Claims
- 1-112. (Canceled)
- 113. A labeled member of a binding pair useful for mediated catalytic electrochemistry, comprising:
a) a binder selected from the group consisting of proteins, protein fragments, recombinant proteins, recombinant protein fragments, extracellular matrix proteins, ligands, carbohydrates, steroids, hormones, drugs, drug candidates, immunoglobulins, receptors of eukaryotic, prokaryotic or viral origin, and oligonucleotides; and b) an exogenous peptide label containing one or more modified amino acids capable of being oxidized in an oxidation-reduction reaction at potentials below those of naturally occurring amino acids.
- 114. The labeled member of a binding pair of claim 113, wherein the binder is an antibody.
- 115. The labeled member of a binding pair of claim 113, wherein there are at least two modified amino acids in the peptide label.
- 116. The labeled member of a binding pair of claim 113, wherein the modified amino acids in the peptide label are selected from the group consisting of derivatives of tyrosine and derivatives of tryptophan.
- 117. The labeled member of a binding pair of claim 116, wherein the modified amino acids in the peptide label are selected from the group consisting of 5-hydroxytryptophan; 3-aminotyrosine; and 3,4-dihydroxyphenylalanine.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This is a continuation-in-part of application Ser. No. 09/603,217, filed Jun. 26, 2000, which is a divisional application of application Ser. No. 09/179,665, filed Oct. 27, 1998, now U.S. Pat. No. 6,132,971, which is a divisional application of application Ser. No. 08/667,338, filed Jun. 20, 1996, now U.S. Pat. No. 5,871,918, which is a continuation-in-part of application Ser. No. 08/495,817, filed Jun. 27, 1995; and a continuation-in-part of application Ser. No. 09/267,552 filed Mar. 12, 1999, which is a continuation-in-part of application Ser. No. 08/667,338, filed Jun. 20, 1996, now U.S. Pat. No. 5,871,918, which is a continuation-in-part of application Ser. No. 08/495,817, filed Jun. 27, 1995; each of which is incorporated herein by reference.
Divisions (3)
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Number |
Date |
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Parent |
09722065 |
Nov 2000 |
US |
Child |
09991015 |
Nov 2001 |
US |
Parent |
09179665 |
Oct 1998 |
US |
Child |
09603217 |
Jun 2000 |
US |
Parent |
08667338 |
Jun 1996 |
US |
Child |
09179665 |
Oct 1998 |
US |
Continuations (1)
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10884299 |
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Continuation in Parts (5)
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09603217 |
Jun 2000 |
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09722065 |
Nov 2000 |
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Parent |
08495817 |
Jun 1995 |
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Child |
08667338 |
Jun 1996 |
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Parent |
09267552 |
Mar 1999 |
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Child |
09991015 |
|
US |
Parent |
08667338 |
Jun 1996 |
US |
Child |
09267552 |
Mar 1999 |
US |
Parent |
08495817 |
Jun 1995 |
US |
Child |
08667338 |
Jun 1996 |
US |