Claims
- 1. A cholestyramine tablet inner core consisting of directly compressed cholestyramine agglomerates and about 0.3 percent by weight of a lubricant, said agglomerates having a moisture content of 8 to 14 percent and formed from many small irregularly-shaped, jagged-edge particles with relatively few large smooth or flat surfaces wherein said agglomerates, when directly compressed, provide an inner core having a hardness of at least 18 SCU.
- 2. A cholestyramine tablet inner core of claim 1 wherein said agglomerates have a tapped bulk density of 0.45 to 0.5 g/ml.
- 3. A cholestyramine tablet inner core of claim 1 wherein said agglomerates, when directly compressed, provide an inner core having a hardness of 18 to 26 SCU.
- 4. A cholestyramine tablet inner core of claim 1 wherein said lubricant is magnesium stearate.
- 5. A cholestyramine tablet inner core consisting of directly compressed cholestyramine agglomerates and about 0.3 percent by weight of magnesium stearate, said agglomerates having a tapped bulk density of 0.45 to 0.5 g/ml and a moisture content of 8 to 14 percent and formed from many small irregularly-shaped, jagged-edge particles with relatively few large smooth or flat surfaces wherein said agglomerates, when directly compressed, provide an inner core having a hardness of 18 to 26 SCU.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation of application Ser. No. 07/764,115, filed Sep. 23, 1991, now abandoned, which is a continuation of application Ser. No. 07/573,959, filed Aug. 27, 1990, now abandoned, which is a continuation-in-part of application Ser. No. 07/324,167, filed Mar. 16, 1989, now U.S. Pat. No. 4,956,182.
US Referenced Citations (8)
Foreign Referenced Citations (4)
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Oct 1981 |
EPX |
0040590 |
Nov 1981 |
EPX |
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Mar 1988 |
EPX |
0595444 |
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GBX |
Non-Patent Literature Citations (6)
Entry |
Pharmaceutical Dosage Forms-Tablets, vol. 1, H. A. Lieberman and L. Lachman, Marcel Dekker, Inc., New York and Basel, pp. 112-173. |
Pharmaceutical Technology/Fundamental Pharmaceutics, E. L. Parrott, Ph.D. Burgess Publishing Company, Minneapolis, Minn., pp. 74-79. |
Remington's Pharmaceutical Sciences, Eighteenth Edition-1990, Philadelphia College of Pharmacy and Science, pp. 1641-1646. |
Tuerck, et al., "Formula Modifications in a Solvent-Free Tablet Film Coat", J. Pharm. Sci. (1973) 62:1534-1537. |
Jacobsen, et al., "Effect of enterocoated cholestyramine on bowel habit after ileal resection: a double blind crossover study" Britis Medical Journal (1985) 290:1315-1318. |
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Continuations (2)
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Number |
Date |
Country |
Parent |
764115 |
Sep 1991 |
|
Parent |
573959 |
Aug 1990 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
324167 |
Mar 1989 |
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