Diamond Rotors

Information

  • Research Project
  • 10299171
  • ApplicationId
    10299171
  • Core Project Number
    R01GM139055
  • Full Project Number
    1R01GM139055-01A1
  • Serial Number
    139055
  • FOA Number
    PAR-19-253
  • Sub Project Id
  • Project Start Date
    9/10/2021 - 4 years ago
  • Project End Date
    8/31/2025 - a month ago
  • Program Officer Name
    LIU, CHRISTINA
  • Budget Start Date
    9/10/2021 - 4 years ago
  • Budget End Date
    8/31/2022 - 3 years ago
  • Fiscal Year
    2021
  • Support Year
    01
  • Suffix
    A1
  • Award Notice Date
    9/2/2021 - 4 years ago

Diamond Rotors

Project Summary The research in this proposal focuses on the development of methods for fabricating magic-angle spinning (MAS) rotors from single crystal diamond logs for applications (1) in ambient temperature MAS experiments, and (2) dynamic nuclear polarization (DNP) MAS experiments. In particular, there is an ever- increasing push towards rotors that attain higher spinning frequencies for MAS NMR in order to improve sensitivity and resolution. However, the spinning frequencies currently obtainable (~100 kHz) are limited by the strength of the material from which the rotors are fabricated ? typically ZrO2 with flexural strength of ~800 MPa. Above ~120 kHz the ZrO2 rotors explode. Diamond is one of the strongest materials on earth with flexural strengths of 2-5 GPa for single crystal samples and therefore an ideal material to manufacture MAS rotors. Furthermore, diamond is transparent to terahertz radiation, so it is ideal for DNP experiments. Finally, it has excellent thermal properties ? it thermal conductivity is 10x better than Cu. Thus, it is easy to compensate for the aerodynamic heating associated with MAS. Machining diamond cylinders to high tolerance required for rotors requires a novel laser machining processes which we have begun to develop to produce small (?1.3 mm OD) diamond rotors. Here we propose to refine our processes and test them in our available instrumentation. The goal is to produce 1.3 mm, 0.7 mm and a new generation of 0.5 mm rotors that will attain ?r/2?>300 kHz and improve the resolution of MAS spectra by a factor of ~5 over what is currently available. In addition, we anticipate that diamond rotors will lead to larger DNP enhancements. We also describe some applications to amyloid fibrils and membrane proteins where we anticipate that diamond rotors will have a significant scientific impact.

IC Name
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
  • Activity
    R01
  • Administering IC
    GM
  • Application Type
    1
  • Direct Cost Amount
    326303
  • Indirect Cost Amount
    93483
  • Total Cost
    419786
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    859
  • Ed Inst. Type
    OTHER SPECIALIZED SCHOOLS
  • Funding ICs
    NIGMS:419786\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    ISD
  • Study Section Name
    Instrumentation and Systems Development Study Section
  • Organization Name
    MASSACHUSETTS INSTITUTE OF TECHNOLOGY
  • Organization Department
    MISCELLANEOUS
  • Organization DUNS
    001425594
  • Organization City
    CAMBRIDGE
  • Organization State
    MA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    021421029
  • Organization District
    UNITED STATES