Patent Application
20170258344
The invention concerns a device and methods for non-invasive measurement of intracranial pressure (ICP). The monitoring device consists of a mat with one or more piezoelectric elements, optionally also of a device for R-wave detection in the ECG signal and invasive measuring device for determining arterial blood pressure (ABP).
Measurement of intracranial pressure (ICP) is very important for many clinical and diagnostic methods. ICP monitoring is crucial namely for patients at the neurological department and for polytrauma patients, e.g., after an accident. Increased ICP may indicated serious, life-threatening brain injury and practically always requires immediate surgery. High ICP may indicate for example a tumor, edema, acute liver failure and other life-threatening conditions. At the same time, low ICP is also physiologically dangerous, and is accompanied by nausea, migraines or visual impairment.
The most commonly used and the only accurate method of ICP measurement is currently an invasive method, during which pressure sensors are introduced to the brain tissue and the physician needs to drill holes into the patient's skull. This methods poses risks for the patient in terms of health and following recovery, as well as the risk of infection.
Non-invasive methods known so far include measurements of intraocular pressure, otoacoustic emissions or tympanometry, visually stimulated evoked potentials or transcranial Doppler measurement of blood flow. Unfortunately, these methods do not guarantee sufficient accuracy and reliability of measurements.
One non-invasive method used for ICP measurement is described in application US2013289422, including the description of the ICP measuring device based on the relation between the pressure inside a carotid artery and the flow/flow speed of blood inside a carotid artery. The blood flow is measured using a piezoelectric sensor, which is attached to the carotid artery. Deduction of the ICP value is based on the shape of the pulse wave measured using a piezoelectric sensor.
Another approach to ICP measurement is described in document U.S. Pat. No. 6,761,695, which describes a device for determining ICP consisting of a pressure sensor attached to the head of the measured subject. The output of the sensor includes an ICP component and blood pressure component. Then the processor subtracts the blood pressure value from the output signal in the same phase, which yields ICP.
Another possible approach and device for ICP monitoring are described in US2009012430. This device is primarily intended for monitoring of the bloodstream in the brain and it can be used to also determine ICP. The principle consists in an injection of micro-bubbles into the patient's blood stream and following assessment of turbulent flow caused by these micro-bubbles. These vibrations are recorded by a field of accelerometers attached to the patient's head.
Another method for determining ICP is described in US2010049082, which describes a procedure where using a number of vital parameters (pCO2, pO2, blood pressure, blood flow speed . . . ) it is possible to statistically assess the assumed ICP. This method includes two phases of the process: learning, during which data are collected, and simulation, during which data are assigned to potential ICP models. The disadvantage of this procedure is the relatively irrelevant output values that may not always correspond to the truth.
Unlike the above described procedures, the procedure described in U.S. Pat. No. 8,366,627 is significantly more complex and reliable. It uses a pressure sensor (tonometer or catheter) for blood pressure monitoring to calculate the ICP value; the calculation model contains parameters of resistance, submission, blood pressure and blood flow. There are also solutions consisting of a sensor attached to the patient's hand using a band, such as described in US2013085400, which describes a sensor, whose output signal is processed and transferred using mathematical operations to a frequency spectrum and its components. These operations include namely the Fourier transform, Fast Fourier transform or Wavelet transform.
Another alternative approach to measurement of a brain parameter, not directly ICP but a similar parameter, i.e., the blood pressure in the temporal artery, is discussed in US2011213254, which describes a measuring device similar to headphones, which is in contact with the ear but the sensor is placed on across a temporal artery, where it measures pulsation and deduces the blood pressure in the temporal artery.
The specified problems and shortcomings of the stated methods and approaches to calculation of intracranial (ICP) pressure are solved by a device for ICP monitoring consisting of a measuring mat containing at least one piezoelectric sensor. This mat is placed under the head of the patient. Other optional components of this device include a device for heart rate measurement and a sensor for invasive measurement or arterial blood pressure (ABP).
The measuring mat detects micro movements and mechanical vibrations of the head that are caused by the hemodynamics of the patient's blood circulation, thanks to which the pulse wave is reflected in the bloodstream inside the head. Furthermore, ECG is used to detect the R-wave. Another part of the device is a sensor for invasive measurement of ABP. ICP is then calculated from a relation using the time delay of the reflected pulse wave in relation to the moment of the detected R-wave.
An experimental study discovered and verified that relative changes of IPC may be measured even without the necessity to use invasive ABP measurement or to detect the R-wave. The method is based on the detection of a sequence of pulse waves and their reflection in relation to individual pulses and their mutual time delay.
a,
1
b and 1c schematically represent the device and its components.
The device for non-invasive monitoring of intracranial pressure 1 (ICP) includes a measuring mat 2, processor unit 3, device for recording electrical activity of the heart 4 (ECG), device for invasive measurement of arterial blood pressure 5 (ABP), imaging device 6 and network connector 7.
The measuring mat 2 includes at least one piezoelectric sensor 8 and is located in a suitable design under the patient's head in the head support, as shown in
Alternatively the measuring mat 2 may be placed under the mattress 10 on the hospital bed 11 under the patient's head, as depicted in
The measuring device 1 also includes a device for monitoring of electrical activity of the heart 4 (ECG), sensor for invasive measurement of arterial blood pressure 5 (ABP). It is suitable to extend these functions by a standard patient monitor 12 with data output. The output signal is preferably digital; however, analog signal can also be used. If analog output signals are used, it is necessary to use A/D converters 13. Experts familiar with processing of analog signals can design several possible connections of the A/D converter 13 in order for the processor unit 3 to be able to correctly assess signals and calculate ICP. At the same time, any expert familiar with biosignal can use other suitable equipment for monitoring of electric activities of the heart, such as vectorcardiograph (VCG). Alternatively, ballistocardiographic signal can also be used. In an alternative embodiment it is possible to use non-invasive ABP measurement; however, preferred embodiment assumes non-stop monitoring of the patient in an intensive care unit or in an anesthetics and resuscitation department, where ABP is normally measured invasively; this is why this invention is described on the example of an invasive sensor 5 for ABP measurement.
The processor unit 3 is preferably located inside the measuring mat 2, as indicated in
Processor unit 3 is connected with sensors 8, ECG 4 and ABP sensor 5. Signals from these sensors 8 are processed by the processor unit 3 and the processed data are then sent to the displaying device 6. This displaying device 6 may be placed separately, as shown in
The displaying device 6 may display current values, trends, mean values, ICP, ECG, ABP, alternatively other vital functions of the patient in case of the patient monitor 12. The displaying device 6 can be advantageously connected with the hospital system for collection of patient data 15. The displaying device 6 can also display critical states, when the value of the displayed parameter is outside the predefined limit values. Limit values can be adjusted manually in accordance with individual needs of the patient. Critical situations may also be detected if the current ICP value deviates from the long term average. Notification of these situations may again be sent to the system for collection of patient data 15, which then further distributes the information, alternatively information on selected critical situations may be sent directly to the medical staff. The ICP calculation method is based on the existing relation between pressure inside the cranial cavity 16 and the bloodstream hemodynamics 17. This mutual relationship is manifested for example by synchronous changes of ICP and heart activity (as described for instance in article by Wagshul M. et al. (2011) The pulsating brain: A review of experimental and clinical studies of intracranial pulsatility, Fluids and Barriers of the CNS, 8:5). From the mechanical point of view, synchronized ICP and ABP oscillation occurs and it is caused by changes of ABP as well as the volume of blood in brain arteries and vessels. The brain volume changes proportionally to ABP. If the brain were not located in the cranial cavity 16, clear pulsations would be visible. In fact the brain is stored in cerebrospinal fluid, an incompressible fluid, and is enclosed in a hard shell (skull). Increased ABP leads to brain swelling and to higher ICP. When ABP and iCP are locally balanced, the brain cannot increase its volume any more, as it cannot receive any more blood due to the fact that the pressure of blood entering the brain is no longer higher than ICP and the entering pulse wave is reflected. This situation is schematically represented in
This situation is commonly described using the simple Windkessel hydrodynamic model. In common practice the Windkessel model is used to determine the aorta elasticity. This model is solved using differential equations, where the heart 18 is represented as the pulse source and input parameters are flexibility of arteries and vascular resistance. This model enables calculation and description of the pulse wave. Windkessel is described in detail for instance in Westerhof N. et al. (2008) The arterial Windkessel, DOI 10.1007/s11517-008-0359-2.
Analytical solution of these differential equations is impossible, which is why they need to be solved numerically. This model is used for pulse wave reflection in the head. On the basis of physical considerations it may be deduced that the elasticity of bloodstream in the brain C is inversely proportional to ICP and the following equation I therefore applies
From Newton's laws of motion, specifically from the law of inertia, it follows that reflection of the pulse wave is accompanied by a mechanical movement of the head, which is measurable using the above described measuring mat 2. These mechanical head movements are depicted in
The beginning of the mechanical pulse, which corresponds to the R-wave in the ECG signal, and T1 of the pulse wave reflection 20 (mechanical head vibration) determines the time delay T between the R-wave and mechanical movement of the head 20. In the equation for the Windkessel model the R-wave represents the source part of the equation, which describes the activity of the piston pump corresponding to the heart 18. Blood is pumped into the brain under a pressure that equals ABP. The pressure of the brain tissue and cerebrospinal fluid that equals ICP acts against this pressure. The difference between ICP and the arterial pressure is called the cerebral perfusion pressure (CPP). The time delay Tbetween the R-wave and reflection of the pulse wave in the head is then solved as a Winkessei equation using the relation II
CPP˜−A·log(T−T0) (II)
where A is an empirically determined constant,
T0 is the time that would correspond to the reflection time at infinite intracranial pressure. The time when the pulse wave appears on the carotid artery may be used as T0.
In the following steps ICP is calculated using known ABP and CPP. This calculation is done using equation III
ABP−CPP=ICP (III)
As is visible from
The non-invasive method was verified in several tested subjects. The verification equipment included an A/D converter 13, which was connected to the output of the invasive sensor for ICP measurement, output signal from ECG 4 and signal from the measuring mat 2 under the patient's head. All signals were sampled at frequency of 2 kHz.
R-waves of the QRS complex were localized in the obtain ECG signal using standard procedures and the signal was then divided by R-waves into individual sections so that each section covered a time interval (Rn−400, Rn+2000), where Rn is the n-th R-wave and time is measured on sampling points, i.e., each such interval contains a section of signals that start 400 sampling points (0.2 s) before the R-wave and end 2000 sampling points (1 s) after the R-wave. The time range (Rn−400, Rn+2000) was selected for the verification experiment in order to ensure with absolute certainty that the given interval covers two consecutive R-waves. When these intervals are ordered under each other so that the first R-wave are synchronized in time, we get a data matrix for each measured channel, as shown in
A signal from the piezoelectric sensor 8 corresponding to ordered R-waves is depicted in
It may be assumed that during the time of ten consecutive R-waves ABP and ICP remain constant and the circulation system during these ten consecutive heart cycles remains stable.
METHOD II
The device for non-invasive monitoring of intracranial pressure 1 (ICP) includes a measuring mat 2, processor unit 3, displaying unit 6, network connector 7 and devices for measuring a parameter related to arterial blood pressure (ABP), which may be a device for recording electrical activity of the heart 4 or a device for invasive measurement of arterial blood pressure 5.
All calculations and relations are explained on a single hear cycle for the sake of simplicity. In terms of time, this concerns the area between two R-wave, where the first R-wave is considered the start of action T (0). Practically immediately after the R-wave, a whole spectrum of mechanical actions occur in the bloodstream and they are reflected in the final signal in the form of oscillations, peaks, etc. For further processing it is necessary to identify only the peaks significant for further processing.
One of these key peaks is the one that corresponds to the moment the pulse wave is reflected from the head. This time is identified as T1, the time is determined using the maximum value located in area 24, as is shown in
T1˜e−ICP (IV)
The second key parameter is related to the closing of the aortic valve. This phenomenon is mechanically significant and it is known as the water hammer. This time is referred to as T2, in
In accordance with the Moens-Korteweb equation in the following form (equation V)
where ABP refers to the arterial blood pressure;
PWV is the pulse wave velocity; and
a, b, c and d are certain constants,
it holds that T2, when the pulse wave reached the place of measurement of ABP, is inversely proportionate to pressure, i.e, the higher the pressure, the lower the time of arrival of the pressure wave.
The specific equation for determining T2 corresponds to the following equation (VI), as specified in the following text: F. Studni{hacek over (c)}ka: Analysis of biomedical signals using differential geometry invariants, ACTA PHYSICA POLONICA A, 120, A-154, 2011.
ln(T2)˜−ABP (VI)
Some of the other results following from the Moens-Kortweg equation can be found for example in: E. Pinheiro, a Postolache, P. Girão: Non-Intrusive Device for Real-Time Circulatory System Assessment with Advanced Signal Processing Capabilities, MEASUREMENT SCIENCE REVIEW, Volume 10, No. 5, 2010.
Time T0 is introduced to the Windkessel model; this time is related to the moment the pulse wave reflects from the head. From the model it follows that ICP is proportionate to the logarithm of differences of times T1 and T0. Time T0 can be substituted by time when the pulse wave goes through the carotid artery. This time correlates to the time when the pulse wave reaches the radial artery, i.e., the place where standard invasive measurements of ABP are taken using sensor 5. Again, T0 in accordance with the Moens-Kortweg equation is inversely proportional to ABP.
Time T0 could not be experimentally defined; however, it was possible to experimentally verify the correlation between T0 and T2. From the description above it follows that it is not necessary to measure ABP, only the time at which the pulse wave appear in the radial artery. This measurement can be carried out using a sensor for invasive measurement of ABP, as these measurements are carried out standardly in intensive care units. However, in order to detect relative changes of ICP, only data from measuring mat 2 are required, as documented by: F. Studni{hacek over (c)}ka: Analysis of biomedical signals using differential geometry invariants, ACTA PHYSICA POLONICA A, 120, A-154, 2011.
From the equations stated above (IV and VI) and from the previous paragraph, we obtain equation VII
ICP˜ln|(T2−T1)| (VII)
This equation has been experimentally verified on tested subjects, even for situations when the head position changed.
On the basis of the description above, it is clear that for monitoring of relative changes of ICP it is possible to use the ICP monitoring device including only a measuring mat and a processor unit.
To measure absolute ICP values the device needs to include a measuring mat, processor unit and either a device for measurement of electric activities of the heart 4 or ABP monitoring device 5, or alternatively both.
1 device for non-invasive ICP measurement
2 measuring mat
3 processor unit
4 device for measurement of electrical activity of the heart
5 device for invasive measurement of arterial pressure
6 displaying unit
7 network connector
8 sensor (in the mat)
9 extension
10 mattress
11 hospital bed
12 patient monitor
13 A/D converter
14 displaying device
15 system for collection of patient data
16 cranial cavity
17 bloodstream
18 heart
19 area I
20 area II
21 area III
22 maximum ICP
23 maximum mechanical manifestation
24 T1 area
25 T2 area
| Number | Date | Country | Kind |
|---|---|---|---|
| PV 2014-696 | Oct 2014 | CZ | national |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/CZ2015/000114 | 10/1/2015 | WO | 00 |
