonging to vitamin F group; b) tocopheryl derivatives, preferably tocopheryl acetate.

Examples of anti-mould and/or bacteriostatic agents are methyl or propyl p-oxybenzoates.

The active ingredients preferably have derm reconstituting activity. Examples of said active ingredients, which can be used alone or combined each other, are collagen, in the several forms thereof, esurosamine, elastin, amino acids, peptides, mucopolysaccharides.

The compositions of the invention are characterized by a remarkable eudermicity, therefore, they act in an extraordinarily favourable extent on skin stretching and smoothness (anti-wrinkle effect), translucency, on tissue stiffening, turgidity and elasticity, on the reduction of irregular fat accumulation in subcutaneous connective ("cellulitis"). The same favourable effects are exerted by the compositions on skin irritations on children, due to wet linens or sweat, on feet irritations due to maceration, on sun-induced irritations.

Further, the compositions of the invention also carry out a surprising dermatological activity on burns, crural ulcer, wound healings, bedsores, accelerating their recovery.

A particular and surprising aspect of the present invention lies in the fact that the above mentioned compositions, with a formulation excluding the active ingredients of the above point 4, act as stabilizing carriers towards several active ingredients, such as vitamins, hormones, antibiotics. Accordingly, said compositions are useful for the preparation of pharmaceutical compositions containing active ingredients, which are subject to degradation due to environmental conditions (temperature, humidity, oxidants, etc.).

Several stability tests, through chromatographic analysis, established that the compositions of the invention maintain the titre of the active ingredients therein enclosed within the limits fixed at room temperature; particularly some vitamins showed a titre loss not higher then 10% within two years.

The compositions of the invention are prepared according to the techniques which are well-known in dermatology and cosmetics, said compositions may be in the form of creams, lotions, milks, ointments, oils, ampoules, masks, gels, pads, sprays.

According to one of the advantageous embodiments of the invention, both creams and milks can be prepared with the same components.

Tolerability tests, carried out on dermatological and cosmetic compositions of the present invention, proved that said compositions are perfectly tolerated and cause no irritations, thus confirming their high eudermicity.

The following examples further illustrate the invention.

______________________________________EXAMPLE 1To prepare 100 g of "base" cream:Purified water 43.220 gHamamelis water 27.500 gCetyl alcohol 16.000 gFree and esterified sterols 1.000 gMethyl p-oxybenzoate 0.150 gPolyethylene glycol 1,000 monostearate 3.000 gPropyl p-oxybenzoate 0.050 gPropyl gallate 0.030 gPropylene glycol 7.000 gRose essence 0.250 gDisodiun versenate 0.050 gVitamin F 80% 1.250 gPolyglycol esters of saturated or 0.500 gunsaturated C.sub.14 -C.sub.20 fatty acidsEXAMPLE 2To prepare 100 g of Elastin cream:Elastin (anhydrous) 1-2 gLinol-linoleic acid 1.25 gCetyl alcohol 12.00 gPolyethylene glycol 1,000 monostearate 2.25 gPolyglycol esters of saturated or 0.375-0.75 gunsaturated C.sub.14 -C.sub.20 fatty acidsFree and esterified sterols 0.75 gMethyl p-oxybenzoate 0.13 gPropyl p-oxybenzoate 0.07 gPropyl gallate 0.30 gVersenic acid sodium salt 0.05 gHamamelis water 20.50 gPropylene glycol 5.25 gPurified water 55.975-54.600 gRose essence 0.20 g.EXAMPLE 3To prepare 100 g of Collagen cream:Soluble collagen (anhydrous)) 1.20 gVitamin F (polyunsaturated fatty acid) 1.15 gElastin 0.50 gEsurosamine 0.50 gVitamin E (Tocopheryl acetate) 0.20 gCetyl alcohol 7.50 gPolyethylene glycol 1,000 monostearate 3.00 gPolyglycol esters of saturated or 1.50 gunsaturated fatty acidsFree and esterified sterols 1.50 gMethyl p-oxybenzoate 0.10 gPropyl p-oxybenzoate 0.01 gPropyl gallate 0.02 gVersenic acid sodium salt 0.05 gPCV-1845/2 Givaudan essence 0.30 gPurified water 82.47 g.EXAMPLE 4To prepare 100 g of detergent milk:Purified water 45.050 gHamamelis water 27.500 gCetyl alcohol 2.500 gFree and esterified sterols 1.000 gPolyglycol esters of saturated or 5.000 gunsaturated C.sub.14 -C.sub.20 fatty acidsElastin 1.000 gEsurosamine 1.000 gMethyl p-oxybenzoate 0.130 gPolyethylene glycol 1,000 monostearate 0.750 gPropyl p-oxybenzoate 0.070 gPropyl gallate 0.300 gPropylene glycol 14.000 gPCV-1845/2 Givaudan essence 0.200 gVersenic acid sodium salt 0.050 gVitamin F 80% 1.250 gVitamin E (Tocopheryl-acetate) 0.200 g.______________________________________

Claims

1. A dermatological and cosmetic composition consisting of the following:

an emulsifying and self-emulsifying agent, having o/w activity formed by a mixture containing (as % w/w)

______________________________________1') a polyethylene glycol mono- or distearate 0.5-5.0%;2') a polyglycol ester of a saturated or 1.0-10.0%; unsaturated C.sub.14 -C.sub.20 fatty acid3') cetyl alcohol and 0.75-1.50% of free 1.0-16.0%; or esterified sterols2) sodium versenate and an antioxidant agent 0.1-5.0%;3) an anti-mold and bacteriostatic agent 0.05-0.1%;4) an active ingredient having anti-wrinkle effect 1-30%;5) purified water F.U. q.s. to 100%.______________________________________

2. The composition according to claim 1, wherein said antioxidant agent 2) is a member selected from the group consisting of polyunsaturated fatty acids, and tocopherol derivatives, said active ingredient component 4) is a member selected from the group consisting of collagen, esurosamine, elastin, amino acids, peptides, mucopolysaccharides and mixtures thereof.

3. The composition according to claim 1, wherein said active ingredient 4) is a member selected from the group consisting of vitamins, hormones and antibiotics.

4. The composition according to claim 1, wherein said agent 1') is polyethylene glycol monostearate wherein polyethylene glycol has molecular weight of 1000.

5. The composition according to claim 2, wherein said antioxidant agent is tocopheryl acetate.

6. The composition according to claim 1, wherein said agent 3) is methyl or propyl p-oxybenzoate.

7. The composition according to claim 1, in the form of a milk, a lotion, a cream, an ointment, an oil, an ampoule, a mask, a gel, a pad, or a spray.

8. A dermatological and cosmetic composition consisting of the following:

______________________________________1) an emulsifying and self-emulsifying agent, having o/w activity formed by a mixture containing (as % w/w)1') a polyethylene glycol mono- or distearate 0.5-5.0%;2') a polyglycol ester of a saturated or 1.0-10.0%; unsaturated C.sub.14 -C.sub.20 fatty acid3') cetyl alcohol 1.0-16.0%;2) sodium versenate and an antioxidant agent 0.05-0.1%;3) an anti-mold and bacteriostatic agent 0.05-0.1%;4) an active ingredient having anti-wrinkle effect 1-30%;5) purified water F.U. q.s. to 100%.______________________________________

9. The composition according to claim 8 wherein said active ingredient is elastin, esurosamine or mixtures thereof.

10. The composition according to claim 8 wherein said antioxidant is tocopheryl acetate.