Development of a DNA Vaccine Against Influenza Virus

Information

  • Research Project
  • 6934015
  • ApplicationId
    6934015
  • Core Project Number
    R43AI065016
  • Full Project Number
    1R43AI065016-01
  • Serial Number
    65016
  • FOA Number
  • Sub Project Id
  • Project Start Date
    5/1/2005 - 19 years ago
  • Project End Date
    10/31/2006 - 18 years ago
  • Program Officer Name
    CHO, DAVID
  • Budget Start Date
    5/1/2005 - 19 years ago
  • Budget End Date
    10/31/2006 - 18 years ago
  • Fiscal Year
    2005
  • Support Year
    1
  • Suffix
  • Award Notice Date
    4/26/2005 - 19 years ago
Organizations

Development of a DNA Vaccine Against Influenza Virus

DESCRIPTION (provided by applicant): The likely emergence of natural influenza pandemic viruses and the recent expansion of influenza-infected animal carrier reservoirs argue for the rapid development and stockpile of an effective universal influenza vaccine. Currently, no vaccine or other treatment has been stockpiled to prevent widespread disease and death resulting from a natural epidemic or pandemic influenza virus strain. Based upon high protein sequence conservation, we identified cross strain-consensus influenza virus proteins that cannot be altered significantly without compromising viral replication. We aim to develop a hemagglutinin-independant plasmid DNA vaccine encoding these proteins and carry the vaccine toward Iicensure by conducting pre-clinical anti-viral vaccine efficacy, safety-toxicity, pathogenicity, biodistribution and genomic integration studies in appropriate animal models. The resulting pre-clinical data will be included in an IND filing with the initial indication being the elderly. These efforts are designed to be completed within 1 year in a manner that will generate an influenza DNA vaccine that can be manufactured for long-term stockpile.

IC Name
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
  • Activity
    R43
  • Administering IC
    AI
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    500000
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    856
  • Ed Inst. Type
  • Funding ICs
    NIAID:500000\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    VICAL, INC.
  • Organization Department
  • Organization DUNS
    183192855
  • Organization City
    SAN DIEGO
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    92121
  • Organization District
    UNITED STATES