Claims
- 1. A method for detecting preeclampsia by measuring bioactive lipids comprising:
obtaining a sample from a pregnant patient; assaying the sample to determine the concentration of at least one bioactive lipid in the sample, wherein the lipid is selected from the group consisting of a glycerophosphatidyl compound, a lysophospholipid and a sphingolipid; comparing the level of bioactive lipid in the sample to a control value or a prior sample from the pregnant patient; and correlating the concentration in the sample to preeclampsia.
- 2. The method of claim 1, wherein the bioactive lipid is a lysophospholipid selected from the group consisting of LPA, LPI, LPG, LPS, LPC, and LPE.
- 3. The method of claim 1, wherein the bioactive lipid is a sphingolipid selected from the group consisting of S-1-P, SPC and sphingomyellin.
- 4. The method of claim 1, wherein the bioactive lipid is a glycerophospatidyl compound selected from the group consisting of GPA, GPI, GPG, GPS, GPC and GPE.
- 5. The method of claim 1, wherein the step of assaying the sample comprises measuring the concentration of a molecular species of the lysophospholipid.
- 6. The method of claim a, wherein the step of assaying the sample comprises measuring the concentration of the lipid and measuring the concentration of molecular species of the lipid and expressing the concentrations as a ratio.
- 7. The method of claim 1, wherein the specimen is serum.
- 8. The method of claim 1, wherein the specimen is plasma.
- 9. The method of claim 1, wherein the specimen is urine.
- 10. The method of claim 1, wherein the assaying step is repeated over time with a plurality of samples from the pregnant patient to monitor the condition.
RELATED INFORMATION
[0001] This application is a continuation-in-part of co-pending application Ser. No. 09/585,138 filed on Jun. 1, 2000, U.S. Pat. No. 6,461,830. The priority of this prior application is expressly claimed, and the disclosure is hereby incorporated by reference in their entirety.
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09585138 |
Jun 2000 |
US |
Child |
10267556 |
Oct 2002 |
US |