Device, system and method to affect the mitral valve annulus of a heart

Information

  • Patent Grant
  • 7351259
  • Patent Number
    7,351,259
  • Date Filed
    Monday, May 10, 2004
    20 years ago
  • Date Issued
    Tuesday, April 1, 2008
    16 years ago
Abstract
A device for modifying the shape of a mitral valve annulus. In one embodiment, the device includes a connector disposed between first and second anchors, the first and second anchors each adapted to be deployed in a coronary sinus adjacent the mitral valve annulus to anchor the device in the coronary sinus; and an actuation element adapted to receive a proximally or distally directed actuation force from an actuator and to transmit the actuation force to the first and second anchors simultaneously. The invention also includes a system for modifying the shape of a mitral valve annulus, including a percutaneous deployment apparatus, including an actuator; and a percutaneous mitral valve annuloplasty device with a connector disposed between first and second anchors, the first and second anchors each adapted to be deployed in a coronary sinus adjacent the mitral valve annulus to anchor the device in the coronary sinus; and an actuation element adapted to receive a distally proximally directed actuation force from the actuator and to transmit the actuation force to the first and second anchors simultaneously. The invention also includes a method of using such devices and systems.
Description
BACKGROUND OF THE INVENTION

The human heart generally includes four valves. Of these valves, a most critical one is known as the mitral valve. The mitral valve is located in the left atrial ventricular opening between the left atrium and left ventricle. The mitral valve is intended to prevent regurgitation of blood from the left ventricle into the left atrium when the left ventricle contracts. In preventing blood regurgitation the mitral valve must be able to withstand considerable back pressure as the left ventricle contracts.


The valve cusps of the mitral valve are anchored to muscular wall of the heart by delicate but strong fibrous cords in order to support the cusps during left ventricular contraction. In a healthy mitral valve, the geometry of the mitral valve ensures that the cusps overlie each other to preclude regurgitation of the blood during left ventricular contraction.


The normal functioning of the mitral valve in preventing regurgitation can be impaired by dilated cardiomyopathy caused by disease or certain natural defects. For example, certain diseases may cause dilation of the mitral valve annulus. This can result in deformation of the mitral valve geometry to cause ineffective closure of the mitral valve during left ventricular contraction. Such ineffective closure results in leakage through the mitral valve and regurgitation. Diseases such as bacterial inflammations of the heart or heart failure can cause the aforementioned distortion or dilation of the mitral valve annulus. Needless to say, mitral valve regurgitation must not go uncorrected.


One method of repairing a mitral valve having impaired function is to completely replace the valve. This method has been found to be particularly suitable for replacing a mitral valve when one of the cusps has been severely damaged or deformed. While the replacement of the entire valve eliminates the immediate problem associated with a dilated mitral valve annulus, presently available prosthetic heart valves do not possess the same durability as natural heart valves.


Various other surgical procedures have been developed to correct the deformation of the mitral valve annulus and thus retain the intact natural heart valve function. These surgical techniques involve repairing the shape of the dilated or deformed valve annulus. Such techniques, generally known as annuloplasty, require surgically restricting the valve annulus to minimize dilation. Here, a prosthesis is typically sutured about the base of the valve leaflets to reshape the valve annulus and restrict the movement of the valve annulus during the opening and closing of the mitral valve.


Many different types of prostheses have been developed for use in such surgery. In general, prostheses are annular or partially annular shaped members which fit about the base of the valve annulus. The annular or partially annular shaped members may be formed from a rigid material, such as a metal, or from a flexible material.


While the prior art methods mentioned above have been able to achieve some success in treating mitral regurgitation, they have not been without problems and potential adverse consequences. For example, these procedures require open heart surgery. Such procedures are expensive, are extremely invasive requiring considerable recovery time, and pose the concomitant mortality risks associated with such procedures. Moreover, such open heart procedures are particularly stressful on patients with a compromised cardiac condition. Given these factors, such procedures are often reserved as a last resort and hence are employed late in the mitral regurgitation progression. Further, the effectiveness of such procedures is difficult to assess during the procedure and may not be known until a much later time. Hence, the ability to make adjustments to or changes in the prostheses to obtain optimum effectiveness is extremely limited. Later corrections, if made at all, require still another open heart surgery.


An improved therapy to treat mitral regurgitation without resorting to open heart surgery has recently been proposed. This is rendered possible by the realization that the coronary sinus of a heart is near to and at least partially encircles the mitral valve annulus and then extends into a venous system including the great cardiac vein. As used herein, the term “coronary sinus” is meant to refer to not only-the coronary sinus itself but in addition, the venous system associated with the coronary sinus including the great cardiac vein. The therapy contemplates the use of a device introduced into the coronary sinus to reshape and advantageously affect the geometry of the mitral valve annulus.


Devices of this type generally include an elongated flexible member having a cross sectional dimension for being received within the coronary sinus of the heart and an anchor at each end. When placed in the coronary sinus, the devices reshape the mitral valve annulus, or at least a portion of it, to promote effective valve sealing action and eliminate or reduce mitral valve regurgitation. Device structures and methods of implanting the same are fully described, for example, in copending U.S. patent applications Ser. No. 10,011,867, filed Dec. 5, 2001, titled ANCHOR AND PULL MITRAL VALVE DEVICE AND METHOD, Ser. No. 10/066,426, filed Jan. 30, 2002, titled FIXED LENGTH ANCHOR AND PULL MITRAL VALVE DEVICE AND METHOD, Ser. No. 10/142,637, filed May 8, 2002, titled BODY LUMEN DEVICE ANCHOR, DEVICE AND ASSEMBLY, and Ser. No. 10/331,143, filed Dec. 26, 2002, titled SYSTEM AND METHOD TO EFFECT THE MITRAL VALVE ANNULUS OF A HEART. The disclosures of the foregoing patent applications are incorporated herein by reference.


The foregoing therapy has many advantages over the traditional open heart surgery approach. Since the therapy may be employed in a comparatively noninvasive procedure, mitral valve regurgitation may be treated at an early stage in the mitral regurgitation progression. Further, the therapy may be employed with relative ease by any minimally invasive cardiologist. Still further, since the heart remains completely intact throughout the procedure, the effectiveness of the procedure in reducing mitral valve regurgitation may be readily determined, such as by echocardiography or fluoroscopy. Moreover, should adjustments be deemed desirable, such adjustments may be made during the procedure and before the patient is sent to recovery.


Unfortunately, the human anatomy does impose some obstacles to this recently proposed procedure for treating mitral regurgitation. More specifically, the coronary sinus/great cardiac vein runs in the atrioventricular groove between the left atrium and left ventricle. The left circumflex artery originates from the left main coronary artery and courses within the atrioventricular groove. One to three large obtuse marginal branches extend from the left circumflex artery as it passes down the atrioventricular groove. These principal branches supply blood to (perfuse) the lateral free wall of the left ventricle. In approximately 15% of the population, the left circumflex artery is a dominant source of blood to the left posterior descending artery for perfusing and supporting the viability of the left ventricle. When the circumflex artery is superior to the coronary sinus, the obtuse marginal branches extending towards the ventricular wall may run either underneath the coronary sinus or above the coronary sinus. Hence, when placing a mitral valve therapy device in the coronary sinus/great cardiac vein of a patient, great care must be taken to prevent occlusion of this coronary artery system.


Even when great care is taken to avoid occlusion of the coronary arteries during placement of a prosthetic device in the cardiac venous system, arterial perfusion of the heart may be unacceptably reduced by the device. Copending U.S. patent application Ser. No. 10/366,585, filed Feb. 12, 2003, and titled METHOD OF IMPLANTING A MITRAL VALVE THERAPY DEVICE, the disclosure of which is incorporated herein by reference, discloses a method of optimizing patient outcome while performing a procedure in the venous system of a patient's heart. As described in that patent application, a mitral valve therapy device is placed within the coronary sinus adjacent to the mitral valve annulus of the patient's heart. The effectiveness of the device in reducing mitral valve regurgitation is evaluated, and arterial perfusion of the heart is assessed. Depending on the outcome of the evaluation and assessment, the position of the device may require adjustment or the device may have to be removed. Removal of the device may be advisable, for example, if exchange to a device of different dimension would be more appropriate for that patient.


SUMMARY OF THE INVENTION

The present invention provides a mitral valve therapy device that reshapes the mitral valve annulus. One aspect of the invention is a device for modifying the shape of a mitral valve annulus, including a connector disposed between first and second anchors, the first and second anchors each adapted to be deployed in a coronary sinus adjacent the mitral valve annulus to anchor the device in the coronary sinus; and an actuation element adapted to receive a distally or proximally directed actuation force from an actuator and to transmit the actuation force to the first and second anchors simultaneously to, for example, change the shape of one or both anchors. The device may include a lock adapted to lock the first and second anchors in their deployed configuration, and the lock may be adapted to unlock in response to an unlocking force.


The device may also include a second actuation element adapted to receive a second actuation force from an actuator and to transmit the second actuation force to the first and second anchors simultaneously. The first actuation force may be a proximally directed force and the second actuation force may be a distally directed force, with the first and second actuation elements being adapted to move toward each other in response to the first and second actuation forces. The first and second actuation elements may be a lock adapted to lock the first and second anchors in a deployed configuration.


In some embodiments the device includes an extension extending between the first anchor and the second anchor, with the connector being further adapted to move with respect to the extension in response to the first and second actuation forces. The extension and the connector may each communicate with the first anchor to change the first anchor's shape in response to relative movement between the extension and the connector.


Another aspect of the invention is a system for modifying the shape of a mitral valve annulus including a percutaneous deployment apparatus with an actuator; and a percutaneous mitral valve annuloplasty device including a connector disposed between first and second anchors, the first and second anchors each adapted to be deployed in a coronary sinus adjacent the mitral valve annulus to anchor the device in the coronary sinus; and an actuation element adapted to receive a distally or proximally directed actuation force from the actuator and to transmit the actuation force to the first and second anchors simultaneously to, for example, change the shape of one or both anchors. The device may include a lock adapted to lock the first and second anchors in their deployed configuration, and the lock may be adapted to unlock in response to an unlocking force from an unlocking actuator, such as a tether adapted to deliver a proximally directed unlocking force on the lock.


In some embodiments the actuator is a first actuator and the actuation element of the percutaneous mitral valve annuloplasty device is a first actuation element, and the deployment apparatus further includes a second actuator and the percutaneous mitral valve annuloplasty device further includes a second actuation element adapted to receive an actuation force from the second actuator and to transmit the second actuation force to the first and second anchors simultaneously. The first actuator (e.g., a tether) may be adapted to deliver a proximally directed actuation force and the first actuation element of the mitral valve annuloplasty device may be adapted to receive the proximally directed actuation force. The second actuator (such as a catheter) may be adapted to deliver a distally directed actuation force and the second actuation element of the mitral valve annuloplasty device may be adapted to receive the distally directed actuation force, the first and second actuation elements being adapted to move toward each other in response to the first and second actuation forces. The first and second actuation elements of the mitral valve annuloplasty device form a lock adapted to lock the first and second anchors in a deployed configuration.


In some embodiments the device includes an extension extending between the first anchor and the second anchor, with the connector being further adapted to move with respect to the extension in response to the first and second actuation forces. The extension and the connector may each communicate with the first anchor to change the first anchor's shape in response to relative movement between the extension and the connector.


Yet another aspect of the invention is a method of modifying the shape of a mitral valve annulus including the following steps: inserting a percutaneous mitral valve annuloplasty device into a coronary sinus adjacent to the mitral valve annulus, with the mitral valve annuloplasty device including a connector disposed between first and second anchors; and applying a distally or proximally directed actuation force to the mitral valve annuloplasty device to deploy the first and second anchors simultaneously, e.g., to change the shape of the first anchor or the first and second anchors. In some embodiments the mitral valve annuloplasty device includes a lock, the method further including the step of locking the first and second anchors in a deployed configuration. The method may also include the step of unlocking the first and second anchors, such as by applying a proximally directed force on the lock.


In some embodiments the actuation force is a first actuation force (such as a proximally directed force), with the method further including the step of applying a second actuation force (such as a distally directed force) to the mitral valve annuloplasty device to deploy the first and second anchors simultaneously.


In some embodiments the step of applying an actuation force includes moving a first actuation element of the mitral valve annuloplasty device toward a second actuation element of the mitral valve annuloplasty device. The method in this embodiment may also include locking the first and second actuation elements together to lock the anchors in a deployed configuration and moving the first and second actuation elements apart to unlock the anchors from the deployed configuration.


In some embodiments the applying step includes the step of applying a first actuation force, the method further including the steps of moving the second anchor proximally while the first anchor remains substantially in place within the coronary sinus and applying a second actuation force to further deploy the anchors.


Other aspects of the invention will be understood from the following detailed description.





BRIEF DESCRIPTION OF THE DRAWINGS

The invention, together with further aspects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like reference numerals identify identical elements, and wherein:



FIG. 1 is a superior view of a human heart with the atria removed;



FIG. 2 is a perspective side view illustrating a mitral valve therapy device embodying the present invention during deployment or release; and



FIG. 3 is a perspective side view illustrating the device of FIG. 2 in a fully locked and deployed condition within the coronary sinus of a heart.





DETAILED DESCRIPTION OF THE INVENTION

Referring now to FIG. 1, it is a superior view of a human heart 10 with the atria removed to expose the mitral valve 12, and the coronary sinus 14 of the heart 10. Also generally shown in FIG. 1 are the pulmonary valve 22, the aortic valve 24, and the tricuspid valve 26 of the heart 10.


The mitral valve 12 includes an anterior cusp 16, a posterior cusp 18 and an annulus 20. The annulus encircles the cusps 16 and 18 and maintains their spacing to provide a complete closure during a left ventricular contraction. As is well known, the coronary sinus 14 partially encircles the mitral valve 12 adjacent to the mitral valve annulus 20. As is also known, the coronary sinus is part of the venous system of the heart and extends along the AV groove between the left atrium and the left ventricle. This places the coronary sinus essentially within the same plane as the mitral valve annulus making the coronary sinus available for placement of the mitral valve therapy device of the present invention therein.



FIG. 2 shows a percutaneous mitral valve annuloplasty device 30 embodying the present invention in the coronary sinus 14. As may be noted in FIG. 2, the device 30 includes a distal anchor 34, a connecting member 38, and a proximal anchor 36.


The anchors 34 and 36 and the connecting member 33 may be formed from the same material to provide an integral structure. More specifically, the device 30 may be formed of most any biocompatible material such as stainless steel or Nitinol, a nickel/titanium alloy of the type well known in the art having shape memory. Nitinol may be preferred for its shape memory properties.


As will be further noted from FIG. 2, the connecting member 38 is formed of a rigid coil having a central, longitudinal passage. Through this passage extends a locking extension 42 which extends through the passage from the distal anchor 34. The locking extension 42 forms part of a deployment mechanism which further includes a lock formed from a locking element 44 and an eyelet 46. The locking element 44 is arrowhead-shaped and is dimensioned to be lockingly received by the eyelet 46 as may be seen in FIG. 3.


The deployment mechanism is controlled by a pair of tethers including a first tether 50 and a second tether 52 which extend through an inner deployment catheter 54. Extending over the inner deployment catheter 54 is an outer deployment catheter 56. Tethers 50 and 52 and catheter 54 serve as percutaneous actuators for deploying device 30 to treat mitral valve regurgitation, repositioning device 30 within the coronary sinus, or removing device 30 from the patient.


When the device 30 is to be deployed, a distally directed force is applied through the end of the inner catheter 54 as it is held against eyelet 46. The first tether 50, which is looped through the locking element 44, applies a proximally directed force to locking element 44, as indicated by arrow 60. This pulls the locking element 44 into and through the eyelet 46, and/or pushes eyelet 46 over locking element 44, depending on the relative movements of those elements. Once through the eyelet 46, the locking element 44 self-expands to remain locked by the eyelet 46 as seen in FIG. 3. As the locking element 44, and hence the locking extension 42, is pulled proximally, both the anchors 34 and 36 expand outwardly together and eventually anchor to the coronary sinus 14. The lock formed by locking element 44 and eyelet 46 helps maintain expansion of the anchors against the coronary sinus wall.


The relative sizes of anchors 34 and 36 may be chosen so that neither anchor is firmly lodged against the coronary sinus wall until the lock is locked. Alternatively, the distal anchor 34, proximal anchor 36 and connecting member 38 may be so dimensioned as to be able to anchor the distal anchor 34 in the coronary sinus before the locking element 44 is received by the eyelet 46. This would permit the device 30 to be pulled in a proximal direction after firm engagement of the distal anchor with the coronary sinus but before full deployment of the proximal anchor to cinch the coronary sinus and reshape the mitral valve annulus. The locking element 44 may then be pulled through the eyelet 46 to expand the anchors further to firmly lodge the proximal anchor against the coronary sinus wall and to lock the device in that position.


If after deployment, it is considered prudent to release the device 30 from the coronary sinus for, for example, removal or repositioning of the device 30, the second tether 52, which is looped through the eyelet 46, is pulled in the proximal direction. This causes the eyelet 46 to be pulled over and from the locking element 44. The locking extension 42 will spring back in a distal direction to cause the first anchor 34 and second anchor 36 to contract inwardly together and disengage the coronary sinus 14 together. In this manner, the device 30 is easily and readily released from the coronary sinus for removal or repositioning of the device 30.


The device may be formed from a single piece of Nitinol wire. First, the wire is folded in half to form a coextending wire pair. The wire pair is then coiled at one end to form the eyelet. Then, the wire pair is bent just distal of the eyelet to form the second anchor 36. The wire pair is then tightly coiled distal to the anchor 36 to form the rigidly coiled connecting member 36 having the central, longitudinal passage. Proximal the coiled connecting member 38, the wire pair is again bent to form the first anchor 34. The wire pair is then bent back from the distal anchor 34 and fed through the passage of the connecting member 38. Then the wire is twisted once to form the arrowhead-shaped locking element 44.

Claims
  • 1. A device for modifying the shape of a mitral valve annulus comprising: a connector disposed between first and second anchors, the first and second anchors each adapted to be deployed in a coronary sinus adjacent the mitral valve annulus to anchor the device in the coronary sinus; andan actuation element adapted to receive a distally or proximally directed actuation force from an actuator and to transmit the actuation force to expand the first and second anchors simultaneously.
  • 2. The device of claim 1 wherein the first anchor is further adapted to change shape in response to the actuation force.
  • 3. The device of claim 1 wherein the first and second anchors are each adapted to change shape in response to the actuation force.
  • 4. The device of claim 1 further comprising a lock adapted to lock the first and second anchors in a deployed configuration.
  • 5. The device of claim 4 wherein the lock is further adapted to unlock in response to an unlocking force.
  • 6. The device of claim 4 wherein the lock comprises first and second lock elements, the first anchor and the first lock element being formed from a single wire.
  • 7. The device of claim 4 wherein the actuation element is integral with the lock.
  • 8. The device of claim 1 wherein the first anchor is formed from wire.
  • 9. The device of claim 8 wherein the first anchor is formed in a substantially figure eight configuration.
  • 10. The device of claim 1 wherein the actuation element is a first actuation element, the actuation force is a first actuation force, the device further comprising a second actuation element adapted to receive a second actuation force from an actuator and to transmit the second actuation force to the first and second anchors simultaneously.
  • 11. The device of claim 10 wherein the first actuation force is a proximally directed force and the second actuation force is a distally directed force, the first and second actuation elements being adapted to move toward each other in response to the first and second actuation forces.
  • 12. The device of claim 11 wherein the first and second actuation elements comprise a lock adapted to lock the first and second anchors in a deployed configuration.
  • 13. The device of claim 11 further comprising an extension extending between the first anchor and the second anchor, the connector being further adapted to move with respect to the extension in response to the first and second actuation forces.
  • 14. The device of claim 13 wherein the extension and the connector each communicate with the first anchor to change the first anchor's shape in response to relative movement between the extension and the connector.
  • 15. The device of claim 14 wherein the first anchor is integral with the extension.
  • 16. The device of claim 15 wherein the first anchor is integral with the connector.
  • 17. The device of claim 13 further comprising a lock adapted to lock the first and second anchors in a deployed configuration, wherein the first and second anchors, the lock, the connector and the extension are all formed from a single wire.
  • 18. A system for modifying the shape of a mitral valve annulus comprising: a percutaneous deployment apparatus comprising an actuator; anda percutaneous mitral valve annuloplasty device comprising a connector disposed between first and second anchors, the first and second anchors each adapted to be deployed in a coronary sinus adjacent the mitral valve annulus to anchor the device in the coronary sinus; and an actuation element adapted to receive a distally or proximally directed actuation force from the actuator and to transmit the actuation force to the first and second anchors simultaneously.
  • 19. The device of claim 18 wherein the first anchor is adapted to change shape in response to the actuation force.
  • 20. The device of claim 18 wherein the first and second anchors are each adapted to change shape in response to the actuation force.
  • 21. The device of claim 18 wherein the percutaneous mitral valve annuloplasty device further comprises a lock adapted to lock the first and second anchors in a deployed configuration.
  • 22. The device of claim 21 wherein the lock is further adapted to unlock in response to an unlocking force.
  • 23. The device of claim 22 wherein the deployment apparatus further comprises an unlocking actuator adapted to deliver an unlocking force to the lock.
  • 24. The device of claim 23 wherein the unlocking actuator comprises a tether adapted to deliver a proximally directed unlocking force on the lock.
  • 25. The system of claim 18 wherein the actuator is a first actuator and the actuation element of the percutaneous mitral valve annuloplasty device is a first actuation element, the deployment apparatus further comprising a second actuator and the percutaneous mitral valve annuloplasty device further comprising a second actuation element adapted to receive an actuation force from the second actuator and to transmit the second actuation force to the first and second anchors simultaneously.
  • 26. The system of claim 25 wherein the first actuator is adapted to deliver a proximally directed actuation force and the first actuation element of the mitral valve annuloplasty device is adapted to receive the proximally directed actuation force.
  • 27. The device of claim 26 wherein the first actuator is a tether.
  • 28. The device of claim 26 wherein the second actuator is adapted to deliver a distally directed actuation force and the second actuation element of the mitral valve annuloplasty device is adapted to receive the distally directed actuation force, the first and second actuation elements being adapted to move toward each other in response to the first and second actuation forces.
  • 29. The device of claim 28 wherein the second actuator is a catheter.
  • 30. The device of claim 28 wherein the first and second actuation elements of the mitral valve annuloplasty device comprise a lock adapted to lock the first and second anchors in a deployed configuration.
  • 31. The device of claim 28 further comprising an extension extending between the first anchor and the second anchor, the connector being further adapted to move with respect to the extension in response to the first and second actuation forces.
  • 32. The device of claim 31 wherein the extension and the connector each communicate with the first anchor to change the first anchor's shape in response to relative movement between the extension and the connector.
CROSS-REFERENCE

This application claims the benefit of U.S. Provisional Application No. 60/476,870, filed Jun. 5, 2003, which application is incorporated herein by reference.

US Referenced Citations (175)
Number Name Date Kind
3995623 Black et al. Dec 1976 A
4055861 Carpentier et al. Nov 1977 A
4164046 Cooley Aug 1979 A
4485816 Krumme Dec 1984 A
4550870 Krumme et al. Nov 1985 A
4588395 Lemelson May 1986 A
4830023 de Toledo et al. May 1989 A
5061277 Carpentier et al. Oct 1991 A
5250071 Palermo Oct 1993 A
5261916 Engelson Nov 1993 A
5265601 Mehra Nov 1993 A
5350420 Cosgrove et al. Sep 1994 A
5441515 Khosravi et al. Aug 1995 A
5474557 Mai Dec 1995 A
5514161 Limousin May 1996 A
5554177 Kieval et al. Sep 1996 A
5562698 Parker Oct 1996 A
5584867 Limousin et al. Dec 1996 A
5601600 Ton Feb 1997 A
5676671 Inoue Oct 1997 A
5733325 Robinson et al. Mar 1998 A
5824071 Nelson et al. Oct 1998 A
5891193 Robinson et al. Apr 1999 A
5895391 Farnholtz Apr 1999 A
5899882 Waksman et al. May 1999 A
5908404 Elliot Jun 1999 A
5928258 Khan et al. Jul 1999 A
5935161 Robinson et al. Aug 1999 A
5961545 Lentz et al. Oct 1999 A
5978705 KenKnight et al. Nov 1999 A
5984944 Forber Nov 1999 A
6015402 Sahota Jan 2000 A
6027517 Crocker et al. Feb 2000 A
6077295 Limon et al. Jun 2000 A
6077297 Robinson et al. Jun 2000 A
6096064 Routh Aug 2000 A
6099549 Bosma et al. Aug 2000 A
6099552 Adams Aug 2000 A
6129755 Mathis et al. Oct 2000 A
6171320 Monassevitch Jan 2001 B1
6190406 Duerig et al. Feb 2001 B1
6210432 Solem et al. Apr 2001 B1
6254628 Wallace et al. Jul 2001 B1
6275730 KenKnight et al. Aug 2001 B1
6342067 Mathis et al. Jan 2002 B1
6345198 Mouchawar et al. Feb 2002 B1
6352553 van der Burg et al. Mar 2002 B1
6352561 Leopold et al. Mar 2002 B1
6358195 Green et al. Mar 2002 B1
6395017 Dwyer et al. May 2002 B1
6402781 Langberg et al. Jun 2002 B1
6419696 Ortiz et al. Jul 2002 B1
6442427 Boute et al. Aug 2002 B1
6503271 Duerig et al. Jan 2003 B2
6537314 Langberg et al. Mar 2003 B2
6569198 Wilson et al. May 2003 B1
6589208 Ewers et al. Jul 2003 B2
6602288 Cosgrove et al. Aug 2003 B1
6602289 Colvin et al. Aug 2003 B1
6623521 Steinke et al. Sep 2003 B2
6626899 Houser et al. Sep 2003 B2
6629534 St. Goar et al. Oct 2003 B1
6629994 Gomez et al. Oct 2003 B2
6643546 Mathis et al. Nov 2003 B2
6656221 Taylor et al. Dec 2003 B2
6709425 Gambale et al. Mar 2004 B2
6716158 Raman et al. Apr 2004 B2
6718985 Hlavka et al. Apr 2004 B2
6723038 Schroeder et al. Apr 2004 B1
6733521 Chobotov et al. May 2004 B2
6764510 Vidlund et al. Jul 2004 B2
6776784 Ginn Aug 2004 B2
6790231 Liddicoat et al. Sep 2004 B2
6793673 Kowalsky et al. Sep 2004 B2
6797001 Mathis et al. Sep 2004 B2
6800090 Alferness et al. Oct 2004 B2
6810882 Langberg et al. Nov 2004 B2
6824562 Mathis et al. Nov 2004 B2
6908478 Alferness et al. Jun 2005 B2
6949122 Adams et al. Sep 2005 B2
6960229 Mathis et al. Nov 2005 B2
6964683 Kowalsky et al. Nov 2005 B2
6966926 Mathis Nov 2005 B2
20010018611 Solem et al. Aug 2001 A1
20010044568 Langberg et al. Nov 2001 A1
20010049558 Liddicoat et al. Dec 2001 A1
20020016628 Langberg et al. Feb 2002 A1
20020035361 Houser et al. Mar 2002 A1
20020042621 Liddicoat et al. Apr 2002 A1
20020042651 Liddicoat et al. Apr 2002 A1
20020049468 Streeter et al. Apr 2002 A1
20020055774 Liddicoat May 2002 A1
20020065554 Streeter May 2002 A1
20020087173 Alferness et al. Jul 2002 A1
20020095167 Liddicoat et al. Jul 2002 A1
20020103533 Langberg et al. Aug 2002 A1
20020138044 Streeter et al. Sep 2002 A1
20020151961 Lashinski et al. Oct 2002 A1
20020169502 Mathis Nov 2002 A1
20020183835 Taylor et al. Dec 2002 A1
20020183836 Liddicoat et al. Dec 2002 A1
20020183837 Streeter et al. Dec 2002 A1
20020183838 Liddicoat et al. Dec 2002 A1
20020183841 Cohn et al. Dec 2002 A1
20030004572 Goble et al. Jan 2003 A1
20030018358 Saadat Jan 2003 A1
20030069636 Solem et al. Apr 2003 A1
20030078465 Pai et al. Apr 2003 A1
20030078654 Taylor et al. Apr 2003 A1
20030083538 Adams et al. May 2003 A1
20030083613 Schaer May 2003 A1
20030088305 Van Schie et al. May 2003 A1
20030105520 Alferness et al. Jun 2003 A1
20030130730 Cohn et al. Jul 2003 A1
20030130731 Vidlund et al. Jul 2003 A1
20030135267 Solem et al. Jul 2003 A1
20030144697 Mathis et al. Jul 2003 A1
20030171776 Adams et al. Sep 2003 A1
20030212453 Mathis et al. Nov 2003 A1
20030236569 Mathis et al. Dec 2003 A1
20040010305 Alferness et al. Jan 2004 A1
20040019377 Taylor et al. Jan 2004 A1
20040039443 Solem et al. Feb 2004 A1
20040073302 Rourke et al. Apr 2004 A1
20040098116 Callas et al. May 2004 A1
20040102839 Cohn et al. May 2004 A1
20040111095 Gordon et al. Jun 2004 A1
20040127982 Machold et al. Jul 2004 A1
20040133220 Lashinski et al. Jul 2004 A1
20040133240 Adams et al. Jul 2004 A1
20040133273 Cox Jul 2004 A1
20040138744 Lashinski et al. Jul 2004 A1
20040148019 Vidlund et al. Jul 2004 A1
20040148020 Vidlund et al. Jul 2004 A1
20040148021 Cartledge et al. Jul 2004 A1
20040153147 Mathis Aug 2004 A1
20040158321 Reuter et al. Aug 2004 A1
20040176840 Langberg Sep 2004 A1
20040193191 Starksen et al. Sep 2004 A1
20040193260 Alferness et al. Sep 2004 A1
20040220654 Mathis et al. Nov 2004 A1
20040220657 Nieminen et al. Nov 2004 A1
20040243227 Starksen et al. Dec 2004 A1
20040249452 Adams et al. Dec 2004 A1
20040260342 Vargas et al. Dec 2004 A1
20050010240 Mathis et al. Jan 2005 A1
20050021121 Reuter et al. Jan 2005 A1
20050027351 Reuter et al. Feb 2005 A1
20050027353 Alferness et al. Feb 2005 A1
20050033419 Alferness et al. Feb 2005 A1
20050038507 Alferness et al. Feb 2005 A1
20050065598 Mathis et al. Mar 2005 A1
20050096666 Gordon et al. May 2005 A1
20050119673 Gordon et al. Jun 2005 A1
20050137449 Nieminen et al. Jun 2005 A1
20050137450 Aronson et al. Jun 2005 A1
20050137451 Gordon et al. Jun 2005 A1
20050137685 Nieminen et al. Jun 2005 A1
20050149179 Mathis et al. Jul 2005 A1
20050149180 Mathis et al. Jul 2005 A1
20050149182 Alferness et al. Jul 2005 A1
20050177228 Solem et al. Aug 2005 A1
20050187619 Mathis et al. Aug 2005 A1
20050197692 Pai et al. Sep 2005 A1
20050197693 Pai et al. Sep 2005 A1
20050197694 Pai et al. Sep 2005 A1
20050209690 Mathis et al. Sep 2005 A1
20050216077 Mathis et al. Sep 2005 A1
20050222678 Lashinski et al. Oct 2005 A1
20050261704 Mathis et al. Nov 2005 A1
20050272969 Alferness et al. Dec 2005 A1
20060020335 Kowalsky et al. Jan 2006 A1
20060030882 Adams et al. Feb 2006 A1
20060142854 Alferness et al. Jun 2006 A1
20060191121 Gordon Aug 2006 A1
Foreign Referenced Citations (37)
Number Date Country
0893133 Jan 1999 EP
0903110 Mar 1999 EP
0968688 Jan 2000 EP
1050274 Nov 2000 EP
1095634 May 2001 EP
0741604 Dec 1955 GB
WO 9856435 Dec 1998 WO
WO 0044313 Aug 2000 WO
WO 0060995 Oct 2000 WO
WO 0060995 Oct 2000 WO
WO 0074603 Dec 2000 WO
WO 0100111 Jan 2001 WO
WO0130248 May 2001 WO
WO 0150985 Jul 2001 WO
WO 0154618 Aug 2001 WO
WO 0187180 Nov 2001 WO
WO 0200099 Jan 2002 WO
WO 0201999 Jan 2002 WO
WO 0205888 Jan 2002 WO
WO 0219951 Mar 2002 WO
WO 0234118 May 2002 WO
WO 0247539 Jun 2002 WO
WO 02053206 Jul 2002 WO
WO 02060352 Aug 2002 WO
WO 02062263 Aug 2002 WO
WO 02062270 Aug 2002 WO
WO 02062408 Aug 2002 WO
WO 02076284 Oct 2002 WO
WO 02078576 Oct 2002 WO
WO 02096275 Dec 2002 WO
WO 03015611 Feb 2003 WO
WO 03049647 Jun 2003 WO
WO 03059198 Jul 2003 WO
WO 03063735 Aug 2003 WO
WO 2004045463 Jun 2004 WO
WO2004084746 Oct 2004 WO
WO 2005046531 May 2005 WO
Related Publications (1)
Number Date Country
20050004667 A1 Jan 2005 US
Provisional Applications (1)
Number Date Country
60476870 Jun 2003 US