Devices comprising a heat source material and activation chambers for the same

Information

  • Patent Grant
  • 10036574
  • Patent Number
    10,036,574
  • Date Filed
    Friday, June 27, 2014
    10 years ago
  • Date Issued
    Tuesday, July 31, 2018
    5 years ago
Abstract
A device is provided comprising a heat source material which is a phase change material and which undergoes an exothermic phase change upon activation by an activating agent to generate heat, a heat source chamber holding the heat source and an activation chamber providing the activating agent, and a barrier separating the interior of the heat source chamber from the interior of the activation chamber, wherein the activation chamber is deformable and wherein deformation of the activation chamber causes rupture of the barrier to allow contact between the activating agent and the heat source material. Embodiments also provide an activation chamber for use in the device and comprising an activating agent to trigger activation of a heat source material.
Description
RELATED APPLICATIONS

The present application is a National Phase entry of PCT Application No. PCT/EP2014/063785, filed Jun. 27, 2014, which claims the benefit of GB Application No. 1311620.7, filed Jun. 28, 2013, each of which is incorporated herein by reference in its entirety.


FIELD

Embodiments relate to devices comprising a heat source material and configured to activate the heat source material.


BACKGROUND

Devices including a heat source material require a mechanism for activating the heat source on demand.


SUMMARY

According to a first aspect, a device is provided comprising: a heat source material which is a phase change material and which undergoes an exothermic phase change upon activation by an activating agent to generate heat; a heat source chamber within which the heat source material is held; an activation chamber providing the activating agent; and a barrier separating the interior of the heat source chamber from the interior of the activation chamber, wherein the activation chamber is deformable and wherein deformation of the activation chamber causes rupture of the barrier to allow contact between the activating agent and the heat source material.


In some embodiments, the device may further comprise a housing within which the heat source and activation chambers are located, and wherein the activation chamber is deformable by applying pressure to a deformable portion of the housing.


In some embodiments, any deformation of the heat source chamber caused by a user applying manual pressure to said chamber will not cause rupture of the barrier.


In some embodiments, the activation chamber may comprise a deformable body forming a chamber having an opening which is sealed by the barrier.


In some embodiments, the body of the activation chamber may be shaped to facilitate rupture of the barrier upon deformation.


In some embodiments, the body of the activation chamber may comprise an internal protrusion which facilitates rupture of the barrier when the body is deformed.


In some embodiments, the heat source chamber may have an opening which is aligned with an opening of the activation chamber and both openings are sealed by a barrier.


In some embodiments, the phase change material may be sodium acetate trihydrate.


In some embodiments, the activating agent may be a solid material.


In some embodiments where the heat source material is sodium acetate trihydrate, the activating agent may comprise a sodium acetate crystal or a sodium acetate trihydrate crystal.


In some embodiments, the device further includes a nicotine source which releases nicotine upon being heated by the heat source material. The nicotine source may comprise tobacco.


According to a second aspect, an activation chamber is provided for use in a device according to an embodiment of the first aspect, the activation chamber comprising an activating agent to trigger activation of a heat source material.


In some embodiments the activation chamber is a blister.


In some embodiments, the activating agent is provided in the form of a powder, tablet or in a monolithic form.


In some embodiments, the activating agent is provided as a layer or coating on or in the activation chamber.





BRIEF DESCRIPTION OF THE DRAWINGS

For the purposes of example only, embodiments are described below with reference to the accompanying drawings, in which:



FIG. 1 is a schematic illustration of a device according to one possible embodiment.



FIG. 2 is a schematic illustration of an exploded view of the device illustrated in FIG. 1.



FIG. 3 is a schematic illustration of a device according to an alternative embodiment.



FIG. 4 is a cross-sectional view of an embodiment of the activation chamber.



FIG. 5 is a cross-sectional view of an alternative embodiment of the activation chamber.



FIG. 6 is a schematic illustration of a section of housing of a device according to one possible embodiment.



FIG. 7 is a schematic illustration of a section of housing of a device including an activation chamber according to one possible embodiment.



FIG. 8 is a schematic illustration of an inhalation device including a heatable material.





DETAILED DESCRIPTION

Embodiments relate to a simple, small and reliable mechanism for activating a heat source material to initiate the generation of heat. Such a mechanism may be incorporated into a device including a heat source and optionally other elements.


A heat source material is a material which will emit heat when activated. The material may be a phase change material which undergoes a phase change upon activation and thereby releases heat. For example, the material may be a super-cooled phase change material.


Various devices may include a heat source. For example, packaging or containers for food and drink products may include a heat source so that contents may be heated “on the move.” Such containers may include the food or drink, or these may be introduced into the container prior to activating the heat source.


Other devices may be used to heat medical supplies to a target temperature before use.


A heat source material may be included in non-combustible smoking articles. These may include devices which heat a nicotine-containing compound, such as tobacco, to trigger the release of nicotine without generating smoke from the combustion of tobacco. In such devices, a heat source is required which will heat the nicotine-containing compound on demand and will quickly and reliably heat the nicotine-containing compound in a predictable way (i.e., over a known period and to a known temperature).


In all of the aforementioned devices and in other examples of devices including a heat source, it is important to be able to control the activation of the heat source. What is more, it is important to be able to reliably and quickly trigger the heat source when desired.


The heat source material and the activating agent are stored separately within the devices. The heat source material is held in a heat source chamber whilst the activating agent is provided by the activation chamber. The interiors of these chambers are separated by a barrier. When the heat source material is to be triggered, the barrier is ruptured to allow contact between the heat source material and the activating agent.


In some embodiments, the heat source material is phase change material which emits heat upon undergoing a phase change.


There are several classes of phase change materials (PCMs). Suitable PCMs should exhibit stability as a supercooled fluid at room temperature and/or at the possible storage temperatures. In addition, the PCMs should be readily and reliably activated by contact with an activating agent. In some embodiments, the phase change is from liquid to solid, although other types of phase change materials may be used.


In some embodiments, the heat source material included in the device is a hydrated salt PCM. Suitable hydrated salts include sodium acetate trihydrate, sodium hydroxide monohydrate, barium hydroxide octahydrate, magnesium nitrate hexahydrate and magnesium chloride hexahydrate. In some embodiments which may be advantageous, the heat source material is sodium acetate trihydrate. It is stable at room temperature and is non-hazardous. The phase change of sodium acetate trihydrate from liquid to solid can also be reliably and quickly initiated by a variety of activating agents at least some of which can be incorporated into a separate chamber and transferred into contact with the heat source material.


Nucleation is the process by which the phase change of the PCM from liquid to solid is initiated and it may be classed as either heterogeneous or homogeneous nucleation. In heterogeneous nucleation, an insoluble foreign body, such as a dust particle or a feature on the wall of the container holding the PCM, acts as the centre upon which the first ions or molecules become attached and oriented, rapidly attracting additional entities to form a solid crystal. In homogeneous nucleation, a few ions or molecules arrive stochastically into the correct orientation in the course of their random movement through the bulk of the liquid phase, providing a site which then attracts additional ions or molecules and hence forms a growing solid crystal entity.


The introduction of a solid crystalline entity, such as a small crystal of sodium acetate, (a so-called “seed” crystal) into the bulk of the liquid phase immediately provides a very large number of sites which will attract ions or molecules from the bulk liquid phase. The introduction of a seed crystal into a super-cooled system thus accelerates the crystallization process by eliminating the need for random molecular interactions.


In some embodiments where the heat source material is sodium acetate trihydrate, the activating agent may include one or more of the following: solid sodium acetate or solid sodium acetate trihydrate. In some embodiments, the solid form may comprise, for example, one or more crystals, a coating or layer, powder, granules or a monolithic form, such as a molded or pressed tablet or similar form. In some embodiments, the solid form may be formed by allowing a relatively small volume of liquid SAT crystallize to form a monolithic form.


In some embodiments, an activating agent, such as one comprising sodium acetate or sodium acetate trihydrate in a solid form, may be provided in the form of a pressed, molded or printed monolithic form, such as a tablet or other solid form suitable for inclusion in the activation chamber as described herein. In some embodiments, a solid monolithic form of sodium acetate trihydrate may be formed in situ within the activation chamber. The activation chamber may be formed and filled with the sodium acetate trihydrate in an unstable liquid form. This unstable liquid will then solidify within the activation chamber, forming a solid mass which may be used to trigger a phase change in a supercooled liquid SAT heat source material. What is more, the solid mass will also be capable of transmitting pressure from the deformation of the activation chamber body to the barrier to facilitate its rupture.


In some embodiments, it is desirable to select an activating agent which is stable and, in some embodiments, is stable when exposed to elevated temperatures, for example during the forming and sealing of the activation chamber in which it is to be stored.


In some embodiments, the activating agent may be a solid comprising one or more of a salt, for example, common salt NaCl, Chalk (CaCO3), and a cellulose derivative, for example, Carboxymethyl Cellulose (CMC). The solid may comprise, for example, one or more crystals, a coating or layer, powder, granules or a monolithic form, such as a molded or pressed tablet or similar form.


In some embodiments, the activating agent may comprise a solid non-hygroscopic material, for example, metal filings such as iron, copper, aluminum or stainless steel filings. A potential advantage of using a solid non-hygroscopic material rather than a solid hygroscopic material as the activating agent is that a solid non-hygroscopic material is less prone to liquefying in the event that moisture enters the activation chamber 4.


In embodiments, the heat source material 3 and the activating agent 5 are stored separately in the device 1 so that the chance of accidental activation is minimized. The two components are stored in separate chambers and are separated by a barrier. The heat source chamber 2 holds the heat source material 3 and the activation chamber 4 provides the activating agent 5. The barrier 6 preventing the activating agent 5 from contacting the heat source material 3 before such contact is desired is a rupturable film and is configured to allow the activating agent 5 provided by the activation chamber 4 to come into contact with the heat source material 3 so that the heat source is activated and heat is generated.


In some embodiments, contact between the activating agent 5 and the heat source material 3 may be as a result of the activating agent being displaced through the ruptured barrier 6 and into the heat source chamber 2. This displacement may, for example, be as a result of the deformation of the activating chamber. Alternatively or in addition, following rupture of the barrier, there may be displacement of the heat source material 3 out of the heat source chamber 2 and into the activation chamber 4, so that the heat source material 3 and the activating agent 5 come into contact.


The rupture of the barrier 6 is achieved by deforming the activation chamber 4. In some embodiments, the deformation of the activation chamber 4 additionally causes displacement of the activating agent 5 so that it may contact the heat source material.


In some embodiments, the activation chamber 4 is deformed upon the application of manual pressure by a user. This pressure may be applied directly, for example by the user pressing on the device 1 with a digit. Thus, in some embodiments, the user may apply the pressure directly onto the surface of the activation chamber 4, by pressing directly on the body of the activation chamber 4. The digit may either be in direct contact with the outer surface of the activation chamber 4 or it may be in contact with a deformable section of housing which is in contact with or otherwise transmits the pressure to the activation chamber.


Alternatively, the pressure may be applied indirectly, for example with the pressure being transmitted by a mechanical means. Thus, in some embodiments, the device further comprises an actuating mechanism by which the user deforms the activation chamber 4. In some embodiments, the actuating mechanism may comprise a button, optionally a spring-loaded and/or sliding button. Various other types of actuating mechanisms are also envisaged, including a plunger or a lever. In some embodiments, for example, the actuating mechanism may be configured to be depressed, pulled, twisted or squeezed to deform the activation chamber 4. In the embodiment illustrated in FIG. 3, the device includes a housing 11 with a deformable portion 12 which surrounds both the heat source chamber 2 and activation chamber 4. The activation chamber 4 is surrounded by a housing at least a portion of which 12 is deformable so that manual pressure applied by the user on the deformable portion of the housing 12 is transmitted to the body of the activation chamber 4 to deform it.


In some embodiments, the heat source chamber 2 is generally not deformable upon application of manually applied pressure, i.e., the heat source chamber 2 is rigid. In other embodiments, the heat source chamber may be deformable but may not be deformable in a manner or to an extent that will or is likely to cause the rupture of the rupturable barrier. In some embodiments that may be advantageous in certain circumstances, the rupturable barrier may only be ruptured as a result of deformation of the activation chamber.


In some embodiments, the device 10 includes a housing 11 which includes a deformable portion 12 aligned with the activation chamber 4 to allow the transmission of pressure from the external surface of the deformable portion 12 of the housing 11 to the activation chamber 4 to allow deformation of the chamber 4, rupture of the barrier 6 and, optionally, displacement of the activating agent 5 stored within the activation chamber 4 through the barrier 6. In some embodiments, the rest of the housing 11 (aside from the deformable portion 12 aligned with the activation chamber 4) may be generally a rigid structure. In some embodiments, portions of the housing 11 may be provided with sufficient rigidity for them to provide a reaction surface against which the deformable parts of the device, for example the deformable activation chamber 4 may be pressed. This may assist in enabling the pressure applied to the activation chamber 4 to cause deformation of at least a part of the activation chamber 4 and the consequent rupture of the barrier 6.


As shown in FIGS. 1 to 3, the device 1, 10 may be configured so that the activation chamber 4 is directly adjacent to the heat source chamber 2 so that the activating agent and the heat source material may come into contact with one another once the barrier 6 separating them has been ruptured. In such embodiments, an opening 8 in the heat source chamber 2, the rupturable barrier 6 and an opening 7 in the activation chamber 4 may all be aligned. In alternative embodiments (which are not illustrated), there may be a further chamber or passage into or through which the activating agent and/or heat source material pass in order to come into contact with each other and initiate heat generation.


In some embodiments, the activation chamber 4 suitable for use in embodiments may comprise a deformable body which transmits the pressure applied to the activation chamber, and a barrier which is ruptured, preferably in a predetermined and predicable manner, when the body is deformed. In some embodiments, the activation chamber comprises an activating agent held within the chamber. In other embodiments, the activating agent may be provided as an integral part of the activation chamber, for example in the form of a layer or coating. This layer or coating may, for example, be provided on an internally facing surface of the activation chamber 4, such as the internal surface of the deformable body and/or the internal surface of the barrier.


In some embodiments, the activation chamber may comprise a laminate, either forming the deformable body or part thereof, or forming the barrier. In some of these embodiments, the laminate may include a layer comprising the activating agent. This activating agent layer may be located on the surface of the laminate which is inside the activation chamber prior to deformation of the chamber and rupture of the barrier. Alternatively or in addition, the layer of activating agent may be within the multi-layer laminate structure so that it is not exposed until the laminate is torn or ruptures.


In some embodiments, the activating agent provided in such a layer or coating may be displaced by the deformation of the activation chamber 4 to the extent that the activating agent extends into the heat source chamber 2.


In some embodiments, the activating agent 5 may remain in the activation chamber following deformation of the activation chamber and then, in order for there to be contact between the activating agent and the heat source material, it may be necessary for the heat source material to enter the activation chamber 4.


Where it is desirable or necessary for the heat source material to enter the activation chamber following rupture of the rupturable barrier, this may be encouraged by the creation of a region of relatively low pressure in the activation chamber. In one possible embodiment, the activation chamber may have a lower internal pressure than the heat source chamber when it is sealed. When the rupturable barrier is then ruptured, the heat source material from the adjacent heat source chamber is drawn into the activation chamber. Alternatively or in addition, the activation chamber may be configured to create a region of relatively low pressure following rupture of the rupturable barrier. For example, the activation chamber may be formed from a resiliently deformable material so that, following deformation of the body of the chamber to cause rupture of the barrier, the body of the chamber will revert to its original form, thereby drawing the heat source material from the adjacent heat source chamber into the activation chamber.


Alternatively or in addition, the heat source material may be encouraged to enter the activation chamber by capillary action. The activation chamber may be shaped to draw the heat source material into it by capillary action when the barrier is ruptured.


Where it is desirable or necessary for the activating agent to exit the activation chamber following rupture of the rupturable barrier, this may be encouraged by the creation of a region of relatively high pressure in the activation chamber. In one possible embodiment, the activation chamber may have a higher internal pressure than the heat source chamber when it is sealed. When the rupturable barrier is then ruptured, the activating agent may be expelled from the activation chamber into the adjacent heat source chamber.


According to some embodiments, the activation chamber in which the activating agent is stored is a blister or a blister-like element. As used herein, the term “blister” refers to a structure such as is found in a blister pack or bubble pack. Such packs are examples of pre-formed packaging used for small consumer goods, foods, and pharmaceuticals.


As used herein, the blister comprises a body forming a chamber, the body being made from a material such as, for example, a thermoformed plastic. The chamber has an opening which is closed by a barrier layer which may be attached to the body, for example around the opening. The barrier layer may be adhered to the body by any suitable means. In some embodiments, the barrier layer is film, foil, membrane or plastic sheet material. In some embodiments, the barrier layer ruptures by physically breaking or tearing under the pressure exerted on it. Alternatively or in addition, in some embodiments, it may be the seal between the body and the barrier layer which ruptures, so that the barrier layer and body become separated, thereby at least partially exposing the previously sealed opening.


In some embodiments, the body of the activation chamber and the barrier may be formed from the same or similar materials. For example, in some embodiments, the body and barrier may be formed from a plastic material (such as, for example, polyvinyl chloride, optionally laminated with polychlorotrifluoroethylene, or multi-layer materials comprising cyclic olefin copolymers or polymers, polypropylene, polyethylene, or glycol-modified polyethylene terephthalate), or a foil (such as, for example, an aluminum-based foil, including aluminum-containing laminates). In some embodiments, the body of the activation chamber and the barrier may be made of a water resistant material in order to reduce the likelihood of moisture reaching the activating agent. For example, the barrier layer could be made of cold-formed aluminum or from polyvinylidene chloride (PVDC). In some embodiments, the rupturable portion of the activation chamber may comprise or consist of a local weakening of the material, for example by locally adjusting the thickness of the material.


Illustrative examples of activation chambers in the form of blisters are shown in FIGS. 4 and 5. The activation chamber 4 may comprise a body 14 formed from a deformable material and having an opening 7 which is sealed by a barrier 6 with the activating agent (not shown) located within the chamber. In some embodiments, the body 14 of the activation chamber 4 may be formed from a plastic or other deformable material. In alternative embodiments, the body 14 of the activation chamber could be formed from a second foil layer, for example comprising a foil laminate. The body of the activation chamber is configured to deform when a user applies manual pressure directly or indirectly to the surface of the activation chamber. The extent to which the body of the activation chamber deforms in response to pressure will be dependent, at least to an extent, upon the material of the body, its thickness and the shape of the body.


In some embodiments, the barrier 6 is attached to the body 14 of the activation chamber 4 in order to seal the opening 7. This may be achieved by attaching the barrier to the body of the activation chamber, for example around the opening. This attachment may, for example, be achieved by fusion or welding of the materials of the barrier and the body, or by using an adhesive. Sealing the activation chamber 4 by attaching the rupturable barrier 6 to the body 14 has the advantage that the whole activation chamber, including the activating agent, may be formed and supplied as a separate component and easily added to the other components of the device.


In alternative embodiments, the activation chamber may be sealed by a rupturable barrier which is not attached to the body of the activation chamber. For example, the body of the activation chamber may be sealed as a result of the opening of the body being aligned with and abutting another component of the device. In some embodiments, the opening of the activation chamber may abut a rupturable barrier which is attached to and/or forms part of another component of the device, such as the heat source chamber. Such an arrangement would mean that the contents of the activation chamber cannot exit without rupture of the barrier. This arrangement also allows the deformation of the activation chamber to apply sufficient force to the barrier to rupture it.


In some embodiments, the body of the heat source chamber has an opening which is sealed by a rupturable barrier. This may be achieved by attaching the barrier to the body of the heat source chamber, for example around the opening. This attachment may, for example, be achieved by fusion or welding of the materials of the barrier and the body, or using an adhesive. Sealing the heat source chamber by attaching the rupturable barrier to the body has the advantage that the whole heat source chamber including the heat source material may be formed and supplied as a separate component and therefore easily added to the other components of the device.


In some embodiments, both the heat source and activation chambers are individually sealed by a rupturable barrier. The barriers and the openings of the chambers that they respectively seal can be aligned within the device to allow the deformation of the activation chamber to cause rupture of both barriers to allow contact between the activating agent and the heat source material.


The rupture of the barrier 6 is caused by the deformation of the activation chamber 4. In some embodiments, deformation of the chamber will increase the pressure within the sealed chamber forcing the container to rupture or burst at a weak point which will generally be the rupturable barrier or a point at which the barrier is attached to a chamber body. In some embodiments, the activating agent held within the activation chamber is a solid material. Upon deformation of the activation chamber, the solid activating agent may become pressed against the rupturable barrier, thereby transmitting and focusing the force applied to the body of the activation chamber and facilitating rupture. Once the barrier has ruptured, the activating agent will, at least partially, pass through the ruptured barrier and out of the activation chamber.


In the embodiment illustrated in FIG. 1, the activating agent 5 is a solid material which may be forced through the barrier 6. Upon deformation of the activation chamber 4, the activating agent 5 is pressed against the barrier 6. Eventually, the force exerted on the barrier 6 by the activating agent 5 will cause the barrier 6 to rupture. This release of the resistance to the applied pressure will cause at least part of the activating agent to be pushed through the ruptured barrier and into the heat source chamber 2 and into contact with the heat source material.


In some embodiments, the activation chamber may include additional or alternative means for focusing the force applied to the rupturable barrier as a result of the activation chamber being deformed. The activation chamber may include a protrusion which contacts the rupturable barrier upon deformation of the activation chamber. If the protrusion contacts the barrier over a relatively small surface area, the force applied to the barrier will be focused and this will facilitate rupture. One embodiment including such a protrusion is illustrated in FIG. 5. The activation chamber 4 has a body 14 which is shaped to include a protrusion 15. When the body 14 is deformed by application of pressure, as indicated by the arrow A, the protrusion 15 formed on the inner surface of the body 14 comes into contact with the barrier 6 and focuses the force applied by the deformation and displacement of the shaped portion of the activation chamber body onto a local area of the barrier, facilitating rupture. A similar effect could be achieved by providing protrusions which are held within the activation chamber but which are not an integral part of it. Thus, one or more solid shaped articles could be included with the activating agent in the activation chamber 4, and these articles would be pressed against the barrier upon deformation of the activation chamber to facilitate rupture. Such shaped articles could be provided with sharp edges, points or the like to ensure that they facilitate rupture of the barrier. In some embodiments, the shaped articles have a shape which ensures that, whatever the orientation of the shaped article within the activation chamber, the pressure applied to the outer surface of the chamber is focused onto a relatively small area of the rupturable barrier, in order to facilitate rupture.


In some embodiments where shaped articles are provided with sharp edges, points or the like to facilitate rupture of the barrier, the sharp edges or points may also activate the heat source material upon contact therewith, for example by providing nucleation sites. Alternatively or in addition, where shaped articles are provided to facilitate rupture of the barrier (either with or without sharp edges), these articles may have roughened surfaces which can provide a large number of nucleation sites to activate the heat source material upon contact therewith.


In some particular embodiments, the means or articles, including those discussed above, for focusing the force applied to the rupturable barrier may comprise a coating or layer comprising an activating agent.


In some embodiments, the barrier 6 is able to re-seal itself after having been ruptured. For example, the barrier 6 may comprise a layer of resilient material the resilience of which causes the layer to reseal after having been ruptured. Such a barrier 6 may be in the form of a rubber septum. In some such embodiments, the activation chamber 4 may be provided with one or more sharp protrusions which are brought into contact with and rupture the barrier 6 when the activation chamber 4 is deformed under pressure applied by a user. The one or more sharp protrusions may activate the heat source material upon contact with it. The one or more sharp protrusions may comprise a metal, for example, iron, copper, aluminum or stainless steel. The activation chamber 4 itself may be resilient so that it regains its original shape when pressure ceases to be applied to it so that the one or more protrusions are withdrawn from the barrier 6 which then re-seals itself. Accordingly, in some embodiments, the activation chamber 4 is re-usable.


In some embodiments, the barrier may be constructed to ensure that, upon rupture, the ruptured barrier has sharp edges which may activate the heat source material upon contact therewith, for example by providing nucleation surfaces. Alternatively or in addition, the means provided to rupture the barrier may be configured to ensure that, upon rupture, the ruptured barrier has sharp edges which may activate the heat source material upon contact therewith, for example by providing nucleation surfaces. The sharp edges may be capable of activating the heat source material and so, in some embodiments, these sharp edges of the barrier formed upon rupture are the activating agent and it may not be necessary for any other activating agent to be present.


In yet further embodiments, other parts of the device may include means for facilitating rupture of the barrier upon deformation of the activation chamber. FIG. 6 shows a possible configuration of a housing part 20 which is configured to receive and hold the activation chamber 4. The activation chamber 4 may, for example, be a blister along the lines described above. The housing part 20 has a body 21 which includes a lip 22 surrounding an opening 24 into which one or more protrusions 23 radially extend. When incorporated into the device, the activation chamber blister sits on the lip 22 of the housing body 21, so that the barrier spans the opening 24 and rests upon the lip 22 with the protrusion(s) 23, as shown in FIG. 7. Upon deformation of the activation chamber 4, the chamber, and in particular the barrier 6, is pushed against the lip 22 and the protrusions 23. The pressure can facilitate rupture of the barrier at the points at which the protrusions 23 contact the barrier 6. The housing part 20, and in particular the lip 22, provides a reaction surface against which the activation chamber may be pressed to ensure that it deforms upon application of pressure, so as to rupture the rupturable barrier.


In alternative embodiments, the activation chamber 4 and heat source chamber 2 are positioned adjacent to one another and in abutment, and the heat source chamber may be provided with protrusions or the like to facilitate rupture of the barrier 6 upon deforming the activation chamber 4. In some embodiments, the heat source chamber may provide a reaction surface against which the activation chamber may be pressed to ensure that it deforms upon application of pressure, so as to rupture the rupturable barrier.


The barrier is selected from a material which will rupture when placed under the types of pressure the device is designed to transmit from a user manually actuating the device. The barrier may be a film or membrane. The material will be selected to provide the requisite strength and rupturability. For example, the material and thickness of the barrier is selected to rupture or tear based on the degree and direction of force which may be applied (directly or indirectly) by the user to the surface of the activation chamber. In addition, it is important that the barrier material is inert with respect to the materials it is in contact with during storage and use. In some embodiments the barrier may be provided with pre-weakened areas to facilitate rupture. In some embodiments, the barrier may be a foil, film, membrane or sheet. In other embodiments, the rupturable barrier may be a pre-weakened portion of the body of the activation chamber.


In certain embodiments, the physical size or volume of the activating agent 5 will be significantly smaller than the size or volume of the heat source material 3. As a result, it may be desirable for the activation chamber 4 to be as small and/or slim as possible, so that it does not substantially dictate the size and/or shape of the device. In some embodiments, therefore, due to the constrained geometry of such a device 1, the size and shape of the activation chamber 4 holding the activating agent 5 may be optimized to ensure the rupturable barrier 6 ruptures with only a small deformation of the body of the activation chamber 4. A slim configuration of a blister-like activation chamber 4 is illustrated in FIGS. 4 and 5, where it can be seen that the application of pressure by a user on the body 14 of the activation chamber 4 as indicated by the arrow A does not need to deform the body 14 very much before the contents of the chamber (not shown) and/or a protrusion 15 contact the barrier 6 and apply a rupturing pressure.


In some embodiments, the external dimensions of the activation chamber include: a diameter of between about 2 to about 10 mm, between about 5 to about 9 mm, between about 6 to about 8 mm or a diameter of about 7 mm; and a depth of between about 0.4 and 5 mm, between about 0.7 to about 3 mm, between about 1 mm to about 2 mm, or a depth of about 1 mm.


In some specific embodiments, the device is an inhalation device configured to heat a heatable material to volatilize at least one component of the heatable material to form an inhalable vapor. As used herein, the term ‘heatable material’ includes any material that provides volatilize components upon heating.


In some embodiments, the inhalation device is a nicotine delivery system. In such embodiments, the heatable material may comprise a source of nicotine. In some embodiments, the heatable material may include any tobacco-containing material and may, for example, include one or more of tobacco, tobacco derivatives, tobacco extracts, treated or modified tobacco such as expanded tobacco and reconstituted tobacco, or tobacco substitutes. For the avoidance of doubt, in the context of the present invention, the heatable material is not combusted and smoke is not generated. Nevertheless, the heatable material does provide a source of components which are volatilize upon use and are to be inhaled by the user.


In some embodiments, as illustrated in FIG. 8, such an inhalation device 30 comprises a housing 31 within which the heat source material 32 is held in a heat source chamber, and a heatable material 34 is held in a separate heating chamber, the heat source chamber and the heating chamber being arranged to allow transfer of heat from the heat source chamber to the heatable material, so that at least one component of the heatable material may be volatilize. The device further includes an activation chamber holding an activating agent which may be displaced from the activation chamber to the heat source chamber upon deforming the activation chamber by applying pressure to a deformable portion 33 of the housing. The activation chamber and the activation process may be as described above. In some embodiments, the inhalation device additionally includes a mouthpiece 35 through which the volatilized component(s) may be inhaled.


In order to address various issues and advance the art, the entirety of this disclosure shows by way of illustration various embodiments in which that which is claimed may be practiced and provide for superior devices for initiating a heat source material and methods of manufacturing and using the same. The advantages and features of the disclosure are of a representative sample of embodiments only, and are not exhaustive and/or exclusive. They are presented only to assist in understanding and teach the claimed features. It is to be understood that advantages, embodiments, examples, functions, features, structures, and/or other aspects of the disclosure are not to be considered limitations on the disclosure as defined by the claims or limitations on equivalents to the claims, and that other embodiments may be utilized and modifications may be made without departing from the scope and/or spirit of the disclosure. Various embodiments may suitably comprise, consist of, or consist essentially of, various combinations of the disclosed elements, components, features, parts, steps, means, etc. In addition, the disclosure includes other inventions not presently claimed, but which may be claimed in future.

Claims
  • 1. A heating device comprising: a heat source material which is a phase change material and which undergoes an exothermic phase change upon activation by an activating agent to generate heat;a heat source chamber within which the heat source material is held;an activation chamber providing the activating agent;a barrier separating the interior of the heat source chamber from the interior of the activation chamber, wherein the activation chamber is deformable and wherein deformation of the activation chamber causes rupture of the barrier to allow contact between the activating agent and the heat source material, the contact activating the exothermic phase change of the phase change material, anda housing to receive a nicotine source arranged to release nicotine upon being heated by the generated heat.
  • 2. The heating device as claimed in claim 1, wherein the heat source chamber and the activation chamber are located in the housing, and wherein the activation chamber is deformable by a user applying manual pressure to a deformable portion of the housing.
  • 3. The heating device as claimed in claim 1, wherein the heat source chamber is deformable by a user applying manual pressure to the heat source chamber and is arranged so that any deformation of the heat source chamber caused by a user applying manual pressure to the chamber will not cause rupture of the barrier.
  • 4. The heating device as claimed in claim 1, wherein the activation chamber comprises a deformable body having an opening which is sealed by the barrier.
  • 5. The heating device as claimed in claim 1, wherein the activation chamber is shaped to facilitate rupture of the barrier upon deformation of the activation chamber.
  • 6. The heating device as claimed in claim 1, wherein the activation chamber comprises an internal protrusion which facilitates rupture of the barrier when the activation chamber is deformed.
  • 7. The heating device as claimed in claim 1, wherein the heat source chamber has an opening which is aligned with an opening of the activation chamber and both openings are sealed by the barrier.
  • 8. The heating device as claimed in claim 1, wherein the phase change material is a formulation comprising sodium acetate trihydrate.
  • 9. The heating device as claimed in claim 1, wherein the activating agent is a solid material.
  • 10. The heating device as claimed in claim 8, wherein the activating agent comprises solid sodium acetate or solid sodium acetate trihydrate.
  • 11. The heating device as claimed in claim 1, wherein the activating agent is a solid and comprises one or more of a salt, chalk, or a cellulose derivative.
  • 12. The heating device as claimed in claim 1, wherein the activating agent comprises a solid non-hygroscopic material.
  • 13. The heating device as claimed in claim 12, wherein the activating agent comprises metal filings.
  • 14. The heating device as claimed in claim 1, wherein the barrier comprises a layer of resilient material, wherein the resilience of the layer causes the layer to re-seal after rupturing.
  • 15. The heating device as claimed in claim 1, wherein the nicotine source comprises tobacco.
  • 16. An activation chamber for use in the heating device as claimed in claim 1, the activation chamber comprising the activating agent to trigger activation of the heat source material.
  • 17. The activation chamber as claimed in claim 16, wherein the activation chamber is a blister.
  • 18. The activation chamber as claimed in claim 16, wherein the activating agent is provided in the form of a powder, a tablet, or in a monolithic form.
  • 19. The activation chamber as claimed in claim 16, wherein the activating agent is provided as a layer or a coating on the activation chamber.
  • 20. The activation chamber as claimed in claim 16, wherein the activating agent is provided as a layer or a coating in the activation chamber.
Priority Claims (1)
Number Date Country Kind
1311620.7 Jun 2013 GB national
PCT Information
Filing Document Filing Date Country Kind
PCT/EP2014/063785 6/27/2014 WO 00
Publishing Document Publishing Date Country Kind
WO2014/207250 12/31/2014 WO A
US Referenced Citations (284)
Number Name Date Kind
2462563 Seyforth Feb 1949 A
2689150 Corce Sep 1954 A
2888208 Fedit May 1959 A
3040991 Fedit Jun 1962 A
3043524 Boris Jul 1962 A
3258015 Herbert et al. Jun 1966 A
3289949 Roth Dec 1966 A
3347231 Chang Oct 1967 A
3522806 Szekely Aug 1970 A
3647143 Gauthier et al. Mar 1972 A
3658059 Steil Apr 1972 A
3733010 Riccio May 1973 A
3856185 Riccio Dec 1974 A
3864326 Babington et al. Feb 1975 A
3913843 Cambio, Jr. Oct 1975 A
3943942 Anderson Mar 1976 A
4149548 Bradshaw Apr 1979 A
4284089 Ray Aug 1981 A
4299274 Campbell et al. Nov 1981 A
4299355 Hakkinen Nov 1981 A
4303541 Wasel-Nielen et al. Dec 1981 A
4393884 Jacobs Jul 1983 A
4412930 Koike et al. Nov 1983 A
4429835 Brugger et al. Feb 1984 A
4694841 Esparza Sep 1987 A
4746067 Svoboda May 1988 A
4765348 Honeycutt Aug 1988 A
4771795 White et al. Sep 1988 A
4776353 Lilja et al. Oct 1988 A
4819665 Roberts et al. Apr 1989 A
4827950 Banerjee et al. May 1989 A
4892109 Strubel Jan 1990 A
4907606 Lilja Mar 1990 A
4913168 Potter et al. Apr 1990 A
4917119 Potter et al. Apr 1990 A
4917120 Hill Apr 1990 A
4924883 Perfetti et al. May 1990 A
4938236 Banerjee et al. Jul 1990 A
4941483 Ridings et al. Jul 1990 A
4947874 Brooks et al. Aug 1990 A
4955399 Potter et al. Sep 1990 A
5019122 Clearman et al. May 1991 A
5020509 Suzuki et al. Jun 1991 A
5040552 Schleich et al. Aug 1991 A
5042509 Banerjee et al. Aug 1991 A
5060667 Strubel Oct 1991 A
5060671 Counts et al. Oct 1991 A
5076292 Sensabaugh et al. Dec 1991 A
5080115 Templeton Jan 1992 A
5093894 Deevi et al. Mar 1992 A
5095921 Losee et al. Mar 1992 A
5097850 Braunshteyn et al. Mar 1992 A
5099861 Clearman et al. Mar 1992 A
5105831 Banerjee et al. Apr 1992 A
5119834 Shannon et al. Jun 1992 A
5133368 Neumann Jul 1992 A
5143048 Cheney, III Sep 1992 A
5144962 Counts et al. Sep 1992 A
5146934 Deevi et al. Sep 1992 A
5159940 Hayward et al. Nov 1992 A
5167242 Turner et al. Dec 1992 A
5179966 Losee et al. Jan 1993 A
5188130 Hajaligol et al. Feb 1993 A
5224498 Deevi Jul 1993 A
5230715 Iizuna Jul 1993 A
5235992 Sensabaugh, Jr. Aug 1993 A
5261424 Sprinkel Nov 1993 A
5269327 Counts et al. Dec 1993 A
5285798 Banerjee et al. Feb 1994 A
5293883 Edwards Mar 1994 A
5305733 Walters Apr 1994 A
5312046 Knoch et al. May 1994 A
5327915 Porenski et al. Jul 1994 A
5345951 Serrano et al. Sep 1994 A
5357984 Farrier et al. Oct 1994 A
5369723 Counts et al. Nov 1994 A
5396911 Casey et al. Mar 1995 A
5400808 Turner et al. Mar 1995 A
5408574 Deevi et al. Apr 1995 A
5415186 Casey et al. May 1995 A
5443560 Deevi et al. Aug 1995 A
5454363 Sata Oct 1995 A
5461695 Knoch Oct 1995 A
5474059 Cooper Dec 1995 A
5483953 Cooper Jan 1996 A
5501236 Hill et al. Mar 1996 A
5511538 Haber Apr 1996 A
5517981 Taub et al. May 1996 A
5534020 Cheney, III Jul 1996 A
5538020 Farrier Jul 1996 A
5549906 Santus Aug 1996 A
5564442 MacDonald et al. Oct 1996 A
5593792 Farrier et al. Jan 1997 A
5613505 Campbell et al. Mar 1997 A
5645749 Wang Jul 1997 A
5649554 Sprinkel et al. Jul 1997 A
5659656 Das Aug 1997 A
5687912 Denyer Nov 1997 A
5699786 Oshima et al. Dec 1997 A
5711292 Hammarlund Jan 1998 A
5736110 Angelillo et al. Apr 1998 A
5778899 Saito et al. Jul 1998 A
5819756 Mielordt Oct 1998 A
5845649 Saito et al. Dec 1998 A
5865186 Volsey Feb 1999 A
5921233 Gold et al. Jul 1999 A
5935486 Bell et al. Aug 1999 A
5938125 Ritsche et al. Aug 1999 A
5984953 Sabin Nov 1999 A
6000394 Blaha-Schnabel Dec 1999 A
6041790 Smith et al. Mar 2000 A
6053176 Adams et al. Apr 2000 A
6079405 Justo Jun 2000 A
6085741 Becker Jul 2000 A
6089857 Matsuura et al. Jul 2000 A
6113078 Rock Sep 2000 A
6116231 Sabin Sep 2000 A
6129080 Pitcher et al. Oct 2000 A
6158676 Hughes Dec 2000 A
6164287 White Dec 2000 A
6178963 Baik Jan 2001 B1
6209457 Kenworthy et al. Apr 2001 B1
6223745 Hammarlund et al. May 2001 B1
6230703 Bono May 2001 B1
6234459 Rock May 2001 B1
6244573 Rock Jun 2001 B1
6248257 Bell et al. Jun 2001 B1
6267110 Tenenboum et al. Jul 2001 B1
6283116 Yang Sep 2001 B1
6289889 Bell Sep 2001 B1
6347789 Rock Feb 2002 B1
6427878 Greiner-Perth et al. Aug 2002 B1
6595209 Rose et al. Jul 2003 B1
6598607 Adiga et al. Jul 2003 B2
6644383 Joseph Nov 2003 B2
6648306 Rock Nov 2003 B2
6669176 Rock Dec 2003 B2
6708846 Fuchs et al. Mar 2004 B1
6723115 Daly Apr 2004 B1
6761164 Amirpour et al. Jul 2004 B2
6769436 Horian Aug 2004 B2
6799572 Nichols et al. Oct 2004 B2
6803545 Blake et al. Oct 2004 B2
6827080 Fish Dec 2004 B2
6886556 Fuchs May 2005 B2
6953474 Lu Oct 2005 B2
6968888 Kolowich Nov 2005 B2
7041123 Stapf et al. May 2006 B2
7077130 Nichols et al. Jul 2006 B2
7081211 Li et al. Jul 2006 B2
7088914 Whittle et al. Aug 2006 B2
7163014 Nichols et al. Jan 2007 B2
7234459 Del Bon Jun 2007 B2
7235187 Li et al. Jun 2007 B2
7290549 Banerjee et al. Nov 2007 B2
7303328 Faraldi et al. Dec 2007 B2
7335186 O'Neil Feb 2008 B2
7373938 Nichols et al. May 2008 B2
7434584 Steinberg Oct 2008 B2
7540286 Cross et al. Jun 2009 B2
7548374 Raymond et al. Jun 2009 B2
7581540 Hale et al. Sep 2009 B2
7581718 Chang Sep 2009 B1
7585493 Hale et al. Sep 2009 B2
7645442 Hale et al. Jan 2010 B2
7665461 Zierenberg et al. Feb 2010 B2
7832397 Lipowicz Nov 2010 B2
7834295 Sharma et al. Nov 2010 B2
7987846 Hale et al. Aug 2011 B2
8118021 Cho Feb 2012 B2
8156944 Han Apr 2012 B2
8342184 Inagaki et al. Jan 2013 B2
8365742 Hon Feb 2013 B2
8375957 Hon Feb 2013 B2
20010042927 Rock Nov 2001 A1
20010054421 Jaser et al. Dec 2001 A1
20020043260 Layer et al. Apr 2002 A1
20020078951 Nichols et al. Jun 2002 A1
20020078955 Nichols et al. Jun 2002 A1
20020089072 Rock Jul 2002 A1
20020121624 Usui Sep 2002 A1
20030052196 Fuchs Mar 2003 A1
20030097164 Stapf et al. May 2003 A1
20030101984 Li Jun 2003 A1
20030105192 Li et al. Jun 2003 A1
20030106551 Sprinkel, Jr. et al. Jun 2003 A1
20030111637 Li et al. Jun 2003 A1
20030159702 Lindell et al. Aug 2003 A1
20030209240 Hale et al. Nov 2003 A1
20030217750 Amirpour et al. Nov 2003 A1
20030226837 Blake et al. Dec 2003 A1
20040065314 Layer et al. Apr 2004 A1
20040068222 Brian Apr 2004 A1
20040083755 Kolowich May 2004 A1
20040177849 Del Bon Sep 2004 A1
20040234699 Hale et al. Nov 2004 A1
20040234914 Hale et al. Nov 2004 A1
20040234916 Hale et al. Nov 2004 A1
20040255941 Nichols et al. Dec 2004 A1
20040261782 Furumichi et al. Dec 2004 A1
20050007870 Faraldi et al. Jan 2005 A1
20050016549 Banerjee et al. Jan 2005 A1
20050045193 Yang Mar 2005 A1
20050063686 Whittle et al. Mar 2005 A1
20050079166 Damani et al. Apr 2005 A1
20050133029 Nichols et al. Jun 2005 A1
20050196345 Diederichs et al. Sep 2005 A1
20050236006 Cowan Oct 2005 A1
20060027233 Zierenberg et al. Feb 2006 A1
20060032501 Hale et al. Feb 2006 A1
20060102175 Nelson May 2006 A1
20060118128 Hoffman Jun 2006 A1
20060137681 Von Hollen et al. Jun 2006 A1
20060191546 Takano Aug 2006 A1
20060196885 Leach et al. Sep 2006 A1
20070023043 Von Hollen et al. Feb 2007 A1
20070028916 Hale et al. Feb 2007 A1
20070031340 Hale et al. Feb 2007 A1
20070102533 Rosell et al. May 2007 A1
20070125362 Ford et al. Jun 2007 A1
20070131219 Ford et al. Jun 2007 A1
20070138207 Bonney et al. Jun 2007 A1
20070175476 Lipowicz Aug 2007 A1
20070204864 Grychowski et al. Sep 2007 A1
20070222112 Christ et al. Sep 2007 A1
20070283972 Monsees et al. Dec 2007 A1
20070289720 Sunol et al. Dec 2007 A1
20080038363 Zaffaroni et al. Feb 2008 A1
20080149118 Oglesby et al. Jun 2008 A1
20080156326 Belcastro et al. Jul 2008 A1
20080216828 Wensley et al. Sep 2008 A1
20080241255 Rose et al. Oct 2008 A1
20080257367 Paterno et al. Oct 2008 A1
20080276947 Martzel Nov 2008 A1
20080312674 Chen et al. Dec 2008 A1
20090015717 Arnao et al. Jan 2009 A1
20090071477 Hale et al. Mar 2009 A1
20090078711 Farone et al. Mar 2009 A1
20090090349 Donovan Apr 2009 A1
20090090351 Sunol et al. Apr 2009 A1
20090095287 Emarlou Apr 2009 A1
20090107492 Ooida Apr 2009 A1
20090114215 Boeck et al. May 2009 A1
20090151717 Bowen et al. Jun 2009 A1
20090162294 Werner Jun 2009 A1
20090180968 Hale et al. Jul 2009 A1
20090199843 Farone et al. Aug 2009 A1
20090217923 Boehm et al. Sep 2009 A1
20090230117 Fernando et al. Sep 2009 A1
20090260641 Monsees et al. Oct 2009 A1
20090260642 Monsees et al. Oct 2009 A1
20090280043 Ferguson Nov 2009 A1
20090301363 Damani et al. Dec 2009 A1
20090301471 Stirzel Dec 2009 A1
20090302019 Selenski et al. Dec 2009 A1
20100006092 Hale et al. Jan 2010 A1
20100025023 Schmidt et al. Feb 2010 A1
20100031968 Sheikh et al. Feb 2010 A1
20100043809 Magnon Feb 2010 A1
20100065052 Sharma et al. Mar 2010 A1
20100068154 Sharma et al. Mar 2010 A1
20100089381 Bolmer et al. Apr 2010 A1
20100181387 Zaffaroni et al. Jul 2010 A1
20100236546 Yamada et al. Sep 2010 A1
20100242974 Pan Sep 2010 A1
20100258585 Jamison Oct 2010 A1
20100300467 Kuistila et al. Dec 2010 A1
20100307518 Wang Dec 2010 A1
20100313901 Fernando et al. Dec 2010 A1
20110005535 Xiu Jan 2011 A1
20110030671 Ferguson et al. Feb 2011 A1
20110192408 Inagaki et al. Aug 2011 A1
20110283458 Gillette et al. Nov 2011 A1
20110290266 Koeller et al. Dec 2011 A1
20120006342 Rose et al. Jan 2012 A1
20120006343 Renaud et al. Jan 2012 A1
20120132196 Vladyslavovych May 2012 A1
20120145189 Knopow et al. Jun 2012 A1
20130061861 Hearn Mar 2013 A1
20150142088 Riva Godoy May 2015 A1
20150223520 Phillips Aug 2015 A1
20160168438 Harding Jun 2016 A1
20170196262 Brereton Jul 2017 A1
20170231281 Hatton Aug 2017 A1
Foreign Referenced Citations (249)
Number Date Country
262137 May 1968 AT
306224 Mar 1973 AT
321190 Mar 1975 AT
321191 Mar 1975 AT
2002364521 Jun 2003 AU
2146954 Oct 1996 CA
2414161 Jan 2002 CA
2414191 Jan 2002 CA
2520759 Oct 2004 CA
2492255 Jul 2006 CA
2668465 May 2009 CA
2641869 Jun 2010 CA
513656 Oct 1971 CH
698603 Sep 2009 CH
1038085 Dec 1989 CN
1043076 Jun 1990 CN
1045691 Oct 1990 CN
1059649 Mar 1992 CN
1123000 May 1996 CN
1123001 May 1996 CN
1126426 Jul 1996 CN
1158757 Sep 1997 CN
1287890 Mar 2001 CN
1293591 May 2001 CN
1293596 May 2001 CN
102212340 Oct 2001 CN
1578895 Feb 2005 CN
102131411 Jul 2011 CN
102499466 Jun 2012 CN
102604599 Jul 2012 CN
202351223 Jul 2012 CN
1100884 Mar 1961 DE
1425872 Nov 1968 DE
1290499 Mar 1969 DE
1813993 Jun 1970 DE
1425871 Oct 1970 DE
2315789 Oct 1973 DE
4105370 Aug 1992 DE
4307144 Jan 1995 DE
29509286 Oct 1995 DE
4420366 Dec 1995 DE
29700307 May 1997 DE
19854007 May 2000 DE
19854009 May 2000 DE
10058642 Jun 2001 DE
10007521 Aug 2001 DE
10064288 Aug 2001 DE
10164587 Jul 2003 DE
102005024803 Jun 2006 DE
102005023278 Nov 2006 DE
202006013439 Nov 2006 DE
102005056885 May 2007 DE
102006041544 Aug 2007 DE
102006041042 Mar 2008 DE
102006047146 Apr 2008 DE
102007011120 Sep 2008 DE
102008034509 Apr 2009 DE
102008013303 Sep 2009 DE
202009010400 Dec 2009 DE
102008038121 Feb 2010 DE
202010011436 Dec 2010 DE
102010046482 Mar 2012 DE
114399 Jun 1969 DK
488488 Mar 1989 DK
540774 Jul 1995 DK
540775 Aug 1997 DK
33668 Aug 1981 EP
0033668 Aug 1981 EP
0076897 Apr 1983 EP
0149997 Jul 1985 EP
0194257 Sep 1986 EP
0371285 Jun 1990 EP
0418464 Mar 1991 EP
0430559 Dec 1991 EP
0520231 Dec 1991 EP
0491952 Jul 1992 EP
0354661 Apr 1997 EP
540775 Jul 1997 EP
0824927 Feb 1998 EP
653218 Sep 1998 EP
1064083 Jan 2001 EP
1064101 Jan 2001 EP
1111191 Jun 2001 EP
1128741 Sep 2001 EP
1128742 Sep 2001 EP
1148905 Oct 2001 EP
2003997 Oct 2001 EP
1203189 May 2002 EP
1217320 Jun 2002 EP
1298993 Apr 2003 EP
1299499 Apr 2003 EP
1299500 Apr 2003 EP
1301152 Apr 2003 EP
1349601 Oct 2003 EP
1390112 Feb 2004 EP
1409051 Apr 2004 EP
1439876 Jul 2004 EP
1490452 Dec 2004 EP
1506792 Feb 2005 EP
1609376 Dec 2005 EP
1625334 Feb 2006 EP
1625335 Feb 2006 EP
1625336 Feb 2006 EP
1536703 Sep 2006 EP
1702639 Sep 2006 EP
1749548 Feb 2007 EP
1867357 Dec 2007 EP
1891867 Feb 2008 EP
1996880 Dec 2008 EP
2044967 Apr 2009 EP
2277398 Jul 2009 EP
2083642 Aug 2009 EP
2138058 Dec 2009 EP
2138059 Dec 2009 EP
2179229 Apr 2010 EP
2191735 Jun 2010 EP
2227973 Sep 2010 EP
2234508 Oct 2010 EP
2241203 Oct 2010 EP
2138057 Nov 2010 EP
2246086 Nov 2010 EP
2249669 Nov 2010 EP
2257195 Dec 2010 EP
2303043 Apr 2011 EP
2368449 Sep 2011 EP
2408494 Jan 2012 EP
2523752 Nov 2012 EP
2542131 Jan 2013 EP
262308 Jun 1982 ES
1418189 Nov 1965 FR
2573985 Jun 1986 FR
2604093 Mar 1988 FR
2700697 Jul 1994 FR
2730166 Aug 1996 FR
2818152 Jun 2002 FR
2842791 Jan 2005 FR
2873584 Nov 2006 FR
910166 Nov 1962 GB
922310 Mar 1963 GB
958867 May 1964 GB
1104214 Feb 1968 GB
1227333 Apr 1971 GB
1379688 Jan 1975 GB
1431334 Apr 1976 GB
2323033 Sep 1998 GB
2342874 Apr 2000 GB
2388040 Nov 2003 GB
2412326 Sep 2005 GB
2412876 Oct 2005 GB
2448478 Oct 2008 GB
2487851 Aug 2012 GB
63083 Mar 1995 IE
1289590 Oct 1998 IT
49061986 Jun 1974 JP
50096908 Aug 1975 JP
53014173 Feb 1978 JP
55094260 Jul 1980 JP
57110260 Jul 1982 JP
57177769 Nov 1982 JP
62205184 Sep 1987 JP
63153666 Jun 1988 JP
01191674 Aug 1989 JP
02-092986 Apr 1990 JP
02092986 Apr 1990 JP
02127493 May 1990 JP
03041185 Feb 1991 JP
H 062164 Jan 1994 JP
2519658 Jul 1996 JP
08228751 Sep 1996 JP
3053426 Oct 1998 JP
11178562 Jul 1999 JP
3016586 Mar 2000 JP
2000119643 Apr 2000 JP
3078033 Aug 2000 JP
3118462 Dec 2000 JP
3118463 Dec 2000 JP
2002253593 Sep 2002 JP
2002336290 Nov 2002 JP
2003034785 Feb 2003 JP
2004504580 Feb 2004 JP
2005516647 Jun 2005 JP
2006219557 Aug 2006 JP
2007516015 Jun 2007 JP
2007522900 Aug 2007 JP
2008509907 Apr 2008 JP
2010526553 Aug 2010 JP
2066337 Sep 1996 RU
2098446 Dec 1997 RU
2285028 Oct 2006 RU
502503 Oct 2006 SE
WO8601730 Mar 1986 WO
WO9527411 Oct 1995 WO
WO9805906 Feb 1998 WO
WO9835552 Aug 1998 WO
WO9914402 Mar 1999 WO
WO9947273 Sep 1999 WO
WO9947806 Sep 1999 WO
WO9013326 Nov 1999 WO
WO0028843 May 2000 WO
WO0104548 Jan 2001 WO
WO0140717 Jun 2001 WO
WO0163183 Aug 2001 WO
WO0205620 Jan 2002 WO
WO0205640 Jan 2002 WO
WO0206421 Jan 2002 WO
WO0207656 Jan 2002 WO
WO0224262 Mar 2002 WO
WO02051466 Jul 2002 WO
WO02096532 Dec 2002 WO
WO03037412 May 2003 WO
WO03049792 Jun 2003 WO
WO03083007 Oct 2003 WO
WO 2004089126 Oct 2004 WO
WO2004098324 Nov 2004 WO
WO2004104491 Dec 2004 WO
WO2004104492 Dec 2004 WO
WO2004104493 Dec 2004 WO
WO2006022714 Mar 2006 WO
WO2007054167 May 2007 WO
WO2007078273 Jul 2007 WO
WO2007090594 Aug 2007 WO
WO2007098337 Aug 2007 WO
WO2007116915 Oct 2007 WO
WO2008015441 Feb 2008 WO
WO2008051909 May 2008 WO
WO2008069883 Jun 2008 WO
WO2008151777 Dec 2008 WO
WO2009006521 Jan 2009 WO
WO2009042955 Apr 2009 WO
WO2009079641 Jun 2009 WO
WO2009092862 Jul 2009 WO
WO2009118085 Oct 2009 WO
WO2009152651 Dec 2009 WO
WO2009155957 Dec 2009 WO
WO2009156181 Dec 2009 WO
WO2010017586 Feb 2010 WO
WO2010047389 Apr 2010 WO
WO2010053467 May 2010 WO
WO2010060537 Jun 2010 WO
WO2010102832 Sep 2010 WO
WO2010107613 Sep 2010 WO
WO2011045609 Apr 2011 WO
WO2011088132 Jul 2011 WO
WO2011101164 Aug 2011 WO
WO201117580 Sep 2011 WO
WO2011109304 Sep 2011 WO
WO2012054973 May 2012 WO
WO2012078865 Jun 2012 WO
WO2012100430 Aug 2012 WO
Non-Patent Literature Citations (17)
Entry
UKIPO Search Report dated Jan. 17, 2013 for UK Patent Application No. GB1216621.1 filed Sep. 18, 2012.
International Search Report and Written Opinion dated Jun. 30, 2014 for International Patent Application No. PCT/GB2013/052433 filed Sep. 18, 2013.
International Preliminary Report on Patentability dated Mar. 24, 2015 for International Patent Application No. PCT/GB2013/052433 filed Sep. 18, 2013.
International Search Report and Written Opinion dated Dec. 9, 2013 for International Patent Application No. PCT/EP2013/068797 filed Sep. 11, 2013.
International Preliminary Report on Patentability dated Mar. 31, 2015 for International Patent Application No. PCT/EP2013/068797 filed Sep. 11, 2013.
International Preliminary Report on Patentability dated Jun. 1, 2015 for International Patent Application No. PCT/EP2014/063785 filed Jun. 27, 2014.
International Search Report dated Oct. 30, 2014 for International Application No. PCT/EP2014/063785.
Application and File History for U.S. Appl. No. 14/428,344, filed Mar. 13, 2015, inventors Phillips et al.
International Search Report and Written Opinion for International Application No. PCT/EP2014/064365 dated Oct. 7, 2014.
International Search Report and Written Opinion for International Application No. PCT/EP2014/063785 dated Oct. 30, 2014.
Japanese Office Action, Application No. 2016-522550, dated Jan. 31, 2017, 4 pages (7 pages with translation).
Russian Office Action, Application No. 2016103729, dated Apr. 12, 2017, 12 pages (15 pages with translation).
Chinese Office Action, Application No. 201480037049.2, dated May 9, 2017, 23 pages (28 pages with translation).
Japanese Office Action, Application No. 2016-522550, dated Jul. 4, 2017, 4 pages ( 7 pages with translation).
Chinese Office Action, Application No. 201380047284.3, dated Nov. 13, 2017, 21 pages (30 pages with translation).
Japanese Office Action, Application No. 2017-017842, dated Dec. 1, 2017, 3 pages (6 pages with translation).
Japanese Office Action, Application No. 2016-522646, dated Dec. 15, 2016, 6 pages.
Related Publications (1)
Number Date Country
20160146506 A1 May 2016 US