Claims
- 1. A multi-chambered dialysis machine, comprising:
a. a fluid input; b. a fluid output in fluid communication with the fluid input; c. a blood separation chamber in fluid communication with the input and output; and d. a blood processing chamber in fluid communication with the input, the output, and the blood separation chamber.
- 2. The multi-chambered dialysis machine of claim 1, wherein the blood separation chamber is adapted to at least one of (i) separate plasma from blood cells or (ii) remove an unwanted blood component.
- 3. The multi-chambered dialysis machine of claim 2, wherein the blood separation chamber is adapted to perform at least one of (i) plasmaphaeresis or (ii) aphaeresis.
- 4. The multi-chambered dialysis machine of claim 3, wherein the blood processing chamber further comprises:
a. a first hollow fiber module adapted to provide plasma differential precipitation; b. an acidifier in fluid communication with the first hollow fiber module; c. a heparinizer in fluid communication with the acidifier; d. a second hollow fiber module in fluid communication with the heparinizer; and e. an adsorption column in fluid communication with the second hollow fiber module.
- 5. The multi-chambered dialysis machine of claim 2, where the blood processing chamber is adapted to process blood plasma to remove an unwanted substance by at least one of (i) secondary precipitation and filtration or (ii) selective precipitation and filtration.
- 6. The multi-chambered dialysis machine of claim 5, wherein the unwanted substance comprises at least one of (i) an intrinsic particle, (ii) LDL, (iii) CRP, (iv) fibrinogen, or (v) a material added to perfused blood.
- 7. The multi-chambered dialysis machine of claim 6 wherein the material added to perfused blood comprises at least one of (i) HDL, (ii) a gene, (iii) a drug, or (iv) a chelating agent.
- 8. The multi-chambered dialysis machine of claim 1, wherein the blood processing chamber further comprises:
a. a precipitator; and b. a filter.
- 9. The multi-chambered dialysis machine of claim 1, wherein the blood processing chamber further comprises at least one of (i) an oxygenator, (ii) an enricher, (iii) a heater, or (iv) a pump.
- 10. The multi-chambered dialysis machine of claim 9, where the oxygenator comprises at least one of (i) a gas exchanger adapted to oxygenate withdrawn deoxygenated venous blood to a predetermined level of oxygenation or (ii) a heater adapted to increase blood temperature.
- 11. The multi-chambered dialysis machine of claim 9, wherein the enricher is adapted to at least one of (i) receive oxygenated blood or (ii) provide an additional component to the blood.
- 12. The multi-chambered dialysis machine of claim 11, wherein the additional component comprises at least one of (i) a drug or (ii) a substance needed to stabilize an atherosclerotic plaque.
- 13. The multi-chambered dialysis machine of claim 12, wherein the substance comprises at least one of (i) HDL, (ii) apoprotein (apoA-1), (iii) a statin, (iv) a chelating agent, (v) a gene, or (vi) hyperbaric oxygen.
- 14. The multi-chambered dialysis machine of claim 9, wherein the pump is adapted to receive processed blood and pump the received processed blood back into the coronary arterial system of the patient.
- 15. The multi-chambered dialysis machine of claim 14, wherein the pump is adapted to pump blood at a predetermined volume, perfusion pressure (flow), and appropriate temperature.
- 16. The multi-chambered dialysis machine of claim 9, wherein the heater is adapted to warm blood to between around 35° C. to around 45° C.
- 17. The multi-chambered dialysis machine of claim 9, wherein the enricher is adapted to provide to the passing blood at least one of (i) a predetermined dose of a drug or (ii) a therapeutic agent.
- 18. The multi-chambered dialysis machine of claim 9, wherein each of the oxygenator, the enricher, the heater, and the pump comprise a chamber separate from each other chamber.
- 19. The multi-chambered dialysis machine of claim 18, wherein each chamber is arranged in a predetermined serial fluid communication path with respect to each other chamber, the input, and the output.
- 20. The multi-chambered dialysis machine of claim 19, wherein the predetermined serial fluid communication path is adapted to first remove unwanted materials from blood, then to oxygenate the blood, then to warm the blood, then to enrich the blood with nutrients or drugs, and then to pump the blood back to the coronary system.
RELATION TO PRIOR APPLICATIONS
[0001] The present invention claims priority through U.S. Provisional Application No. 60/389,965, filed Jun. 19, 2002.
Provisional Applications (1)
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Number |
Date |
Country |
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60389965 |
Jun 2002 |
US |