Determining the Impact of Swallowing Impairment in People recovering from Severe COVID-19 Infection

Information

  • Research Project
  • 10163657
  • ApplicationId
    10163657
  • Core Project Number
    R01DC011020
  • Full Project Number
    3R01DC011020-08S1
  • Serial Number
    011020
  • FOA Number
    PA-18-935
  • Sub Project Id
  • Project Start Date
    6/1/2020 - 4 years ago
  • Project End Date
    2/28/2021 - 3 years ago
  • Program Officer Name
    SHEKIM, LANA O
  • Budget Start Date
    6/1/2020 - 4 years ago
  • Budget End Date
    2/28/2021 - 3 years ago
  • Fiscal Year
    2020
  • Support Year
    08
  • Suffix
    S1
  • Award Notice Date
    8/11/2020 - 3 years ago

Determining the Impact of Swallowing Impairment in People recovering from Severe COVID-19 Infection

Project Summary/Abstract The recent spread of COVID-19 has led to an international pandemic, with >4 million confirmed cases to date worldwide, of which >1.3 million confirmed cases and >80,000 deaths have been reported in the USA. Infected individuals commonly experience severe respiratory difficulties and pneumonia, leading to hospital admission and the need for intensive care and mechanical ventilation. Emerging evidence suggests that impaired taste and smell may be early markers of the disease, and that in severe cases, there may be neurological damage in in the medulla, an important brainstem control site for both respiration and swallowing. Given the overlapping neuroanatomical regulation of breathing and swallowing, we hypothesize that dysphagia (swallowing impairment) will be common in People recovering from Severe COVID-19 (PrSC-19) and associated with poorer outcomes. Through this grant supplement, we propose to extend our existing work characterizing dysphagia profiles in different clinical populations to study dysphagia and its impact in PrSC- 19. To understand the prevalence and pathophysiology of dysphagia in PrSC-19, we will conduct detailed analyses of videofluoroscopies performed during the standard of care, post-discharge from intensive care to regular medical care units within the acute care setting. Given the current limitations in performing swallowing assessments for inpatients who test positive for COVID-19, we will also establish 3 regional research clinics that will offer comprehensive swallowing assessments to PrSC-19 after discharge from acute care to rehabilitation or the community. These assessments will include the collection of case history information, videofluoroscopy, use of a novel digital stethoscope to measure respiratory-swallow coordination, measures of other risk factors for dysphagia (e.g. bulbar muscle strength) and patient-reported outcomes. Detailed analyses of the videofluoroscopies will identify specific measures of swallowing that fall outside the range of normal variation based on comparison to healthy reference values established through our research program exploring swallowing physiology on liquids of different consistencies.

IC Name
NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
  • Activity
    R01
  • Administering IC
    DC
  • Application Type
    3
  • Direct Cost Amount
    125000
  • Indirect Cost Amount
    10000
  • Total Cost
    135000
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    173
  • Ed Inst. Type
  • Funding ICs
    NIDCD:135000\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
  • Study Section Name
  • Organization Name
    UNIVERSITY HEALTH NETWORK
  • Organization Department
  • Organization DUNS
    208469486
  • Organization City
    TORONTO
  • Organization State
    ON
  • Organization Country
    CANADA
  • Organization Zip Code
    M5G 2C4
  • Organization District
    CANADA