Microwave ablation (MWA) is a form of thermal ablation used in interventional radiology to treat cancer. MWA is known for its quicker patient recovery and fewer complications and can serve as an alternative when surgical resection cannot be applied. MWA uses electromagnetic waves in the microwave energy spectrum (300 megahertz to 300 gigahertz) to produce tissue-heating effects, i.e., to heat tumors to cytotoxic temperatures. MWA is generally used for minimally invasive treatment and/or palliation of solid tumors in patients. MWA offers several advantages over other ablation technologies such as radiofrequency (RF) and cryoablation including higher temperatures than RF, larger ablation zone volumes, shorter ablation times, and better ablation performance near arteries, which act as heat sinks. Selective delivery of energy to the prescribed tissue volume (i.e. the tumor and its margins) is achieved by means of interstitial placement of a microwave antenna directly into the tumor. Current MWA technology may be employed either laparoscopically or percutaneously, and thus, is considered to be minimally invasive. However, the extent to which MWA is minimally invasive depends on a length and a diameter of the interstitial microwave antenna. In general, a MWA antenna is expected to have a small overall diameter, a low reflection coefficient, and localized specific absorption rate (SAR) and heating patterns.
Most MWA antennas employ coaxial cables as their feed lines. Coaxial cable, however, is an unbalanced structure and current can flow on the outer surface of its outer conductor if the cable is not properly terminated. If not properly suppressed, this current can lead to unwanted heating of the healthy tissue along the insertion path of the antenna along the coaxial cable. This current can also cause the reflection coefficient of the antenna to be dependent on the insertion depth into the tissue.
Coaxial baluns have been the most ubiquitous solution for overcoming problems associated with the unbalanced currents flowing on the outer surface of the outer conductor of the coaxial cables. A coaxial balun is generally implemented by encompassing the outer conductor of the coaxial cable with another conducting cylinder. The inner surface of this extra cylinder and the outer surface of the outer conductor of the coaxial cable form a transmission line. The length of the balun and its termination are chosen such that a very large impedance is seen at the tip of the balun by the unbalanced currents. This high impedance prevents flow of unbalanced currents beyond the tip of the balun and greatly reduces the level of unwanted heating along the shaft of the antenna. While coaxial baluns help the antenna in providing a fairly localized SAR pattern, they increase the overall diameter and, as a result, the invasiveness of the MWA antenna.
A sector of the outer conductor of the coaxial cable along with its inner conductor may be extended beyond the feed point. These two extended conductors act as two arms of a dipole antenna, where each arm of the dipole may be a quarter of a wavelength long. Since currents flowing on the arms of this dipole antenna oppose each other, a very low feed point impedance is achieved. This very low feed point impedance almost shorts the current at the feed point and prevents its flow on the outer surface of the outer conductor. However, while unwanted current is effectively suppressed, the impedance match is poor requiring an impedance matching structure.
In an example embodiment, an antenna is provided that includes, but is not limited to, a first dipole arm and a second dipole arm. The first dipole arm is connected to a first conductor and is formed of a first conducting material. The first dipole arm extends in an axial direction from the first conductor. The second dipole arm is connected to a second conductor that is distinct from the first conductor and is formed of a second conducting material. The second dipole arm extends in the axial direction from the second conductor and is wound around the first dipole arm to form a number of loops. The second dipole arm does not contact the first dipole arm. An axial length of the second dipole arm in the axial direction is less than 90% of an axial length of the first dipole arm in the axial direction
In another example embodiment, an antenna system is provided that includes, but is not limited to, a coaxial cable and an antenna. The coaxial cable includes, but is not limited to, a center conductor extending a length of the coaxial cable, a dielectric material surrounding the center conductor along the length of the coaxial cable, and a conductive shield surrounding the dielectric material along the length of the coaxial cable. The antenna includes a first dipole arm and a second dipole arm. The first dipole arm is connected to the center conductor and is formed of a first conducting material. The first dipole arm extends in an axial direction from the center conductor. The second dipole arm is connected to the conductive shield that is distinct from the center conductor and is formed of a second conducting material. The second dipole arm extends in the axial direction from the conductive shield and is wound around the first dipole arm to form a number of loops. The second dipole arm does not contact the first dipole arm. An axial length of the second dipole arm in the axial direction is less than 90% of an axial length of the first dipole arm in the axial direction.
In yet another example embodiment, a microwave ablation system is provided that includes, but is not limited to, a coaxial cable, an antenna, a signal generator, and a connector. The coaxial cable includes, but is not limited to, a center conductor extending a length of the coaxial cable, a dielectric material surrounding the center conductor along the length of the coaxial cable, and a conductive shield surrounding the dielectric material along the length of the coaxial cable. The antenna includes a first dipole arm and a second dipole arm. The first dipole arm is connected to the center conductor and is formed of a first conducting material. The first dipole arm extends in an axial direction from the center conductor. The second dipole arm is connected to the conductive shield that is distinct from the center conductor and is formed of a second conducting material. The second dipole arm extends in the axial direction from the conductive shield and is wound around the first dipole arm to form a number of loops. The second dipole arm does not contact the first dipole arm. An axial length of the second dipole arm in the axial direction is less than 90% of an axial length of the first dipole arm in the axial direction.
Other principal features of the disclosed subject matter will become apparent to those skilled in the art upon review of the following drawings, the detailed description, and the appended claims.
Illustrative embodiments of the disclosed subject matter will hereafter be described referring to the accompanying drawings, wherein like numerals denote like elements.
With reference to
With reference to
Coaxial cable 102 may include a center conductor 200 extending a length of coaxial cable 102, a dielectric material 202 surrounding center conductor 200 along the length of coaxial cable 102, a conductive shield 204 surrounding dielectric material 202 along the length of coaxial cable 102, and an insulating jacket 206 surrounding conductive shield 204 along the length of coaxial cable 102. Insulating jacket 206 may be a catheter in which first antenna 100a and all or a portion of coaxial cable 102 are inserted. Center conductor 200 is generally circular and may be formed of a solid conductive material such as copper plated steel wire, silver plated steel wire, silver plated copper wire, silver plated copper clad steel wire, copper wire, copper clad aluminum wire, steel wire, etc. Coaxial cable 102 may have a variety of diameters. Dielectric material 202 may include foamed polyethylene, solid polyethylene, polyethylene foam, polytetrafluoroethylene, air, air space polyethylene, vacuum, etc. Conductive shield 204 may be formed of a solid or braided conductive material such as copper, steel, aluminum, silver plated copper, silver plated copper clad steel, etc. Insulating jacket 206 can be made from many different insulating materials such as polyvinyl chloride or another plastic material. One or more of the materials may be biocompatible and suitable for insertion into living tissue.
Coaxial cable 102 may be formed of one or more rigid, semi-rigid, or flexible sections. The characteristic impedance may be off the shelf and range between approximately 20 and approximately 300 ohms or be designed to have a selected characteristic impedance within, above, or below this range as understood by a person of skill in the art using various dielectric and conductive materials, diameters, and thicknesses.
A center conductor width 224 defines a cross-section width of center conductor 200. When center conductor 200 has a circular cross-section, center conductor width 224 is a diameter of center conductor 200. For illustration, center conductor width 224 is approximately 0.51 millimeters (mm). A dielectric material width 226 defines a cross-section width of dielectric material 202 that surrounds center conductor 200. For illustration, dielectric material width 226 is approximately 0.58 mm. A conductive shield width 228 defines a cross-section width of conductive shield 204 that surrounds dielectric material 202. For illustration, conductive shield width 228 is approximately 0.36 mm. An insulating jacket width 230 defines a cross-section width of insulating jacket 206 that surrounds conductive shield 204. For illustration, insulating jacket width 230 is approximately 0.21 mm such that coaxial cable 102 has an outer diameter of approximately 2.8 mm. These dimensions yield the same impedance as that of commercially available semi-rigid coaxial cables (e.g. UT-085C) though other types of coaxial cable may be used in alternative embodiments.
First antenna 100a may form a dipole antenna that includes a first dipole arm 208 and a second dipole arm 212. In the illustrative embodiment of
In the illustrative embodiment of
A first antenna dielectric material 210 may surround first dipole arm 208 along a length of first dipole arm 208 and around second end 211 of first dipole arm 208. First antenna dielectric material 210 may be the same material as and/or may be an extension of dielectric material 202.
A second antenna dielectric material 214 may surround first antenna dielectric material 210. A third antenna dielectric material 216 may surround second antenna dielectric material 214. Third antenna dielectric material 216 may be the same material as and/or may be an extension of insulating jacket 206. Third antenna dielectric material 216 may form a catheter body. For example, insulating jacket 206 and third antenna dielectric material 216 may be a catheter in which first antenna 100a and all or a portion of coaxial cable 102 are inserted. First antenna dielectric material 210, second antenna dielectric material 214, and third antenna dielectric material 216 may be selected from foamed polyethylene, solid polyethylene, polyethylene foam, polytetrafluoroethylene, air, air space polyethylene, vacuum, alumina, etc. For illustration, the dielectric materials may include any low loss dielectric materials having a permittivity relative to a vacuum within the range of 1 to 30. For illustration, first antenna dielectric material 210 and third antenna dielectric material 216 are polytetrafluoroethylene, and second antenna dielectric material 214 is air. One or more of first antenna dielectric material 210, second antenna dielectric material 214, and third antenna dielectric material 216 may be formed of the same dielectric material to form a continuous layer of material that surrounds first dipole arm 208 and/or second dipole arm 212.
In the illustrative embodiment of
In the illustrative embodiment of
As understood by a person of skill in the art, the wavelength of operation, λo, of first antenna 100a is defined as λo=c/fo, where c is the effective speed of light in the effective medium formed between first antenna dielectric material 210, second antenna dielectric material 214, insulating jacket 206, and an environment in which antenna 100 is used, such as a body tissue, and fo is a selected operating frequency of a signal carried by center conductor 200 of coaxial cable 102. For illustration, fo, may be between 300 MHz and 300 GHz though 500 MHz and 30 GHz may be preferred. The wavelength of operation, λo, is a wavelength at the selected operating frequency in a medium in which first antenna 100a is selected to operate. For example, the medium also includes first antenna dielectric material 210, second antenna dielectric material 214, and third antenna dielectric material 216 as well as the body tissue into which antenna 100 is inserted to perform MWA.
First dipole arm 208 has a first dipole arm length 222 measured between the feed plane defined parallel to the x-z plane indicated by x-y-z reference frame 300 and an end plane also defined parallel to the x-z plane. For illustration, first dipole arm length 222 may be a multiple of 0.25λo, such as 0.25λo, 0.5λo, 0.75λo, etc. The feed plane and the end plane are perpendicular to an axial direction that is parallel to the y-axis of x-y-z reference frame 300. Center line 242 is also parallel to the y-axis.
Second dipole arm 212 has a second dipole arm length 220 measured between the feed plane and second end 215 of second dipole arm 212 in direction that is parallel to the y-axis. First dipole arm length 222 is also measured from the feed plane in a direction that is parallel to the y-axis. Selection of second dipole arm length 220 is discussed further below.
Feed vector 218 also extends through an edge of first end 213 of second dipole arm 212 that connects to conductive shield 204. First end 209 of first dipole arm 208 is a feed end of first dipole arm 208. First end 213 of second dipole arm 212 is a feed end of second dipole arm 212. First dipole arm 208 and second dipole arm 212 are not connected to and do not contact or touch each other at any point.
A first dipole arm width 234 defines a cross-section width of first dipole arm. When first dipole arm 208 has a circular cross-section, first dipole arm width 234 is a diameter of first dipole arm 208. For illustration, first dipole arm width 234 is equal to center conductor width 224 and is approximately 0.51 millimeters (mm). A first antenna dielectric material width 236 defines a cross-section width of first antenna dielectric material 210 that surrounds first dipole arm 208. For illustration, first antenna dielectric material width 236 is equal to dielectric material width 226 and is approximately 0.58 mm. A second antenna dielectric material width 238 defines a cross-section width of second antenna dielectric material 214 that surrounds first antenna dielectric material 210. For illustration, second antenna dielectric material width 238 is equal to conductive shield width 228 and is approximately 0.36 mm. A third antenna dielectric material width 240 defines a cross-section width of third antenna dielectric material 216 that surrounds second antenna dielectric material 214. For illustration, third antenna dielectric material width 240 is equal to insulating jacket width 230 and is approximately 0.21 mm such that first antenna 100a also has an outer diameter of approximately 2.8 mm. No balun is used with first antenna 100a so that first antenna 100a is minimally invasive based on the wavelength of operation, λo, selected for use to perform MWA.
Referring to
A separation width 404 defines a radial separation distance between a center of first dipole arm 208 defined by center line 242 and a center of second dipole arm 212 defined by a second center line 410. Separation width 404 may vary as it is measured radially around first dipole arm 208 depending on a shape of the conductor of first dipole arm 208 and the conductor of second dipole arm 212 and on a shape formed by first dipole arm 208 and second dipole arm 212. Separation width 404 is measured in a plane that is parallel to the x-z plane and can be used for a complete loop or turn of second dipole arm 212 to compute a mean value.
An overall length of the conductor of second dipole arm 212 can be computed using lt=√{square root over (lh2+(πND)2)}, where lt is the overall length, lh is second dipole arm length 220, N is the number of loops or turns of second dipole arm 212, and D is a mean value of an inner diameter 406 of conductive shield 204 and an outer diameter 408 of conductive shield 204. D is also twice separation distance 404. Second dipole arm length 220 lh is selected to simultaneously have a simulated reflection coefficient, |S11|, that is less than −10 dB, and a compact specific absorption rate (SAR) pattern at the selected operating frequency fo. To achieve this, second dipole arm length 220 lh is less than first dipole arm length 222 by at least 10% of first dipole arm length 222 such that lh≤0.9*lm, where lm is first dipole arm length 222.
Second dipole arm length 220 is selected such that a good impedance match and a localized SAR pattern is achieved at the frequency of operation. Second dipole arm length 220 lh can be chosen between 0.1λo to 0.2λo, inclusive. The overall length lt is selected to be 0.25λo+m*0.5λo, where m=0, 1, 2, . . . subject to fine-tuning as understood by a person of skill of art. For illustration, the overall length Lt may be selected as 0.25λo, 0.75λo, 1.25λo, 1.75λo, etc. N can be determined using N=√{square root over (lt2−lh2)}/(πD).
Referring to
A current flowing on an outer surface of conductive shield 204 was substantially reduced for lt having odd values for integer multiples Nm. For example, a first region 500a, shown referring to
A second region 500b and a third region 500c had a normalized current density between ˜−22 decibels (dB) and ˜−24 dB for lt=λo/2 for second dipole arm 212b in the illustrative embodiment shown referring to
A fourth region 500d had a normalized current density between ˜−22 decibels (dB) and ˜−28 dB for lt=3λo/4 for second dipole arm 212c in the illustrative embodiment shown referring to
A fifth region 500e and a sixth region 500f had a normalized current density between ˜−22 decibels (dB) and ˜−24 dB for lt=λo for second dipole arm 212d in the illustrative embodiment shown referring to
To maintain a localized SAR pattern while obtaining a decent impedance (less than −10 dB) match, lt=3λo/4 is selected as an optimal value. Using lt=3λo/4, a current direction along second dipole arm 212 reverses a distance equal to λo/4 away from the feed end of second dipole arm 212 becoming aligned with the current direction along first dipole arm 208. As a result, an input impedance of first antenna 100a increases and the impedance match with coaxial cable 102 improves. Wrapping second dipole arm 212 around first dipole arm 208 also helps first antenna 100a produce symmetric SAR patterns.
Using the provided illustrative dimensions for coaxial cable 102 and first antenna 100a, and selecting the operating frequency as 1.9 gigahertz (GHz), lm=23 mm was chosen for first dipole arm length 222, and an optimized value of lh=18 mm was chosen for second dipole arm 212 or lh≤0.783*lm making second dipole arm length 220 lh 21.7% less than first dipole arm length 222. The frequency of 1.9 GHz was chosen because the power amplifier used in experiments worked in the 1.8 GHz to 2 GHz range. This frequency is close to the 2.45 GHz ISM band that is commonly used in commercial MWA systems. The results presented herein relative to first antenna 100a are expected to be applicable to other operating frequencies including 2.45 GHz. Full-wave electromagnetic (EM) simulations were performed using CST Microwave Studio to design first antenna 100a for operation in egg white. Egg white was chosen because it simplifies real-time monitoring of an ablation zone as it forms. The frequency-dependent dielectric properties of egg white were measured using an Agilent vector network analyzer (E8364A) and an Agilent dielectric probe kit (85070E). These properties were imported into CST Microwave Studio for running the full-wave EM simulations.
Second dipole arm cross-section length 400 lc=0.51 mm was selected as mentioned previously because a longer length degrades the simulated reflection coefficient, |S11|, and a shorter length decreases a power handling capability of second dipole arm 212. Therefore, lc=0.51 mm—the same value as first dipole arm width 234—provided a good compromise between the power handling capability, low simulated reflection coefficient (|S11|) and a localized SAR pattern. lt=3λo/4 was used as discussed previously resulting in N=9.9 for second dipole arm 212c computed by solving
which is also twice separation distance 404.
Referring to
Referring to
Referring to
A prototype of first antenna 100a operating at 1.9 GHz was fabricated. Laser fabrication technology was used to fabricate second dipole arm 212 out of C122 seamless round copper tube with inner and outer diameters of 1.67 mm and 2.38 mm, respectively. The fabricated second dipole arm 212 was soldered to a UT-085C semi-rigid coaxial cable that was used to feed first antenna 100a. The inner diameter of conductive shield 204 was 1.67 mm (the same value as the C122 copper tube) and as a result, the soldered joint did not adversely affect the performance of first antenna 100a. Insulating jacket 206 and third antenna dielectric material 216 were formed using a fluorinated ethylene propylene heat shrink the far end of which was sealed by epoxy to completely envelop first antenna 100a. After the epoxy cured for 48 hours, a heat gun was used to shrink a diameter of the heat shrink to 2.8 mm. Before conducting an ablation experiment, first antenna 100a was placed inside egg white and its pre-ablation |S11| was measured using a vector network analyzer (Agilent E5071C). Second |S11| curve 602 of
The fabricated first antenna 100a was used to perform an ablation experiment in egg white. An output of a signal generator (HP 8350B sweep oscillator) was fed as an input to a solid-state power amplifier (DMS 7066). An output of the amplifier was fed to coaxial cable 102 that fed the fabricated first antenna 100a. The ablation experiment was performed at 1.9 GHz for 5 minutes at a power level of 40 W. The |S11| of the fabricated first antenna 100a was monitored during the ablation experiment using a circulator and a power meter. The level of |S11| was observed to be less than −10 dB during the entire ablation process, which indicates that fabricated first antenna 100a remained matched to coaxial cable 102 as the dielectric properties of the egg white changed. This observation is in agreement with the measured post-ablation |S11| shown in third |S11| curve 604 of
Referring to
Referring to
Referring to
Referring to
First dipole arm extension 1200 is formed of a conductive material that may be the same material as and/or may be an extension of first dipole arm 208. First dipole arm extension 1200 may be formed of conducting wire having one or more of a helical section, etc. A cross-section of first dipole arm extension 1200 may be circular, square, elliptical, rectangular, etc. though it is typically circular when formed as an extension of first dipole arm 208 as shown in
When combined, first dipole arm 208 and first dipole arm extension 1200 have first dipole arm length 222 measured between feed vector 218 and end vector 219. First dipole arm extension 1200 has first dipole arm extension length 1204 measured between second end 211 of first dipole arm 208 and end vector 219. A first dipole arm extension width 1206 defines a cross-section width of first dipole arm extension 1200. When first dipole arm extension 1200 has a circular cross-section, first dipole arm extension width 1206 is a diameter of first dipole arm extension 1200. For illustration, first dipole arm extension width 1206 is equal to center conductor width 224 and to first dipole arm width 234 and is approximately 0.51 millimeters (mm). For further illustration, a length of first dipole arm 208 may be equal to second dipole arm length 220 between first end 209 and second end 211 of first dipole arm 208. For still further illustration, second separation distance 1210 may be 0.5 mm though first dipole arm extension 1200 may be located at other heights up to that defined by separation width 404.
A number of turns of second dipole arm 212 may be selected as 10 using N=√{square root over (lt2−lh2)}/(πD) with lt=3λo/4 with lh=14 mm. Again, second dipole arm length 220 lh can be chosen between 0.1λo and 0.2λo, inclusive. A number of turns of first dipole arm extension 1200Nh2 may be selected as 3 using Nh2=√{square root over (lt22−lh22)}/(πDh2), where the overall length of first dipole arm extension 1200 is lt2=10 mm, first dipole arm extension length 1204 is lh2=4, and Dh2=1.0 mm, where Dh2 is twice second separation distance 1210. Based on these dimensions, first dipole arm length 222 lm=18 mm based on (14+4) mm.
In the illustrative embodiment of first antenna 100a, first dipole arm length 222 of first dipole arm 208 was 23 mm. In the illustrative embodiment of second antenna 100b, first dipole arm 208 was reduced in length by 9 mm to 14 mm. To compensate, first dipole arm extension 1200 was formed as a helix with Nh2=3 turns. A helix with Dh2=1 mm and Nh2=3 turns has an overall length of lt2=10 mm, resulting in an overall first arm length of first dipole arm 208 and of first dipole arm extension 1200 of 24 mm, which is approximately equal to 23 mm. lh=14 mm was chosen for second dipole arm 212 or lh≤0.778*lm making second dipole arm length 220 lh 22.2% less than first dipole arm length 222.
Referring to
Referring to
Referring to
First antenna 100a and second antenna 100b are balun-free dipole antennas that generate localized heating patterns in microwave ablation. The dipole antenna of first antenna 100a is created by extending the outer and inner conductors of coaxial cable 102. One dipole arm is a helical outer conductor (second dipole arm 212) encompassing the other arm that is the extended center conductor 200 that is the inner conductor of coaxial cable 102. In the illustrative embodiment, the overall lengths of second dipole arm 212 and first dipole arm 208 are three quarters and one quarter of a wavelength, respectively. The current direction in the conductor of second dipole arm 212 reverses direction a quarter of a wavelength away from the feed point becoming aligned with the current direction in the conductor of first dipole arm 208. This creates a low input impedance, choking the current on an outer surface of conductive shield 204 of coaxial cable 102. The fields produced by the currents flowing on the dipole arms destructively interfere closer to the feed point, while constructively interfering further from it, which helps first antenna 100a and second antenna 100b produce nearly spherical ablation zones. First antenna 100a and second antenna 100b can be used to perform minimally invasive ablation therapy within flexible and maneuverable embodiments.
First antenna 100a and second antenna 100b have several advantages compared to previous MWA antennas: 1) first antenna 100a and second antenna 100b generate localized ablation zones without using a balun, 2) the length of the radiating section of first antenna 100a and second antenna 100b can be made compact; and 3) first antenna 100a and second antenna 100b do not need an impedance matching network. As understood by a person of skill in the art, at least some of the dimensions described herein are a function of the wavelength and/or characteristics of coaxial cable 102 selected for the MWA antenna system and/or a size determined based on a type of procedure. Additionally, for simplicity of construction some of the width dimensions are illustrated as the same though this is not required.
As used in this disclosure, the term “connect” includes join, unite, mount, couple, associate, insert, hang, hold, affix, attach, fasten, bind, paste, secure, bolt, screw, rivet, pin, nail, clasp, clamp, cement, fuse, solder, weld, glue, form over, slide together, layer, and other like terms. The phrases “connected on” and “connected to” include any interior or exterior portion of the element referenced. Elements referenced as connected to each other herein may further be integrally formed together. As a result, elements described herein as being connected to each other need not be discrete structural elements. The elements may be connected permanently, removably, or releasably.
As used in this disclosure, the term “mount” includes join, unite, connect, couple, associate, insert, hang, hold, affix, attach, fasten, bind, paste, secure, bolt, screw, rivet, pin, nail, clasp, clamp, cement, fuse, solder, weld, glue, form over, slide together, layer, and other like terms. The phrases “mounted on” and “mounted to” include any interior or exterior portion of the element referenced. These phrases also encompass direct connection (in which the referenced elements are in direct contact) and indirect connection (in which the referenced elements are not in direct contact, but are mounted together via intermediate elements). Elements referenced as mounted to each other herein may further be integrally formed together. As a result, elements described herein as being mounted to each other need not be discrete structural elements. The elements may be mounted permanently, removably, or releasably.
The word “illustrative” is used herein to mean serving as an example, instance, or illustration. Any aspect or design described herein as “illustrative” is not necessarily to be construed as preferred or advantageous over other aspects or designs. Further, for the purposes of this disclosure and unless otherwise specified, “a” or “an” means “one or more”. Still further, the use of “and” or “or” in the detailed description is intended to include “and/or” unless specifically indicated otherwise.
The foregoing description of illustrative embodiments of the disclosed subject matter has been presented for purposes of illustration and of description. It is not intended to be exhaustive or to limit the disclosed subject matter to the precise form disclosed, and modifications and variations are possible in light of the above teachings or may be acquired from practice of the disclosed subject matter. The embodiments were chosen and described in order to explain the principles of the disclosed subject matter and as practical applications of the disclosed subject matter to enable one skilled in the art to utilize the disclosed subject matter in various embodiments and with various modifications as suited to the particular use contemplated. It is intended that the scope of the disclosed subject matter be defined by the claims appended hereto and their equivalents.
This invention was made with government support under ECCS1406090 awarded by the National Science Foundation. The government has certain rights in the invention.
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Number | Date | Country | |
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20190207316 A1 | Jul 2019 | US |