DEVELOPMENT OF IMPROVED SKIN TESTS FOR TUBERCULOSIS

Information

• Research Project
• 2776814

• ApplicationId

  2776814

• Core Project Number

  R43AI041800

• Full Project Number

  1R43AI041800-01A1

• Serial Number

  41800

• FOA Number

• Sub Project Id

• Project Start Date

  9/30/1999 - 25 years ago

• Project End Date

  9/30/2000 - 24 years ago

• Program Officer Name

  GINSBERG, ANN M.

• Budget Start Date

  9/30/1999 - 25 years ago

• Budget End Date

  9/30/2000 - 24 years ago

• Fiscal Year

  1999

• Support Year

  1

• Suffix

  A1

• Award Notice Date

  9/27/1999 - 25 years ago

Organizations

• CORIXA CORPORATION

A defined skin test for detecting M. tuberculosis (Mtb) could have significant advantages over PPD in terms of sensitivity and specificity. Such a test could be used in persons infected with HIV, and could be used to distinguish Mtb from BCG immunization. We have identified new antigens of Mtb that stimulate human PBMC in vitro, and that elicit positive DH responses in the guinea pig model of tuberculosis. The goal of this proposal is to evaluate these antigens for the development of an intradermal skin test for the specific and sensitive detection of M. tuberculosis infections. PROPOSED COMMERCIAL APPLICATIONS: The market for a tuberculosis skin test is very large, exceeding $50,000,000 if it would be used to replace PPD. If it is used in a subset of infected individuals, such as HIV infected, the market would be smaller, but should still exceed $25,000,000 per year.

IC Name

• Activity

  R43

• Administering IC

  AI

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  856

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  ZRG5

• Study Section Name

• Organization Name

  CORIXA CORPORATION

• Organization Department

• Organization DUNS

• Organization City

  Hamilton

• Organization State

  MT

• Organization Country

  UNITED STATES

• Organization Zip Code

  59840

• Organization District

  UNITED STATES