Claims
- 1. A compound of the formula: ##STR21## wherein R.sup.1 is an unsubstituted phenyl, thienyl or furyl group or a phenyl group substituted with 1 to 3 substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl and hydroxyl, R.sup.2 is a phenyl group, Z.sup.1 is a group of the formula: ##STR22## wherein R.sup.3 and R.sup.4 are taken together with the adjacent nitrogen atom to which they are attached to form a pyrrolidino, piperidino, homopiperidino, morpholino, piperazino, N-(C.sub.1 -C.sub.4) alkylpiperazino, N-phenyl (C.sub.1 14 C.sub.4) alkylpiperazino or N-phenylpiperazino group, ##STR23## is a group of the formula ##STR24## A.sup.1 is a C.sub.3 -C.sub.4 alkylene group, and A.sup.2 is a C.sub.2 -C.sub.4 alkylene group or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 2. The compound according to claim 1, wherein R.sup.1 is a phenyl group or a halophenyl group.
- 3. The compound according to claim 1, wherein R.sup.1 is a phenyl group or a halophenyl group and --NR.sup.3 R.sup.4 is a piperidino group.
- 4. 1-(3-Piperidinopropoxy)-1,5-diphenylpentane, or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
- 5. 1-(3-Piperidinopropoxy)-1-(p-fluorophenyl)-5-phenylpentane, or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
- 6. 1-(3-Piperidinopropoxy)-1,4-diphenylbutane, or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
- 7. 1-(3-Piperidinopropoxy)-1-(p-fluorophenyl)-4-phenylbutane, or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
Priority Claims (2)
Number |
Date |
Country |
Kind |
54-40032 |
Apr 1979 |
JPX |
|
54-103340 |
Aug 1979 |
JPX |
|
Parent Case Info
This is a continuation-in-part application of our copending application Ser. No. 136,565 filed on April 2, 1980, now U.S. Pat. No. 4,388,469, issued June 14, 1983.
US Referenced Citations (5)
Foreign Referenced Citations (2)
Number |
Date |
Country |
196386 |
Mar 1958 |
ATX |
505848 |
Sep 1954 |
CAX |
Non-Patent Literature Citations (5)
Entry |
J. Pharmacol. Exptl. Therap., vol. 112, pp. 318-325 (1954). |
J. Pharm. Sci., vol. 54, pp. 1373-1376 (1965). |
Farmaco (Pavia), Ed. Sci., vol. 19, pp. 688-702 (1964). |
Sperber, Nathan et al., J. Am. Chem. Soc., vol. 71, pp. 887-890 (1949). |
Conant, James Bryant, "The Chemistry of Organic Compounds", MacMillan Co. Publ., p. 264 (1947). |
Continuations (1)
|
Number |
Date |
Country |
Parent |
136565 |
Apr 1980 |
|