Patent Application
20080013047
The present invention relates to a system for evaluating and improving eyesight.
The macula is the region of the retina that is used for high acuity vision, as is typically required for reading. Patients suffering from macular damage (e.g., Age-related Macular Degeneration or AMD) may undergo eccentric viewing therapy to regain the ability to recognize objects and text by using peripheral regions of the retina.
To diagnose macular damage, a patient may undergo various types of examinations, including automated perimetry or campimetry, in which the patient is positioned in front of a test surface and is asked to maintain focus on a fixation target. A computer actuates a light source or other visual stimulus to present at a specific point on the test surface. The patient is asked to actuate a data entry device in response to perceived test stimuli and the examiner or computer records the patient input and associated spatial information. In this way, a visual field map is created.
In a first embodiment of the invention, a computer is used to map the sight perception of a patient and/or for therapeutically stimulating the patient. The method includes providing a target focal stimulation on a luminous background stimulation field so that the patient may focus upon the target and thereby keep the patient's retina in a fixed position. A temporary peripheral visual stimulation is then created in a region that is peripheral to the fixation target. The peripheral visual stimulation is darker than the background field. A computer records whether the patient was able to see the peripheral stimulation and stores the patient response data in a manner that maintains association with the position of the peripheral visual stimulation. The process is then repeated with additional stimuli and response recordations to create automatically, in computer media, a peripheral vision map.
The background, focal, and peripheral stimuli may be provided by a computerized display. By varying the contrast between the peripheral stimuli and the background stimulation-field during the mapping process, a multidimensional perception map may be created that has at least two spatial dimensions and a contrast dimension.
A target retinal region may be selected for corrective treatment based on the output of the mapping procedure. For example, the target retinal region may be an area that is selected by comparing contrast values in the visual perception map to a threshold contrast value.
Improved precision and accuracy may be obtained by fixing the distance and angle of the patient's head with respect to the stimuli. For example, the patient's eyes may be fixed with a head-positioning device, such as a chinrest attached to a computer display. The user may be provided with a data entry device for activation in response to visual perception of the peripheral test stimuli. In order to maintain and record a patient's continued gaze at the target focal stimulus, the computer may change the focal stimulus (fixation target) and a user may be asked to record those changes.
The data output of a perimetry testing procedure of the first embodiment may be to determine the peripheral retinal region(s) that receives the treatment. The perimetry method used may be the mapping procedure of the above first embodiment. The temporary peripheral visual stimuli may be allocated to positions peripheral to the focal stimulation that are selected based upon data output of a testing procedure so as to bias the allocation of stimuli to target visual field regions determined to have a high potential responsiveness to therapeutic stimulation. To increase precision and accuracy in selecting the peripheral region for treatment, the mapping and treatment procedures of the above embodiments may be performed while fixing the head of a patient in substantially the same fixed position with respect to the stimuli.
In another embodiment of the invention, a computer is used to map the visual sensitivity of the central field of a patient. The method includes providing a visible landmark target on a background field so that the patient may focus upon the target and thereby keep the patient's retina in a determined position. Various transient peripheral visual stimulations are then presented within a region that is peripheral to the fixation target. The peripheral visual stimuli increase incrementally in their contrast to the background medium in order to identify the viewer's visual sensitivity at that test point. The stimulus may be presented as darker than the background field (e.g. a light grey stimulus on a white background incrementally growing blacker) or may be lighter than the background field (e.g. a dark grey stimulus on a black background incrementally growing whiter). A computer records whether the patient was able to see the peripheral stimulation and at what degree of contrast, and then stores the patient response data in a manner that maintains association with the position and contrast of the peripheral visual stimulation. The process is then repeated with additional stimuli and response recordations to create automatically, in computer media, a peripheral vision map.
In another embodiment of the invention, a computer is used to treat a patient for improved visual perception, such as may be obtained with eccentric viewing. The method includes providing a target focal stimulation on a background stimulation field so that the patient may focus upon the target and thereby keep the patient's retina in a determined position. A transient peripheral visual stimulation is then presented in a region that is peripheral to the fixation target. The peripheral visual stimulation differs in contrast from the background field by being lighter or darker. A computer records if, and at what level of contrast, the patient was able to see the peripheral stimulation and stores the patient response data in a manner that maintains an association with the position of the peripheral visual stimulation. The process is then repeated with additional stimuli and response recordations to a visual perception map data set. The computer system may use the map data set to select a region for therapeutic stimuli and actuate a series of therapeutic stimulations biased to that region.
In an embodiment of the invention, a device is used for therapeutic stimulation of the visual field of a patient. The device includes a source of focal stimulation, a source of negative relative luminance peripheral stimuli and a computer system. The computer system includes a processor and computer-executable instructions. The system is adapted to accept a visual field map data set, use the data set to select a peripheral region for therapy, and to repeatedly create peripheral visual stimulation in the selected region. The device may allocate a finite number of stimuli so as to create a bias toward the selected region and may allocate the majority of the stimuli to the region. The system may be adapted to determine and record, to computer media, the presence or absence of the patient's visual perception in response to the peripheral visual stimulations, so as to update the visual field map data set. The updated visual field map may be used to update the region selected for therapy.
In yet another embodiment of the invention, a computer related-medium has computer-executable instructions for performing a method that includes providing, a target focal stimulation on a luminous background stimulation field for the patient to visually fixate upon, creating a temporary peripheral visual stimulation that is darker than the background field in a region peripheral to the focal stimulation, determining and recording to computer media the presence or absence of the patient's visual perception in response to the peripheral visual stimulation, and repeating the steps of creating the stimulation and determining visual perception while varying the position of the peripheral visual stimuli to create automatically, in computer media, a peripheral vision map.
In a related embodiment, the computer-related medium includes instructions for performing a method that includes using the peripheral vision map to allocate a finite number of therapeutic stimuli to an identified visual field region of the patient. The identified visual field region may be a region of high therapeutic potential. The map may be a multi-dimensional map that includes a contrast dimension.
The foregoing features of the invention will be more readily understood by reference to the following detailed description, taken with reference to the accompanying drawings, in which:
Definitions. As used in this description and the accompanying claims, the following terms shall have the meanings indicated, unless the context otherwise requires:
“Brightness” means a level of illumination measured with reference to an absolute quantity associated with an illuminated surface or to its visual perception; and “Luminance” means a level of brightness weighted by the spectral response of the human eye, as described by Born and Wolf, Principles of Optics, 7th edition, Cambridge University Press, 1999, pp. 194-198.
In illustrative embodiments of the present invention, a testing procedure has a patient or other user visually fixate on a visual fixation target stimulus (hereinafter a “target”) while a computer displays peripheral visual stimuli and records user input related to visual perception of the stimuli. In this way, the computer builds a visual field map. An eccentric viewing treatment procedure may then be performed by stimulating areas of the retina identified by the testing procedure. These procedures and devices for implementation of the procedures may be used to treat patients with visual problems such as macular degeneration. The techniques may also prove to have benefit to patients with other visual disorders such as: optic nerve damage, glaucoma, and other retinal problems. Additionally, the techniques may improve peripheral acuity in optically healthy humans; the techniques may be used, for example, by air traffic controllers, military personnel and airport baggage screeners.
The testing and treatment procedures may feature a high degree of flexibility in the types of test stimuli presented; for example, colors, shapes, and contrast ratios may be changed, combinations of shapes and characters and words or sentences may be used as stimuli. The stimuli may be static, moving, scrolling, or have other dynamic effects. The testing and therapy programs may be tailored for a specific patient's known or estimated level of global or localized visual function.
The patient is instructed by the computer program or health care provider to fix their gaze upon a target fixation stimulus (step 120). The fixation target can be, for example, a square, ring or circle permanently positioned on the computer display. The computer display may have a high level of brightness or luminance, and the fixation target may be darker than the background. Alternately, the background may be substantially black with a substantially more luminous fixation target, or may utilize contrasting colors. The computer then selects a region peripheral to the target in which to present a peripheral visual stimulus (step 130). The stimulus may be, for example, a darkened dot on a white display background, a luminous object on a dark background, or a colored object on a background of a contrasting color. The region may be selected from a list, selected randomly, or selected randomly and filtered (e.g., displayed only if the randomly selected region fits with predetermined constraints). If the computer display has a highly luminous background, stimulus of varying darkness (and thus varying contrast ratio) may be used; in this case, the computer will also select the darkness level for the given stimulus.
The peripheral visual stimulus is then presented on the display (step 140). By flashing the stimulus only briefly (e.g., for a duration of 200 ms,) the patient will have insufficient time to avert their gaze, so the retina will remain centered around the target, helping to ensure accurate testing results. Alternately, the stimulus may be flashed for a longer time and the patient induced to re-fixate on the target.
The patient is instructed to respond to perception of the flashed peripheral stimuli (step 150). For example, if the patient sees the stimulus, the patient may press a keyboard button, touch screen, mouse button, give a voice command for automatic speech recognition, make a gesture or use any other suitable computer input method. Touch-screens have the advantage of being able to rapidly record positional information and thus may be used to confirm the accuracy of a patient response. The touch-screen may be of the type that may be operated only with a stylus, finger, or both. Patients with physical handicaps may require special input devices, for example, mouth-actuated or foot-actuated devices.
The process of
If peripheral stimuli of varying contrasts are used, the map produced will be three dimensional, having two spatial coordinates, and a contrast (sensitivity) coordinate. Such a three dimensional map may be referred to as a “photopic contrast sensitivity function,” or CSF. CSF testing with a light background is especially useful, since it is a much more sensitive test of visual edge detection. As a result, the testing method of
One way to build a CSF data set is to gradually increase the contrast presented to the patient (e.g., darken the displayed peripheral stimulus) until detected by the patient. The contrast may be increased while a stimulus is displayed, or increased globally so that the absolute or mean contrast is increased while stimuli flash at various peripheral points. Such a systematic approach is, however, not necessary to arrive at a three dimensional map—a random sampling should also work. Alternate or additional dimensions may also be included, for example, patient response time.
After the patient's head is positioned, the patient is instructed to focus on a fixation target (step 230). The fixation target location and features may need to be adjusted to be appropriate for the patient's central vision function; for example, a patient with exceptionally poor vision may require a larger target. A retinal performance map, such as the output of the procedure of
As in the testing procedure, the stimulation may be a dark spot on a luminous (e.g., white) background that is flashed for less than 1 second. After the stimulation is presented (step 250), the user records visual perception of the stimulation, if any (step 260). As for the testing procedure of
Optionally, the visual perception data may be used to update the map (step 290), either continuously or intermittently. By recording and analyzing the user responses, the computer can determine if the patient has reached a particular level of visual performance (step 270). Optionally, if a benchmark or milestone level of performance has been reached, the computer can provide a different, or more advanced, level of therapy (step 280). If the milestone has not been achieved, or to cement gains, the therapy is continued from step 240 by selecting another display position for another peripheral stimulus. Alternately, if performance is not increasing, the level may be reduced. Of course, a patient may be able to terminate the program at any time, and the computer will maintain a record of performance for analysis by a healthcare professional or for setting a difficulty level for future therapy sessions. The user may also be able to pause the program to take a break.
Alteration of the difficultly level may include changing the peripheral stimulus. By using dark stimuli on a light background (white or lightly colored), a wide variety of stimuli may be presented. Examples of various types of peripheral stimuli that may be displayed by a computer on a light background include:
In a related embodiment, therapeutic stimuli are targeted to a particular retinal sub-region. This sub-region may be adaptively modified based on campimetric data recorded as part of intermittent test sessions during therapy. For example, the size of the region may be decreased based on recorded shrinkage of a zone of deteriorated vision as recorded via the user input device.
The use of a multidimensional map may allow selection of a region of the retina for treatment that may be different than the regions of high-sensitivity that would be typically identified by conventional perimetry. For example, selection of the region for treatment could be based on parameters such as the degree of response to contrast, or patient response times for different retinal regions. Alternately or in addition, selection of the region for treatment could be based on position relative to the impaired area of the visual field.
In either the testing or therapy procedures, the computer system may record and analyze statistical information regarding patient performance and may associate this information with other information about the patient (e.g., demographic or health information). Such statistical information may include false negative and false positive responses, and mean or median response times and may be global or segmented based on retinal region. The system may provide additional levels of analysis such as graphs, charts, and trend information. The various statistical information may be used to adjust treatment (e.g., level or visual region) or to provide or adjust incentives to patients (e.g., reward points, scores or praise).
In embodiments, the devices, methods and algorithmic embodiments of the methods may utilize dynamic target fixation stimuli and/or dynamic peripheral stimuli. Such dynamic stimuli are the subject of co-pending U.S. Patent Application No. 60/867,449 for “: Dynamic Fixation and Peripheral Stimuli for Visual Field Testing and Therapy”, attorney docket No. 2890/114, filed Nov. 28, 2006 and hereby incorporated in its entirety herein. Additional disclosure regarding therapeutic stimulation devices and methods are given in U.S. Pat. No. 6,464,356 and U.S. Patent Application Publication No. 2005-0213033, both to Sabel; both are incorporated herein by reference in their entirety.
A therapeutic procedure uses the following steps:
In alternative embodiments, the disclosed methods for visual testing and therapy may be implemented as a computer program product for use with a computer system. Such implementations may include a series of computer instructions fixed either on a tangible medium, such as a computer readable medium (e.g., a diskette, CD-ROM, ROM, or fixed disk) or transmittable to a computer system, via a modem or other interface device, such as a communications adapter connected to a network over a medium. The medium may be either a tangible medium (e.g., optical or analog communications lines) or a medium implemented with wireless techniques (e.g., microwave, infrared or other transmission techniques). The series of computer instructions embodies all or part of the functionality previously described herein with respect to the system. Those skilled in the art should appreciate that such computer instructions can be written in a number of programming languages for use with many computer architectures or operating systems.
Furthermore, such instructions may be stored in any memory device, such as semiconductor, magnetic, optical or other memory devices, and may be transmitted using any communications technology, such as optical, infrared, microwave, or other transmission technologies. It is expected that such a computer program product may be distributed as a removable medium with accompanying printed or electronic documentation (e.g., shrink wrapped software), preloaded with a computer system (e.g., on system ROM or fixed disk), or distributed from a server or electronic bulletin board over the network (e.g., the Internet or World Wide Web). Of course, some embodiments of the invention may be implemented as a combination of both software (e.g., a computer program product) and hardware. Still other embodiments of the invention are implemented as entirely hardware, or entirely software (e.g., a computer program product).
The described embodiments of the invention are intended to be merely exemplary and numerous variations and modifications will be apparent to those skilled in the art. All such variations and modifications are intended to be within the scope of the present invention as defined in the appended claims.
This application claims priority to U.S. Provisional Application Ser. No. 60/817,898, entitled “Diagnostic and Training System for Eccentric Viewing,” filed Jun. 30, 2006, and which is hereby incorporated in its entirety by reference herein.
| Number | Date | Country | |
|---|---|---|---|
| 60817898 | Jun 2006 | US |
