Claims
- 1. A compound having the structure: ##STR7## wherein (a) n is 2 or 3;
- (b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;
- (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;
- (d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen;
- (e) W is O or S; and
- (f) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.
- 2. The compound of claim 1 wherein X is oxygen or sulphur and W is oxygen.
- 3. The compound of claim 2 wherein each Y is independently selected from the group consisting of hydrogen, methyl and ethyl; and Z is selected from the group consisting of hydrogen, C.sub.4 -C.sub.6 branched alkanyl having 2 branches, C.sub.3 -C.sub.6 cycloalkanyl, and phenyl.
- 4. The compound of claim 3 wherein X is oxygen, both Y are methyl, and Z is t-butyl.
- 5. The compound of claim 3 wherein Het is selected from the group consisting of 2 or 3-furyl, 2 or 3-thienyl, 2 or 3-pyrrolyl either unsubstituted or alkyl substituted on nitrogen, 2, 4, or 5 thiazolyl, 2 or 5-oxazolyl, 2, 4, or 5-imidazolyl either unsubstituted or alkyl-substituted on nitrogen, 3, 4, or 5-isoxazolyl, 3, 4, or 5-isothiazolyl, 3, 4, or 5-pyrazolyl unsubstituted or alkyl-substituted on nitrogen, 2 or 5-oxadiazolyl, 2 or 5-thiadiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidinyl, pyrazinyl, indolyl, quinolyl, isoquinolyl, imidazothiazolinyl, imidazopyridinyl, or imidazoimidazolinyl.
- 6. The compound of claim 5 wherein X is oxygen, and Het is selected from the group consisting of 2-furyl; 5-methyl-2-furyl; 3-furyl; 2-thienyl; 5-nitro-2-thienyl; 3-thienyl; N-methyl-2-pyrrolyl; 2-thiazolyl; or 2-pyridyl.
- 7. The compound of claim 6 wherein both Y are methyl, and Z is t-butyl.
- 8. A composition comprising a compound of claim 1 and a pharmaceutically-acceptable carrier.
- 9. A method of treating inflammation or pain comprising administration, to a human or lower animal in need of such treatment, of a safe and effective amount of a compound of claim 1.
- 10. A method of treating arthritis comprising daily peroral administration, to a human in need of such treatment, of from about 1 mg/kg to about 20 mg/kg of a compound of claim 1.
- 11. A composition comprising a compound of claim 7 and a pharmaceutically-acceptable carrier.
- 12. A method of treating inflammation or pain comprising administration, to a human or lower animal in need of such treatment, of a safe and effective amount of a compound of claim 7.
- 13. A method of treating arthritis comprising daily peroral administration, to a human in need of such treatment, of from about 1 mg/kg to about 20 mg/kg of a compound of claim 7.
Parent Case Info
This is a divisional of U.S. Ser. No. 08/595,113, filed Feb. 1, 1996 now U.S. Pat. No. 5,750,543.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4670457 |
Doria et al. |
Jun 1987 |
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4849428 |
Dobson et al. |
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5262430 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
595113 |
Feb 1996 |
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