DEVELOPMENT OF HERBAL SUPPRESSORS FOR ALCOHOL INTAKE

Information

• Research Project
• 2046687

• ApplicationId

  2046687

• Core Project Number

  R41AA010172

• Full Project Number

  1R41AA010172-01

• Serial Number

  10172

• FOA Number

• Sub Project Id

• Project Start Date

  9/26/1994 - 30 years ago

• Project End Date

  8/31/1995 - 29 years ago

• Program Officer Name

• Budget Start Date

  9/26/1994 - 30 years ago

• Budget End Date

  8/31/1995 - 29 years ago

• Fiscal Year

  1994

• Support Year

  1

• Suffix

• Award Notice Date

  9/26/1994 - 30 years ago

Organizations

• Natural Pharmacia International Inc.

The long-term objective of this STTR application is to focus on the development of herbal suppressors for alcohol intake. Our preliminary study of a Chinese herbal medicine called XJL (NPI-028) indicated that NPI-028 could significantly improve the motor impairment of rats intoxicated with alcohol. In addition, a significant suppression (-50%) of alcohol intake was observed in a free-choice alcohol intake study with alcohol-preferring rats. Since the efficacy and safety of NPI-028 has been established empirically over thousands of years in China, this greatly enhances the possibility of its future development into a therapeutic agent with clinical significance and commercial value. The objective of this phase I STTR program is to focus on the identification and evaluation of herbal components in two selected Chinese herbs. Fractionation of the herbal components will be conducted at the Natural Pharmacia International with a powerful high speed countercurrent chromatography system, and their effects on free-choice alcohol intake will be performed at the Center for Alcohol Studies, University of North Carolina, employing alcohol preferring rats and monkeys. The funding of this program will provide an opportunity to establish scientific justification for the second phase of the STTR program.

IC Name

• Activity

  R41

• Administering IC

  AA

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  273

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SRCA

• Study Section Name

• Organization Name

  NATURAL PHARMACIA INTERNATIONAL, INC.

• Organization Department

• Organization DUNS

• Organization City

  Burlington

• Organization State

  MA

• Organization Country

  UNITED STATES

• Organization Zip Code

  01803

• Organization District

  UNITED STATES