Various aspects of the present disclosure relate generally to devices and methods for delivering agents. More specifically, in embodiments, the present disclosure relates to devices for delivery of powdered agents, such as hemostatic agents.
In certain medical procedures, it may be necessary to stop or minimize bleeding internal to the body. For example, an endoscopic medical procedure may require hemostasis of bleeding tissue within the gastrointestinal tract, for example in the esophagus, stomach, or intestines.
During an endoscopic procedure, a user inserts a sheath of an endoscope into a body lumen of a patient. The user utilizes a handle of the endoscope to control the endoscope during the procedure. Tools are passed through a working channel of the endoscope via, for example, a port in the handle, to deliver treatment at the procedure site near a distal end of the endoscope. The procedure site is remote from the operator.
To achieve hemostasis at the remote site, a hemostatic agent may be delivered by a device inserted into the working channel of the endoscope. Agent delivery may be achieved through mechanical systems, for example. Such systems, however, may require numerous steps or actuations to achieve delivery, may not achieve a desired rate of agent delivery or a desired dosage of agent, may result in the agent clogging portions of the delivery device, may result in inconsistent dosing of agent, or may not result in the agent reaching the treatment site deep within the GI tract. The current disclosure may solve one or more of these issues or other issues in the art.
Each of the aspects disclosed herein may include one or more of the features described in connection with any of the other disclosed aspects.
In one example, a device for delivering an agent may comprise a chamber for receiving agent through an agent inlet; and a body received within the chamber. The body may be movable in first and second directions along a longitudinal axis of the chamber. In a first configuration of the body, an amount of the agent may flow into the chamber via the agent inlet. In a second configuration of the body, the agent may be prevented from flowing into the chamber via the agent inlet. When the body is transitioned from the first configuration to the second configuration, the amount of the agent may be moved from a first position along the longitudinal axis of the chamber to a second position along the longitudinal axis of the chamber.
Any of the devices described herein may have any of the following features. When the body is in the second configuration, fluid may flow into the chamber via a fluid inlet and combines with the amount of the agent. The fluid inlet may be located between (a) an outlet for delivering the fluid combined with the amount of the agent from the chamber and (b) the agent inlet. A spring may be attached to the body. The body may transition from the first configuration to the second configuration due to a restorative force of the spring. The device may include a yoke and at least one track for receiving the yoke. In the first configuration, the yoke may contact the body. The body may transition from the first configuration to the second configuration when the yoke ceases contacting the body. A gear may have gear teeth, wherein the body includes body teeth for mating with the gear teeth. Only a portion of a circumference of the gear may include gear teeth, and wherein the body transitions from the first configuration to the second configuration when the gear teeth do not engage with the body teeth. An arm may have a finger and a guide may have a protrusion. The body may transition from the first configuration to the second configuration when the finger contacts the protrusion. A source of agent may be coupled to the body. The chamber is a first chamber, further comprising a second chamber, wherein the body defines a body opening, wherein, in the first configuration, the body opening is in fluid communication with the agent inlet, and wherein, in the second configuration, the body opening is in not in fluid communication with the agent inlet and is in fluid communication with a chamber opening between the first chamber and the second chamber. The body may be connected to an arm via a hinge. The arm may be connected to a trigger. Depressing the trigger may cause the arm to pivot and cause the body to move in the first direction. Releasing the trigger may cause the arm to pivot and cause the body to move in the second direction, transitioning the body from the first configuration to the second configuration. The chamber opening may be proximal of the agent inlet.
In another example, a device for delivering an agent may comprise: a source of agent; a mixing chamber in fluid communication with the source of agent via an agent inlet; and a body received within the mixing chamber and movable between a first configuration and a second configuration. In the first configuration, a distal end of the body is proximal of the agent inlet, and the agent flows from the agent inlet into the mixing chamber. When the body is transitioned from the first configuration to the second configuration, the distal end of the body may push the agent distally toward a fluid inlet. In the second configuration, the distal end of the body may be distal to the agent inlet and proximal of the fluid inlet, such that the agent is permitted to mix with fluid received form the fluid inlet.
Any of the devices described herein may have any of the following features. The body may be attached to a spring. A restoring force of the spring may cause the body to transition from the first configuration to the second configuration.
In another example, a device for delivering an agent may comprise a first chamber in fluid communication with an agent inlet; a second chamber in fluid communication with a fluid inlet; and a wall formed between the first chamber and the second chamber. The wall may define a chamber opening between the first chamber and the second chamber. A body may be received within the first chamber and define a body opening. The body may be configured to be transitioned from a first configuration, in which the body opening is in fluid communication with the agent inlet and not in fluid communication with the chamber opening, to a second configuration, in which the body opening is in fluid communication with the chamber opening and not in fluid communication with the agent inlet.
Any of the devices disclosed herein may have any of the following features. The body may be connected to a pivotable arm via a hinge. The pivotable arm may be connected to a trigger. The trigger may be operative to control a flow of fluid through the fluid inlet.
It may be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed. As used herein, the terms “comprises,” “comprising,” or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements, but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. The term “distal” refers to a direction away from an operator, and the term “proximal” refers to a direction toward an operator. The term “exemplary” is used in the sense of “example,” rather than “ideal.” The term “approximately,” or like terms (e.g., “substantially”), includes values+/−10% of a stated value.
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate aspects of the present disclosure and together with the description, serve to explain the principles of the disclosure.
Embodiments of this disclosure relate to a metering/actuation mechanism to deliver an agent (e.g., a powdered agent) from a delivery system to a site of a medical procedure. The actuation mechanism may deliver a predetermined amount of powder or particles in a desired form to be propelled by, or combined with, a fluid, for delivery to a treatment site.
A combination of agent and fluid may be delivered from outlet 34 of body 12. As used herein, the terms “distal”/“first direction” may refer to a direction toward outlet 34, and the terms “proximal”/“second direction” may refer to the opposite direction. Outlet 34 may be in fluid communication with a catheter 36 or other component for delivering the combination of agent and fluid to a desired location within a body lumen of a patient.
Body 112 may include a protrusion 122, which may define a lumen 124 in fluid communication with lumen 114 via an opening 126. An end of lumen 124 opposite opening 126 may define a fluid inlet 120. Protrusion 112 may be configured to be connected to a source of fluid. For example, protrusion 112 may include ridges, grooves, or other features to facilitate connection with a source of fluid. When a source of fluid is connected to protrusion 112, the source of fluid may be in fluid communication with fluid inlet 120, lumen 124, opening 126, lumen 114, and outlet 134.
Body 112 may also include a receptacle 140, which may be defined by walls 142 that protrude radially outward from body 112 in a direction perpendicular to a longitudinal axis of lumen 114. Receptacle 140 may be in fluid communication with lumen 114 via an agent inlet 118. Receptacle 140 of body 112 may be configured to receive a enclosure 14 (or other source) storing an agent 16 (
Enclosure 14 may have an opening 141 formed at an end of enclosure 14 received by receptacle 142. Enclosure 14 includes threads, grooves, ridges, or other structures for mating with corresponding features of walls 142 or other portions of body 112. For example, enclosure 14 may be screwed into receptacle 140. When enclosure 14 is received in receptacle 140, enclosure 14 may be in fluid communication with lumen 114 via opening 141 and agent inlet 118.
Moving longitudinally along lumen 114 from first end 116 of body 112 to second end 117 of body 112, agent inlet 118 may be closest to first end 116. Fluid inlet 120 may be between agent inlet 118 and outlet 134. Agent outlet 134 may be at second end 117. Agent inlet 118 and fluid inlet 120 may be offset from one another along a perimeter of lumen 114. For example, agent inlet 118 and fluid inlet 120 may be opposite one another (e.g., diametrically opposed to one another), in addition to being longitudinally offset from one another. Alternatively, agent inlet 118 and fluid inlet 120 may be aligned along a longitudinal line extending axially down an outside of body 112 (i.e., on the same side of body 112, with no circumferential offset).
A plunger or other body 150 may be slidably received within lumen 114. The combination of plunger 150 and body 112 (including lumen 114) may function like a syringe. Plunger 150 may be slidable along an entire length of lumen 114 that has a cross-sectional width large enough to receive plunger 150. For example, plunger 150 may be slidable from the portion of lumen 114 near first end 116 up until tapering walls of body 112 near outlet 134 prevent further advancement of plunger 150. Surfaces defining lumen 114 may alternatively have protrusions (not shown) extending into lumen 114 that prevent passage of plunger 150 past the protrusions. For example, such a protrusion may extend into lumen 114 proximally of fluid inlet 120/opening 126 to prevent plunger 150 from moving distally past fluid inlet 120/opening 126.
In the second configuration (
An operation of metering assembly 100 will now be described.
Plunger 150 may then be transitioned to the second configuration (
Then, plunger 150 may be transitioned back to the first configuration (
Flow of fluid through fluid inlet 120 may be controlled by a valve, such as a button valve (not shown). The same actuation mechanism (e.g., actuation mechanism 30) may control both movement of plunger 150 and the valve, or separate actuation mechanisms may be used. For example, actuation mechanism 30 (e.g., a trigger) may be configured to transition plunger 150 to the second configuration (
Fluid inlet 120 may have features to prevent flow of agent 16 from lumen 114 into fluid inlet 120. For example, a filter or sieve of appropriate size may be disposed in lumen 114, opening 126, or fluid inlet 120, which prevents agent 16 from flowing through the filter or sieve. Additionally or alternatively, an orientation of fluid inlet 120 may be such that gravity prevents agent 16 from flowing into fluid inlet 120. For example, fluid inlet 120 may be above opening 126, or opening 126 may be formed in a top surface of body 112. The terms above, top, etc. may refer to an orientation with respect to the force of gravity, rather than an orientation depicted in the Figures.
A venting hole (not shown) may be formed in body 112 to allow air to flow into lumen 114 as plunger 150 is pulled proximally, to prevent formation of vacuum effects in lumen 114 due to movement of plunger 150, which may have a sealed contact with surfaces defining lumen 114. Such a venting hole may prevent suction effects in catheter 36 (
As described above,
Runners 214 may be disposed at an end of arms 206, 208 opposite the ends connected to spring 210. Runners 214 may be configured to be received within tracks 202. Tracks 202 may include openings (not shown) that receive arms 206, 208. Runners 214 may project outward perpendicularly to longitudinal axes of arms 206, 208, to retain runners 214 in tracks 202. Runners 214 may be wider than the openings, to prevent arms 206, 208 from disengaging from tracks 202.
Arms 206, 208 may also include tabs 216 for contacting plunger 250. Tabs 216 may project from arms 206, 208, toward the other of arms 206, 208. Tabs 216 may be disposed near runners 214. Arms 206, 208 may each be formed of a single, unitary piece of material, including runners 214 and tabs 216. Alternatively, runners 214 and/or tabs 216 may be formed of another material and fixed to arms 206, 208.
As shown in
Runners 214 may be slidably disposed in tracks 222, 224, so that runners 214 may slidably move proximally and distally along tracks 222, 224. Runners 214 may be retained within tracks 222, 224 by any suitable mechanism. For example, tracks 222, 224 may have walls that retain runners 214.
A spring 220 may extend from a proximal end of plunger 250 (e.g., near flange 244). Spring 220 may be fixedly coupled to plunger 250 and to another surface of delivery system 100, proximal to plunger 250.
As shown in
Activation of actuation mechanism 30 (e.g., a trigger or lever) may cause yoke 204 to move in the second direction (the proximal direction), riding along tracks 222, 224. For example, yoke 204 may be mounted in a structure (not shown) such as a lever or a trigger, which may be activated/pulled by a hand or finger squeeze. Pivot pins 211 may be used to mount yoke 204 to the structure such that arms 206, 208 may pivot about pivot pins 211. Tabs 216 may exert a force on flange 244 or another portion of plunger 250 in the second direction (the proximal direction). The force of tabs 216 on plunger 250 may cause plunger 250 to move in the second direction, along with yoke 204. Plunger 250 may exert a force on spring 220, causing spring 220 to compress. As plunger 250 moves proximally, agent 16 may begin to flow through agent inlet 118, as described above with respect to
When yoke 204 reaches inflection point X, arms 206, 208 of yoke 204 may begin to separate from one another and pivot about pivot pins 11. When arms 206, 208 are sufficiently separated, tabs 216 will cease contacting flange 244 or another portion of plunger 250, as shown in
When actuation mechanism 30 is released, yoke 204 may move in the first direction (distally). Runners 214 may ride tracks 222, 224 in the first direction. Spring 210 may expand, returning to its natural length. Yoke 204 may then re-engage with plunger 250. For example, tabs 216 may be flexible or bendable only in the second direction and include shape memory material or a spring, so that, as tabs 216 pass flange 244 of plunger 250, tabs 216 are temporarily pressed against arms 206, 208, until tabs 216 are past flange 244 of plunger 250. Tabs 216 may then return to their expanded configuration due to shape memory properties or a spring. Tabs 216 may then engage with plunger 250, distally of flange 244 or another portion of plunger 250. Alternatively or additionally, a geometry of yoke 204 and plunger 250 may be such that tabs 216 may slip past flange 244. Once tabs 216 engage with plunger 250, actuation assembly 200 may again be in the first configuration of
Plunger 350 may include teeth 360, which are configured to engage with teeth of toothed portion 304. As shown in
Gear 302 may be disposed on an opposite side of body 140 (
A protruding portion 346 of plunger 350 near distal portion 342 of plunger 350 and proximal to a tapered tip 344 of plunger 350 may have a larger cross section than a remainder of plunger 350 proximal to protruding portion 346. Protruding portion 346 may include a recess 348. Recess 348 may receive a seal 362, such as an O-ring seal. Seal 362 may prevent undesired movement of agent 16 or fluid. Alternatively, other portions of protruding portion 346 or plunger 350 may receive a seal. Although one protruding portion 346 and seal 362 is shown, plunger 350 may include other protruding portions and seals (e.g., proximally of teeth 360). Positioning of seal(s) may be chosen so as to facilitate the flow of agent 16 and fluid, as described with respect to
Before a user activates actuation mechanism 30, plunger 350 may be in the configuration shown in
When a user activates actuation mechanism 30, gear 302 may begin to rotate about its axis. Toothed portion 304 may engage with teeth 360, exerting a force on plunger 350 in the second (proximal) direction, causing plunger 350 to move in the second (proximal) direction. As plunger 350 moves in the second direction, it may compress spring 320, which may exert a restorative force on plunger 350 in the first direction. Plunger 350 may continue to move in the second direction until it reaches the configuration of
As gear 302 continues to rotate, a last tooth of toothed portion 304 may disengage from teeth 360, and smooth portion 306 may face plunger 350. As shown in
After actuation mechanism 30 is released, gear 302 may return to a configuration in which toothed portion 304 is ready to engage with teeth 360. For example, a ratcheting mechanism may be used to position gear 302 in the configuration of
Actuation assembly 400 may include an arm 402. Arm 402 may have a finger 404 projecting substantially perpendicularly from a longitudinal axis of arm 402. Finger 404 may be configured to engage with a surface of plunger 450. For example, plunger 450 may include a flange 444 on a proximalmost end of plunger 444. Finger 404 may be positioned distally of flange 444, so that when arm 402 moves proximally, it engages with and exerts a force on flange 444, pulling plunger 450 proximally. Arm 402 may be attached to an actuation mechanism, such as actuation mechanism 30, which may include a trigger, lever, or other structure. When actuation mechanism 30 is activated, arm 402 may move in the second direction, via, e.g., the trigger or lever.
Actuation assembly 400 may also include a guide 410. Guide 410 may be an elongated member extending along a longitudinal axis, or may be a surface of body 112. Guide 410 may extend generally parallel to arm 402. Guide 410 may include a protrusion 412, which may extend toward arm 402. Protrusion 412 may have rounded surfaces, as shown in
A spring 460 may be fixed to a portion of arm 402, such as a portion of arm 402 near finger 404. As discussed in further detail below, spring 460 may be configured to deliver a force in a direction that is transverse to a longitudinal axis of plunger 450 and/or guide 410. A spring 420 may be fixed to a proximal end of plunger 450 and may have any of the qualities of springs 220, 320, described above.
In operation, before a user activates actuation mechanism 30, actuation assembly 400 may be in the first configuration of
A user may activate actuation mechanism 30, causing arm 402 to move in the second direction (proximally), as described above. Fluid may begin flowing through fluid inlet 120, or a flow of fluid may be delayed until a time described below. As arm 402 moves in the second direction, finger 404 may contact flange 444 (or another portion of plunger 450), exerting a force on plunger 450 in the second direction. Plunger 450 may move in the second direction, along with arm 402. As plunger 450 moves in the first direction, plunger 450 may compress spring 420. Movement of arm 402 may also compress spring 460, if spring 460 is aligned such that a component of spring 460 extends parallel to arm 402, as shown in the Figures. Initially, guide 410, including protrusion 412, may not interfere with movement of arm 402. As plunger 450 moves proximally past agent inlet 118, agent 16 may begin to flow through agent inlet 118.
When finger 404 encounters protrusion 412 of guide 410, protrusion 412 may exert a force on finger 404 that causes finger 404 to move in a direction that is transverse to a longitudinal axis of plunger 450 (a direction that is at least partially downward in the figures). As shown in
A restoring force of spring 420 may cause plunger 450 to move in the first (distal) direction (to the left in the Figures). Plunger 450 may contact agent 16 that has passed through agent inlet 18, pushing agent 16 distally toward fluid inlet 120 until spring 420 is at its natural length again (e.g., when a position of plunger 450 corresponds to a position of plunger 150 in
A first lumen or chamber 546 may be formed in body 512. First lumen 546 may be in fluid communication with an outlet, such as outlet 34. A nozzle 544 may include an opening 545. An interior chamber of nozzle 544 may be in fluid communication with first lumen 546 via opening 545. Nozzle 544 may be disposed within first lumen 546 or may otherwise be in communication with first lumen 546. Nozzle 544 may receive fluid from an inlet (e.g., fluid inlet 120). A flow of fluid into nozzle 544 may be controlled by a valve 540, such as a button valve, which may control passage of fluid into passage 542 which is in fluid communication with nozzle 544. Valve 540 may be opened by depressing a trigger 548. Trigger 548 may compress a spring 550, which may exert a force on a button 552, which may open valve 540.
Trigger 548 may also be connected to an arm 560, which may be pivotable about a point Y. Arm 560 may be connected to a slider, piston, plunger, or other body 562, via a hinge or similar structure. An opening 564 may be formed in slider 562. Slider 562 may be slidably received within a second lumen or chamber 514 of body 512. Second lumen 514 may have a longitudinal axis that extends parallel or approximately parallel to a longitudinal axis of first lumen or chamber 546. Second lumen 514 may be in fluid communication with enclosure 14, via an agent inlet 518. A wall 572 may separate first lumen 546 from second lumen 514. An opening 570 may be formed in wall 572, placing first lumen 546 in fluid communication with second lumen 514. Opening 570 may be longitudinally aligned with or approximately aligned with opening 545 of nozzle 544. Opening 570 may be proximal to agent inlet 518.
When trigger 548 is depressed or released, arm 560 may rotate about point Y. Slider 562 may, via its pivoting connection with arm 560, move in the second direction (proximally) or in the first direction (distally). In some configurations (
Delivery system 10 may optionally be shipped with metering assembly 500 in the first configuration, with trigger 548 depressed via a collar or other mechanism, compressing spring 550. Thus, delivery system 10 may optionally be shipped with a dose of agent 16 disposed within opening 564. Prior to use (e.g., prior to connection with a source of pressurized fluid), a user may remove the collar, which may result in spring 550 returning to a natural length, returning trigger 548 to an undepressed state, and transitioning metering assembly 500 to the second configuration of
In both the first configuration and the second configuration, enclosure 14 may not be in fluid communication with nozzle 544 (which is a source of fluid). Agent 16 may be shuttled via opening 564, but opening 564 and other components of metering assembly 500 may be configured so that enclosure 14 is never in fluid communication with a source of fluid (e.g., nozzle 544).
Alternatively, delivery system 10 may be shipped in the second configuration, with trigger 548 undepressed, and no agent may be received within opening 564. A user may depress trigger 548 so as to initially place metering assembly 500 in the first configuration to cause a dose of agent 16 to enter opening 564, as described above. For example, the user may transition metering assembly 500 to the first configuration prior to connecting delivery system 10 to a source of fluid, so that fluid is prevented from flowing when trigger 548 is depressed. Alternatively, if the fluid source is connected to delivery system 10 prior to the first transition of metering assembly 500 to the first configuration, a flow of fluid without agent 16 may pass through outlet 34 when metering assembly 500 is transitioned to the first configuration (depressing of trigger 548 causes opening of valve 540, as discussed above). Trigger 548 may then be released to transition metering assembly 500 to the second configuration and to shuttle a dose of agent 16 into first lumen 546, as described above.
As a further alternative, a valve (not shown) may be present in lumen 546 (e.g., near outlet 34). The valve may prevent flow of agent 16 past the valve. During manufacture, trigger 548 may be depressed once and then released (transitioning metering assembly 500 to the first configuration and then back to the second configuration), causing a dose of agent 16 to be present in lumen 546. The dose of agent 16 may be prevented from exiting outlet 34 until depressing of trigger 548 by a user causes a flow of fluid, as described in further detail below. A flow of fluid may cause the valve to open.
Once a dose of agent 16 is deposited within lumen 546, as a result of the actions described above, a user may depress trigger 548 while delivery system 10 is connected to a source of fluid, placing metering assembly 500 into the first configuration (
In
Metering assembly 600 may include a body 612, which may have any of the properties of bodies 12, 112, 512, above. Body 612 may be configured to receive enclosure 14, by any of the mechanisms described above with respect to bodies 12, 112, 512. A first lumen or chamber 614 may be formed in body 612. A longitudinal axis of lumen 614 may extend substantially perpendicularly to a longitudinal axis of enclosure 14.
A plunger 650 may be slidably received within lumen 614. Plunger 50 may include a hole 664 formed therein. A longitudinal axis of hole 664 may extend substantially parallel to a longitudinal axis of enclosure 14, and substantially perpendicularly to a longitudinal axis of lumen 614. Hole 664 may extend through an entirety of plunger 650, substantially perpendicularly to a longitudinal axis of plunger 650. Seals 668 may be disposed about an outer perimeter of plunger 650. Each seal 668 may be fitted, for example, about a groove 670 formed on an outer surface of plunger 650. Seals 668 may have properties (e.g., material and dimensions) such that plunger 650 is slidable within lumen 614 but fluids, agent 16, or other materials may not pass between seals 668 and a surface that defines lumen 614.
Plunger 650 may be moved from a first configuration (see
Trigger 648 may be operative to control a flow of fluid, as described in further detail below. For example, a valve 640 may have any of the properties of valve 540. Valve 640 may be opened by depressing trigger 648. Trigger 648 may compress a spring 651, which may exert a force on a button 652, which may open valve 640.
Metering assembly 600 may also include a mixing assembly 680 to facilitate mixing of agent 16 with fluid. Mixing assembly 600 may include a first nozzle 682 which receives fluid from a fluid inlet 620. Fluid inlet 620 may be in fluid communication with a passage 642 extending from valve 640. Valve 640 may control fluid flow through fluid inlet 620. Fluid may pass from fluid inlet 620, into nozzle 682, and into a mixing chamber 684. Mixing chamber 684 may be in fluid communication with lumen 614 via a passage 692, depending upon a position of plunger 650, as discussed below. As discussed in further detail below, fluid from fluid inlet 620 and agent 16 may combine together in mixing chamber 684. The combined fluid and agent 16 may pass through a second nozzle 686 in order exit at outlet 634.
In operation, when trigger 648 is not depressed by an operator, plunger 650 may be in the position shown in
Depressing trigger 648 may cause fluid to flow through valve 640, and through fluid inlet 620. Depressing trigger 648 may also cause plunger 650 to transition to the configuration shown in
As with the first configuration (
Components of metering assembly 600, including trigger 648, plunger 650, and valve 640, may be configured so as to appropriately time a release of agent 16 and/or fluid into mixing chamber 684. For example, fluid may flow through fluid inlet 620 before, after, or simultaneously to the initial flow of agent 16 into mixing chamber 684.
In an alternative, when trigger 648 is not depressed, plunger 650 may be in a configuration such that opening 664 is not aligned with and in fluid communication with agent inlet 618. For example, plunger 650 may be displaced to the right of where it is shown in
While principles of the present disclosure are described herein with reference to illustrative examples for particular applications, it should be understood that the disclosure is not limited thereto. Those having ordinary skill in the art and access to the teachings provided herein will recognize additional modifications, applications, and substitution of equivalents all fall within the scope of the examples described herein. Accordingly, the invention is not to be considered as limited by the foregoing description.
This application claims the benefits of priority to U.S. Provisional Patent Application No. 62/957,519, filed Jan. 6, 2020, the entirety of which is incorporated herein by reference.
Number | Date | Country | |
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62957519 | Jan 2020 | US |