Claims
- 1. A device for multiparallel synthesis or screening comprising
(a) a plurality of reaction wells for receiving a fluid or solid, (b) a means for introducing the fluid or solid into one or more reaction wells of said plurality, and (c) a plurality of removable sealing elements each of which is positioned across, or spans two sides of, a reaction well when in a sealing position.
- 2. A device for multiparallel synthesis or screening comprising
(a) a plurality of reaction wells that form a three dimensional array for receiving a fluid or solid, and (b) a means for introducing the fluid or solid into a plurality of inlets at two or more adjacent faces or surfaces of the three-dimensional array.
- 3. A device for multiparallel synthesis or screening comprising
(a) a plurality of reaction wells for receiving a fluid or solid, (b) a means for introducing a fluid or solid into a first row of reaction wells, (c) a means for introducing a fluid or solid into a second row of reaction wells which is perpendicular to the first row of reaction wells, and (d) a means for introducing a fluid or solid into a column of reaction wells which is perpendicular to the first row and the second row of reaction wells.
- 4. A device according to claim 1, wherein the sealing elements are tapered, cylindrical, or rod-shaped.
- 5. A device according to claim 1, wherein the sealing elements are tapered pins.
- 6. A device according to claim 1, wherein the sealing elements have varying diameters.
- 7. A device according to claim 1, wherein the fluid or solid is introduced through one or more openings in the sealing elements.
- 8. A device according to claims 1, 2, or 3, wherein the reaction wells further comprise solid-phase supports that do not contain preformed functionalities or linkers.
- 9. A device according to claims 1, 2, or 3, wherein the reaction wells are made of polypropylene, polyethylene, PTFE, or stainless steel.
- 10. A device according to claims 1, 2, or 3 wherein the smallest side of a reaction well is at least about 10 mm.
- 11. A device according to claims 1, 2, or 3 wherein at least about 1 mg of a reaction product is produced.
- 12. A device according to claims 1, 2, or 3, wherein two or more layers of said reaction wells are stacked to form a three-dimensional array.
- 13. A device according to claim 2, wherein the three-dimensional array is connected to one or more three-dimensional arrays.
- 14. A method for synthesizing or screening compounds comprising
(a) introducing a fluid or solid into a first row of reaction wells, (b) introducing a fluid or solid into a second row of reaction wells that lie perpendicular to the first row of reaction wells, (c) introducing a fluid or solid into a column of reaction wells that lie perpendicular to each of the first row and the second row of reaction wells, and (d) inserting a plurality of removable sealing elements.
- 15. A method for synthesizing or screening compounds comprising
(a) introducing a fluid or solid into a plurality of inlets at two or more adjacent faces or surfaces of a three-dimensional array that comprises a plurality of reaction wells, and (b) inserting a plurality of removable sealing elements.
- 16. A method according to claims 14 or 15, wherein each of the plurality of removable sealing elements is positioned across, or spans two sides of, a reaction well when in a sealing position.
- 17. A method according to claims 14 or 15 further comprising performing one or more washing steps after introducing one or more fluids or solids.
- 18. A method according to claims 14 or 15, wherein the fluid or solid is added using syringes or tubes.
- 19. A method according to claims 14 or 15, wherein at least one milligram of a reaction product is produced.
- 20. A method according to claims 14 or 15, wherein the fluid or solid is added using a pump.
- 21. A method according to claims 14 or 15 further comprising using a solid-phase support made of polypropylene, polyethylene, perfluoroelastomer, or PTFE.
- 22. A method for synthesizing an array of compounds comprising using the device of claims 1, 2, or 3 to produce at least one milligram of a reaction product.
- 23. A method according to claims 14 or 15, wherein the fluid or solid comprises small molecule reactants.
- 24. A method according to claims 14 or 15, wherein functionalization, linking, or cleavage is performed in the reaction wells.
REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of a U.S. Provisional Application No. 60/361,827 filed on Mar. 4, 2002, which is incorporated herein.
Provisional Applications (1)
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Number |
Date |
Country |
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60361827 |
Mar 2002 |
US |