Claims
- 1. A compound of the formula: ##STR21## wherein R.sup.1 and R.sup.2 are each independently an aryl group optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, nitro, cyano, di(C.sub.1 -C.sub.4)alkylamino, amino, benzyloxy, hydroxyl, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 alkanoylamino, C.sub.1 -C.sub.4 alkylamino and N-(C.sub.1 -C.sub.4)alkyl-N-(C.sub.1 -C.sub.4)alkanoylamino; Z.sup.1 is a group of the formula: ##STR22## wherein R.sup.3 and R.sup.4 are each independently a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or an ar(C.sub.1 -C.sub.4)alkyl group or, when taken together with the adjacent nitrogen atom to which they are attached, represent a nitrogen-containing 5 to 7-membered saturated heterocyclic group optionally having an oxygen atom or an additional nitrogen atom as the hetero atom in addition to the said nitrogen atom and, in case of having the additional nitrogen atom, bearing a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, an ar(C.sub.1 -C.sub.4)alkyl group or a phenyl group thereon; A.sup.1 is a C.sub.3 -C.sub.6 alkylene group; and A.sup.2 is a C.sub.2 -C.sub.4 alkylene group, and non-toxic, pharmaceutically acceptable acid addition salts thereof.
- 2. The compound according to claim 1, wherein A.sup.1 is a trimethylene group or a tetramethylene group.
- 3. The compound according to claim 1, wherein R.sup.1 is a phenyl group optionally substituted with 1 or 2 substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, di(C.sub.1 -C.sub.4)alkylamino, benzyloxy, hydroxyl, C.sub.1 -C.sub.4 alkylthio, R.sup.2 is a phenyl group optionally substituted with C.sub.1 -C.sub.4 alkyl and A.sup.1 is a C.sub.3 -C.sub.6 alkylene group.
- 4. The compound according to claim 1, wherein R.sup.1 is a phenyl group or a halogenophenyl group, R.sup.2 is a phenyl group and A.sup.1 is a trimethylene group or a tetramethylene group.
- 5. The compound according to claim 1, wherein R.sup.1 is a phenyl group or a halogenophenyl group, R.sup.2 is a phenyl group, Z.sup.1 is a piperidino group and A.sup.1 is a trimethylene group or a tetramethylene group.
- 6. O-[3-(N,N-Dimethylamino)propyl]-1,4-diphenyl-1-butanone oxime, and non-toxic, pharmaceutically acceptable acid addition salts thereof.
- 7. O-[2-(N,N-Dimethylamino)ethyl]-1,4-diphenyl-1-butanone oxime, and non-toxic, pharmaceutically acceptable acid addition salts thereof.
- 8. O-[3-(N,N-Dimethylamino)propyl]-1,5-diphenyl-1-pentanone oxime, and non-toxic, pharmaceutically acceptable acid addition salts thereof.
- 9. O-(3-Piperidinopropyl)-1,4-diphenyl-1-butanone oxime, and non-toxic, pharmaceutically acceptable acid addition salts thereof.
- 10. O-(3-Piperidinopropyl)-1-(p-fluorophenyl)-4-phenyl-1-butanone oxime, and non-toxic, pharmaceutically acceptable acid addition salts thereof.
- 11. A pharmaceutical composition comprising a pharmaceutically effective amount of at least one of the compounds as claimed in claim 1 and a pharmaceutically acceptable diluent or carrier.
- 12. A method for causing vasolidation which comprises, administering to a subject an effective cerebral vasodilating amount of the compound of claim 1.
- 13. A method for improving brain functions which comprises administering to a subject an effective brain function improving amount of the compound of claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
54-40032 |
Apr 1979 |
JPX |
|
54-103340 |
Aug 1979 |
JPX |
|
Parent Case Info
This application is a divisional of copending application Ser. No. 308,655 filed on Oct. 5, 1981, now U.S. Pat. No. 4,459,410, which is a continuation-in-part of application Ser. No. 136,565 filed on Apr. 2, 1980, now U.S. Pat. No. 4,388,469.
US Referenced Citations (3)
Foreign Referenced Citations (2)
Number |
Date |
Country |
196386 |
Mar 1958 |
ATX |
505848 |
Sep 1954 |
CAX |
Divisions (1)
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Number |
Date |
Country |
Parent |
308655 |
Oct 1981 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
136565 |
Apr 1980 |
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