TREA

Development of AAV vectors for long-term expression of eCD4-Ig

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Information

  • Research Project
  • 9410355
  • ApplicationId
    9410355
  • Core Project Number
    R44AI134269
  • Full Project Number
    1R44AI134269-01
  • Serial Number
    134269
  • FOA Number
    PA-16-302
  • Sub Project Id
  • Project Start Date
    8/1/2017 - 7 years ago
  • Project End Date
    1/31/2018 - 7 years ago
  • Program Officer Name
    CONLEY, TONY J.
  • Budget Start Date
    8/1/2017 - 7 years ago
  • Budget End Date
    1/31/2018 - 7 years ago
  • Fiscal Year
    2017
  • Support Year
    01
  • Suffix
  • Award Notice Date
    7/25/2017 - 7 years ago
Organizations
Information

Development of AAV vectors for long-term expression of eCD4-Ig

ABSTRACT / SUMMARY / PROJECT DESCRIPTION A single intramuscular injection of an adeno-associated virus (AAV) vector that expresses eCD4-Ig has the potential to treat or prevent HIV-1 infection for a lifetime. eCD4-Ig is a synthetic antibody or ?immunoadhesin? constructed by fusing parts of the viral receptor (CD4) and coreceptor (CCR5) to the constant region of an antibody. Because eCD4-Ig binds the HIV-1 envelope glycoprotein (Env) through the same contacts used by Env to recognize its receptor and coreceptor, eCD4-Ig neutralizes 100% of HIV-1 isolates and presents fundamental barriers to viral escape. We have previously shown that rhesus macaques inoculated with AAV expressing eCD4-Ig exhibited sterilizing protection against high-dose intravenous challenges with simian- human immunodeficiency virus (SHIV). Now, we propose several practical innovations designed to maximize the concentrations of eCD4-Ig in plasma that are sustained over the long term by AAV-transduced muscle.

IC Name
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
  • Activity
    R44
  • Administering IC
    AI
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    299239
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    855
  • Ed Inst. Type
  • Funding ICs
    NIAID:299239\
  • Funding Mechanism
    SBIR-STTR RPGs
  • Study Section
    ADDT
  • Study Section Name
    AIDS Discovery and Development of Therapeutics Study Section
  • Organization Name
    EMMUNE, INC
  • Organization Department
  • Organization DUNS
    079628064
  • Organization City
    JUPITER
  • Organization State
    FL
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    33458
  • Organization District
    UNITED STATES