Claims
- 1. A device for use in correcting fine superficial facial lines comprising:
- (a) a syringe having a barrel fitted with a fine gauge needle, the needle having a gauge in the range from 31 to 33, inclusive,
- (b) an aqueous suspension of fibrillar noncrosslinked atelopeptide collagen contained within the barrel, the collagen having a concentration in the suspension in the range of 10 to 50 mg/ml, the collagen further being comprised of fibrils of uniform size whereby the uniform size of the fibrils results in improved flow characteristics and enhanced extrudability of the suspension through the fine gauge needle such that the suspension exhibits an extrusion plot in which there is a smooth substantially linear increase in force up to a substantially constant force in the range of 10 to 30 newtons with an average of about 25 newtons.
- 2. The device of claim 1 wherein said collagen concentration is 30 to 40 mg/ml.
- 3. The device of claim 1 wherein the needle gauge is 32.
- 4. The device of claim 2 wherein the needle gauge is 32.
- 5. The device of claim 4 wherein the barrel has an inner diameter of 4 to 10 mm and the volume of suspension in the barrel is 0.4 to 0.7 cc, inclusive.
- 6. The device of claim 1 wherein said uniform size fibrils are formed by passing the collagen through a 50 mesh screen.
Parent Case Info
This application is a continuation of application Ser. No. 07/677,403, filed Mar. 29, 1991, now abandoned.
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Number |
Name |
Date |
Kind |
3949073 |
Daniels et al. |
Apr 1976 |
|
4424208 |
Wallace et al. |
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4488911 |
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Non-Patent Literature Citations (1)
Entry |
Sherwood Medical Catalog-Apr. 5, 1989 p. 4 under Needles & Syringe Section. |
Continuations (1)
|
Number |
Date |
Country |
Parent |
677403 |
Mar 1991 |
|