Claims
- 1. A method for detecting an analyte, comprising the steps of:
(a) providing a surface adapted for SERS and SPR measurements; (b) providing at least one analyte associated with said surface; and (c) detecting at least one SPR spectral feature and at least one SERS spectral feature characteristic of said analyte.
- 2. The method of claim 1, wherein said surface has at least one enhancing structure thereon.
- 3. The method of claim 1, wherein said surface has a metal layer thereon.
- 4. The method of claim 2, wherein said enhancing structure comprises a nanoparticle structure.
- 5. The method of claim 4, wherein said nanoparticle structure is a fractal structure.
- 6. The method of claim 2, wherein said enhancing structure comprises a metal.
- 7. The method of claim 6, wherein said metal is selected from the group consisting of gold and silver.
- 8. The method of claim 3, wherein said metal layer comprises a metal selected from the group consisting of gold and silver.
- 9. A device for detecting an analyte, comprising:
a first surface adapted to enhance Raman signals; a second surface adapted to provide surface plasmon resonance; a source of electromagnetic radiation; a SERS signal detector associated with said first surface; and a SPR signal detector associated with said second surface.
- 10. The device of claim 9, further comprising means for comparing said SERS signal and said SPR signal.
- 11. A device for detecting an analyte, comprising:
a prism having a surface having at least two areas thereon; one of said areas having a metal layer thereon adapted to provide surface plasmon resonance conditions; another of said areas having enhancing structures adapted to provide surface enhanced Raman spectroscopic conditions; at least one analyte receptor associated with each of said areas; and at least one detector associated with each of said areas.
- 12. The device of claim 11, further comprising means for storing signals produced by each of said detectors.
- 13. A system for detecting an analyte, comprising:
a first surface adapted to enhance Raman signals; a second surface adapted to provide surface plasmon resonance; a source of electromagnetic radiation associated with each of said first and second surfaces; a SERS signal detector associated with said first surface; a SPR signal detector associated with said second surface; and means for comparing said SERS signal and said SPR signal.
- 14. A system for detecting an analyte, comprising:
a surface having means for enhancing Raman signals and means for providing surface plasmon resonance; a source of electromagnetic radiation; means for detecting a SERS signal; means for detecting a SPR signal; and means for comparing said SERS signal and said SPR signal.
- 15. The method of claim 1, further comprising binding an analyte receptor to at least one of said surface and said enhancing structure.
- 16. The device of claim 9, further comprising an analyte receptor associated with at least one of said first surface and said second surface.
- 17. The system of claim 13, further comprising an analyte receptor associated with at least one of said first surface and said second surface.
RELATED APPLICATION
[0001] This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Patent Application Serial No. 60/323,981, filed Sep. 21, 2001. This application also claims priority to U.S. Provisional Patent Application Serial No. 60/156,195, filed Sep. 27, 1999, now abandoned, and to United States Utility patent application Ser. Nos. 09/670,453, filed Sep. 26, 2000, 09/815,909, filed Mar. 23, 2001, and 09/925,189 filed Aug. 8, 2001. Each of the above patent applications is incorporated herein fully by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60323981 |
Sep 2001 |
US |