Claims
- 1. A compound of the formula ##STR12## wherein: Y is an alkylene bridge of 3 to 9 carbon atoms optionally interrupted by one or two oxygen atoms, by cyclohexyl, or by an olefinic linkage;
- R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen, lower-alkyl, lower-alkenyl, halogen, nitro, lower-alkoxy, lower-alkylthio, difluoromethyl, trifluoromethyl, amino, lower-alkanoylamino, di-lower-alkylamino, hydroxy, lower-alkenoyl, lower-alkanoyl, hydroxymethyl and carboxy;
- R, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are each hydrogen or alkyl or hydroxyalkyl of 1-3 carbon atoms; and
- R.sub.8 is hydrogen or lower-alkanoyl;
- or a pharmaceutically acceptable acid-addition salt thereof.
- 2. A compound according to claim 1 wherein Y is an alkylene bridge of 3 to 9 carbon atoms; R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen, halogen and lower-alkyl; R, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen; and the dihydrooxazolyl group is in the p-position of the phenyl ring with respect to the furan-substituted side-chain.
- 3. 2-{4-[6-(2-Furanyl)hexyloxy]phenyl]-4,5-dihydrooxazole, according to claim 2.
- 4. 2-{4-[7-(2-Furanyl(heptyloxy]phenyl}-4,5-dihydrooxazole, according to claim 2.
- 5. 2-{4-[5-(5-Acetyl-2:furanyl)pentyloxy]phenyl}-4,5-dihydrooxazole, according to claim 2.
- 6. 2-{4-[5-(5-Acetyl-2-furanylpentyloxy]-2-bromophenyl}-4,5-dihydrooxazole, according to claim 2.
- 7. 2-{3,5-Dichloro-4-[5-(2-furanyl)pentyloxy]phenyl}-4,5-dihydrooxazole, according to claim 2.
- 8. 2-{3,5-Dichloro-4-[5-(5-acetyl-2-furanyl)pentyloxy]phenyl}-4,5-dihydrooxazole, according to claim 2.
- 9. A composition for combatting picornaviruses which comprises an antivirally effective amount of a compound according to claim 1 in admixture with a suitable carrier or diluent.
- 10. A method for combatting picornaviruses which comprises contacting the locus of said viruses with a composition according to claim 9.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 751,348, filed July 2, 1985, now abandoned, in turn a continuation-in-part of application Ser. No. 624,301, filed June 25, 1984, now abandoned, in turn a continuation-in-part of application Ser. No. 527,583, filed Aug. 29, 1983, now abandoned.
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Number |
Name |
Date |
Kind |
3945998 |
Anderson |
Mar 1976 |
|
4268678 |
Diana et al. |
May 1981 |
|
4615725 |
Weissmuller |
Oct 1986 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
2043188 |
Mar 1972 |
DEX |
46-21866 |
Jun 1971 |
JPX |
757999 |
Sep 1956 |
GBX |
Non-Patent Literature Citations (2)
Entry |
Henry et al., (1973) J. Med. Chem., 16(11), pp. 1287-1291. |
R. J. Ash et al., Antimicrobial Agents and Chemotherapy 16, 301-305 (1979). |
Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
751348 |
Jul 1985 |
|
Parent |
624302 |
Jun 1984 |
|
Parent |
527583 |
Aug 1983 |
|