Devices, systems, and methods for medicament delivery

Description

BRIEF DESCRIPTION OF THE DRAWINGS

A wide variety of potential embodiments will be more readily understood through the following detailed description of certain exemplary embodiments, with reference to the accompanying exemplary drawings in which:

FIG. 1 is a perspective view of an exemplary embodiment of a system 1000;

FIG. 2 is a front view of an exemplary embodiment of a system 1000;

FIG. 3 is a side view of an exemplary embodiment of a system 1000;

FIG. 4 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a first operative position;

FIG. 5 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a second operative position;

FIG. 6 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a third operative position;

FIG. 7 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a fourth operative position;

FIG. 8 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a fifth operative position;

FIG. 9 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a sixth operative position;

FIG. 10 is a flowchart of an exemplary embodiment of a method 10000;

FIG. 11 is a perspective view of an exemplary embodiment of system 1000;

FIG. 12 is a perspective cross-sectional view taken along lines B-B of FIG. 11;

FIG. 13 is a perspective view of an exemplary embodiment of actuation stick 2200;

FIG. 14 is a cross-sectional view of an exemplary embodiment of gas venting mechanism 8000 taken along lines A-A of FIG. 3;

FIG. 15 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 15000;

FIG. 16 is a perspective view of an exemplary embodiment an auto-injector 16000;

FIG. 17 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 17000;

FIG. 18A is an end view of an exemplary embodiment of a system 18000;

FIG. 18B is a cross-sectional view taken along lines A-A of FIG. 18A of an exemplary embodiment of a system 18000;

FIG. 19 is a cross-sectional view taken along lines A-A of FIG. 18A of an exemplary embodiment of a system 19000;

FIG. 20 is a cross-sectional view taken along lines A-A of FIG. 18A of an exemplary embodiment of a system 20000;

FIG. 21A is a cross-sectional view taken along lines A-A of FIG. 18A of an exemplary embodiment of a system 21000;

FIG. 21B is a front view of an exemplary embodiment of a system 21000;

FIG. 22A is a cross-sectional view taken along lines A-A of FIG. 18A of an exemplary embodiment of a system 22000;

FIG. 22B is a front view of an exemplary embodiment of a system 22500;

FIG. 23 is a cross-sectional view taken along lines A-A of FIG. 18A of an exemplary embodiment of a system 23000;

FIG. 24 is a perspective view of an exemplary embodiment an auto-injector 24000;

FIG. 25 is a perspective view of an exemplary embodiment an auto-injector 25000; and

FIG. 26 is a block diagram of an exemplary embodiment an information device 26000.

DETAILED DESCRIPTION
Definitions

When the following terms are used substantively herein, the accompanying definitions apply:

a—at least one.

activate—to actuate and/or set in motion and/or action.

activity—an action, act, step, and/or process or portion thereof.

actuating portion—that part that puts something into action.

actuation lock—a device adapted to prevent actuation, such as, for example a pivotable, translatable, keyed, squeezable, and/or removable lock.

actuator—a mechanism that puts something into action.

adapted to—suitable or fit for a particular purpose.

and/or—either in conjunction with or in alternative to.

apparatus—a mechanism and/or device.

arm—an elongated structural member, which need not be solely linear.

auto-injector—device that allows a user to deliver a medicament without having to manually prepare the injection. Exemplary devices include pen delivered injectors, syringes, needleless injectors, gas powered auto-injectors, and/or any other auto-injector and/or medical device used to inject a medicament into a user/patient, etc.

automatically—acting or operating in a manner essentially independent of external influence or control. For example, an automatic light switch can turn on upon “seeing” a person in its view, without the person manually operating the light switch.

axis—a straight line about which a body or geometric object rotates or may be conceived to rotate.

can—is capable of, in at least some embodiments.

channel—a conduit for one or more fluids.

compressed gas—a substantially pressurized substance, such as helium, nitrogen, and/or carbon dioxide, etc., in a gaseous form.

comprising—including but not limited to.

contain—to hold within.

contents—a contained compressed gas.

credit card—a card (usually plastic) that assures a seller that the person using it has a satisfactory credit rating and that the issuer will see to it that the seller receives payment for the merchandise and/or services delivered. Typically measuring in size from approximately 3 to approximately 4 inches in length, such as approximately 3.40 inches, 3.375 inches, 85 millimeters, etc., and from approximately 1.75 to approximately 2.75 inches in width, such as approximately 2.10 inches, 2.2125 inches, 2.5 inches, 55 millimeters, etc.

data—distinct pieces of information, usually formatted in a special or predetermined way and/or organized to express concepts.

define—to establish the outline, form, or structure of.

device—a machine, manufacture, and/or collection thereof.

discharge—to release from confinement; to emit.

driving force—a force sufficient to cause, directly or indirectly, expulsion of an injectable medicament from one or more vials and/or from an auto-injector.

dry substance—a material that is substantially free from liquid or moisture.

eject—to expel.

embedded system—a programmed hardware device comprising a microprocessor controlled by an operating system and/or control logic that is specifically designed for a particular kind of application. The operating system and/or control logic of an embedded system comprises a limited set of pre-defined functions that cannot be modified or added to by additional user-installed software, although some embedded systems allow a user to modify values of variables and/or parameters of the pre-defined functions. Exemplary devices that can comprise embedded systems are: medical devices, calculators, automobiles, airplanes, vending machines, toys, programmable logic controllers, appliances, refrigerators, microwave ovens, clothes washers, thermostats, alarm systems, sprinkler systems, lighting controllers, electronic equipment, laser printers, CD players, DVD players, watches, and/or digital cameras, etc.

escape port—an opening for the exit of a gas.

expulsion—the act of forcibly ejecting a fluid via a designed outlet of a container.

expulsion pressure—a force applied over an area of a liquid, the force sufficient to expel the liquid in a predetermined manner.

extend—to move out and/or away from.

extendable—able to move out and/or away from.

fluid—a gas and/or liquid.

fluidly coupleable—able to be related via a fluid.

force initiator—a source, such as a compressed gas container, spring, and/or chemical reaction, etc., capable of supplying a driving force.

frangible—a device that is capable of being broken and/or penetrated to allow fluid to flow therethrough.

haptic—involving the human sense of kinesthetic movement and/or the human sense of touch. Among the many potential haptic experiences are numerous sensations, body-positional differences in sensations, and time-based changes in sensations that are perceived at least partially in non-visual, non-audible, and non-olfactory manners, including the experiences of tactile touch (being touched), active touch, grasping, pressure, friction, traction, slip, stretch, force, torque, impact, puncture, vibration, motion, acceleration, jerk, pulse, orientation, limb position, gravity, texture, gap, recess, viscosity, pain, itch, moisture, temperature, thermal conductivity, and thermal capacity.

hard real-time—relating to computer systems that provide an absolute deterministic response to an event. Such a response is not based on average event time. Instead, in such computer systems, the deadlines are fixed and the system must guarantee a response within a fixed and well-defined time. Systems operating in hard real-time typically interact at a low level with physical hardware via embedded systems, and can suffer a critical failure if time constraints are violated. A classic example of a hard real-time computing system is the anti-lock brakes on a car. The hard real-time constraint, or deadline, in this system is the time in which the brakes must be released to prevent the wheel from locking. Another example is a car engine control system, in which a delayed control signal might cause engine failure or damage. Other examples of hard real-time embedded systems include medical systems such as heart pacemakers and industrial process controllers.

hazardous condition—a situation marked by risk, danger, and/or peril.

housing—something that covers, encloses, protects, holds, and/or supports.

in reaction to—responding indirectly and/or directly to.

indicate—to show, mark, signify, denote, evidence, evince, manifest, declare, enunciate, specify, explain, exhibit, present, reveal, disclose, and/or display.

indicator—a device and/or substance that indicates.

information device—any device capable of processing information, such as any general purpose and/or special purpose computer, such as a personal computer, workstation, server, minicomputer, mainframe, supercomputer, computer terminal, laptop, wearable computer, and/or Personal Digital Assistant (PDA), mobile terminal, Bluetooth device, communicator, “smart” phone (such as a Treo-like device), messaging service (e.g., Blackberry) receiver, pager, facsimile, cellular telephone, a traditional telephone, telephonic device, a programmed microprocessor or microcontroller and/or peripheral integrated circuit elements, an ASIC or other integrated circuit, a hardware electronic logic circuit such as a discrete element circuit, and/or a programmable logic device such as a PLD, PLA, FPGA, or PAL, or the like, etc. In general any device on which resides a finite state machine capable of implementing at least a portion of a method, structure, and/or or graphical user interface described herein may be used as an information device. An information device can comprise components such as one or more network interfaces, one or more processors, one or more memories containing instructions, and/or one or more input/output (I/O) devices, one or more user interfaces coupled to an I/O device, etc.

injectable medicament—a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.

input/output (I/O) device—any sensory-oriented input and/or output device, such as an audio, visual, haptic, olfactory, and/or taste-oriented device, including, for example, a monitor, display, projector, overhead display, keyboard, keypad, mouse, trackball, joystick, gamepad, wheel, touchpad, touch panel, pointing device, microphone, speaker, video camera, camera, scanner, printer, haptic device, vibrator, tactile simulator, and/or tactile pad, potentially including a port to which an I/O device can be attached or connected.

liquid—a body of matter that exhibits a characteristic readiness to flow, little or no tendency to disperse, and relatively high incompressibility.

longitudinal—of or relating to longitude or length.

machine instructions—directions adapted to cause a machine, such as an information device, to perform a particular operation or function.

machine readable medium—a physical structure from which a machine can obtain data and/or information. Examples include a memory, punch cards, etc.

may—is allowed to, in at least some embodiments.

memory device—an apparatus capable of storing analog or digital information, such as instructions and/or data. Examples include a nonvolatile memory, volatile memory, Random Access Memory, RAM, Read Only Memory, ROM, flash memory, magnetic media, a hard disk, a floppy disk, a magnetic tape, an optical media, an optical disk, a compact disk, a CD, a digital versatile disk, a DVD, and/or a raid array, etc. The memory device can be coupled to a processor and/or can store instructions adapted to be executed by processor, such as according to an embodiment disclosed herein.

method—a process, procedure, and/or collection of related activities for accomplishing something.

microprocessor—an integrated circuit comprising a central processing unit.

mixable—dissolvable, dispersible, and/or capable of being put into so that the dry substance is diffused and/or commingled in the liquid.

needle—a hollow, slender, sharp-pointed instrument used for injection. Includes cannulas.

network—a communicatively coupled plurality of nodes.

network interface—any device, system, or subsystem capable of coupling an information device to a network. For example, a network interface can be a telephone, cellular phone, cellular modem, telephone data modem, fax modem, wireless transceiver, ethernet card, cable modem, digital subscriber line interface, bridge, hub, router, or other similar device.

non-co-axial—not having co-linear axes.

output device—an apparatus configured to visually, audibly, and/or haptically render information to a human. Examples include an audible output sub-system (e.g., speaker, horn, buzzer, and/or piezoelectric transducer, etc.), a visual output sub-system (e.g., flag, marker, light, liquid crystal display (LCD), light emitting diode (LED), optical fiber, organic polymer display, electric paper, screen, display, monitor, and/or tube, etc.), and a haptic output sub-system (e.g., buzzer, vibrator, bulging portion, tactile stimulator, cooler, and/or heater, etc.), etc.

patient—a receiver of an injectable medicament, such as a human, mammal, animal, etc.

piston—a sliding piece which either is moved by, or moves against, fluid pressure.

pivotable—capable of pivoting.

plurality—the state of being plural and/or more than one.

predetermined—established in advance.

processor—a device and/or set of machine-readable instructions for performing one or more predetermined tasks. A processor can comprise any one or a combination of hardware, firmware, and/or software. A processor can utilize mechanical, pneumatic, hydraulic, electrical, magnetic, optical, informational, chemical, and/or biological principles, signals, and/or inputs to perform the task(s). In certain embodiments, a processor can act upon information by manipulating, analyzing, modifying, converting, transmitting the information for use by an executable procedure and/or an information device, and/or routing the information to an output device. A processor can function as a central processing unit, local controller, remote controller, parallel controller, and/or distributed controller, etc. Unless stated otherwise, the processor can be a general-purpose device, such as a microcontroller and/or a microprocessor, such the Pentium IV series of microprocessor manufactured by the Intel Corporation of Santa Clara, Calif. In certain embodiments, the processor can be dedicated purpose device, such as an Application Specific Integrated Circuit (ASIC) or a Field Programmable Gate Array (FPGA) that has been designed to implement in its hardware and/or firmware at least a part of an embodiment disclosed herein.

programmable logic controller (PLC)—a solid-state, microprocessor-based, hard real-time computing system that is used, via a network, to automatically monitor the status of field-connected sensor inputs, and automatically control communicatively-coupled devices of a controlled system (e.g., actuators, solenoids, relays, switches, motor starters, speed drives (e.g., variable frequency drives, silicon-controlled rectifiers, etc.), pilot lights, ignitors, speakers, tape drives, printers, monitors, displays, etc.) according to a user-created set of values and user-created logic and/or instructions stored in memory. The sensor inputs reflect measurements and/or status information related to the controlled system. A PLC provides any of: automated input/output control; switching; counting; arithmetic operations; complex data manipulation; logic; timing; sequencing; communication; data file manipulation; report generation; control; relay control; motion control; process control; distributed control; and/or monitoring of processes, equipment, and/or other automation of the controlled system. Because of its precise and hard real-time timing and sequencing capabilities, a PLC is programmed using ladder logic or some form of structured programming language specified in IEC 61131-3, namely, FBD (Function Block Diagram), LD (Ladder Diagram), ST (Structured Text, Pascal type language), IL (Instruction List) and/or SFC (Sequential Function Chart). Because of its precise and real-time timing and sequencing capabilities, a PLC can replace up to thousands of relays and cam timers. PLC hardware often has good redundancy and fail-over capabilities. A PLC can use a Human-Machine Interface (HMI) for interacting with users for configuration, alarm reporting, and/or control.

puncturer—a device adapted to penetrate using a substantially sharp and/or tapered point, tip, edge, or the like.

pusher—a device adapted to convert fluid pressure to mechanical movement.

render—make perceptible to a human, for example as data, commands, text, graphics, audio, video, animation, and/or hyperlinks, etc., such as via any visual, audio, and/or haptic means, such as via a display, monitor, electric paper, ocular implant, cochlear implant, speaker, etc.

repeatedly—again and again; repetitively.

reservoir—a receptacle or chamber for storing and/or directing movement of a fluid.

resist—to avoid and/or remain firm against the actions, effects, and/or force of.

retract—to pull inward.

safety tab—a removable device configured to prevent actuation of an auto-injector when the safety tab is in one orientation, and allow actuation when in another orientation.

sensed variable—a measured parameter.

set—a related plurality.

sheath—a protective cover.

shield—a protective device or structure.

soft real-time—relating to computer systems that take a best efforts approach and minimize latency from event to response as much as possible while keeping throughput up with external events overall. Such systems will not suffer a critical failure if time constraints are violated. For example, live audio-video systems are usually soft real-time; violation of time constraints can result in degraded quality, but the system can continue to operate. Another example is a network server, which is a system for which fast response is desired but for which there is no deadline. If the network server is highly loaded, its response time may slow with no failure in service. This is contrasted with the anti-lock braking system where a slow down in response would likely cause system failure, possibly even catastrophic failure.

spring—an elastic device, such as a coil of wire, that regains its original shape after being compressed or extended.

status—a state or condition.

store—to place, hold, and/or retain data, typically in a memory.

substantially—to a great extent or degree.

system—a collection of mechanisms, devices, data, and/or instructions, the collection designed to perform one or more specific functions.

tip—a terminal end.

transfer—to convey from one place to another.

translatable—capable of being transferred from one place to another and/or of being moved with respect to something else.

triggerable—capable of being actuated.

use indication—information regarding a use of an auto-injector, such as information regarding any of auto-injector selection; auto-injector maintenance; auto-injector expiration; auto-injector replacement; medicament expiration; medicament selection; medicament mixing; injection delay; safety guard removal; auto-injector positioning; auto-injector orientation; actuator location; injection hazard avoidance; auto-injector actuation; injection duration; injection status; injection error; auto-injector removal; auto-injector reuse; auto-injector recycling; and auto-injector disposal, etc.

user input—human-provided information.

user interface—any device for rendering information to a user and/or requesting information from the user. A user interface includes at least one of textual, graphical, audio, video, animation, and/or haptic elements. A textual element can be provided, for example, by a printer, monitor, display, projector, etc. A graphical element can be provided, for example, via a monitor, display, projector, and/or visual indication device, such as a light, flag, beacon, etc. An audio element can be provided, for example, via a speaker, microphone, and/or other sound generating and/or receiving device. A video element or animation element can be provided, for example, via a monitor, display, projector, and/or other visual device. A haptic element can be provided, for example, via a very low frequency speaker, vibrator, tactile stimulator, tactile pad, simulator, keyboard, keypad, mouse, trackball, joystick, gamepad, wheel, touchpad, touch panel, pointing device, and/or other haptic device, etc. A user interface can include one or more textual elements such as, for example, one or more letters, number, symbols, etc. A user interface can include one or more graphical elements such as, for example, an image, photograph, drawing, icon, window, title bar, panel, sheet, tab, drawer, matrix, table, form, calendar, outline view, frame, dialog box, static text, text box, list, pick list, pop-up list, pull-down list, menu, tool bar, dock, check box, radio button, hyperlink, browser, button, control, palette, preview panel, color wheel, dial, slider, scroll bar, cursor, status bar, stepper, and/or progress indicator, etc. A textual and/or graphical element can be used for selecting, programming, adjusting, changing, specifying, etc. an appearance, background color, background style, border style, border thickness, foreground color, font, font style, font size, alignment, line spacing, indent, maximum data length, validation, query, cursor type, pointer type, autosizing, position, and/or dimension, etc. A user interface can include one or more audio elements such as, for example, a volume control, pitch control, speed control, voice selector, and/or one or more elements for controlling audio play, speed, pause, fast forward, reverse, etc. A user interface can include one or more video elements such as, for example, elements controlling video play, speed, pause, fast forward, reverse, zoom-in, zoom-out, rotate, and/or tilt, etc. A user interface can include one or more animation elements such as, for example, elements controlling animation play, pause, fast forward, reverse, zoom-in, zoom-out, rotate, tilt, color, intensity, speed, frequency, appearance, etc. A user interface can include one or more haptic elements such as, for example, elements utilizing tactile stimulus, force, pressure, vibration, motion, displacement, temperature, etc.

valve—a device that regulates flow through a pipe and/or through an aperture by opening, closing, and/or obstructing a port and/or passageway.

vent—to release from confinement.

via—by way of and/or utilizing.

vial—a closable vessel.

DETAILED DESCRIPTION

Exposure, such as via ingestion, inhalation, and/or injection, to certain allergens, toxins, and/or other substances can cause profound reactions for some and/or all people and/or animals. For example, certain people are highly allergic to certain substances, such as peanuts, shellfish, particular drugs, certain proteins, bee venom, insect bites, etc. The allergic response to the exposure can lead to anaphylactic shock, which can cause a sharp drop in blood pressure, hives, and/or substantial breathing difficulties caused by severe airway constriction. As another example, inhalation of certain nerve agents can cause severe physiological trauma. Responding rapidly to such exposures can prevent injury and/or death. For example, in response to an exposure leading to anaphylactic shock, an injection of epinephrine (i.e., adrenaline) can provide substantial and/or complete relief from the reaction. As another example, injection of an antidote to a nerve agent can greatly reduce and/or eliminate the potential harm of the exposure. As yet another example, rapid injection of certain drugs, such as a beta blocker, blood thinner, nitroglycerine, antihistamines, insulin, and opioids, etc., can provide substantial relief from various dangerous medical conditions.

Thus, certain exemplary embodiments provide systems, devices, and/or methods for rapidly injecting a medicament.

Certain exemplary embodiments comprise an apparatus, comprising: a compressed gas container; a plurality of vials adapted to store a liquid medicament, each vial defining a longitudinal axis, the longitudinal axes of the plurality of vials parallel and non-co-axial, the plurality of vials fluidly coupleable to an actuating portion of a contents of the gas container; and a plurality of pistons, each piston adapted to move within a corresponding vial from the plurality of vials, the plurality of pistons adapted to, in response to discharge of the actuating portion of the contents of the compressed gas container, transfer at least a portion of the liquid medicament from the plurality of vials and through a needle that is extendable into a patient. Certain exemplary embodiments comprise a method comprising a plurality of activities, comprising: discharging an actuating portion of a contents of a compressed gas container, the compressed gas container contained within an apparatus; in reaction to said discharging activity, moving a piston within a vial, the vial one of a plurality of vials contained within the apparatus, each vial adapted to store a liquid medicament, each vial defining a longitudinal axis, the longitudinal axes of the plurality of vials parallel and non-co-axial, the plurality of vials fluidly coupleable to a contents of the gas container; and transferring a liquid medicament from the vial and through a needle that is extendable into a patient.

FIG. 1 is a perspective view, FIG. 2 is a front view, and FIG. 3 is a side view, of an exemplary embodiment of a system 1000, which can comprise a housing 1100, which, in certain operative embodiments, can comprise a handheld portion 1800 separated via an actuation guard 1200 from an actuation bar 1300. Actuation guard 1200 can prevent accident activation of system 1000. Housing 1100 can be constructed of a durable material, such as stainless steel, aluminum, polycarbonate, etc., to protect a compressed gas container, medicament, injection apparatus and/or user of system 1000. The injection apparatus can be actuated by a fluid pressure, such as pressure provided by the compressed gas, which upon completion of its actuation duties can escape housing 1100 via gas escape opening, such as via status indicator 1400.

A status of a system 1000 can be determined via status indicator 1400, which can provide a view, such as via a UV blocking, photo-sensitive, and/or translucent window, into an interior of housing 1100. Viewable through the window can be a status of medicament carried by housing 1100, a location of a needle and/or injection apparatus for the medicament, and/or an activation status of system 1000. For example, if the medicament has aged to the point of discoloration, which aging might or might not render the medication useless, harmful, etc., status indicator 1400 can allow that situation to be determined. In certain exemplary embodiments, gas can escape housing 1100 via status indicator 1400 and/or another opening in housing 1100.

Certain exemplary embodiments of system 1000 can provide a compact medicament delivery mechanism that can efficiently and/or rapidly deliver a prescribed dose. The length (L) and width (W) of system 1000 can be similar to that of a credit card, and the thickness (T) can be less than one inch. Thus, certain exemplary embodiments of system 1000 can provide a conveniently carried, easy-to-use, easy to activate drug delivery apparatus that can require little to no training to safely carry, use, and/or dispose of.

To assist a user in positioning system 1000 in a correct orientation for injection, system 1000 and/or housing 1100 can provide various tactile clues. For example, a top 1110 of housing 1100 can be rounded, and a bottom 1120 of actuation bar 1300 of housing 1100 can be flat. Other tactile clues are also possible, such as bulges, ribs, grooves, gaps, roughened surfaces, indentations, etc.

FIG. 4 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a first operative position. FIGS. 5, 6, 7, 8, and 9 show system 1000 of FIG. 4 in second, third, fourth, fifth, and sixth operative positions, respectively.

System 1000 can comprise a housing 1100, handheld portion 1800, actuation guard 1200, and/or actuation bar 1300. System 1000 can comprise system actuator 2000, gas reservoirs 3000, medicament actuator 4000, medicament storage assembly 5000, medicament carrier 9000, needle assembly 6000, use indicator 7000, and/or gas vent mechanism 8000, etc.

Upon removal, release, rotation, and/or relocation of actuation guard 1200, system actuator 2000 can be adapted to rapidly discharge an actuating portion of a contents of a compress gas container. For example, system actuator 2000 can comprise a compressed gas container 2400, which initially can contain a compressed gas 2500, an actuating portion of which can be released from container 2400 by penetration of a gas port 2600 via a point of a puncturer 2700. Upon removal and/or relocation of actuation guard 1200, actuation bar 1300 can be moved closer to and/or in contact with handheld portion 1800. Upon removal and/or relocation of actuation guard 1200, gas container 2400 can be brought into contact with puncturer 2700 via extension of a pre-compressed spring 2300 and/or movement of a actuation stick 2200. Thus, actuation guard 1200 can prevent accident activation of system 1000 and/or unintended discharge of an actuating portion of the contents 2500 of gas container 2400.

Once gas port 2600 has been punctured, an actuating portion of compressed gas 2500 can escape from container 2400 and flow via gas reservoirs 3000, such as gas channel 3100. The flowing gas can meet and/or apply gas pressure to medicament actuator 4000, which can comprise a pusher 4100, which can travel within a sleeve 1500 defined by walls 1520. Sleeve 1500 can be constructed of metal, stainless steel, aluminum, plastic, polycarbonate, etc. Seals 4200, such as o-rings, can resist gas leakage, such as past pusher 4100 and/or out of housing 1100. Thus, pusher 4100 can function as a piston traveling within a cylinder, although it is not necessarily required that the cross-sectional shape of sleeve 1500 be round.

Medicament actuator 4000 can interface with medicament storage assembly 5000. For example, medicament actuator 4000 can comprise a plurality of plungers 4300, each of which can be capped with a piston 4400 which can sealingly slide and/or move within a corresponding vial 5100 containing a liquid medicament 5200. For example, in response to pressure applied by an actuating portion of the contents 2500 of compressed gas container 2400, pusher 4100 can cause plungers 4300 and/or pistons 4400 to simultaneously move. The number of corresponding sets of plungers 4300, pistons 4400, and/or vials 5100 can be 2, 3, 4, 5, 6, or more. Pistons 4400 can be constructed of a resilient, durable, and/or sealing material, such as a rubber. Each plunger 4300 from the plurality of plungers can define a longitudinal axis, the longitudinal axes (e.g., axes 4310, 4320, 4330, 4340) of the plurality of plungers parallel, non-coaxial, and/or co-planar.

Each vial 5100 from the plurality of vials can be substantially cylindrical with a substantially round and/or substantially elliptical cross-sectional shape. Thus, each vial 5100 can define a longitudinal axis, the longitudinal axes of the plurality of vials parallel, non-coaxial, and/or co-planar. The longitudinal axis of each vial can be co-axial with the longitudinal axis of its corresponding plunger.

Each vial can be capped at one end with a frangible 5300, which can be burst when piston 4400 generates sufficient pressure upon medicament 5200, thereby allowing at least a portion of medicament 5200 to flow out of vial 5100 and into medicament carrier 9000. Thus, the plurality of vials can be fluidly coupleable to the actuating portion of the contents 2500 of gas container 2400.

Medicament carrier 9000 can hold each of vials 5100 and can travel within sleeve 1500. Medicament carrier 9000 can comprise a plurality of channels 9200 adapted to receive medicament 5200 as it exits its respective vial 5100, and direct medicament 5200 to a common conduit 9300. Medicament carrier 9000 can interface with needle assembly 6000 and/or use indicator 7000.

From common conduit 9300, medicament 5200 can enter needle assembly 6000, such as into a single needle 6100 via which medicament can approach needle tip 6200. As medicament actuator 4000 and/or medicament carrier 9000 are driven toward actuator bar 1300, needle tip 6200 can penetrate an end 6400 of needle sheath 6300 and exit actuator bar 1300 at needle port 1340.

Referring to FIG. 5, upon movement of actuation bar 1300 closer to handheld portion 1800, sheath seat 1330 can come in contact with sheath tip 6400, thereby causing sheath 6300 to buckle and/or crumble. As actuator bar 1300 comes in contact with handheld portion 1800, bar stop 1320 can approach medicament carrier stop 9400, while carrier spring 1600 is compressed.

Referring to FIG. 6, as at least a portion of contents 2500 of gas container 2400 escapes, it can flow through channel 3100. The gas, which can still be relatively pressurized, can begin to accumulate behind pusher 4100 to form an expanding gas chamber 3200 and to cause medicament actuator 4000, medicament storage assembly 5000, and medicament carrier 9000 to slide together within sleeve 1500. As medicament actuator 4000, medicament storage assembly 5000, and medicament carrier 9000 slide closer to actuator bar 1300, spring 1600 becomes increasingly compressed between bar stop 1320 and medicament carrier stop 9400. As medicament actuator 4000, medicament storage assembly 5000, and medicament carrier 9000 slide closer to actuator bar 1300, needle tip 6200 can extend further from actuator bar 1300 and sheath 6300 can become further compressed and/or deformed. At its ultimate extension point, needle tip 6200 can extend from housing 1100 from approximately 0.25 millimeters to approximately 20 millimeters, including all values and subranges therebetween, such as up to approximately 2 millimeters, greater than approximately 5 millimeters, from approximately 5.13 millimeters to approximately 9.98 millimeters, etc.

Referring to FIG. 7, as gas chamber 3200 continues to expand, medicament carrier 9000 can be driven until medicament carrier stop 9400 contacts actuator bar stop 1300 thereby resisting further travel of medicament carrier 9000. At that point, additional expansion of gas chamber 3200 can cause medicament actuator 4000, pusher bar 4100, plungers 4300, and/or pistons 4400 to initiate travel with respect to medicament storage assembly 5000, thereby generating an expulsion pressure in vials 5100, and/or thereby rupturing frangibles 5300 and allowing medicament 5200 to enter medicament carrier 9000, and begin flowing through medicament channels 9200, medicament conduit 9300, needle 6100, and/or out needle tip 6200 and into a patient. Alternatively, frangibles 5300 can be replaced and/or augmented by a frangible located at or near where medicament conduit 9300 couples to needle 6100. Frangibles 5300 can be constructed of a thin, taught, resilient, durable, and/or sealing material potentially having a predetermined yield strength, such as a rubber, such as chromo butyl rubber, and/or of a relatively brittle material potentially having a predetermined yield strength, such as ceramic, certain plastics, such as polystyrene, etc.

As medicament carrier stop 9400 contacts actuator bar stop 1300, medicament carrier hooks 9600 can engage with engagement receivers 7100 in use indicator 7000.

Referring to FIG. 8, as gas chamber 3200 continues to expand, medicament actuator 4000, pusher bar 4100, plungers 4300, and/or pistons 4400 can continue moving until they complete their travel within medicament storage assembly 5000, thereby expelling a predetermined dose of medicament 5200 from vials 5100, out of needle assembly 6000, external to housing 1100, and/or into the patient. As gas chamber 3200 reaches its maximum size, medicament actuator 4000, pusher bar 4100, plungers 4300, and/or pistons 4400 can continue moving until they complete their travel with respect to medicament carrier 9000, thereby causing gas release actuator 9700 to engage with gas release valve 8200. Engagement of gas release actuator 9700 with gas release valve 8200 can cause within gas chamber 3200 to exit gas chamber 3200, discharge away from pistons 4400, and/or exhaust from system 1000 and/or housing 1100, such as via status indicator 1400 and/or a gas escape port located on housing 1100).

Referring to FIG. 8 and FIG. 9, as sufficient gas is vented from gas chamber 3200, the pressure applied by the gas in gas chamber 3200 can decrease until the force applied by the gas on medicament actuator 4000 is less than the force of compressed spring 1600. Thus, spring(s) 1600 can begin to expand, thereby moving medicament carrier 9000, vial assembly 5000, and medicament actuator 4000 away from actuator bar 1300 and helping to exhaust gas from gas chamber 3200. As medicament carrier 9000 moves, use indicator 7000 can travel with it, due to the engaged relationship of medicament carrier hooks 9600 and engagement receivers 7100 and/or engagement catches 7200 in use indicator 7000. As use indicator 7000 moves away from actuation bar 1300, sheath 6300 can travel with it, thereby creating a gap between sheath tip 6400 and needle port 1340, and thereby exposing a previously non-visible colored portion 1350 of actuation bar 1300 and/or providing an indication that system 1000 has been used (and likely substantially exhausted of its medicament), thereby discouraging any further attempts to use system 1000.

As medicament carrier 9000 moves away from actuator bar 1300, needle 6100 can retract into sheath 6300 which un-buckles and/or un-deforms towards its original shape. Eventually, needle 6100 can retract completely within the boundaries of housing 1100, thereby tending to prevent accidental needle sticks after the initial injection and/or potentially reducing and/or eliminating a sharps hazard.

In certain exemplary embodiments, system actuator 2000 can comprise a finger triggered, twistable, pivotable, and/or lever-operated mechanism. For example, system actuator 2000 can comprise a twistable handle that can screw into gas port 2600. In certain exemplary embodiments, system actuator 2000 can be a finger trigger located on a side of the housing.

FIG. 10 is a flowchart of an exemplary embodiment of a method 10000 for operating a medicament delivery apparatus. At activity 10100, an actuation lock for the apparatus is released. At activity 10200, an actuating portion of the contents of a compressed gas container are released. At activity 10300, via pressure provided by the released gas, a needle is extended from the apparatus. At activity 10400, via pressure provided by the released gas, a piston applies pressure to a medicament stored in one of a plurality of vials. At activity 10500, a frangible containing the medicament in the vial is burst. At activity 10600, the medicament flows from the vial, through the needle, and into a patient. At activity 10700, once a predetermined dose is expelled and/or injected, the needle is withdrawn from the patient and/or retracted into the pre-use bounds of the apparatus. At activity 10800, the apparatus is rendered unusable for additional injections and/or indicated as previously utilized.

FIG. 11 is a perspective view of an exemplary embodiment of system 1000, showing actuation guard 1200 removed from housing 1100, so that actuation guard 1200 no longer separates actuator bar 1300 from handheld portion 1800. Actuation guard 1200 can comprise a grippable portion 1220 that can be gripped by a user to pull actuation guard 1200 away from housing 1100, thereby allowing system 1000 to be activated, such as via slapping actuator bar 1300 against a thigh of the user. Actuation guard 1200 can comprise an actuation stick separator portion 1240, that can keep separate actuation stick prongs 2240 when actuation guard 1200 is installed on housing 1100. Actuation guard 1200 can comprise a guard portion 1260 that can separate actuator bar 1300 from handheld portion 1800 when system 1000 is not in use and/or when system 1000 has not been used.

FIG. 12 is a perspective cross-sectional view taken along lines B-B of FIG. 11, and FIG. 13 is a perspective view of an exemplary embodiment of actuation stick 2200. Referring to FIGS. 12 and 13, system 1000 can comprise housing 1100, actuation bar 1300, and system actuator 2000, which can comprise prong squeezer 1390, actuation stick 2200, prong retainer 2100, spring 2300, upper spring retainer 2260, gas container 2400, gas port 2600, and/or puncturer 2700. When actuation bar 1300 is pressed firmly against a user's body, such as via slapping housing actuation bar against the user's thigh, buttocks, and/or arm, prong squeezer 1390 can urge prong tips 2220 of prongs 2240 of actuation stick 2200 toward one another. Note that prong tips 2200 can have a triangular, wedge, angular, and/or frustro-conical shape. As prongs tips 2220 slide along the angled V-groove of prong squeezer 1390, prong catches 2230 can substantially loose contact with prong retainer 2100. This can allow compressed spring 2300 to rapidly urge actuation stick 2200 and gas container 2400 toward puncturer 2700, which can penetrate gas port 2600, thereby allowing gas to escape from gas container 2400. Although any of many different types of gas containers can be utilized, an exemplary gas container can be obtained from Leland Limited, Inc. of South Plainfield, N.J.

FIG. 14 is a cross-sectional view of an exemplary embodiment of gas venting mechanism 8000 of system 1000 taken along lines A-A of FIG. 3. System 1000 can comprise handheld portion 1800, actuator bar 1300, sleeve 1500. As pistons 4440 near the limit of their travels, medicament 5200 can be expelled along medicament path 5900, which can extend past frangible 5300, through medicament channels 9200, medicament conduit 9300, and needle 6100, and into the body of a user, such as subcutaneously, intramuscularly, and/or at a depth of from approximately 0.25 millimeters to approximately 20 millimeters, including all values and subranges therebetween, such as up to 2 millimeters, greater than 5 millimeters, etc.

As pistons 4440 near the limit of their travels, engagement of gas release actuator 9700 with gas release valve 8200 can cause compressed spring 8300 to move valve arm such that o-ring 8400 is urged away from its seat 8500. This movement can reveal a passage 8600, via which gas can exit gas chamber 3200 along gas exhaust path 8900, which can extend between sleeve inner walls 1520 and outer walls 9100 of medicament carrier 9000. Eventually, gas exhaust path 8900 can extend between handheld portion 1800 and actuator bar 1300. Likewise, an alternative embodiment of valve 8200, made of rubber or any other resilient material, can be placed across seat 8500 to provide a seal that, once gas release actuator 9700 interacts with valve 8200, allows valve 8200 to bend or flap upwards away from seat 8500, causing the gas to escape via passage 8600.

The following paragraphs expands on the above and describe various exemplary embodiments relating to compact auto-injectors that can comprise and/or utilize a vial or a plurality of vials to store and/or contain an injectable medicament. These auto-injectors can have a compact form factor, such as approximately the size of a credit card. There are many methods of delivering such medicaments in such compact devices. The below descriptions cover multiple methods and/or mechanisms that can effectively administer a medicament using a compact auto-injector.

Exemplary Embodiment One
Methods of Utilizing an Auto-Injector

This exemplary embodiment describes a method of implementing an auto-injector utilizing a spring and/or gas driven system to administer a medicament and/or comprises a needle protection system.

An embodiment for delivering medicament from a chamber can comprise a vial or plurality of vials; said chamber in communication with a needle that can be concealed initially by some shield and/or sheath; extending said needle from the sheath at least 1 mm and/or inserting the needle past a needle insertion point to an injection site at a depth of at least 5 mm; the application of a force that can originate from the contents of a gas cylinder and/or by means of a spring or multiple springs sufficient to eject medicament held within said chamber into the needle and/or through the needle insertion point to a depth of at least 5 mm to deliver up to 5 ml of medicament into the injection site in less than 5 seconds; wherein the medicament can be injected and/or held through the use of a vial system that comprises a plunger, vial(s), reservoir, and/or needle that can be located within said chamber; wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial(s), reservoir, and/or needle to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; wherein the needle insertion point can be located more superficial than the injection site; wherein the needle can have a length of at least 6 mm and/or the medicament can be ejected at a pressure of at least 25 p.s.i. at a rate of at least 0.20 ml/sec; and/or wherein the needle can retract into the shield and/or housing and/or a needle protection portion slides over the needle following delivery of the medicament.

FIG. 15 shows an exemplary embodiment an auto-injector 15000. Though the figure shows the force mechanism used as being a compressed gas container 2400, the force method can be created by a spring force (See description of FIGS. 18A and 18B below). The top of the housing 1110 can be laser-welded to ensure stability due to high pressure. Likewise, the entire housing 1130 can be a sealed housing, and may be made smaller by eliminating screws and/or pins holding the base 1310 and/or top 1110 to the housing. In FIG. 15, this can be completed by adding hooks 1360 to the base 1310. The hooks 1360 can allow the base 1310 to slide into the housing 1130, thus pushing the detents 2225 inward and allowing for the puncturing of the gas cylinder 2400 by activating the compressed spring 2300. These hooks 1360 can also click into the housing 1130, making the base 1310 unable to move post-injection; this eliminates re-use of the device and acts as an indicator to determine if the device has been used or if the device has not been activated. The gas release mechanism is also a novel addition to the device. A rubber flap 8210 (also referred to as a gas release flap) and/or other resilient material can be located inside the plunger bar 4350. A solid piece 9710 or member can stick up from the reservoir near the top of the vials. Once the plunger bar 4350 dispenses the medicament, this piece 9710 can push the rubber flap up, thereby releasing excess gas in the system. The puncturing device for the gas cylinder could be a roll-pin 2710 that is sliced at a 45 degree angle to ensure sharpness for puncturing.

FIG. 16 shows the safety tab 1210 used to protect the user from accidental activation. FIG. 16 also shows an extended portion 1215 of the safety tab 1210 with grooves 1218 added to it. This can aid the user in removing the safety tab 1210 by creating a larger gripping surface and/or a more tactile feel to the tab.

Exemplary Embodiment Two
Chemical Reaction

This exemplary embodiment involves an auto-injection system that utilizes a chemical reaction as an activation mechanism to deliver the medicament into a patient. It also comprises a needle protection system.

This exemplary embodiment comprises a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that contains a single needle or needle cannula at the distal end; the needle can be protected by some sheath/shield; a chemical reaction capable of occurring when one chemical is allowed to interact with another chemical and/or a substance that may create such a reaction through the use of some activation mechanism; and said chemical reaction that can generate a force that is strong enough to drive said plunger, vial, reservoir, and needle towards the distal end of the housing; the needle exiting said sheath/shield and entering an injection site; the plunger(s) slideable in the vial(s) that contain the medicament; and said medicament exiting the vials into through the reservoir and needle cannula into the injection site; upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.

FIG. 17 is a view of the compact injector 17000 with several modifications to allow for a chemical reaction to occur as the primary force method in order to deliver the medication. In the particular drawing, the puncturing pin 2712 can include a rough surface 2714. Likewise, the container 2401 used in the device can have a similar rough material and/or surface 2402, and can contain mostly Sodium Azide (NaN3). Once the spring 2300 (attached to the container) is activated, the two rough surfaces 2714, 2402 can simultaneously come in contact with each other to create a spark and puncture the Azide container. This can create an immediate chemical reaction because of the spark. The reaction (2 NaN3−>2 Na+3 N2) can form hot nitrogen gas and sodium in order to create enough force to inject the medication. A modification to this figure can be made to include another container at the top in place of the puncturing pin that can break open from the force of the spring and second container, thus mixing the two chemicals and can cause a chemical reaction to occur in order to produce the force needed.

Exemplary Embodiment Three
The Spring Driven Injector

Certain exemplary embodiments of the auto-injector can use a spring or multiple springs to inject the medicament into a patient. The novelty of this system can lie in the orientation of the activation springs and the vial system (that comprises the plunger, vial(s), reservoir and the needle/cannula) system. Because the activation springs can be located in parallel to the vial system, the device can be smaller than existing devices on the market (that are linear in nature), potentially having a form factor that is approximately the size of a credit card.

Certain exemplary embodiments can comprise a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament and/or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that contains a single needle or needle cannula at the distal end; the needle protected by some sheath/shield; the housing further comprising at least one spring (this can comprise a gas spring, coil spring, leaf spring, etc.) wherein the spring(s) is parallel to the plunger, vial(s), and reservoir system and is in communication with a solid member (that can be made of rubber, plastic, metal, and/or some other resilient material) that is also in communication with the proximal end of the plunger such that when the spring(s) is activated, a force is applied on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and needle to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; the solid member is displaced away from the plunger, which can allow for the retraction of the entire needle, reservoir, vial(s), and plunger assembly towards proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or for a needle protection portion to slide over the needle following delivery of the medicament.

FIGS. 18A and 18B shows several views of the spring driven injector 18000. The primary force used to push down the pusher bar 4360, vial system 5110, reservoir 9210, and needle 6100 can be provided by compressed springs 2410. In the cross-section drawing (FIG. 18B), two springs 2410 can be located on the outside of the central chamber (containing the pusher bar 4360, vials 5110, reservoir 9210, and needle 6100). The springs 2410 can be held in place by a rod 2412 coupled with hooks 2414. Each spring 2410 can have a rolling solid member 2420 attached to it that is also connected to a bar 2422 that is held into a notch/indentation in the reservoir 9210 near the bottom of the vials 5110. Furthermore, a solid beam 4365 can wrap around the top of the pusher bar 4360 and can attach to the aforementioned bar 2422. The bar 2422 can slide in and out of the reservoir 9210 and the solid beam 4365, but only if the rolling solid member 2420 is rolled away from the reservoir 9210 and beam 4365. The device can be activated by the user pulling out the safety mechanism 1211 and pushing downward on the outside sleeve 1112. This can cause the hooks 2414 from the rods holding the springs 2410 in place to pinch inward, thereby releasing the springs 2410 forcefully downward. As the springs 2410 are driven downward, the rolling solid member 2420 and bar 2422 can roll down through the solid member passage 2430, which detours out of and away from the reservoir 9210. As the rolling solid member 2420 is moved, the solid beam 4365 wrapped around the pusher bar 4360 can come down as well, pushing the needle 6100 into the user. The medication can then be delivered into the user and/or patient once the rolling solid member 2420 goes down even further, which can be continually driven by the force of the springs 2410. The solid member 2420 passage eventually can turn away from the vial system 5100 and reservoir 9210 (also shown in the side view drawing as a hidden line). This can slide the bar 2422 out of the reservoir 9210 and out of the beam 4365, allowing for the retracting springs 1610 to push the pusher bar 4360, vials 5100, reservoir 9210, and needle 6100 back into the housing.

Exemplary Embodiment Four
Pulley System

This exemplary embodiment can utilize a pulley system as the activation mechanism for injecting medicament into the patient and that can also comprise a needle protection system.

Certain exemplary embodiments can comprise a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that can contain a single needle or needle cannula at the distal end; the needle that can be protected by some sheath/shield; the housing further comprising one or more spring pulley system(s) that can constitute a spring connected to some slideable resilient material such as a string, wire, wire coil, flat metallic band, etc. at the proximal end of the housing, and said material that can travel through a channel in the housing from the proximal end of the housing towards the distal end of the housing and then returning through a parallel channel towards the proximal end wherein this material is connected to a solid member (made of rubber, plastic, metal, and/or some other resilient material); the solid member in communication with the proximal end of the plunger such that when the spring is activated the spring can produce enough force to allow the pulley system to operate by having the resilient material, such as a cord, which can forcefully travel towards the proximal end of the housing and can cause the cord to move the solid member in communication with the plunger, vial(s), reservoir, and/or needle towards the distal end; wherein the needle can exit said sheath/shield and can enter an injection site; the plunger(s) slideable in the vial(s) that can contain the medicament; and said medicament can exit the vials into through the reservoir and/or needle cannula into the injection site; upon exit of the desired contents of the vial, the solid member can be displaced away from the plunger allowing for the entire needle, reservoir, vial(s), and/or plunger assembly to retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion to slide over the needle following delivery of the medicament.

A pulley system 2435 is shown in the device 19000 depicted in FIG. 19 as the primary method for forcing the pusher bar 4360′, vials 5110′, reservoir 9210′, and needle 6100 down for medicament injection. Similar to the above spring-driven injector 18000, the activation springs 2410′ can be located parallel to the vial system 5110′ and the device can be activated by the user pushing down on the outside sleeve 1112′ of the device. The use of a pulley system 2435 can create a mechanical advantage, producing the proper force needed to efficiently push down the vial system 5100′ and deliver the proper dose of medication. FIG. 19 shows a bar 2422′ that can be connected to the end of the rod/spring member. This bar 2422′ can be connected to the pulley system 2435 (that can comprise some resilient and/or moveable material). The other end of the pulley system 2435 can be connected on top of the pusher bar 4360′ to a beam 4366 that can be able to slide when moved to a certain position. As the springs 2410′ are driven downward, the pulley system 2435 can pull the pusher bar 4360′, vials 5100′, reservoir 9210′, and needle 6100 down as well. Similar to the spring-driven injector, the solid beam member 4366 on top of the pusher bar 4360′ can slide down the solid member passage 2430′ and eventually dislodge from the pusher bar 4360′. Once this occurs, the entire system can retract back within the housing due to the force from the retracting springs 1610′.

Exemplary Embodiment Five
The Needleless Injector

This exemplary embodiment can comprise a Needleless Injector that can be gas and/or spring activated and that can allow for a user to inject a medicament into a patient without the use of a needle. The use of a plurality of vials can be considered the novel component and can allow the device to be compact in nature, such as having the approximate length and width similar to that of a credit card.

Certain exemplary embodiments for delivering medicament from a chamber can comprise a plurality of vials; the said chamber in communication with a passage into a small injection opening; the application of a force that can originate from the contents of a gas cylinder and/or by means of at least one spring that can eject medicament held within said chamber into the passage to the small injection opening, which can be defined and/or created by the housing and/or a small sterile rod that can be a needle or cannula allowing for the slight puncturing of the injection site in order to allow the medicament to be delivered, and through the tip of this small injection opening to a depth of at least 1 mm, that can deliver up to 5 ml of medicament into the injection site; wherein the medicament can be injected and held through the use of a vial system that comprises a plunger, vial(s), and/or reservoir all located within said chamber; wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial(s), and/or reservoir to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered through the reservoir into the small injection opening; wherein the injection opening point can be located more superficial than the injection site; wherein the medicament can be ejected at a pressure of at least 25 p.s.i. (For example, in such embodiments, the pressure to deliver a dose of 0.5 cc's could be about 100 pounds of force).

FIG. 20 depicts the components of the needleless injector 20000. The injector can be activated by removing a safety tab 1212 and pushing down on the housing 1131. The rod 2412 with hooks holding the spring 2410 in place can be initiated by the base 1312 moving upwards and pushing the hooks inward. The spring 2410 can drive the high pressure gas cylinder 2400 into a puncturing pin 2716, releasing the gas cylinder contents. The gas cylinder contents can push down the pusher bar 4361, vials 5100, and reservoir 9212 into the small opening 6114 at the base of the device near the injection site. The small opening 6114 allows passage of a medicament or agent and also a slight puncturing of the injection site. A tiny cannula 6110 and/or needle can be located at the bottom of the reservoir 9212 and/or can be used for slightly puncturing the injection site. The cannula defines a tiny orifice 6112 therein for passage of the medicament or agent. This slight puncture can allow the medicament stored in the vial 5100 to flow through the reservoir 9212 and into the injection site. Once the pressure is released, the entire system (including the pusher bar, vials, and reservoir) can be pushed back up within the housing by the retracting springs 1610.

Exemplary Embodiment Six
The Multi-Pharmaceutical Injector

This exemplary embodiment can comprise a compact auto-injector that can incorporate a plurality of vials, allowing for multiple medicaments to be injected at one time or at different times. The use of a plurality of vials can be considered the novel component and also can have the advantage of creating a device that is compact in nature, such as one having the length and width of a credit card. The device also can comprise a needle protection system.

Certain exemplary embodiments for delivering medicament from a chamber can comprise a plurality of vials; the said chamber or chambers in communication with a needle or needles that can be concealed initially by shields and/or sheaths; that can extend said needle from the said sheath at least 1 mm and can insert the needle past a needle insertion point to an injection site at a depth of at least 5 mm; the application of a force and/or forces that can originate from the contents of a gas cylinder and/or multiple gas cylinders, and/or by means of a spring and/or springs sufficient to eject medicament held within said chamber into the needle and through the needle insertion point; wherein the medicament can be injected and held through the use of a vial system and/or vial systems that can comprise a plunger, vial, reservoir, and/or needle all located within said chamber(s); wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial, reservoir, and/or needle to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; wherein the needle insertion point can be located more superficial than the injection site. The device potentially having a multitude of said components (including but not limited to vials, plungers, gas cylinders, springs, needles, reservoirs, sheaths, shields, chambers, and/or retracting springs) in order to administer multiple medicaments into a patient at one time and/or at different times, as one dose and/or in multiple doses, depending on when each individual system is activated. The device can have selectors and/or other mechanisms to allow the user to choose which medicament to administer. Each individual system can comprise an activation mechanism (such as a spring and/or gas cylinder), a chamber within said housing, and a plunger, vial, reservoir, needle, and/or retraction spring; wherein upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly retracts towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.

A method for administering multiple pharmaceuticals is depicted in FIGS. 21A and 21B. The injector 21000 can include medicament selectors 5500 in order to allow the user to select which medicament to inject. The user can select the medicaments by sliding one or more selectors 5500 upward into their final position. An audible click or some other indicator may occur to alert the user to this final position. Moving the selector or multiple selectors upwards can allow a pin 5510 to snap into the plunger rod 5512 and/or into the pusher bar, which can create an entire portion that can push the vial system downwards and can inject the medication through the vial, the reservoir and/or needle. (This method can also be used with the Needleless injector method as described earlier in this document) Methods such as this embodiment could be extremely useful in applications for anti-nerve agents or pain therapies. The device 21000 can also include a resilient material, such as rubber, to seal the selector openings and that can also slide within the housing once the selector 5500 is pushed upward. Once the aforementioned pins 5510 are in place, the device can function and activate similarly to that described above. A safety mechanism can be modified to eliminate the sliding selectors from being prematurely pushed upwards.

Exemplary Embodiment Seven
The Wet/Dry Injector

This exemplary embodiment can comprise a compact auto-injector that can have the ability to mix two or more medicaments in either a liquid or powder form to create one injectable medicament. The novel component of this device can be considered to be the use of a plurality of vials to deliver the medicament. The device also can comprise a needle protection system.

An exemplary delivery system can comprise a housing, plurality of vials, plunger for each vial, a mixing activation mechanism, an activation chamber or vial, single needle or needle cannula, and/or a medicament or medicaments stored within each vial. Pre-injection, two or more medicaments can be stored separately in a vial and/or storage compartment and can communicate with each other once the mixing activation mechanism is initialized. The mixing activation mechanism could comprise a button, trigger, threaded rod, and or some other member that removes a piece or portion and/or punctures a piece or portion that is preventing each medicament to communicate with each other. The mixing activation mechanism may comprise a membrane, piece, and/or portion that may be removed pre-injection by the user in order to allow the separate vials and/or storage containers to communicate with each other. The mixing activation mechanism can be a piece that is manipulated in some way by the user in order to cause the contents of each compartment to mix with each other. This communication may occur by shaking the device and/or may occur automatically with the mixing activation mechanism. For instance, the mixing activation mechanism may cause each medicament to be released into an activation chamber, which may itself be a separate vial. This mixed medicament can be the medicament that will be injected into the patient. The delivery system further encompassing the mixed medicament vial or plurality of mixed medicament vials in communication with the plunger(s) at the proximal end of the housing and in communication with a reservoir that can contain a single needle or needle cannula at the distal end; the needle can be protected by some sheath/shield; the housing can further comprise a passage that is also in communication with the proximal end of the plunger such that when the spring(s) is activated from the distal or proximal end, a force can be applied through the passage on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and/or needle to travel towards the distal end of the housing; wherein the force provided can be caused by a spring, bar, contents from a gas cylinder, and/or other force mechanism; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.

FIGS. 22A and 22B depict a novel method for injecting lyophilized medications, and/or powdered biologics that could need to be reconstituted pre-injection. FIG. 22A shows a mechanism to mix and/or create an injectable medicament from two or more separate aforementioned substances. The figure depicts multiple vials 5110 that could have two substances in each vial separated by a pierceable membrane 5112 and/or other frangible piece. The vials in this embodiment can have one wet substance 5210 (such as sterilized water) and one dry substance 5220 (such as glucagon powder). The user can take off the safety tab 1230, which can prevent the user from accidental injection and/or pre-mature activation of the device. Once the safety device 1230 is removed, the user can twist and/or rotate the twisting portion 5150 at the top of the housing. By rotating this top portion, the rods 5152 attached to this portion (which can be threaded rods) can move downward. These rods 5152 can be located in the vials 5110 and/or through the pusher bar 4362. The rods 5152 can have a sharp piercing portion on the distal end which can aid in puncturing the aforementioned pierceable membrane 5112 that can separate the substances in the vial. Once the piercing rod 5152 punctures the frangible and/or pierceable membrane, the substances can mix together to form one medicament. The user can also shake the entire housing in order to aid in this mixing process.

Exemplary Embodiment Eight
Needle-End Safety System

Certain exemplary embodiments can comprise a safety system that can allow a user to remove some cap, bar, lock at the same end of an auto-injector housing where the needle is located. This can allow the device to be ready for activation while still protecting the needle at the same time. Many auto-injectors, such as most pen-like injectors, have the activation safety mechanism on the opposite end of where the needle is located. In an emergency situation, the user may mistake this safety cap as protecting the needle, when in fact this is not the case. There have been many documented cases of digital injection into a user's thumb or finger because of this reason. Having the safety mechanism at the same end of the needle can eliminate this risk.

Exemplary Embodiment Nine
Auto-Injector with Feedback

The use of auto-injectors and drug delivery systems is common in the medical industry. Auto-injectors can deliver a range of medicaments into a patient, ranging from chronic therapies to critical care injectables. As more therapies are developed, the need for a vehicle to deliver these therapies is ever-increasing. Certain auto-injectors currently on the market can lack attributes that can allow the user to understand the device's functionality and/or operation. Thus, there is perceived a need for an auto-injector that can provide audible, haptic, and/or visual feedback to the user in order to effectively train and/or guide the user on how to properly operate the auto-injector and/or to mitigate user-related hazards that could occur when the device is not used correctly.

The incidence of use-related hazards associated with auto-injectors is increasing. Common problems associated with certain injectors on the market include poor design, sharps exposure, and poor instruction. Many auto-injectors on the market are in the form of an apparatus that resembles a pen or marker. The safety mechanism for most of these devices can cause patient confusion as it is often protecting the activation mechanism and not the location where the needle protrudes out of the device. There have been numerous cases of the user accidentally injecting the needle into their own thumb or finger because of this hazard. Examples of devices that incorporate this design can include certain pen-type auto-injectors for allergic emergencies, and/or certain anti-nerve agent auto-injectors currently supplied to both domestic and foreign militaries. These devices, and most auto-injectors on the market, also can allow the needle to remain protruding out after use, thereby potentially causing a post-injection sharps hazard. Further, many of these injectors exhibit poor instruction and/or labeling. Due to the cylindrical design of certain auto-injectors, the surface area for labeling can be small, rounded, and therefore can prevent a user from easily reading important information regarding the use of the device. For many injectors that are used in emergency situations, it can be important that the user be able to use the device correctly and efficiently. The user might not take or have time to read the instructions on the device during such a critical scenario.

For one or more of these reasons, an interactive auto-injector or medical device is described that can provide a user with visual, haptic, and/or audible feedback in order to mitigate the aforementioned risks and/or to allow for easy injection of medications.

Certain exemplary embodiments can provide an interactive auto-injector and/or a method of providing audible, haptic, and/or visual feedback to a user when operating the auto-injector. An auto-injector can be defined as any device that allows a user to deliver a medicament without having to manually prepare the injection. This can include pen delivered injectors, syringes, needleless injectors, gas powered auto-injectors, and/or any other auto-injector and/or medical device used to inject a pharmaceutical into a user/patient, etc.

Certain exemplary embodiments can provide an auto-injector that can comprise an information device and/or system comprising at least one sensor (e.g., a pressure sensor, proximity sensor, tactile sensor, and/or biometric input device, etc.), switch (e.g., gate switch, microswitch, and/or pushbutton, etc.), embedded system (e.g., microprocessor, memory, embedded operating system, system bus, input/output interface, and/or network interface, etc.), audible output sub-system (e.g., speaker, horn, buzzer, and/or piezoelectric transducer, etc.), visual output sub-system (e.g., flag, marker, light, liquid crystal display (LCD), light emitting diode (LED), optical fiber, organic polymer display, electric paper, screen, display, monitor, and/or tube, etc.), haptic output sub-system (e.g., buzzer, vibrator, bulging portion, tactile stimulator, cooler, and/or heater, etc.), and/or any other component and/or sub-system that would aid in providing audible, visual, and/or haptic feedback to a user of the auto-injector, along with appropriate circuitry, control system(s), housing(s), shielding, electrical conductors, and/or power source(s), etc.

Certain embodiments of auto-injectors can comprise a housing, safety mechanism, activation mechanism (such as a spring means or compressed gas cylinder), a vial or container for storing the medicament, and a needle for delivering the medicament. Certain exemplary embodiments can provide one or more audible, visual, and/or haptic outputs to guide and/or instruct the user how to use the auto-injector properly. Sensors and/or switches can be placed on the safety tab, on the bottom of the device where the needle comes out, and/or where the inner sleeve slides up to activate the device. Visual outputs can be placed at each of the aforementioned locations as well and/or instead. An audible output sub-system can be placed anywhere on the device for audible feedback. A haptic output sub-system can be placed anywhere on the device. These electronically-triggered and/or active components and/or sub-systems can be incorporated into the labeling of the device and/or as a separate component to provide this visual, haptic, and/or audible feedback.

For example, the user can push a button or switch on the device to initiate the audible, haptic, and/or visual output sub-system. A pre-recorded audible voice can tell the user to pull up on the safety tab, while a visual and/or haptic output can be rendered on the safety tab to provide a visual and/or haptic clue to the user as to where the safety tab is located. Once the safety tab is pulled up correctly, a sensor or switch could trigger the next step for the voice to announce, for example, asking the user to place the base of the device on the outer portion of their thigh while also triggering a visual output to light the base of the device. By way of further example, the user can be provided a visual clue in which at least a portion of the base of the device is lighted and/or colored red, and/or the user can be provided a haptic clue in which the base on the device is moved and/or the base is heated sufficiently (such as to between approximately 105 degrees F. and approximately 120 degrees F., including all values and subranges therebetween) to substantially warm, yet not burn, the user's skin. The embedded operating system, which can run in hard real-time to avoid delays that might be significant and/or life-threatening, can also recognize a failure to complete a step in a certain specific timeframe and cause the step to be repeated if necessary and/or provide negative feedback if the user fails to perform a step properly (e.g., via input from a sensor or switch, the operating system can timely notice that the device is not placed on the skin of the thigh correctly and can cause the audible output subsystem to tell the user to repeat the placement step). Once the user places the device on the thigh properly, the sensor or switch could trigger the next audible, visual, and/or haptic clue and/or output, such as asking the user to push down on the outside sleeve of the device with force. By instructing the user step-by-step through each task, user error and/or risks of certain hazards can be reduced and/or eliminated.

Certain exemplary embodiments can provide a compact, credit card-sized auto-injector used to deliver a variety of medicaments, such as pharmaceuticals and/or agents. Though this auto-injector can eliminate many problems associated with certain pen-style auto-injectors, such as the sharps hazard and/or the poor safety tab design, there can be a need for an interactive auto-injector in order to aid in user instruction of the device and/or to help ensure the device is used properly any and/or every time it is needed. The following, and the attached figures, further describes such an auto-injector.

FIG. 23 portrays an auto-injector 23000 having a housing 1131 similar to the length and width of a credit card, an activation mechanism on one side and a vial system 5100 non-coaxial with the activation mechanism. The activation mechanism can comprise a compressed spring 2410 and compressed gas cylinder 2400 used as the force mechanism, and a puncturing mechanism 2718 to dispel the contents of the compressed gas cylinder 2400. A vial system 5100 can be comprised of a pusher bar 4363, plungers, vial(s)/medicament storage container(s), a reservoir 9214, a needle 6100, and a needle sheath. Retraction springs 1610 located at the base of the reservoir 9214 can push the needle 6100 back within the housing 1131 after injection. A slideable base 1314 can be used to activate the activation mechanism, which can be transparent to show the location of the aforementioned needle. A safety tab 1232 can be located between the base 1314 and the housing 1131 and/or can keep the activation mechanism from being activated while protecting the user from the needle 6100. Sensors 9810A, 9810B and/or switches, which can help trigger audible, haptic, and/or visual feedback, can be located on the base 1314 and/or on the safety tab 1232. A button 9805 and/or switch, which can help trigger audible, haptic, and/or visual feedback subsystem(s), can be located on the housing 1131. The feedback sub-system(s) can be activated based on inputs received and/or interpreted by the embedded operating system.

For example, an audible output sub-system 9820 located in the housing 1131 can provide audible feedback to the user of the device. The audible output sub-system 9820 can be comprised of one or more piezoelectric transducers, small and/or large cones and/or speakers, sensors, capacitors, memories, power sources (e.g., battery, fuel cell, spring-actuated generator, etc.) housing, wires, and any other electronic components needed to provide recorded audible feedback to a user. The audible output sub-system 9820 can be activated by the aforementioned button 9805 or switch on the housing 1131. The speaker can provide instructions for how the device is used and/or certain medication requirements.

As another example, visual outputs can be located throughout the device, and/or on the base, safety tab, labeling, and/or housing to provide visual clues to the user. These visual outputs can be activated by the operating system once a sensor or switch is triggered. An LCD, optical polymer, LED, electric paper, and/or other form of display, monitor, and/or screen and/or other visual output can provide data to the user such as dosage amount, expiration date, instructions, Federal Drug Administration (FDA) requirements, and/or other labeling requirements, etc.

Referring to FIGS. 24 and 25, the user can push the button on the housing to, via the embedded processor, activate the audible, haptic, and/or visual feedback sub-system on the auto-injector. For example, a voice from the audible output sub-system (now activated) can provide an audible message to the user, such as “Please remove the safety tab.” The safety tab 1232′ can also light up from visual outputs 9822A located on the safety tab 1232′. Once the safety tab is removed, a sensor 9810C can be triggered that can also trigger the next audible task from the audible output sub-system 9820. The visual outputs (e.g. LEDs) 9822A and sensors (e.g., 9810C) activate the audible instructions for using the device, and to indicate key components of the device. If the safety tab 1232′ is not removed within a certain timeframe, the first voice response can be repeated. The button or switch can be pressed several times or held in order to stop the process (in case the injector does not need to be used or the button was pressed accidentally). After the safety tab 1232′ is removed, the next audible clue can be annunciated, such as “Please place the base of the device on the outer portion of your thigh.” The base 1314′ can simultaneously light up during this audible clue, providing a visual clue that demonstrates where the base is located and/or what portion of the base should be placed on the thigh. A sensor or switch, located on the base 1314′, can be used to help determine if the auto-injector is placed correctly on the injection site. The same switch and/or sensor, and/or another switch and/or sensor located on the base 1314′ can help trigger the next audible message, such as “Push down on the top of the device to activate the injector.” That switch and/or sensor can also trigger one or more visual outputs 9822B to light up the labeling 9830 and/or an arrow pointing down toward the injection site (as shown in FIG. 24). The visual outputs (LEDs) 9822B with the label 9830 highlight placement of the injector and proper activation.

Certain exemplary embodiments can comprise a compact auto-injector that can have the ability to mix two or more medicaments, agents, solutes, solvents, etc., in either a liquid or powder form and/or create one injectable medicament. Certain exemplary embodiments can include an interactive system that can provide haptic, audible, and/or visual feedback to provide the user with instructions, hints, and/or clues in order to use the device properly. The auto-injector also can comprise a needle protection system.

The delivery system can comprise the mixed medicament vial or plurality of mixed medicament vials in mechanical and/or fluid communication with the plunger(s) at the proximal end of the housing and in mechanical and/or fluid communication with a reservoir that can contain a single needle or needle cannula at the distal end. The needle can be protected by a sheath and/or shield. The housing can comprise a passage that is also in mechanical and/or fluid communication with the proximal end of the plunger such that when the spring(s) is activated from the distal or proximal end, a force can be applied through the passage on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and/or needle to travel towards the distal end of the housing. The applied force can be caused by a spring, bar, contents from a gas cylinder, and/or other force mechanism. The plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered. Upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.

The interactive system can comprise a speaker sub-system that can comprise piezos and/or other components to produce audible sounds and/or human voice; a haptic sub-system that can provide haptic feedback to the user; a visual sub-system that can comprise light emitting diodes, LCD's, optical fibers, and/or other components that can produce visual outputs such as light and/or color; a processor that can be used to control the activation of such components; a power source such as a battery that can power the aforementioned interactive system; and/or switches, buttons, and/or sensors that can activate certain visual, haptic, and/or audible clues at a particular moment.

FIG. 25 depicts a novel method and device 25000 for injecting lyophilized medications, and/or powdered biologics that might need to be reconstituted pre-injection. FIG. 25 shows a mechanism to mix and/or create an injectable medicament from two or more separate aforementioned substances. FIG. 25 depicts multiple vials 5110 that can have, for example, at least two substances in each vial separated by one or more pierceable membranes and/or other frangible pieces. The vials 5110 can have at least one wet substance 5210 (such as sterilized water) and at least one dry substance 5220 (such as glucagon powder). The user can take off the safety tab, which can prevent the user from accidental injection and/or pre-mature activation of the device. Once the safety tab and/or device is removed, the user can twist and/or rotate the twisting portion 5150′ at the top of the housing. By rotating this top portion, the rods 5152′ attached to this portion (which can be threaded rods) can move downward. These rods 5152′ can be located in the vials 5110 and/or through the pusher bar 4364. The rods 5152′ can have a sharp piercing portion on the distal end which can aid in puncturing the aforementioned pierceable membrane(s) that can separate the substances in the vial 5110. Once the piercing rod punctures the frangible and/or pierceable membrane(s), the substances previously separated thereby can mix together to form one medicament. The user can also shake the entire housing 1132 in order to aid in this mixing process. The device 25000 includes an activation mechanism 2416, and delivers mixed medicament from the vials 5110 through the reservoir 9215 and to the needle 6100.

The device 25000 can include an electronic/interactive system to provide visual, haptic, and/or audible feedback to the user. This interactive system can include a microprocessor 9807 to control the specific feedback components, a speaker subsystem 9820, a haptic sub-system, a sub-system of switches and/or sensors (see switches and/or sensors 9810D, 9810E, 9810F), a subsystem of LEDs or optics, a battery power source 9808, and any other component needed to produce audible or visual outputs. FIG. 25 portrays these components located throughout the device; however, the actual placement of these components is flexible. The user can activate the interactive system by pushing a button 9804 or switch located on the housing 1132 of the device. This button 9804 or switch can activate the processor 9807 which can then send signals to the audible output sub-system, haptic output sub-system, and/or visual output sub-system. The audible output sub-system 9820 can provide an audible clue for the initial task, which can be in the form of a human, humanesque, and/or understandable voice stating, “Please remove the safety tab.” A signal can also be sent simultaneously to the safety tab visual output (potentially one or more LEDs) to provide a visual light and/or color clue to the user as to where the safety tab is located. Once the safety tab is removed, a switch or sensor 9810E can send a signal to the processor 9807 and activate the next audible, haptic, and/or visual clue. This can be a human voice that states “Please twist the top portion of the injector to activate the mixing mechanism.” As with the safety tab, an LED or some other visual clue then can be activated, lighting up the mixing activation mechanism 5150′, and/or a haptic clue can be activated, such as vibrating, warming, cooling, bulging, moving, changing a texture of, etc., the mixing activation mechanism 5150′. A switch or sensor 9810D located near or on the mixing activation mechanism 5150′ can be used to ensure that the mixing was complete and to trigger the next audible and/or visual clue by the processor. A voice next can state, “Please shake gently to mix the solution.” After a certain amount of time, the processor 9807 then can send a signal to the audible output sub-system for the next task. This can be a voice that says, “Please place the injector on the outer portion of your thigh.” A visual indicator of where the base/injector should be placed also can be simultaneously activated. A switch, sensor, or button 9810F then can recognize the correct placement of the device (and the base 1315) and trigger the next audible and visual clue. This can be a voice stating, “Push down on the top of the injector to activate the injection.” Likewise, an arrow or some other visual and/or haptic clue can light up and/or be rendered to show the motion of how the injector should be pushed. The last clue can be an audible clue that states, “Hold in place for several seconds, remove, and dispose of properly,” indicating that the injection is complete. Additional audible, haptic, and/or visual feedback sub-systems can be used to provide the user with important information such as the expiration of the drug, improper use, and/or error. For instance, the device's LEDs or optics can blink, a display can render a message, a vibrator can vibrate, and/or an audible beep and/or voice can be activated after a particular time stamp is reached that corresponds to the expiration of the drug and/or device. As another example, once an auto-injector has been used, a message can be displayed describing proper disposal and/or recycling techniques.

FIG. 26 is a block diagram of an exemplary embodiment of an information system and/or device 26000, which in certain operative embodiments can comprise, for example, the interactive, integral, embedded, audible, haptic, and/or visual feedback system, such as described herein. Information system and/or device 26000 can comprise any of numerous components, such as for example, one or more network interfaces 26100, one or more processors 26200 running an embedded, real-time, hard real-time, and/or soft real-time operating system, one or more memories 26300 containing instructions 26400, one or more input/output (I/O) devices 26500, and/or one or more user interfaces 26600 coupled to I/O device 26500, etc.

In certain exemplary embodiments, via one or more user interfaces 26600, such as a graphical user interface, a user can view a rendering of information related to selecting, purchasing, obtaining, operating, maintaining, re-using, and/or disposing of an auto-injector. In certain exemplary embodiments, instructions 26400 can be modified and/or updated via replacing a removable memory 26300 and/or via replacing instructions 26400 (such as, e.g., via flashing an EEPROM, etc.). In certain exemplary embodiments, instructions 26400 can be modified and/or updated via downloading replacement instructions via network interface 26100. System 26000 can comprise a programmable logic controller.

Still other practical and useful embodiments will become readily apparent to those skilled in this art from reading the above-recited detailed description and drawings of certain exemplary embodiments. It should be understood that numerous variations, modifications, and additional embodiments are possible, and accordingly, all such variations, modifications, and embodiments are to be regarded as being within the spirit and scope of this application.

Thus, regardless of the content of any portion (e.g., title, field, background, summary, abstract, drawing figure, etc.) of this application, unless clearly specified to the contrary, such as via an explicit definition, assertion, or argument, with respect to any claim, whether of this application and/or any claim of any application claiming priority hereto, and whether originally presented or otherwise:

there is no requirement for the inclusion of any particular described or illustrated characteristic, function, activity, or element, any particular sequence of activities, or any particular interrelationship of elements;

any elements can be integrated, segregated, and/or duplicated;

any activity can be repeated, performed by multiple entities, and/or performed in multiple jurisdictions; and

any activity or element can be specifically excluded, the sequence of activities can vary, and/or the interrelationship of elements can vary.

Accordingly, the descriptions and drawings are to be regarded as illustrative in nature, and not as restrictive. Moreover, when any number or range is described herein, unless clearly stated otherwise, that number or range is approximate. When any range is described herein, unless clearly stated otherwise, that range includes all values therein and all subranges therein. Any information in any material (e.g., a United States patent, United States patent application, book, article, etc.) that has been incorporated by reference herein, is only incorporated by reference to the extent that no conflict exists between such information and the other statements and drawings set forth herein. In the event of such conflict, including a conflict that would render invalid any claim herein or seeking priority hereto, then any such conflicting information in such incorporated by reference material is specifically not incorporated by reference herein.

Claims

1. A method of training a user in an operation of a medical injector, the method comprising: activating an electronic circuit system to output a recorded speech output, the electronic circuit system coupled to a housing associated with the medical injector, the recorded speech output associated with a first instruction;removing a safety lock from the housing, the safety lock configured to limit movement of a base when the safety lock is coupled to the housing, a first switch of the electronic circuit system being actuated when the safety lock is removed, the electronic circuit system producing a second instruction when the first switch is actuated;placing, after the removing the safety lock, the base against a target location; andmoving, after the placing, the base from a first position to a second position relative to the housing, a portion of the base actuating a second switch of the electronic circuit system when the base is moved to the second position, the electronic circuit system producing a third instruction when the second switch is actuated.
2. The method of training the user in the operation of the medical injector of claim 1, wherein: the activating the electronic circuit system includes manipulating a button coupled to the housing; andthe moving the base is performed independently from the manipulating the button.
3. The method of training the user in the operation of the medical injector of claim 1, wherein: the recorded speech output is a first recorded speech output; andthe second instruction includes a second recorded speech output that identifies the base and the target location.
4. The method of training the user in the operation of the medical injector of claim 1, wherein: the base includes a protrusion configured to retain the base in the second position; andthe safety lock includes a protrusion that separates the base from the housing to limit movement of the base when the safety lock is coupled to the housing.
5. The method of training the user in the operation of the medical injector of claim 1, wherein: the medical injector is an epinephrine autoinjector.
6. The method of training the user in the operation of the medical injector of claim 1, wherein: the moving the base causes an energy storage member within the housing to produce a force to inject a medicament from within a medicament container, the medicament container being within the housing.
7. The method of training the user in the operation of the medical injector of claim 6, wherein: the portion of the base is a first portion; andthe moving the base causes a second portion of the base to release an actuation member within the housing, the actuation member actuating the energy storage member to produce the force when the actuation member is released.
8. The method of training the user in the operation of the medical injector of claim 1, wherein: the electronic circuit system includes a speaker and a light output device;the recorded speech output is a first recorded speech output; andthe second instruction includes a light output produced by the light output device and a second recorded speech output produced by the speaker.
9. The method of training the user in the operation of the medical injector of claim 1, wherein: the electronic circuit system includes a memory component and a processor, the memory component storing a computer-executable instruction associated with any of the first instruction the second instruction, or the third instruction; andthe processor executes the computer-executable instruction when at least one of the first switch is actuated or the second switch is actuated.
10. The method of training the user in the operation of the medical injector of claim 1, wherein the activating an electronic circuit system to output a recorded speech output includes repeating the recorded speech output if the safety lock has not been removed from the housing within a predetermined time.
11. The method of training the user in the operation of the medical injector of claim 1, wherein: the housing defines a status window; andthe moving the base causes a use indicator to move within the housing to a position in which the use indicator is viewable through the status window.
12. A method of training a user in an operation of a medical injector, the method comprising: activating an electronic circuit system to output a first use instruction associated with the medical injector;removing a safety lock from a housing associated with the medical injector, the safety lock configured to limit movement of a base when the safety lock is coupled to the housing, a first switch of the electronic circuit system being actuated when the safety lock is removed, the electronic circuit system producing a second use instruction when the first switch is actuated;placing, after the removing the safety lock, the base against a target location; andpressing the base against the target location to move the base relative to the housing from a first position to a second position, a second switch of the electronic circuit system being actuated when the base is moved from the first position to the second position, the electronic circuit system producing a third use instruction when the second switch is actuated.
13. The method of training the user in the operation of the medical injector of claim 12, wherein: the electronic circuit system includes a speaker and a light output device; andany of the first use instruction, the second use instruction, or the third use instruction includes a light output produced by the light output device and a recorded speech output produced by the speaker.
14. The method of training the user in the operation of the medical injector of claim 12, wherein: the electronic circuit system includes a memory component and a processor, the memory component storing a computer-executable instruction associated with any of the first use instruction, the second use instruction, or the third use instruction; andthe processor executes the computer-executable instruction when at least one of the first switch or the second switch is actuated.
15. The method of training the user in the operation of the medical injector of claim 14, wherein the electronic circuit system includes a network interface, the method further comprising: updating the computer-executable instruction via network interface.
16. The method of training the user in the operation of the medical injector of claim 12, wherein the activating an electronic circuit system to output the first use instruction includes repeating the first use instruction output if the safety lock has not been removed from the housing within a predetermined time.
17. The method of training the user in the operation of the medical injector of claim 12, wherein: the housing defines a status window; andthe moving the base causes a use indicator to move within the housing to a position in which the use indicator is viewable through the status window.
18. The method of training the user in the operation of the medical injector of claim 12, wherein: the moving the base causes an energy storage member within the housing to produce a force to inject a medicament from within a medicament container, the medicament container being within the housing.
19. The method of training the user in the operation of the medical injector of claim 18, wherein the moving the base causes a portion of the base to release an actuation member within the housing, the actuation member actuating the energy storage member to produce the force when the actuation member is released.
20. The method of training the user in the operation of the medical injector of claim 1, wherein: the base includes a protrusion configured to retain the base in the second position.
21. The method of training the user in the operation of the medical injector of claim 1, wherein: the base is disposed at a distal end portion of the housing.
22. The method of training the user in the operation of the medical injector of claim 1, wherein: the moving the base includes moving the base linearly relative to the housing.
23. The method of training the user in the operation of the medical injector of claim 12, wherein: the base includes a protrusion configured to retain the base in the second position.
24. The method of training the user in the operation of the medical injector of claim 12, wherein: the base is disposed at a distal end portion of the housing.
25. The method of training the user in the operation of the medical injector of claim 12, wherein: the moving the base includes moving the base linearly relative to the housing.

CROSS-REFERENCES TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 14/244,311, entitled “Devices, Systems, and Methods for Medicament Delivery,” filed Apr. 3, 2014, which is a continuation of U.S. patent application Ser. No. 12/818,496, now U.S. Pat. No. 8,690,827, entitled “Devices, Systems, and Methods for Medicament Delivery,” filed Jun. 18, 2010, which is a continuation of U.S. patent application Ser. No. 10/572,148, now U.S. Pat. No. 7,749,194, entitled “Devices, Systems, and Methods for Medicament Delivery,” filed Mar. 16, 2006, which is a national stage filing under 35 U.S.C. § 371 of International Patent Application No. PCT/US06/03415, entitled “Devices, Systems, and Methods for Medicament Delivery,” filed Feb. 1, 2006, which claims priority to U.S. Provisional Application Ser. No. 60/731,886, entitled “Auto-injector with Feedback” filed Oct. 31, 2005, each of which is incorporated herein by reference in its entirety. International Patent Application No. PCT/US06/03415 claims priority to U.S. Provisional Application Ser. No. 60/648,822 entitled “Devices, Systems, and Methods for Medicament Delivery,” filed Feb. 1, 2005, which is incorporated herein by reference in its entirety.

US Referenced Citations (505)

Number	Name	Date	Kind
2277907	Goodale, Jr. et al.	Mar 1942	A
2960087	Uytenbogaart	Nov 1960	A
3055362	Uytenbogaart	Sep 1962	A
3115133	Morando	Dec 1963	A
3426448	Sarnoff	Feb 1969	A
3688765	Gasaway	Sep 1972	A
3768472	Hodosh et al.	Oct 1973	A
3795061	Sarnoff et al.	Mar 1974	A
3797489	Sarnoff	Mar 1974	A
3945379	Pritz et al.	Mar 1976	A
4086062	Hach	Apr 1978	A
4108177	Pistor	Aug 1978	A
4124024	Schwebel et al.	Nov 1978	A
4149394	Sornes	Apr 1979	A
4226235	Sarnoff et al.	Oct 1980	A
4258713	Wardlaw	Mar 1981	A
4360019	Portner et al.	Nov 1982	A
4424057	House	Jan 1984	A
4441629	Mackal	Apr 1984	A
4484910	Sarnoff	Nov 1984	A
4573976	Sampson et al.	Mar 1986	A
4596556	Morrow et al.	Jun 1986	A
4610666	Pizzino	Sep 1986	A
4613328	Boyd	Sep 1986	A
4617557	Gordon	Oct 1986	A
4624660	Mijers et al.	Nov 1986	A
4640686	Dalling et al.	Feb 1987	A
4643721	Brunet	Feb 1987	A
4666430	Brown et al.	May 1987	A
4673657	Christian	Jun 1987	A
4689042	Sarnoff et al.	Aug 1987	A
4693708	Wanderer et al.	Sep 1987	A
4781697	Slaughter	Nov 1988	A
4782841	Lopez	Nov 1988	A
4784652	Wikström	Nov 1988	A
4795433	Sarnoff	Jan 1989	A
4822340	Kamstra	Apr 1989	A
4826489	Haber	May 1989	A
4853521	Claeys et al.	Aug 1989	A
4865582	Sibalis	Sep 1989	A
4874382	Lindemann et al.	Oct 1989	A
4894054	Miskinyar	Jan 1990	A
4906235	Roberts	Mar 1990	A
4915695	Koobs	Apr 1990	A
4941880	Burns	Jul 1990	A
4959056	Dombrowski et al.	Sep 1990	A
4968302	Schluter et al.	Nov 1990	A
4983164	Hook et al.	Jan 1991	A
5000736	Kaufhold, Jr. et al.	Mar 1991	A
5024656	Gasaway et al.	Jun 1991	A
5037306	van Schoonhoven	Aug 1991	A
5038023	Saliga	Aug 1991	A
5041088	Ritson et al.	Aug 1991	A
5042977	Bechtold et al.	Aug 1991	A
5062603	Smith et al.	Nov 1991	A
5064413	McKinnon et al.	Nov 1991	A
5071353	van der Wal	Dec 1991	A
5085642	Sarnoff et al.	Feb 1992	A
5092842	Bechtold et al.	Mar 1992	A
5092843	Monroe et al.	Mar 1992	A
5104380	Holman et al.	Apr 1992	A
5125898	Kaufhold, Jr. et al.	Jun 1992	A
5167641	Schmitz	Dec 1992	A
5199949	Haber et al.	Apr 1993	A
5224936	Gallagher	Jul 1993	A
5240146	Smedley et al.	Aug 1993	A
5271527	Haber et al.	Dec 1993	A
5279514	Lacombe et al.	Jan 1994	A
5281198	Haber et al.	Jan 1994	A
5286258	Haber et al.	Feb 1994	A
5298023	Haber et al.	Mar 1994	A
5312326	Myers et al.	May 1994	A
5314406	Arias et al.	May 1994	A
5314412	Rex	May 1994	A
5314502	McNichols et al.	May 1994	A
5343519	Feldman	Aug 1994	A
5344407	Ryan	Sep 1994	A
5347453	Maestre	Sep 1994	A
5354284	Haber et al.	Oct 1994	A
5356376	Milijasevic et al.	Oct 1994	A
5363842	Mishelevich et al.	Nov 1994	A
5380281	Tomellini et al.	Jan 1995	A
5383851	McKinnon, Jr. et al.	Jan 1995	A
5383864	van den Heuvel	Jan 1995	A
5387108	Crowell	Feb 1995	A
5394866	Ritson et al.	Mar 1995	A
5399163	Peterson et al.	Mar 1995	A
5399823	McCusker	Mar 1995	A
5404871	Goodman	Apr 1995	A
5405362	Kramer	Apr 1995	A
5417660	Martin	May 1995	A
5466217	Myers et al.	Nov 1995	A
5505192	Samiotes et al.	Apr 1996	A
5514135	Earle	May 1996	A
5540664	Wyrick	Jul 1996	A
5544647	Jewett et al.	Aug 1996	A
5558679	Tuttle	Sep 1996	A
5567160	Massino	Oct 1996	A
5568555	Shamir	Oct 1996	A
5569192	van der Wal	Oct 1996	A
5584815	Pawelka et al.	Dec 1996	A
5610992	Hickman	Mar 1997	A
5615771	Hollister	Apr 1997	A
5616132	Newman	Apr 1997	A
5642731	Kehr	Jul 1997	A
5645534	Chanoch	Jul 1997	A
5662612	Niehoff	Sep 1997	A
5681291	Galli	Oct 1997	A
5692492	Bruna et al.	Dec 1997	A
5695476	Harris	Dec 1997	A
5697916	Schraga	Dec 1997	A
5716338	Hjertman et al.	Feb 1998	A
5728074	Castellano et al.	Mar 1998	A
5740794	Smith	Apr 1998	A
5752235	Kehr et al.	May 1998	A
5772635	Dastur et al.	Jun 1998	A
5792190	Olson et al.	Aug 1998	A
5800397	Wilson et al.	Sep 1998	A
5805423	Wever et al.	Sep 1998	A
5809997	Wolf	Sep 1998	A
5813397	Goodman	Sep 1998	A
5814020	Gross	Sep 1998	A
5820602	Kovelman	Oct 1998	A
5823346	Weiner	Oct 1998	A
5832488	Eberhardt	Nov 1998	A
5837546	Allen et al.	Nov 1998	A
RE35986	Ritson et al.	Dec 1998	E
5846089	Weiss et al.	Dec 1998	A
5848988	Davis	Dec 1998	A
5852590	de la Huerga	Dec 1998	A
5853292	Eggert et al.	Dec 1998	A
5860957	Jacobsen	Jan 1999	A
5868713	Klippenstein	Feb 1999	A
5868721	Marinacci	Feb 1999	A
D407487	Greubel et al.	Mar 1999	S
5925021	Castellano et al.	Jul 1999	A
5928195	Malamud	Jul 1999	A
5941857	Nguyen et al.	Aug 1999	A
5954641	Kehr et al.	Sep 1999	A
5964739	Champ	Oct 1999	A
5970457	Brant et al.	Oct 1999	A
5971953	Bachynsky	Oct 1999	A
5991655	Gross et al.	Nov 1999	A
6002781	Takayama et al.	Dec 1999	A
6015438	Shaw	Jan 2000	A
6030363	Kriesel	Feb 2000	A
6039713	Botich et al.	Mar 2000	A
6045534	Jacobsen et al.	Apr 2000	A
6062901	Liu et al.	May 2000	A
6063053	Castellano et al.	May 2000	A
6074213	Hon	Jun 2000	A
6077106	Mish	Jun 2000	A
6084526	Blotky et al.	Jul 2000	A
6086562	Jacobsen et al.	Jul 2000	A
6096002	Landau	Aug 2000	A
6099504	Gross et al.	Aug 2000	A
6102896	Roser	Aug 2000	A
6119684	Nöhl et al.	Sep 2000	A
6144310	Morris	Nov 2000	A
6149626	Rachynsky et al.	Nov 2000	A
6158613	Novosel et al.	Dec 2000	A
6161281	Dando et al.	Dec 2000	A
6165155	Jacobsen et al.	Dec 2000	A
6175752	Say	Jan 2001	B1
6179812	Botich et al.	Jan 2001	B1
6190326	McKinnon et al.	Feb 2001	B1
6192891	Gravel et al.	Feb 2001	B1
6193695	Rippstein, Jr.	Feb 2001	B1
6202642	McKinnon et al.	Mar 2001	B1
6210359	Patel et al.	Apr 2001	B1
6210369	Wilmot et al.	Apr 2001	B1
6219587	Ahlin et al.	Apr 2001	B1
6221045	Duchon et al.	Apr 2001	B1
6221055	Shaw et al.	Apr 2001	B1
6245046	Sibbitt	Jun 2001	B1
6249717	Nicholson et al.	Jun 2001	B1
6258063	Haar et al.	Jul 2001	B1
6259654	de la Huerga	Jul 2001	B1
6264629	Landau	Jul 2001	B1
6270455	Brown	Aug 2001	B1
6277098	Klitmose et al.	Aug 2001	B1
6285757	Carroll et al.	Sep 2001	B1
6312412	Saied et al.	Nov 2001	B1
6317630	Gross et al.	Nov 2001	B1
6321070	Clark et al.	Nov 2001	B1
6321654	Robinson	Nov 2001	B1
6323780	Morris	Nov 2001	B1
6334070	Nova et al.	Dec 2001	B1
6364866	Furr et al.	Apr 2002	B1
6371939	Bergens et al.	Apr 2002	B2
6377848	Garde et al.	Apr 2002	B1
6387078	Gillespie, III	May 2002	B1
6398760	Danby	Jun 2002	B1
6405912	Giannou	Jun 2002	B2
6411567	Niemiec et al.	Jun 2002	B1
6413236	Van Dyke	Jul 2002	B1
6425897	Overes et al.	Jul 2002	B2
6427684	Ritsche et al.	Aug 2002	B2
6428517	Hochman et al.	Aug 2002	B1
6428528	Sadowski	Aug 2002	B2
6475181	Potter et al.	Nov 2002	B1
6478769	Parker	Nov 2002	B1
6478771	Lavi et al.	Nov 2002	B1
6482185	Hartmann	Nov 2002	B1
6494863	Shaw et al.	Dec 2002	B1
6500150	Gross et al.	Dec 2002	B1
6514230	Munk et al.	Feb 2003	B1
6529446	de la Huerga	Mar 2003	B1
6530900	Daily et al.	Mar 2003	B1
6530904	Edwards et al.	Mar 2003	B1
6535714	Melker et al.	Mar 2003	B2
6539281	Wan et al.	Mar 2003	B2
6540672	Simonsen et al.	Apr 2003	B1
6540675	Aceti et al.	Apr 2003	B2
6544234	Gabriel	Apr 2003	B1
6551276	Mann et al.	Apr 2003	B1
6551298	Zhang	Apr 2003	B1
6554798	Mann et al.	Apr 2003	B1
6558320	Causey, III et al.	May 2003	B1
6560471	Heller	May 2003	B1
6565533	Smith et al.	May 2003	B1
6569123	Alchas	May 2003	B2
6572584	Shaw et al.	Jun 2003	B1
6574166	Niemiec	Jun 2003	B2
6575939	Brunel	Jun 2003	B1
RE38189	Walker et al.	Jul 2003	E
6585685	Staylor et al.	Jul 2003	B2
6585698	Packman et al.	Jul 2003	B1
6589158	Winkler	Jul 2003	B2
6589229	Connelly et al.	Jul 2003	B1
6595956	Gross et al.	Jul 2003	B1
6597794	Cole et al.	Jul 2003	B2
6633796	Pool et al.	Oct 2003	B1
6641566	Douglas et al.	Nov 2003	B2
6645171	Robinson et al.	Nov 2003	B1
6645181	Lavi et al.	Nov 2003	B1
6659980	Moberg et al.	Dec 2003	B2
6679862	Diaz et al.	Jan 2004	B2
6689093	Landau	Feb 2004	B2
6702778	Hill et al.	Mar 2004	B2
6707763	Osberg et al.	Mar 2004	B2
6708050	Carim	Mar 2004	B2
6722916	Buccinna et al.	Apr 2004	B2
6723077	Pickup et al.	Apr 2004	B2
6726661	Munk et al.	Apr 2004	B2
6736796	Shekalim	May 2004	B2
6743635	Neel et al.	Jun 2004	B2
6749437	Chan	Jun 2004	B2
6752781	Landau et al.	Jun 2004	B2
6764469	Broselow	Jul 2004	B2
6767336	Kaplan	Jul 2004	B1
6770052	Hill et al.	Aug 2004	B2
6770056	Price et al.	Aug 2004	B2
6783509	Landau et al.	Aug 2004	B1
6786875	Barker et al.	Sep 2004	B2
6786885	Hochman et al.	Sep 2004	B2
6793646	Giambattista et al.	Sep 2004	B1
6803856	Murphy et al.	Oct 2004	B1
6805686	Fathallah et al.	Oct 2004	B1
6808514	Schneider et al.	Oct 2004	B2
6809653	Mann et al.	Oct 2004	B1
6817986	Slate et al.	Nov 2004	B2
6830560	Gross et al.	Dec 2004	B1
6839304	Niemiec et al.	Jan 2005	B2
6872200	Mann et al.	Mar 2005	B2
6875195	Choi	Apr 2005	B2
6883222	Landau	Apr 2005	B2
6923764	Aceti et al.	Aug 2005	B2
6936029	Mann et al.	Aug 2005	B2
6936032	Bush, Jr. et al.	Aug 2005	B1
6937150	Medema et al.	Aug 2005	B2
6942646	Langley et al.	Sep 2005	B2
6945961	Miller et al.	Sep 2005	B2
6946299	Neel et al.	Sep 2005	B2
6949082	Langley et al.	Sep 2005	B2
6952604	DeNuzzio et al.	Oct 2005	B2
6953445	Wilmot et al.	Oct 2005	B2
6953693	Neel et al.	Oct 2005	B2
6958691	Anderson et al.	Oct 2005	B1
6959247	Neel et al.	Oct 2005	B2
6961285	Niemiec et al.	Nov 2005	B2
6963280	Eskildsen	Nov 2005	B2
6964650	Alexandre et al.	Nov 2005	B2
6969259	Pastrick et al.	Nov 2005	B2
6979316	Rubin et al.	Dec 2005	B1
6979326	Mann et al.	Dec 2005	B2
6985870	Martucci et al.	Jan 2006	B2
6997911	Klitmose	Feb 2006	B2
7014470	Vann	Mar 2006	B2
7072738	Bonney et al.	Jul 2006	B2
7074211	Heiniger et al.	Jul 2006	B1
7093595	Nesbitt	Aug 2006	B2
7104972	Moller et al.	Sep 2006	B2
7113101	Peterson et al.	Sep 2006	B2
7116233	Zhurin	Oct 2006	B2
7118553	Scherer	Oct 2006	B2
7126879	Snyder	Oct 2006	B2
7158011	Brue	Jan 2007	B2
7191916	Clifford et al.	Mar 2007	B2
7229458	Boecker et al.	Jun 2007	B2
7278983	Ireland et al.	Oct 2007	B2
7299981	Hickle et al.	Nov 2007	B2
7343914	Abrams et al.	Mar 2008	B2
7351223	Call	Apr 2008	B2
7416540	Edwards et al.	Aug 2008	B2
7544188	Edwards et al.	Jun 2009	B2
7648482	Edwards et al.	Jan 2010	B2
7648483	Edwards et al.	Jan 2010	B2
7682155	Raven et al.	Mar 2010	B2
7731686	Edwards et al.	Jun 2010	B2
7731690	Edwards et al.	Jun 2010	B2
7749194	Edwards et al.	Jul 2010	B2
7850662	Veasey et al.	Dec 2010	B2
7871393	Monroe	Jan 2011	B2
7875022	Wenger	Jan 2011	B2
7918832	Veasey et al.	Apr 2011	B2
7938802	Bicknell et al.	May 2011	B2
7947017	Edwards et al.	May 2011	B2
8021344	Edwards et al.	Sep 2011	B2
8123719	Edwards et al.	Feb 2012	B2
8149111	Monroe	Apr 2012	B2
8172082	Edwards et al.	May 2012	B2
8206360	Edwards et al.	Jun 2012	B2
8212658	Monroe	Jul 2012	B2
8226610	Edwards et al.	Jul 2012	B2
8231573	Edwards et al.	Jul 2012	B2
8424517	Sutherland et al.	Apr 2013	B2
8544645	Edwards et al.	Oct 2013	B2
8556865	Krulevitch et al.	Oct 2013	B2
8556867	Krulevitch et al.	Oct 2013	B2
8622973	Edwards et al.	Jan 2014	B2
8690827	Edwards et al.	Apr 2014	B2
8899987	Edwards et al.	Dec 2014	B2
8920377	Edwards et al.	Dec 2014	B2
8926594	Edwards et al.	Jan 2015	B2
8932252	Edwards et al.	Jan 2015	B2
9022980	Edwards et al.	May 2015	B2
9056170	Edwards et al.	Jun 2015	B2
9084849	Edwards et al.	Jul 2015	B2
9149579	Edwards et al.	Oct 2015	B2
20010005781	Bergens et al.	Jun 2001	A1
20020000225	Schuler et al.	Jan 2002	A1
20020016567	Hochman	Feb 2002	A1
20020072784	Sheppard, Jr. et al.	Jun 2002	A1
20020074345	Schneider	Jun 2002	A1
20020076679	Aman	Jun 2002	A1
20020079326	Fuchs	Jun 2002	A1
20020090601	Strupat et al.	Jul 2002	A1
20020096543	Juselius	Jul 2002	A1
20020169439	Flaherty	Nov 2002	A1
20020183721	Santini, Jr. et al.	Dec 2002	A1
20020188419	Slate	Dec 2002	A1
20030015191	Armstrong et al.	Jan 2003	A1
20030028145	Duchon et al.	Feb 2003	A1
20030040717	Saulenas et al.	Feb 2003	A1
20030060765	Campbell et al.	Mar 2003	A1
20030065536	Hansen et al.	Apr 2003	A1
20030106824	Wilmot et al.	Jun 2003	A1
20030120212	Dedig et al.	Jun 2003	A1
20030120222	Vaillancourt	Jun 2003	A1
20030130853	Maire	Jul 2003	A1
20030132128	Mazur	Jul 2003	A1
20030233070	De La Serna et al.	Dec 2003	A1
20040019326	Gilbert et al.	Jan 2004	A1
20040039336	Amark et al.	Feb 2004	A1
20040039337	Letzing	Feb 2004	A1
20040039368	Reilly et al.	Feb 2004	A1
20040069667	Tomellini et al.	Apr 2004	A1
20040116854	Abulhaj et al.	Jun 2004	A1
20040138611	Griffiths et al.	Jul 2004	A1
20040143298	Nova et al.	Jul 2004	A1
20040147818	Levy et al.	Jul 2004	A1
20040159364	Landau et al.	Aug 2004	A1
20040210199	Atterbury et al.	Oct 2004	A1
20040220524	Sadowski et al.	Nov 2004	A1
20040225255	Ono	Nov 2004	A1
20040249358	McWethy et al.	Dec 2004	A1
20040267204	Brustowicz	Dec 2004	A1
20050027255	Lavi et al.	Feb 2005	A1
20050033234	Sadowski et al.	Feb 2005	A1
20050033386	Osborn et al.	Feb 2005	A1
20050055014	Coppeta et al.	Mar 2005	A1
20050062603	Fuerst et al.	Mar 2005	A1
20050088289	Rochkind	Apr 2005	A1
20050090781	Baba et al.	Apr 2005	A1
20050090782	Marshall et al.	Apr 2005	A1
20050134433	Sweeney, II	Jun 2005	A1
20050137530	Campbell et al.	Jun 2005	A1
20050148931	Juhasz	Jul 2005	A1
20050148945	Chen	Jul 2005	A1
20050150488	Dave	Jul 2005	A1
20050159705	Crawford et al.	Jul 2005	A1
20050165360	Stamp	Jul 2005	A1
20050168337	Mahoney	Aug 2005	A1
20050171477	Rubin et al.	Aug 2005	A1
20050182358	Veit et al.	Aug 2005	A1
20050183982	Giewercer	Aug 2005	A1
20050186221	Reynolds et al.	Aug 2005	A1
20050190941	Yang	Sep 2005	A1
20050192530	Castellano	Sep 2005	A1
20050197654	Edman et al.	Sep 2005	A1
20050203466	Hommann et al.	Sep 2005	A1
20050209558	Marx	Sep 2005	A1
20050209569	Ishikawa et al.	Sep 2005	A1
20050261742	Nova et al.	Nov 2005	A1
20050267403	Landau et al.	Dec 2005	A1
20050273059	Mernoe et al.	Dec 2005	A1
20050277891	Sibbitt	Dec 2005	A1
20060022806	Auerbach	Feb 2006	A1
20060030819	Young et al.	Feb 2006	A1
20060053036	Coffman et al.	Mar 2006	A1
20060058848	Piraino et al.	Mar 2006	A1
20060074519	Barker et al.	Apr 2006	A1
20060089592	Kadhiresan et al.	Apr 2006	A1
20060111666	Hommann et al.	May 2006	A1
20060111671	Klippenstein	May 2006	A1
20060116639	Russell	Jun 2006	A1
20060129090	Moberg et al.	Jun 2006	A1
20060189938	Hommann et al.	Aug 2006	A1
20060200077	Righi et al.	Sep 2006	A1
20060204939	Bardsley et al.	Sep 2006	A1
20060247578	Arguendas et al.	Nov 2006	A1
20060247579	Friedman	Nov 2006	A1
20060265186	Holland et al.	Nov 2006	A1
20060281435	Shearer	Dec 2006	A1
20070008113	Spoonhower et al.	Jan 2007	A1
20070074722	Giroux et al.	Apr 2007	A1
20070100288	Bozeman et al.	May 2007	A1
20070111175	Raven et al.	May 2007	A1
20070149954	Hood et al.	Jun 2007	A1
20070184847	Hansen et al.	Aug 2007	A1
20070186923	Poutiatine et al.	Aug 2007	A1
20070203247	Phillips et al.	Aug 2007	A1
20070210147	Morrone et al.	Sep 2007	A1
20070213598	Howard et al.	Sep 2007	A1
20070233001	Burroughs et al.	Oct 2007	A1
20070239116	Follman et al.	Oct 2007	A1
20070239140	Chechelski et al.	Oct 2007	A1
20070260210	Conroy	Nov 2007	A1
20070285238	Batra	Dec 2007	A1
20080111685	Olson et al.	May 2008	A1
20080140018	Enggaard et al.	Jun 2008	A1
20080160492	Campbell et al.	Jul 2008	A1
20080171995	Vitullo et al.	Jul 2008	A1
20080228143	Stamp	Sep 2008	A1
20080230057	Sutherland	Sep 2008	A1
20080234625	Dacquay et al.	Sep 2008	A1
20090030285	Andersen	Jan 2009	A1
20090062728	Woo	Mar 2009	A1
20090131875	Green	May 2009	A1
20090143761	Cantor et al.	Jun 2009	A1
20090194104	Van Sickle	Aug 2009	A1
20090240200	Heneveld et al.	Sep 2009	A1
20100060464	Larsen	Mar 2010	A1
20100160894	Julian et al.	Jun 2010	A1
20100169111	Brue et al.	Jul 2010	A1
20100192948	Sutherland et al.	Aug 2010	A1
20100211005	Edwards et al.	Aug 2010	A1
20100250280	Sutherland	Sep 2010	A1
20100250697	Hansen et al.	Sep 2010	A1
20110144574	Kamen et al.	Jun 2011	A1
20110201999	Cronenberg	Aug 2011	A1
20110264033	Jensen et al.	Oct 2011	A1
20110295215	Nielsen et al.	Dec 2011	A1
20120015335	Smith et al.	Jan 2012	A1
20120046613	Plumptre	Feb 2012	A1
20120052837	Reich et al.	Mar 2012	A1
20120071819	Bruggemann et al.	Mar 2012	A1
20120101444	Muller-Pathle et al.	Apr 2012	A1
20120107783	Julian et al.	May 2012	A1
20120165747	Lanin et al.	Jun 2012	A1
20120233834	Szechinski et al.	Sep 2012	A1
20120238960	Smith et al.	Sep 2012	A1
20120253288	Dasbach et al.	Oct 2012	A1
20120259285	Schabbach et al.	Oct 2012	A1
20120271243	Plumptre et al.	Oct 2012	A1
20130079718	Shang et al.	Mar 2013	A1
20130079725	Shang et al.	Mar 2013	A1
20130110050	Boyd et al.	May 2013	A1
20130184649	Edwards et al.	Jul 2013	A1
20130190692	Edwards et al.	Jul 2013	A1
20130266919	Baker et al.	Oct 2013	A1
20140276385	Baker et al.	Sep 2014	A1
20140296824	Edwards et al.	Oct 2014	A1
20140371714	Edwards et al.	Dec 2014	A1
20150011973	Edwards et al.	Jan 2015	A1
20150190591	Edwards et al.	Jul 2015	A1
20150196711	Edwards et al.	Jul 2015	A1
20150302779	Edwards et al.	Oct 2015	A1
20160121056	Edwards et al.	May 2016	A1
20160166768	Edwards et al.	Jun 2016	A1
20160184535	Edwards et al.	Jun 2016	A1
20160235916	Edwards et al.	Aug 2016	A1
20170049954	Edwards et al.	Feb 2017	A1
20170092101	Edwards et al.	Mar 2017	A1
20180102066	Edwards et al.	Apr 2018	A1
20180158374	Zamierowski et al.	Jun 2018	A1
20180204636	Edwards et al.	Jul 2018	A1
20180369506	Edwards et al.	Dec 2018	A1
20190030247	Edwards et al.	Jan 2019	A1
20190030265	Edwards et al.	Jan 2019	A1
20190206220	Edwards et al.	Jul 2019	A1
20190217004	Edwards et al.	Jul 2019	A1
20190279756	Edwards et al.	Sep 2019	A1
20190358399	Edwards et al.	Nov 2019	A1

Foreign Referenced Citations (45)

Number	Date	Country
2004231230	Jun 2006	AU
1043037	Oct 2000	EP
1287840	Mar 2003	EP
1462134	Sep 2004	EP
1518575	Mar 2005	EP
1712178	Oct 2006	EP
2195544	Apr 1988	GB
2006-034845	Feb 2006	JP
WO 9104760	Apr 1991	WO
WO 9302720	Feb 1993	WO
WO 9526009	Sep 1995	WO
WO 9625965	Aug 1996	WO
WO 9730742	Aug 1997	WO
WO 9852632	Nov 1998	WO
WO 9907425	Feb 1999	WO
WO 9910031	Mar 1999	WO
WO 9943283	Sep 1999	WO
WO 2001024690	Apr 2001	WO
WO 2001026020	Apr 2001	WO
WO 2001041849	Jun 2001	WO
WO 2001088828	Nov 2001	WO
WO 2001093926	Dec 2001	WO
WO 2002024257	Mar 2002	WO
WO 2002100469	Dec 2002	WO
WO 2003057283	Jul 2003	WO
WO 2003095001	Nov 2003	WO
WO 2003097133	Nov 2003	WO
WO 2004041330	May 2004	WO
WO 2005050526	Jun 2005	WO
WO 2005077441	Aug 2005	WO
WO 2006045525	May 2006	WO
WO 2006085175	Aug 2006	WO
WO 2006085204	Aug 2006	WO
WO 2006109778	Oct 2006	WO
WO 2006123956	Nov 2006	WO
WO 2006125692	Nov 2006	WO
WO 2007083115	Jul 2007	WO
WO 2007087304	Aug 2007	WO
WO 2007088444	Aug 2007	WO
WO 2008005315	Jan 2008	WO
WO 2008008451	Jan 2008	WO
WO 2008148864	Dec 2008	WO
WO 2010114392	Oct 2010	WO
WO 2013043063	Mar 2013	WO
WO 2013044172	Mar 2013	WO

Non-Patent Literature Citations (75)

Entry
“Solutions for Medical Devices,” 3M Brochure, © 3M, (2006), 80-6201-3490-0, 8 pages.
Tingelstad, M., “Revolutionary Medical Technology Increases Demand for Flexible Interconnects,” [online] May 15, 2006 [retrieved on Nov. 15, 2006] Retrieved from the Internet <URL: http://www.ecnmag.com/index.asp?layout=articlePrint&ArticleID=CA6332947>, 3 pages.
“Flexible circuits / Flex circuits / Flexible Technology Ltd.,” Flexible Technology Limited [online] [retrieved on Aug. 28, 2006] Retrieved from the Internet <URL: http://www.flexibletechnology.com/ >, 2 pages.
“Flexible circuits capabilities of Flexible Technology Limited,” Our Flexible Circuits Capabilities [online] [retrieved on Aug. 28, 2006] Retrieved from the Internet <URL: http://www.flexibletechnology.com/Flexible circuits Capability.htm >, 2 pages.
“Flex Circuits/flexible circuits design guide,” [online] [retrieved on Aug. 28, 2006] Retrieved from the Internet <URL: http://flexiblecircuit.co.uk/Flex Circuits Design Guide.htm >, 7 pages.
“Insect Stings Auto-injector Pouches and Carry Cases,” The Insect Stings On-Line Shop, [online] [retrieved on Jan. 24, 2007] Retrieved from the Internet <URL: http://www.insectstings.co.uk/acatalog/Auto Injector Pouches.html >, 3 pages.
“Anaphylaxis Canada Product Catalogue,” Anaphylaxis Canada > Living with Anaphylaxis > Tools and Resources [online] [retrieved on Jan. 24, 2007] Retrieved from the Internet <URL: http://anaphylaxis.org/content/livingwith/product catalogue.asp >, 9 pages.
“Microfluidics Device Provides Programmed, Long-Term Drug Dosing,” nano techwire.com [online] [retrieved on Nov. 28 ,2006] Retrieved from the Internet <URL: http://nanotechwire.com/news.asp?nid=3141&ntid=124&pg=1 >, 3 pages.
Allan, R., “Medical Electronics: Technology Advances Will Revolutionize Healthcare,” Sep. 30, 2002 [online] [retrieved on Nov. 28, 2006] Retrieved from the Internet <URL: http://www.elecdesign.com/Articles/Index.cfm?AD=1&ArticleID=2041>, 3 pages.
RFID Gazette, “Smart Labels in Healthcare,” Sep. 29, 2005 [online] [retrieved on Nov. 28, 2006] Retrieved from the Internet <URL: http://www.rfidagazeete.org/2005/09/smart labels in.html >, 2 pages.
“Merck Serono Launches easypod(R), First Electronic Growth Hormone Injection Device,” Jan. 30, 2007 [online] [retrieved on Feb. 5, 2007] Retrieved from the Internet <URL: http://www.biz.yahoo.com/prnews/070130/ukm028.html?.v=8>, 3 pages.
Scholz, O., “Drug depot in a tooth,” [online] [retrieved on Feb. 6, 2007] Retrieved from the Internet <URL: http://www.fraunhofer.de/fhg/EN/press/pi/2007/02Mediendienst22007Thema2.jsp?print=true>, 1 page.
Heartsine Technology, samaritan™ Pad Accessories [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet <URL: http://www.heartsine.com/aboutsam-accessories.htm>, 4 pages.
CliniSense Corporation, “Drug delivery devices A potentially harsh environment for drugs,” Stability [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet <URL: http://www.clinisense.com/devices.htm>, 2 pages.
CliniSense Corporation, “LifeTrack Technology A new method to detect improper storage.” Stability [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet <URL: http://www.clinisense.com/tech.htm>, 2 pages.
AED Professionals™ Brochure [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet <URL: http://www.aedprofessionals.com>, 4 pages.
Ruppar, D., “Implant Technologies Expected to Remain a Niche but Effective Method of Drug Delivery,” Drug Delivery Technology, Feb. 2007, vol. 7, No. 2 [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet <URL: http://www.drugdeliverytech-online.com/drugdelivery/200702/templates/pageviewer_print?pg=44&pm=8 >, 8 pages.
Meridian Medical Technologies, Inc., “Pralidoxime Chloride Trainer,” 2006. [retrieved on Feb. 16, 2007] Retrieved from the Internet <URL: http://www.meridianmeds.com/auto-injectors/2pamcl_trainer.html/>, 1 pages.
Gosbee, L. L., “Nuts! I Can't Figure Out How to Use My Life-Saving Epinephrine Auto-Injector,” Joint Commision Journal on Quality and Safety, 30(4):220-223 (Apr. 2004).
Amgen, “Using Aranesp prefilled SureClick autoinjector is a simple 3-step process,” 2006. [retrieved on Feb. 16, 2007] Retrieved from the Internet <URL: http://www.aranesp.com/patient/cia/sureclick/using_three_steps.jsp/>, 4 pages.
McDougall, L., “Addicts to be given personal supply of anti-overdose drug,” The Herald Scotland, May, 28, 2006. Retrieved from the Internet <URL: http://www.heraldscotland.com/sport/spl/aberdeen/addicts-to-be-given-personal-supply-of-anti-overdose-drug-heroin-controversial-lifesaving-plan-projects-aim-to-cut-rising-death-toll-by-making-naloxone-treatment-more-readily-available-1.19181>, 3 pages.
BD Accuspray™ Nasal Spray System, 2004, Retrieved from the Internet <URL: http://www.bd.com/press/pdfs/flu/bd_accuspray.pdf>, 1 page.
Office Action for Israel Patent Application No. 184552, dated Jul. 28, 2011.
International Search Report and Written Opinion for International Patent Application No. PCT/US06/03415, dated Jul. 13, 2006, 10 pages.
Search Report for European Patent Application No. 09150135.3, dated Mar. 15, 2010.
Office Action for European Patent Application No. 09150135.3, dated Jul. 11, 2011.
Combined Search and Examination Report for British Patent Application 0818178.6, dated Dec. 1, 2008.
Examination Report for British Patent Application No. 0818178.6, dated Mar. 23, 2009.
Examination Report for British Patent Application No. 0818178.6, dated Jul. 9, 2009.
Examination Report for British Patent Application No. 0905194.7, dated May 8, 2009.
Office Action for U.S. Appl. No. 10/572,148, dated Jun. 19, 2009.
Office Action for U.S. Appl. No. 10/572,148, dated Feb. 3, 2010.
Office Action for Canadian Patent Application No. 2,644,547, dated Feb. 14, 2014.
Office Action for Chinese Patent Application No. 200780011264.5, dated Mar. 28, 2013.
Office Action for Japanese Patent Application No. 2009-502964, dated May 23, 2011.
Office Action for Japanese Patent Application No. 2009-502964, dated May 21, 2012 (English Translation).
International Search Report and Written Opinion for International Patent Application No. PCT/US07/007626, dated Sep. 29, 2008.
Search and Examination Report for British Patent Application No. 1104754.5, dated May 18, 2011.
Office Action for U.S. Appl. No. 11/621,236, dated Feb. 3, 2009.
Office Action for U.S. Appl. No. 11/621,236, dated Jul. 1, 2009.
Office Action for U.S. Appl. No. 11/621,236, dated Jan. 11, 2010.
Search and Examination Report for British Patent Application No. 1108993.5, dated Jun. 17, 2011.
Office Action for U.S. Appl. No. 11/671,025, dated Mar. 24, 2011.
Office Action for U.S. Appl. No. 11/671,025, dated Sep. 8, 2011.
Office Action for U.S. Appl. No. 11/679,331, dated Feb. 15, 2011.
Office Action for U.S. Appl. No. 11/679,331, dated May 12, 2010.
Examination Report for British Patent Application No. 1019599.8, dated Feb. 7, 2012.
Office Action for U.S. Appl. No. 12/119,016, dated Nov. 3, 2011.
Office Action for U.S. Appl. No. 12/794,020, dated Oct. 25, 2011.
Office Action for U.S. Appl. No. 13/404,699, dated Mar. 10, 2014.
Office Action for U.S. Appl. No. 13/550,893, dated Apr. 28, 2015.
Office Action for U.S. Appl. No. 13/924,037, dated Feb. 13, 2014.
Office Action for U.S. Appl. No. 13/962,336, dated Nov. 20, 2013.
Office Action for U.S. Appl. No. 13/962,336, dated May 27, 2014.
Office Action for U.S. Appl. No. 14/470,165, dated Dec. 26, 2014.
Office Action for U.S. Appl. No. 14/470,165, dated May 26, 2015.
Office Action for U.S. Appl. No. 14/664,426, dated Jun. 9, 2015.
Office Action for U.S. Appl. No. 12/017,405, dated Dec. 7, 2011.
Office Action for U.S. Appl. No. 14/665,659, dated Jun. 23, 2015.
Office Action for U.S. Appl. No. 12/615,636, dated Jan. 25, 2012.
International Search Report and Written Opinion for International Patent Application No. PCT/US09/63983, dated Feb. 25, 2010.
Office Action for Canadian Patent Application No. 2,762,072, dated Mar. 14, 2016.
Office Action for U.S. Appl. No. 14/244,311, dated Oct. 20, 2016.
Office Action for U.S. Appl. No. 14/148,268 dated Jun. 15, 2017.
Knapp, Louise. “A Faster Way to Call 911,” Wired.com [online], [retrieved Jul. 26, 2017] Retrieved from the Internet <https://www.wired.com/2001/03/a-faster-way-to-call-911> (Mar. 10, 2001), 9 pages.
Libov, Charlotte. “EpiPen 101,” Everyday Health [online], [retrieved Jul. 26, 2017] Retrieved from the internet <http://www.everydayhealth.com/allergy/epipen-101.aspx> (Feb. 23, 2012), 2 pages.
Office Action for U.S. Appl. No. 14/993,234, dated Jul. 21, 2017.
Office Action for Australia Patent Application No. 2015249064, dated Aug. 25, 2017.
Office Action for U.S. Appl. No. 15/061,462, dated Oct. 10, 2017.
Final Office Action for U.S. Appl. No. 14/993,234, dated Nov. 2, 2017.
Office Action for U.S. Appl. No. 15/139,826, dated Dec. 4, 2017.
Office Action for U.S. Appl. No. 14/148,268 dated Dec. 13, 2017.
Extended European Search Report for European Patent Application No. 07754184.5, dated Feb. 2, 2018.
Office Action for U.S. Appl. No. 15/061,462, dated Feb. 28, 2018.
Office Action for U.S. Appl. No. 16/145,974, dated May 11, 2020.

Related Publications (1)

	Number	Date	Country
	20170312433 A1	Nov 2017	US

Provisional Applications (1)

	Number	Date	Country
	60731886	Oct 2005	US

Continuations (3)

	Number	Date	Country
Parent	14244311	Apr 2014	US
Child	15651305		US
Parent	12818496	Jun 2010	US
Child	14244311		US
Parent	10572148		US
Child	12818496		US

Devices, systems, and methods for medicament delivery

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