Claims
- 1. A method of preventing, delaying or reversing symptoms and consequences of neurodegenerative disease which comprises the administration to an appropriate subject of an effective amount of gamma tocopherol.
- 2. The method of claim 1 wherein the gamma tocopherol is pure.
- 3. The method of claim 1 wherein the gamma tocopherol is part of a tocopherol mixture.
- 4. A method of delaying or preventing the symptoms and consequences of neurodegenerative disease which comprises the administration to a subject of an effective amount of at least one desmethyl tocopherol.
- 5. The method of claim 1 or 4 wherein the neurodegnerative disease is Alzheimer's disease, Parkinson's disease or amylotrophic lateral sclerosis.
- 6. The method of claim 1 or 4 further defined as comprising administration of at least one additional antioxidant.
- 7. The method of claim 1 or 4 where the tocopherol used is a mixture of isomers.
- 8. The method of claim 1 or 4 where the tocopherol is isolated from natural products.
- 9. The method of claim 1 or 4 where the tocopherol is synthetically prepared.
- 10. The method of claim 1 or 4 where the tocopherol is administered as a prodrug.
- 11. The method of claim 1 or 4 where the tocopherol is administered as a water-soluble ester.
- 12. The method of claim 1 or 4 wherein the amount of tocopherol administered is from about 100 to about 400 mg/day.
- 13. The method of claim 1 or 4 wherein the subject is a patient showing early symptoms of neurological disease.
- 14. The method of claim 1 or 4 where the subject has a history of familial neurological disease.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] Priority is claimed from provisional application U.S. Ser. No. 60/186,456 filed on Mar. 2, 2000, and incorporated by reference herein.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
[0002] The United States Government has rights to this invention insofar as it was supported in part by the National Institutes of Health (NS35747, PO1-AG05119 and 5P50-AG05144).
Provisional Applications (1)
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Number |
Date |
Country |
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60186456 |
Mar 2000 |
US |