Claims
- 1. A compound having the structure: ##STR6## wherein (a) X is selected from the group consisting of O, S, SO and S.sub.2 O;
- (b) each Y is independently selected from hydrogen and methyl;
- (c) Z is t-butyl;
- (d) W is O; and
- (e) R is C.sub.1 -C.sub.7 straight or single-branched alkyl or aryl, saturated or unsaturated with one double bond between non-terminal carbon atoms, or C.sub.3 -C.sub.6 cycloalkanyl or aryl; unsubstituted or monosubstituted with a substituent selected from the group consisting of halo, hydroxy, thiol, phenyl, heteroaryl and heterocycle; R having from 1 to about 7 atoms other than hydrogen.
- 2. The compound of claim 1 wherein R is selected from the group consisting of methyl, ethyl, n-propyl, n-butyl, i-propyl, cyclopropyl, cyclopentyl, 3-cyclopropylpropyl, 2-chloro-2-methylpropyl, 2-hydroxy-2-methylpropyl, 2-methyl-d-propenyl, 3-tetrahydrofuryl.
- 3. The compound of claim 2 wherein X is oxygen.
- 4. The compound of claim 3 wherein R is selected from the group consisting of methyl, ethyl, n-propyl, n-butyl, i-propyl, cyclopropyl, cyclopentyl, 3-cyclopropylpropyl, 2-chloro-2-methylpropyl, 2-hydroxy-2-methylpropyl, 2-methyl-2-propenyl, and 2-methyl-1 -propenyl.
- 5. The compound of claim 4 wherein both Y are hydrogen and R is selected from the group consisting of 2-hydroxy-2-methylpropyl, 2-methyl-d-propenyl, and 2-chloro-2-methyl-propyl.
- 6. The compound of claim 4 wherein both Y are methyl and R is selected from the group consisting of n-butyl, 3-cyclopropylpropyl, and 2-hydroxy-2-methylpropyl.
- 7. The compound of claim 2 wherein X is sulphur.
- 8. The compound of claim 7 wherein R is selected from the group consisiting of butyl and 3-tetrahydrofuryl.
- 9. The compound of claim 8 wherein both Y are methyl and R is 3-tetrahydrofuryl or butyl.
- 10. A composition comprising a compound of claim 1 and a pharmaceutically-acceptable carrier.
- 11. A method of treating inflammation or pain comprising administation, to a human or lower animal in need of such treatment, of a safe and effective amount of a compound of claim 1.
- 12. A method of treating arthritis comprising daily peroral administration, to a human in need of such treatment, of from about 1 mg/kg to about 20 mg/kg of a compound of claim 1.
- 13. A composition comprising a compound of claim 4 and a pharmaceutically-acceptable carrier.
- 14. A method of treating inflammation or pain comprising administation, to a human or lower animal in need of such treatment, of a safe and effective amount of a compound of claim 4.
- 15. A method of treating arthritis comprising daily peroral administration, to a human in need of such treatment, of from about 1 mg/kg to about 20 mg/kg of a compound of claim 4.
- 16. A composition comprising a compound of claim 8 and a pharmaceutically-acceptable carrier.
- 17. A method of treating inflammation or pain comprising administation, to a human or lower animal in need of such treatment, of a safe and effective amount of a compoundof claim 8.
- 18. A method of treating arthritis comprising daily peroral administration, to a human in need of such treatment, of from about 1 mg/kg to about 20 mg/kg of a compound of claim 8.
Parent Case Info
Provisional Application No. 60/019,414 filed Jun. 7, 1996, this application is a 371 of PCT/US97/09945 filed Jun. 6, 1997.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US97/09945 |
6/6/1997 |
|
|
12/7/1998 |
12/7/1998 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/46548 |
12/11/1997 |
|
|
US Referenced Citations (9)
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO 9746548 |
Dec 1997 |
WOX |