Claims
- 1. A compound of the formula wherein said compound is:quinoxaline-2-carboxylic acid 4(R)-carbamoyl-1(S)-(3-chloro-benzyl)-2(S),7-dihydroxy-7-methyl-octyl]-amide; 7,8-difluoro-quinoline-3-carboxylic acid (1S)-benzyl-4(R)-carbamoyl-2(S),7-dihydroxy-7-methyl-otyl)-amide; 6,7,8-trifluoro-quinoline-3-carboxylic acid (1(S)-benzyl-4(R)-carbamoyl-2(S),7-dihydroxy-7-methyl-octyl)-amide; quinoxaline-2-carboxylic acid [4(R)-carbamoyl-1(S)-(3-fluoro-benzyl)-2(S),7-dihydroxy-7-methyl-octyl]-amide; quinoxaline-2-carboxylic acid (1(S)-benzyl-2(S),7-dihydroxy-4(R)-hydroxycarbamoyl-7-methyl-octyl)-amide; quinoxaline-2-carboxylic acid [4(R)-carbamoyl-1(S)-(2-chloro-benzyl)-2(S),7-dihydroxy-7-methyl-octyl]-amide; quinoxaline-2-carboxylic acid [1(S)-(2-fluoro-benzyl)-2(S),7-dihydroxy-4(R)-hydroxycarbamoyl-7-methyl-octyl]-amide; quinoxaline-2-carboxylic acid [4(R)carbamoyl-1(S)-(2-fluoro-benzyl)-2(S),7-dihydroxy-7-methyl-octyl]-amide; quinoxaline-2-carboxylic acid [1(S)-(3,4-difluoro-benzyl)-2(S),7dihydroxy-4(R)-hydroxycarbamoyl-7-methyl-octyl]-amide; quinoxaline-2-carboxylic acid [4(R)-carbamoyl-1(S)-(3,4-difluoro-benzyl)-2(S),7-dihydroxy-7-methyl-octyl]-amide; or quinoxaline-2-carboxylic acid (4(R)-carbamoyl-2(S),7-dihydroxy-7-methyl-1(S)-naphthalen-1-ylmethyl-octyl)-amide.
- 2. A pharmaceutical composition for treating a disorder or condition selected from multiple sclerosis or rheumatoid arthritis in a mammal, comprising an amount of a compound according to claim 1 that is effective in treating such disorder or condition and a pharmaceutically acceptable carrier.
- 3. A method for treating a disorder or condition selected from multiple sclerosis or rheumatoid arthritis in a mammal, comprising administering to a mammal in need of such treatment an amount of a compound according to claim 1, or a pharmaceutically acceptable salt thereof, that is effective in treating or preventing such disorder or condition.
Parent Case Info
This application claims priority from provisional application No. 60/073,801, filed Feb. 5, 1998.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/IB99/00067 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO99/40061 |
8/12/1999 |
WO |
A |
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4923864 |
Rosati |
May 1990 |
A |
Foreign Referenced Citations (1)
Number |
Date |
Country |
0708085 |
Apr 1996 |
EP |
Non-Patent Literature Citations (2)
Entry |
Ng, Howard, P. et al, J. Med. Chem., 42, 1999, 4680-4694.* |
U.S. patent application Ser. No. 09/380,269, filed May 18, 2000. |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/073801 |
Feb 1998 |
US |