Claims
- 1. A process for producing a calcium phosphate coated implantable device, comprising subjecting a porous or non-porous material to a surface treatment until a precipitate enhancing roughened surface with an average peak distance between 10 nm and about 1,000 nm is obtained, and subsequently subjecting the surface to precipitation from a solution to form a coating, with the coating comprising calcium ions, phosphate ions, and an organic biologically active agent.
- 2. The process according to claim 1, wherein the solution has a pH of about 4-10.
- 3. The process according to claim 1, wherein the biologically active agent is selected from the group consisting of growth factors, lipids, (lipo)polysaccaharides, hormones, cytostatic agents, antibiotics, proteins, and mixtures thereof.
- 4. The process according to claim 1, wherein said subjecting the surface to precipitation is carried out in two stages.
- 5. A process according to claim 1 comprising treating titanium or a titanium alloy with an acid solution followed by immersion in an alkaline solution.
- 6. A process according to claim 1 comprising treating porous tantalum with an acid solution followed by immersion in an oxidizing solution.
- 7. A process according to claim 2 wherein the pH is about 6 to about 8.
- 8. A process according to claim 1, wherein the biologically active agents in the implantable device comprise up to 60 percent by weight of the coating.
- 9. A process according to claim 1, wherein the coating is degradable due to a solution mediated process.
- 10. A process according to claim 1, wherein the coating is degradable due to a cell mediated process.
- 11. A process according to claim 1, wherein the biologically active agent comprises an osteoinductive protein.
Priority Claims (1)
Number |
Date |
Country |
Kind |
96201293 |
May 1996 |
EPX |
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Parent Case Info
This application is a divisional of U.S. Pat. application Ser. No. 08/901,294, filed Jul. 3, 1997, which in turn is a Continuation-in-Part of U.S. Patent application Ser. No. 08/855,833, filed May 12, 1997, now abandoned.
US Referenced Citations (7)
Divisions (1)
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Number |
Date |
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Parent |
901294 |
Jul 1997 |
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Continuation in Parts (1)
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Number |
Date |
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855833 |
May 1997 |
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