Claims
- 1. In a method for the preparation of a cation exchanger charged with metal ions adapted for controlling the phosphate level in blood by oral administration, the steps which comprise charging a cation exchanger with from 10% to 100% alkali metal ions before or after it is charged with ions of iron (III), tin, lanthanum, aluminum or zirconium.
- 2. The method of claim 1, wherein the said alkali metal ions are sodium and the said metal ions which react with phosphate ions are iron III ions.
- 3. A phosphate sorbent for oral administration capable of controlling the phosphate level in blood comprising an organic cation exchanger charged with ferric ions in a pharmaceutically acceptable carrier.
- 4. A phosphate sorbent according to claim 3 comprising a weakly acid organic cation exchanger.
- 5. The phosphate sorbent of claim 4 wherein the cation exchanger contains carboxylic acid groups, phosphonic acid groups or amidoxime groups.
- 6. The phosphate sorbent of claim 5 wherein the cation exchanger contains aminocarboxylic acid or iminodicarboxylic acid groups.
- 7. The phosphate sorbent of claim 5 wherein the cation exchanger contains aminoacetic acid or iminodiacetic acid groups.
- 8. The phosphate sorbent of claim 3 wherein the cation exchanger is a strongly acid cation exchanger.
- 9. The phosphate sorbent of claim 3 wherein the cation exchanger has a high degree of cross-linking.
- 10. The phosphate sorbent of claim 8 wherein the cation exchanger contains sulphonic acid groups.
- 11. The phosphate sorbent of claim 3 wherein the cation exchanger has a matrix comprising a polymer or a polycondensation product of an aromatic compound, an acryl, a methacryl or a vinyl compound.
- 12. The phosphate sorbent of claim 3 wherein the cation exchanger has a macroporous matrix.
- 13. The phosphate sorbent of claim 3 wherein the cation exchanger contains alkali metal ions.
- 14. The phosphate sorbent of claim 13 wherein the alkali metal ions are sodium ions.
- 15. The phosphate sorbent of claim 13 wherein the cation exchanger contains calcium or magnesium ions and the alkali metal ions.
- 16. The phosphate sorbent of claim 3 wherein the pharmaceutically acceptable carrier is a capsule having a cationic semipermeable wall.
Priority Claims (1)
Number |
Date |
Country |
Kind |
7703937 |
Apr 1977 |
NLX |
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Parent Case Info
This is a continuation of application Ser. No. 70,630 filed Aug. 29, 1979, now abandoned, which in turn is a division of application Ser. No. 895,057, filed Apr. 10, 1978, now U.S. Pat. No. 4,213,859.
US Referenced Citations (4)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2070032 |
Sep 1981 |
GBX |
Divisions (1)
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Number |
Date |
Country |
Parent |
895057 |
Apr 1978 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
70630 |
Aug 1979 |
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