Claims
- 1. A diagnostic reagent for use in detection of Herpes simplex virus type 1 antibodies or Herpes simplex virus type 2 antibodies in a fluid sample comprising:
- purified and isolated Herpes simplex virus envelope glycoprotein gD-1, purified by selective reversible binding to a monoclonal anti-gD antibody immunoadsorbent, or
- an immunologically active fragment thereof, or
- an immunologically active synthetic replica thereof; and,
- an immunologically acceptable carrier.
- 2. A diagnostic reagent for use in detection of Herpes simplex virus type 1 antibodies or Herpes simplex virus type 2 antibodies in a fluid sample comprising:
- purified and isolated Herpes simplex virus envelope glycoprotein gD-2, or
- an immunologically active fragment thereof, or
- an immunologically active synthetic replica thereof; and,
- an immunologically acceptable carrier.
- 3. A diagnostic reagent according to claim 1 or 2 comprising a polypeptide having an amino acid sequence selected from the group consisting of:
- a) RNH-Met-Ala-Asp-Pro-Asn-Arg-COR',
- b) RNH-Ser-Leu-Lys-Met-Ala-Asp-Pro-Asn-Arg-Phe-Arg-Gly-Lys-Asp-Leu-Pro-COR',
- c) RNH-Lys-Tyr-Ala-Leu-Ala-Asp-Ala-Ser-Leu-Lys-Met-Ala-Asp-Pro-Asn-Arg-Phe-Arg-Gly-Lys-Asp-Leu-Pro-Val-Leu-Asp-Gln-Leu-Thr-Asp-COR', and
- d) RNH-Lys-Tyr-Ala-Leu-Ala-Asp-Ala-Met-Leu-Lys-Met-Ala-Asp-Pro-Asn-Arg-Phe-Arg-Gly-Lys-Asp-Leu-Pro-Val-Leu-Asp-Gln-Leu-Thr-Asp-COR',
- wherein R is hydrogen or one or more amino acids and R' is hydroxyl or one or more amino acids.
CROSS-REFERENCE TO RELATED APPLICATIONS
The present invention is a divisional of co-pending U.S. patent application Ser. No. 148,285 (filed Jan. 29, 1988) which is, in turn, a continuation of U.S. Ser. No. 463,141 (filed Feb. 4, 1983 and issued Nov. 24, 1987 as U.S. Pat. No. 4,762,708) which is, in turn, a continuation-in-part of U.S. patent application Ser. No. 350,021 (filed Feb. 18, 1982 and abandoned Sep. 2, 1983).
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4709011 |
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|
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|
4762708 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
148285 |
Jan 1988 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
463141 |
Feb 1983 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
350021 |
Feb 1982 |
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