DETERMINANTS OF THE SECULAR INCREASE IN NHL

Information

  • Research Project
  • 6172826
  • ApplicationId
    6172826
  • Core Project Number
    R01CA069269
  • Full Project Number
    5R01CA069269-03
  • Serial Number
    69269
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/30/1998 - 26 years ago
  • Project End Date
    8/31/2003 - 21 years ago
  • Program Officer Name
    PATEL, APPASAHEB1 R.
  • Budget Start Date
    9/1/2000 - 24 years ago
  • Budget End Date
    8/31/2003 - 21 years ago
  • Fiscal Year
    2000
  • Support Year
    3
  • Suffix
  • Award Notice Date
    9/26/2000 - 24 years ago
Organizations

DETERMINANTS OF THE SECULAR INCREASE IN NHL

DESCRIPTION: (Adapted from Investigator's Abstract) The investigators' long-term objective is to make possible primary prevention of non-Hodgkin's lymphoma (NHL), an increasingly common and often fatal cancer with an etiology that is incompletely known. The specific aim is to investigate, through a broad interdisciplinary collaboration, the etiologic role of factors that entail immune modulation. The study will be large enough to allow analyses of these factors separately for several distinct subgroups, such as B-cell NHL, T-cell NHL, nodal/extranodal disease and chronic lymphocytic leukemia (CLL). Conditions and exposures to be characterized in detail include: Type-1 allergy, pattern and postponement of infection during childhood, chronic infections, autoimmune diseases, UV-light exposure, vaccinations, drugs that affect the immune system, and - notably for T-cell lymphomas - exposure to EBV and other viruses. Drawing on experience from nationwide collaborative studies between the major research centers in Denmark and Sweden, they propose to conduct a large, nationwide, population-based case-control study. A separate network for rapid case ascertainment will be set up to identify all individuals aged 15-74 years with a newly diagnosed, morphologically confirmed, and histopathologically uniformly classified NHL or CLL. Population controls, frequency-matched to the cases by sex, age, and country, will be regularly selected from population registers. Following informed consent, a blood sample will be obtained from all participants and a telephone interview will be carried out by means of a structured questionnaire. Self-reported information will be extensively completed and validated through linkages to national databases. They anticipate an 80 percent or higher participation rate. During a two-year period (two and a half years for T-cell NHL), they expect to include at least 2,000 patients with B-cell NHL, 400 patients with T-cell NHL, 525 patients with CLL, and approximately 3,000 population controls. The investigators state that the large size enables them to detect, with 80% power at a 5% level, factors that increase NHL by a factor of 1.3 or more for B-cell NHLs, 1.5 or more for T-cell NHLs, and 1.5 or more for CLL at an exposure prevalence of the risk factor in the general population of 1.5%. Major subgroups within B-cell NHL can be analyzed with similar statistical precision. The investigators state that the efficiency of the existing infrastructure, the ready access to nationwide population-based databases, the extensive previous experience with high participation rates, willingness to provide blood samples, and ready access to histopathological specimens provide a unique and effective platform in Scandinavia for such a large and comprehensive study.

IC Name
NATIONAL CANCER INSTITUTE
  • Activity
    R01
  • Administering IC
    CA
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    644289
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    393
  • Ed Inst. Type
  • Funding ICs
    NCI:644289\
  • Funding Mechanism
  • Study Section
    EDC
  • Study Section Name
    Epidemiology and Disease Control Subcommittee 3
  • Organization Name
    STATENS SERUM INSTITUT
  • Organization Department
  • Organization DUNS
  • Organization City
    COPENHAGEN
  • Organization State
  • Organization Country
    DENMARK
  • Organization Zip Code
  • Organization District
    DENMARK