Patent Application
20200360239
Dispenser devices are used to dispense any of a variety of materials to a user. Commonly known dispenser devices include vaping devices, which for example can be operated to deliver Cannabis and other plant preparations to a user. Although these devices can be helpful in providing users with delivered amounts of such preparations, still further improvements are desired. Embodiments of the present invention provide solutions to at least some of these outstanding needs.
Embodiments of the present invention encompass systems, devices, and methods for dispensing a preparation for consumption by a patient or individual. In some cases, a preparation may be provided as a fluid. In some cases, a preparation may include a medicament. In some cases, a preparation may include a Cannabis oil, tincture, extract, derivative, and/or constituent. Exemplary devices may be configured to dispense any of a variety of preparations, such as fluids, gels, pastes, liquids, nanoemulsions, and the like. As used herein, the term “preparation” is intended to include flowable materials that can be dispensed using the disclosed devices and methods. In some embodiments, methods, systems, and devices can be used for the oral or sublingual administration of a Cannabis preparation to a user or individual. In some cases, a dispensing device can be provided as a pen-like or pen-shaped device, which is configured to dispense micro-dose amounts of Cannabis constituents and/or other compounds or molecules. In some cases, dispensing devices can be provided as a disposable onetime use device. According to some embodiments, a dispenser device can include two or more function assemblies that together form a full assemblage of a dispenser device. In some cases, a dispenser device can include an actuator assembly, a cartridge and housing assembly, and a cap assembly. In some cases, a dispenser device can be provided as a single chamber mechanical dispenser device configuration.
According to some embodiments, a dispenser device may be provided in a reusable configuration. In some embodiments, a dispenser device may be provided in a disposable configuration. In some instances, a disposable micro-dosing medicament dispensing device can be inexpensively produced. In some cases, a dispenser device can be provided as a pen-shaped device having a cap. Exemplary embodiments enable a user to select a very precise dose using a dial or knob and then dispense the dose by pushing a dispense button which in turn actuates a plunger or stopper.
In one aspect, embodiments of the present invention encompass dispenser devices for dispensing an amount of a preparation. An exemplary dispenser device includes a control assembly, a viewing assembly, a vial assembly, and a dispenser tip. In some cases, a dispenser device includes a cap. The vial assembly may be at least partially housed by the viewing assembly. The dispenser tip can be coupled with a vial of the vial assembly. A distal nozzle of the dispenser tip can extend distally from a distal aperture of the vial. An interference fit can be present between the vial and the dispenser tip. The viewing assembly and the control assembly can be coupled together and cooperate to inhibit the dispenser tip and the vial from uncoupling from one another.
In another aspect, embodiments of the present invention encompass a dispenser device, where the dispenser device includes a vial assembly, a dispenser tip, a viewing assembly, a control assembly, and a cap. The vial assembly can include a vial, a stopper, and a preparation. The stopper and the preparation can be are disposed within the vial. The vial can include a proximal portion and a distal portion. The dispenser tip can have a proximal portion and a distal portion. The proximal portion of the dispenser tip can be engaged with the distal portion of the vial. The viewing assembly can include a viewing assembly coupling mechanism. The control assembly can include a control assembly coupling mechanism and a dosage knob. The control assembly coupling mechanism can be coupled with the viewing assembly coupling mechanism. The dosage knob can be configured to set a desired dosage amount of the preparation for dispensing by the dispenser device. The cap can be configured to releasably attach with the viewing assembly. The proximal portion of the vial can contact the control assembly at a first contact location, the distal portion of the dispenser tip can contact the viewing assembly at a second contact location, and compression created at the first contact location and the second contact location due to engagement between the control assembly and the viewing assembly can inhibit disengagement between the proximal portion of the dispenser tip and the distal portion of the vial. The distal portion of the vial can include a rim having an outer surface, an inner surface, a distal surface disposed between the outer surface and the inner surface, and a distal aperture. The proximal portion of the dispenser tip can include a flange proximal portion inner surface, a proximal shaft having a proximal shaft surface, and a flange distal portion inner surface disposed between the flange proximal portion inner surface and the proximal shaft surface. The outer surface of the rim of the vial can be apposed to the flange proximal portion inner surface of the proximal portion of the dispenser tip, the inner surface of the rim of the vial can be apposed to the proximal shaft surface of the proximal portion of the dispenser tip, the distal surface of the rim of the vial can be apposed to the flange distal portion inner surface of the proximal portion of the dispenser tip, and the distal aperture of the rim of the vial can be configured to receive the proximal shaft of the dispenser tip.
In some cases, the proximal portion of the dispenser tip includes a proximal body surface, the distal portion of the dispenser tip includes a distal nozzle surface, the dispenser tip includes a distal shaft surface disposed between the proximal body surface and the distal nozzle surface, and a circumference of the distal shaft surface is less than a circumference of the proximal body surface and greater than a circumference of the distal nozzle surface.
In still another aspect, embodiments of the present invention encompass a dispenser device, where the dispenser device includes a vial assembly, a dispenser tip, a viewing assembly, a control assembly, and optionally, a cap configured to releasably attach with the viewing assembly. A vial assembly may include a vial, a stopper, and a preparation. The stopper and the preparation can be disposed within the vial, and the vial can have a proximal portion and a distal portion. The dispenser tip can have a proximal portion and a distal portion. The proximal portion of the dispenser tip can be engaged with the distal portion of the vial and an interference fit can be present between the proximal portion of the dispenser tip and the distal portion of the vial. The viewing assembly can have a viewing assembly coupling mechanism. The control assembly can have a control assembly coupling mechanism and a dosage knob. The control assembly coupling mechanism can be coupled with the viewing assembly coupling mechanism. The dosage knob can be configured to set a desired dosage amount of the preparation for dispensing by the dispenser device. The proximal portion of the vial can contact the control assembly at a first contact location, the distal portion of the dispenser tip can contact the viewing assembly at a second contact location, and compression created at the first contact location and the second contact location due to engagement between the control assembly and the viewing assembly can inhibit disengagement between the proximal portion of the dispenser tip and the distal portion of the vial. The distal portion of the vial can have a rim, the proximal portion of the dispenser tip can have a groove defined at least in part by a flange of the proximal portion of the dispenser tip and a proximal shaft of the proximal portion of the dispenser tip, and the rim of the distal portion of the vial can be received by the groove of the proximal portion of the dispenser tip. The flange can have a proximal portion with a proximal edge, the proximal shaft can have a proximal edge, and the proximal edge of the proximal shaft can be disposed proximal to the proximal edge of the proximal portion of the flange.
In a further aspect, embodiments of the present invention encompass a dispenser device, where the dispenser device includes a vial assembly, a dispenser tip, a viewing assembly, and a control assembly. The vial assembly can have a vial, a stopper, and a preparation. The stopper and the preparation can be disposed within the vial, and the vial can have a proximal portion and a distal portion. The dispenser tip can have a proximal portion and a distal portion, and the proximal portion of the dispenser tip can be engaged with the distal portion of the vial. The viewing assembly can have a viewing assembly coupling mechanism. The control assembly can have control assembly coupling mechanism and a dosage knob. The control assembly coupling mechanism can be coupled with the viewing assembly coupling mechanism. The dosage knob can be configured to set a desired dosage amount of the preparation for dispensing by the dispenser device. The proximal portion of the vial can contact the control assembly at a first contact location, the distal portion of the dispenser tip can contact the viewing assembly at a second contact location, and compression created at the first contact location and the second contact location due to engagement between the control assembly and the viewing assembly can inhibit disengagement between the proximal portion of the dispenser tip and the distal portion of the vial. In some cases, a dispenser device includes a cap configured to releasably attach with the viewing assembly. In some cases, the distal portion of the vial includes a rim, the proximal portion of the dispenser tip includes a groove, and the rim of the distal portion of the vial can be received by the groove of the proximal portion of the dispenser tip. In some cases, the distal portion of the vial includes a rim having an outer surface, the proximal portion of the dispenser tip includes a flange proximal portion inner surface, and the outer surface of the rim of the vial is apposed to the flange proximal portion inner surface of the proximal portion of the dispenser tip. In some cases, the distal portion of the vial includes a rim having an inner surface, the proximal portion of the dispenser tip includes a proximal shaft surface, and the inner surface of the rim of the vial is apposed to the proximal shaft surface of the proximal portion of the dispenser tip. In some cases, the distal portion of the vial includes a rim having a distal surface, the proximal portion of the dispenser tip includes a flange distal portion inner surface, and the distal surface of the rim of the vial is apposed to the flange distal portion inner surface of the proximal portion of the dispenser tip. In some cases, the distal portion of the vial includes a rim having a distal aperture, the proximal portion of the dispenser tip includes a proximal shaft, and the distal aperture of the rim of the vial is configured to receive the proximal shaft of the dispenser tip. In some cases, the proximal portion of the dispenser tip includes a proximal shaft having a vial port opening, the distal portion of the dispenser tip includes a distal nozzle having a distal exit port, and the vial port opening of the proximal shaft of the proximal portion of the dispenser tip is in fluid communication with the distal exit port of the distal nozzle of the distal portion of the dispenser tip. In some cases, the proximal portion of the dispenser tip includes a proximal body surface, the distal portion of the dispenser tip includes a distal nozzle surface, the dispenser tip includes a distal shaft surface disposed between the proximal body surface and the distal nozzle surface, and a circumference of the distal shaft surface is less than a circumference of the proximal body surface and greater than a circumference of the distal nozzle surface. In some cases, the dispenser tip includes a transition surface disposed between the distal nozzle surface and the distal shaft surface. In some cases, the proximal portion of the dispenser tip includes a flange having a proximal portion with a proximal edge, the proximal portion of the dispenser tip includes a proximal shaft having a proximal edge, and the proximal edge of the proximal shaft is disposed proximal to the proximal edge of the proximal portion of the flange. In some cases, a diameter of the proximal edge of the proximal shaft is less than a diameter of the proximal edge of the proximal portion of the flange. In some cases, the proximal portion of the dispenser tip includes a proximal port, the distal portion of the dispenser tip includes a distal port, and the dispenser tip includes a central longitudinal conduit extending between the proximal port of the proximal portion of the dispenser tip and the distal port of the distal portion of the dispenser tip. In some cases, an inner diameter of the distal port of the distal portion of the dispenser tip is less than an inner diameter of the proximal port of the proximal portion of the dispenser tip. In some cases, the distal portion of the dispenser tip includes a distal nozzle, the viewing assembly includes a distal aperture, and the distal nozzle of the dispenser tip extends distally through the distal aperture of the viewing assembly. In some cases, the viewing assembly coupling mechanism includes a threaded section, the control assembly coupling mechanism includes a threaded section, and the threaded section of the viewing assembly coupling mechanism is configured to threadingly engage the threaded section of the control assembly coupling mechanism. In some cases, the viewing assembly coupling mechanism includes a tab, the control assembly coupling mechanism includes an indent, and the indent of the control assembly coupling mechanism is configured to receive the tab of the viewing assembly coupling mechanism. In some cases, the viewing assembly coupling mechanism includes an aperture, the control assembly coupling mechanism includes a tab, and the aperture of the viewing assembly coupling mechanism is configured to receive the tab of the control assembly coupling mechanism. In some cases, the viewing assembly comprises one or more sight windows.
In another aspect, embodiments of the present invention encompass a micro-dosing dispenser device that includes a dispenser tip or pressure-fitting tip assembly and a vial containing a medicament, and the dispenser tip has a shaft (e.g. a cone-shaped shaft) that seals the vial as the dispenser tip snaps onto the vial. In some cases, a vial, a stopper (e.g. a rubber or silicone stopper), and a dispenser tip can be configured to fit inside of a viewing assembly or vial holder, and the viewing assembly can be configured to snap together with a control assembly or main body of the dispenser device, to create a leak-proof, water-tight seal between the dispenser tip and the vial. In some cases, the dispenser tip and the vial can seal with a silicone gasket. In some cases, the dispenser tip has a cone-shaped tip. In some cases, the vial is made of a hard plastic material. In some cases, the vial has a distal rim or lock tip that can be configured for sealing by a dispenser tip. In some cases, dispenser tips can be provided in a variety of different sizes, and different sizes can be used with corresponding preparations having different viscosities. In some cases, a dispenser device may be configured to be disposable, after a desired amount of preparation has been dispensed from a single vial.
In some cases, a dispenser device can be configured to be reusable, and after a desired amount of preparation has been dispenses from a single vial, the used vial can be removed from the dispenser device and replaced with a new vial that is loaded with a Cannabis preparation. In some cases, a dispenser device can be configured for use in dispensing an amount of preparation without requiring the use of a needle (e.g. tissue-piercing injection needle). In some cases, a dispenser device can be configured for use in dispensing a liquid or paste by expelling the liquid or paste in fixed amounts that are measured and are repeatable. An exemplary dispenser device may include an exterior housing having one or more component parts. A dispenser device may also include a serviceable cartridge or vial assembly. A vial assembly may include a vial, a displaceable stopper disposed within the vial, and an amount of preparation contained within the vial. A vial may be coupled with a dispenser tip. In some cases, a housing component may include a viewing assembly configured to receive a cartridge or vial. In some cases, a housing component may include a control assembly, which may include mechanical and/or electronic mechanisms for providing motive force for the displacement of a stopper within a vial. In some cases, the viewing assembly and control assembly can be configured to be attachable with one another, and to be detachable from one another. For example, the viewing assembly and control assembly can be coupled via a threaded engagement, a snap-on engagement, or the like. In some cases, a dispenser device includes a protective cap. In some cases, a cap may include a clip that can be attached with a clothing garment. In some cases, a vial assembly can be provided as a refillable vial assembly. In some cases, a vial assembly can be provided as a replaceable vial assembly. In some cases, a control assembly may include a presetting mechanism that allows a user to preset an amount of preparation (e.g. fluid, liquid, paste, gel, or the like) to be dispensed by the dispenser device. In some cases, a control assembly may include an initiating mechanism that allows a user to initiate the dispensing of an amount of preparation (e.g. fluid, liquid, paste, gel, or the like) from the dispenser device. In some cases, an initiating mechanism may be a dispense button. In some cases, a dispenser device can include a communication and/or control mechanism whereby a user can communicate with and/or control the device via radio, inductive, or light signals, devices, or energy.
In still another aspect, embodiments of the present invention encompass disposable dispenser device. A dispenser device can be configured to be disposable, after a desired amount of preparation has been dispenses from a single vial. In some cases, a dispenser device can be configured for use in dispensing an amount of preparation without requiring the use of a needle (e.g. tissue-piercing injection needle). In some cases, a dispenser device can be configured for use in dispensing a liquid or paste by expelling the liquid or paste in fixed amounts that are measured and are repeatable. An exemplary dispenser device may include an exterior housing having one or more component parts. A dispenser device may also include a serviceable cartridge or vial assembly. A vial assembly may include a vial, a displaceable stopper disposed within the vial, and an amount of preparation contained within the vial. A vial may be coupled with a dispenser tip. In some cases, a housing component may include a viewing assembly configured to house a cartridge or vial. In some cases, a housing component may include a control assembly, which may include mechanical and/or electronic mechanisms for providing motive force for the displacement of a stopper within a vial. In some cases, the viewing assembly and control assembly can be configured to be attachable with one another, and to be detachable from one another. For example, the viewing assembly and control assembly can be coupled via a threaded engagement, a snap-on engagement, or the like. In some cases, a dispenser device includes a protective cap. In some cases, a cap may include a clip that can be attached with a clothing garment. In some cases, a vial assembly can be provided as a single-use vial assembly. In some cases, a control assembly may include a presetting mechanism that allows a user to preset an amount of preparation (e.g. fluid, liquid, paste, gel, or the like) to be dispensed by the dispenser device. In some cases, a control assembly may include an initiating mechanism that allows a user to initiate the dispensing of an amount of preparation (e.g. fluid, liquid, paste, gel, or the like) from the dispenser device. In some cases, an initiating mechanism may be a dispense button. In some cases, a dispenser device can include a communication and/or control mechanism whereby a user can communicate with and/or control the device via radio, inductive, or light signals, devices, or energy.
Embodiments of the present invention encompass systems, devices, and methods for dispensing or administering a precise, customized dose of a preparation or another desired material. Exemplary devices provide the user to select the dosage amount to be dispensed, thus providing the user with reliable control over the outcome of a micro-dosed administration, which may occur in the user themselves, or in another individual such as a patient or consumer. In some embodiments, a device includes a hollow spout for the delivery or dispensing of a preparation, which may include a liquid compound, for example. In some embodiments, a device can include a dose setting and dispensing mechanism that allows the user to control the device in a simple and efficient manner. In some cases, an individual can operate a dispenser device to deliver an amount of a preparation into their own mouth or into another person's mouth, so as to provide an oral or sublingual administration of the preparation. In some cases, an individual can operate a dispenser device to deliver an amount of a preparation into a cup or a container, and then the individual or another person can consume the preparation from the cup or container, so as to provide an oral or sublingual administration of the preparation.
Dispenser device and method embodiments disclosed herein may provide advantages over other delivery modalities, such as vaping, standard tincture droppers, edibles, and the like. Vaping may be inconvenient for public consumption. Standard tincture droppers for sublingual administration may provide uneven or inconsistent drop distributions. Edibles are typically provided in pre-defined amounts (e.g. 2.5 mg dose) which cannot conveniently be subdivided for the administration of smaller dosage amounts. Dispenser device and method embodiments disclosed herein can provide precise and consistent dosages, in any desired amount, in a repeatable fashion, every time. Dispenser device and method embodiments disclosed herein can also provide for the ingestion of whole plant Cannabis oils and tinctures. Dispenser device and method embodiments disclosed herein can provide a user with a discrete and convenient delivery modality which can be carried in a purse or pocket.
Exemplary disposable dispenser devices can be configured to include vials having a 3 milliliter capacity, and to provide a dosing capacity of 0.1mg to 2.5 mg of Cannabis preparation or constituent(s) per dose or a dispensed fixed-amount. Disposable dispenser devices can be configured to dispense sublingually or into any beverage using a water-soluble Cannabis extracted oil formulation.
Exemplary reusable dispenser devices can be configured to include vials having a 3 milliliter capacity, and to provide a dosing capacity of 0.1mg to 2.5 mg of Cannabis preparation or constituent(s) per dose or a dispensed fixed-amount. Reusable dispenser devices can be configured to dispense sublingually or into any beverage using a water-soluble Cannabis extracted oil formulation.
Dispenser devices and methods as disclosed herein are well suited for use in dispensing small amounts of preparations such as liquids, pastes, fluids, and other materials, often measured in small portions of milliliters. Exemplary preparations may include lubricating oils, liquid medicaments, a liquid catalyst, water, liquid glue, liquid dye, or indeed any liquid with appropriate viscosity. In particular, a dispenser device can be used to deliver a measured quantity of a preparation, such as a medicament, into a drink or food that will be consumed by the user. In some instances, it is desirable to mix a preparation (which may include one or more Cannabis constituents) into a glass of water, coffee, soda, or the like before consumption. In some cases, a preparation may benefit from being combined with another fluid such as a beverage, because the preparation (e.g. containing an oil-based vitamin) may have a bad or sour taste if consumed directly. Exemplary dispenser devices and methods disclosed herein can be used to accurately measure and dispense lubricating oil onto a mechanical mechanism to aid in its smooth function and preservation. In many such applications of lubricating oil it may be imperative that the oil not migrate over time beyond the mechanism, thus the need to dispense only by precise means.
According to some embodiments of the present invention, a dispenser device can be used to deliver one or more doses of a preparation (e.g. containing one or more medicamental or Cannabis oils) into a drink, whereby the user can mask an unpleasant or undesirable taste of the medicament. In some cases, a dispenser device can be used for the dosing of medicamental or Cannabis oils. In some cases, a dispenser device can be used to deliver any desired formulary of a medicament or preparation, in order to provide maximum benefit or desired effect to the user. Dispenser devices can be used to deliver precisely measured doses, in a repeatable and reliable manner, with little need for the user to manipulate or measure the medicament itself. In some cases, a dispenser device does not include a needle, an internal or external spike, or a barb.
In some cases, a dispenser device is therefore safer than a syringe. In some cases, a dispenser device is portable, socially acceptable when carried in the open pocket of a shirt, protected from accidental disassembly, and easily adjustable to be set to deliver one of several preset dose amounts without fuss by the user. Exemplary dispenser devices can be used to deliver repeatable and precise dosing of medicaments or preparations upon demand. Embodiments of the present invention encompass dispenser devices that do not leak liquids (e.g. from a vial and/or a dispenser tip), even when a cap is not present on the dispenser device. Exemplary dispenser devices do not require the replacement in installation of a needle or a similar consumable component, prior to the dispensing of a preparation or liquid.
According to some embodiments, a dispenser device can be provided as a small portable device that delivers small pre-measured amounts of a preparation or liquid, not for injection, using a method that is accurate and repeatable, and does not employ an internal or external spike, barb, or needle (e.g. tissue-penetrating features, such as a standard tissue penetrating hypodermic needle) that can injure a user.
Embodiments of the present invention encompass dispenser devices and methods for use in effecting the controlled and measured dispensing of preparations or liquids, such as a dose of a medicament or preparation to food or drink. In some cases, a dispenser device can be used to dispense oils. In some cases, a dispenser device can have the appearance and form-factor of a pen, perhaps similar in size and shape of a high-quality fountain pen. In some cases, dispenser devices can include disposable cartridges or vials that can hold medicaments of differing formulations. In some cases, dispenser devices can employ cartridges or vials without the need of a foil or paper seals that must be pierced by a pin or needle before prior to, or upon or during, the installation of the cartridge into the device.
According to some embodiments, a vial, cartridge, and/or dispenser device can be configured so that a partially used cartridge or vial may be removed and stored safely and cleanly, while another cartridge or vial is installed and used. In some cases, a vial or cartridge may operate to contain the contents therein (e.g. an amount of a preparation) without requiring a seal.
According to some embodiments, the term “fixed amount” as used herein may refer to an amount of a preparation, which may be for example a lubricating oil, a paint, a glue, a catalyst, another chemical, a dose of medicament or one or more Cannabis constituents.
These and other advantages will become evident from the following more detailed description of embodiments of the invention.
Turning now to the drawings,
As shown in
In some cases, a dispenser device can be configured to be controlled by or in communication with a software application or other programming mechanism, whereby the software application or programming mechanism can convert mg (milligrams) of one or more Cannabis constituents or preparations into a corresponding number of clicks or knob rotations of a control assembly, and whereby data can be collected for verifiable analytics. According to some embodiments, a dispenser device can be provided as a single chamber micro-dosing device configured to delivery whole plant cannabis oil and tinctures for oral ingestion. In some cases, a dispenser device can be configured for Bluetooth connectivity, and can be configured to be controlled by or in communication with a controlling dose tracking application.
The dosage knob 132 can be rotatable to a set a desired dosage amount, and upon actuation the dosage knob 132 can cause a shaft to move to a position proportional to a set amount of the preparation or a set dose of one or more Cannabis constituents. In this way, the user or operator can configure the dispenser device 100 to dispense a pre-defined amount of a preparation, which contains a pre-defined dose of one or more Cannabis constituents and/or other compounds or molecules, upon actuation of the dosage knob 132, for example by pressing the dosage knob in the direction indicated by arrow B for a pre-defined distance, which may correspond to a single press or “click” of the dosage knob 132. In this way, the dosage knob 132 is translationally moveable, for example to cause the shaft to drive the plunger to push against the stopper 146, thereby driving the stopper 146 within the vial 142 in a distal direction, so as to dispense a precise amount of the preparation 144 from the vial 142. In turn, the amount of preparation 144 is dispensed through the dispenser tip 160 and out of the device 100. In some cases, the stopper 146 can be a rubber stopper. In some cases, the stopper 146 can be a silicone stopper. Other materials can be used in the construction of the stopper 146. In use, the stopper 146 can operate to seal the end of the vial 142 and to dispense an amount of the preparation 144 when pressed upon, for example by a shaft that is coupled with or otherwise in operative association with the dosage knob 132.
As shown in
According to some embodiments, dispenser device 100 is a micro-dosing dispensing device, wherein a dispenser tip 160 (e.g. pressure-fitting tip assembly) attaches to a vial 142 containing a preparation 144 (e.g. medicament). The dispenser tip 160 can have a con-shaped shaft that seals the vial 142 as the dispenser tip 160 snaps onto the vial 142. In some cases, the vial 142, a stopper 146 (e.g. a rubber stopper), and the dispenser tip 160 fit inside a viewing assembly 150 (e.g. vial holder) which snaps together or otherwise couples with the control assembly 130 to create a leak-proof, water-tight seal. In some cases, the dispenser tip 160 and the vial 142 can seal with a silicone gasket. In some cases, the dispenser tip 160 and vial 142 have a cone-shaped tip. In some cases, the vial 142 is fabricated from a hard plastic material. In some cases, the vial assembly 140 (e.g. vial 142 and stopper 146) has a lock tip at the distal end of the vial 142 for easy seal and removal of different size dispenser tips for the use with different viscosities of preparations or medicaments. In some embodiments, the dispenser device 100 is provided as a disposable dispenser device.
According to some embodiments, the term “cartridge subassembly” may refer to the combination of the vial assembly 140 and the dispenser tip 160. In some cases, the cartridge assembly (e.g. cartridge assembly 700 as identified in
According to some embodiments, cartridge subassembly 700 can operate to hold or contain a preparation 144 (e.g. a liquid) that can be dispensed by the dispenser device 100 in selectable fixed-amount amounts. In some embodiments, an empty cartridge subassembly 700 includes a vial 142, a dispenser tip 160, and a stopper 146. With the addition of a preparation 144 such as a liquid medicament, the empty cartridge subassembly can become a fully-filled cartridge subassembly. As depicted in
In some cases, a dispenser device 100 can be manufactured, sold, or otherwise provided as a multiple-use dispenser device. In some cases, the cartridge subassembly 700 can be configured to have the junction of vial 142 and dispenser tip 160 glued or crimped together, or quasi-permanently joined so as to be a single-use device. In some cases, a dispenser device 100 can be configured for use only with a single-use cartridge subassembly 700. In some cases, a dispenser device 100 can be configured for use only with a disposable liquid cartridge subassembly 700. In some cases, a dispenser device 100 can be configured for use as a multiple-use dispenser device that can also use a single-use and disposable cartridge subassembly 700, as well as a cartridge assembly 700 that is sold or otherwise provided to be refillable.
With regard to use of a refillable cartridge subassembly 700, a user who desires to refill the cartridge subassembly 700 can be instructed to: (A) remove the cartridge subassembly 700 from the dispensing device; (B) snap off (or otherwise remove or uncouple) the dispenser tip 160 from the cartridge subassembly 700; (C) use a tool or rod to return the stopper 146 to the proximal portion of the vial 142 (e.g. by moving the stopper 146 from a distal portion of the vial to a proximal portion of the vial); (D) refill vial 142 with a desired preparation 144 (e.g. liquid); (E) replace the dispenser tip 160 onto the vial 142 by snapping the pieces together; and (F) return the cartridge subassembly 700 back into the dispensing device for setup and use. In use, the dispenser device is operated to dispense an amount of preparation from the cartridge subassembly.
As depicted in
As depicted in
Dosage knob 132 can be used, for example in conjunction with the dosage window 134, to select a fixed-amount of material to be dispensed by the dispenser system 100. In some embodiments, dosage knob 132 is rotated until the value of the desired fixed-amount is visible in the dosage window 134, then the fixed-amount of material is delivered when the user presses down on the dosage knob 132 or on a dispense button as discussed elsewhere herein.
When considering the vial 142 itself, neither the proximal section nor the distal section may have a seal. When a stopper 146 and a dispenser tip 160 are engaged with the vial 142, these two elements can effectively operate to prevent or inhibit material from exiting the vial 142, until the stopper 146 is activated or otherwise forced in a distal direction toward a distal portion of the vial 142. According to some embodiments, the viewing assembly 150 and control assembly 130, when engaged (e.g. via thread connection 370), can operate to compress dispenser tip 160 and vial 142 together, or otherwise prevent or inhibit dispenser tip 160 and vial 142 from coming apart or disengaging from one another. In this way, operation or coupling of the viewing assembly 150 and control assembly 130 can facilitate a seal between the dispenser tip 160 and vial 142.
As noted above, a dispenser tip can operate to effective seal the distal end of a vial containing a preparation. It has been observed that vial assemblies prepared in this way do not require a physical barrier (e.g. heat shrink seal, or nozzle plug) to prevent the preparation from exiting the distal nozzle of the dispenser tip. The preparation material was observed to remain in the vial, even when the vial assembly and dispenser tip combination was shaken, or stored in an ambient environment. Little or no evaporation from the open distal nozzle of the dispenser tip was observed. Such vial assembly and dispenser tip combinations can be manufactured and sold separately.
According to some embodiments, the viewing assembly 150 can contact the dispenser tip 160 at a contact location or zone 390. For example, a distal portion of the dispenser tip 160 can have an outer contact circumference 160B, a distal portion of the viewing assembly 150 can have an inner contact circumference 150B, and the diameter of the outer contact circumference 160B can be substantially equivalent to the diameter of the inner contact circumference 150B, such that the interface between the outer contact circumference 160B and the inner contact circumference 150B provides a contact location 390. Aspects of these elements are also depicted in
Compression created at contact zone or location 390 and contact zone or location 395 due to engagement between the control assembly 130 and the viewing assembly 150 can help to create or maintain a seal or engagement between the dispenser tip 160 and the vial 142, for example as the viewing assembly 150 presses the dispenser tip 160 in a proximal direction (or prevents or inhibits the dispenser tip 160 from moving in a distal direction) and as the control assembly 130 presses the vial 142 in a distal direction (or prevents or inhibits the vial 142 from moving in a proximal direction). In this way, compression created at a first or proximal contact location 395 and a second or distal contact location 390 due to engagement between the control assembly 130 and the viewing assembly 150 operates to inhibit or prevent disengagement, or otherwise inhibit or prevent separation, between the proximal portion of the dispenser tip 160 and the distal portion of the vial 142.
In some cases, the seal between the dispenser tip 160 and vial 142 is tight and can operate as a leak-proof, water-tight seal, fluid-tight seal, and/or a liquid-tight seal. As discussed elsewhere herein, a distal portion of the vial 142 may include a tip (e.g. aa cone-shaped tip) or rim which allows the dispenser tip 160 to snap onto the vial 142. In some cases, the dispenser tip 160 may also seal with a silicone gasket. A dial or dosage knob 132 at a proximal portion of the control assembly 130 can enable a user to select a dosage or amount of preparation to dispense from the dispenser device 100. The dial or dosage knob 132 may operate by turning it clockwise (or counterclockwise) with clicks. Each click may prepare the dispenser device 100 to cause an additional 1/100th of a milliliter of medicament to be dispensed. A dispense button 136 can then depressed, which pushes a shaft 380 against the stopper 146. The stopper 146 then moves toward a distal portion of the vial 142, thereby dispensing an amount of preparation (e.g. fluid medicament) from the vial 142, into the dispenser tip 160, through the dispenser tip 160, and out of the dispenser tip 160 via an exit port of the dispenser tip (with cap 110 removed).
According to some embodiments, the viewing assembly 150 can contact the dispenser tip 160 at a contact location or zone 390. In some cases, this feature can facilitate operation of the dispenser pen 100 without the need for a needle to puncture through the cap 110. According to some embodiments, the dispenser tip 160 may be inserted into the viewing assembly 150, which also holds the vial 142 of a vial assembly, and the viewing assembly 150 can also help to serve as a locking mechanism for maintaining the vial contents within the vial and/or dispenser tip.
According to some embodiments, the dispenser device 100 can be configured so that the shaft 380 and stopper 146 may be operated only one time (e.g. as a disposable dispenser device). In some embodiments, the dispenser device 100 can be configured so that the shaft and stopper 146 may be operated multiple times (e.g. as a reusable dispenser device). In some cases, the viewing assembly or vial holder 150, with a vial 142 (e.g. a glass vial) inserted therein, can be configured so as to align a proximal portion of the vial 142 and the stopper 146 (e.g. a silicone stopper or a rubber stopper) with the shaft 380, creating a pathway for the shaft 380 to push out on the stopper 146. In some embodiments, a gearing mechanism (not shown), which can be operatively associated with the shaft 380 and the dispense button 136, can operate to prevent the shaft 380 from returning to its previous or original position (e.g. retracted) and therefore the dispenser device would not be able to re-dispense an amount of a preparation contained in the vial. In exemplary disposable embodiments, for example, the dispenser device is intended to be used only once, and the gearing mechanism and/or other components of the dispenser device 100 can be made out of less expensive materials, such as polycarbonate. A less expensive device allows for cost savings when a dispenser device need not be used more than once. In some embodiments, the stopper 146 is made of silicone. It has been surprisingly discovered that silicone is an unexpectedly advantageous material to use in fabrication of the stopper 146, because it tends not to absorb components of a Cannabis preparation. Silicone is also advantageous because it is not permeable.
When dispenser tip 160 and vial 142 are fully assembled together, the shaft 160a of the dispenser tip 160 extends into a distal opening of the vial, but not into the main chamber of the vial 142. In this way, there is maximization of the liquid or fluid seal surfaces at the junction between the dispenser tip 160 and vial, and minimization of any waste of preparation 144 (e.g. fluid or liquid) that is stored in the vial 142. Hence, the interface between the dispenser tip 160 and the vial 142 is configured so that the stopper 146 is able to travel in a distal direction to a distal portion of the vial 142 and effectively expel all or most of the preparation 144 contained within the vial 142.
According to some embodiments, when dispenser tip 160 and vial 142 are fully assembled together, a leak-tight junction therebetween is formed. Dispenser tip 160 can be configured so that there is a surface (e.g. surface 620 depicted in
According to some embodiments, once two such surfaces (which may be tapered surfaces) are mated and held together, they form a leak-tight junction.
According to some embodiments, there may be a slight size differential between the outer diameter of the vial rim 500 and the inner surface of the dispenser tip groove 630, such that a press fit, friction fit, or interference fit between the vial 142 and the dispenser tip 160 is created when the vial 142 and dispenser tip 160 are engaged with one another. According to some embodiments, there may be a slight size differential between the surface of the vial at interface 170 and the surface of the dispenser tip at interface 170, such that a press fit, friction fit, or interference fit between the vial 142 and the dispenser tip 160 is created when the vial 142 and dispenser tip 160 are engaged with one another. As a result, the press fit, friction fit, or interference can operate to resist separation of the engaged vial 142 and dispenser tip 160. In some cases, when the vial 142 and dispenser tip 160 are pressed together, a press fit, a friction fit, or an interference fit is formed therebetween.
It was surprisingly discovered that when the distal nozzle of the dispenser tip extends distally from the viewing assembly, as shown in
What is more, as depicted in
According to some embodiments, the stopper 146 may include a plurality of annular rings 146R which operate to create a plurality of seals against the vial, and the annular rings 146R are sized so that the stopper 146 can slide within the interior chamber of the vial 142. In some embodiments, stopper 146 is made of rubber. It is understood that stopper 146 may be made of any suitable material, as a means of example but not of limitation, including plastics, rubbers, silicones, fluoropolymers; or any combination thereof. In some cases, stopper 146 can be provided as a springy metal ring. In some embodiments, stopper 146 is made of silicone. According to some embodiments, a stopper 146 made of silicone and having a plurality of rings 146R (e.g. four rings) can provide certain operational advantages. For example, some known pen devices use an aluminum and rubber seal crimped unto the neck of a vial to create a vacuum seal of the liquid contained therein. Each time an operator needs to use such a pen, the operator must screw on a new needle that pierces through the rubber seal, so as to enable the delivery of the liquid. Such pen devices typically require a stiff rubber stopper having a sufficiently wide diameter, so as to ensure that a high amount of pressure is retained inside the vial at all times. In contrast, some embodiments of the present invention include a stopper made of a softer silicone material with a smaller diameter, optionally with rings, that will give and move easier. By using a softer silicone material with a smaller diameter for the stopper, it is possible to ensure that the pressure is not excessively high which would cause leakage, and that the stopper provides a sufficiently tight seal which facilitates the dispensing of liquids quickly and accurately. In some embodiments, a stopper includes a number of rings or ribs (e.g. 4) which operate to provide a slight grip on the inner wall of the vial (e.g. a glass vial) without sticking to the vial at any point.
According to some embodiments, viewing assembly 150 can be provided as a component of a cartridge and housing assembly. As shown here, the viewing assembly 150 can include an insert section 158 configured to attach with the control assembly 130. In some cases, insert section 158 can operate to couple a cartridge and housing assembly with a control assembly. An insert section 158 may include one or more mount-locking tabs 159 that are configured to secure or couple the viewing assembly 150 with the control assembly 130. For example, the control assembly 130 may have corresponding indents or apertures that are configured to receive or otherwise engage the mount-locking tabs 159. In some cases, as describe elsewhere herein (e.g. in reference to
It has surprisingly been discovered that using silicone as a material for the stopper 146 (instead of, for example, butyl rubber) can be particularly advantageous for various reasons. It has been discovered that a silicone stopper slides easily within a glass vial, whereas a rubber stopper may exhibit stickiness to the vial. Moreover, a silicone stopper has been observed to exhibit less leaking and to retain a better seal, as compared with a butyl rubber stopper. It was also surprisingly discovered that adding more annular rings (e.g. for a total of four rings) to the stopper resulted in improved performance, by helping to reduce any stickiness between the stopper and the vial.
Moreover, it was unexpectedly discovered that by using silicon to fabricate the stopper, the stopper did not require additional processing techniques such as coating or curing, in order to obtain the desired performance. It was surprisingly discovered that silicone did not absorb constituents of the preparation contained within the vial (e.g. Cannabis constituents such as cannabinoids), whereas unwanted absorption was observed with a butyl rubber stopper.
Moreover, it was surprisingly discovered that when using a silicone stopper, Cannabis constituents such as cannabinoids did not deteriorate when they were stored within the vial, as compared with the deterioration which was observed when a preparation containing Cannabis constituents was stored in a vial assembly that included a butyl rubber stopper. When comparative testing between a silicone stopper and a butyl rubber stopper was performed, it was observed that the active cannabinoid content within a vial assembly having a silicone stopper remained more consistent or at higher levels, as compared to the active cannabinoid content within a vial assembly having a butyl rubber stopper. In some cases, the testing was performed over the course of a week.
In some embodiments, a viewing assembly 150 can include one or more material-level sight windows 152. For example, a sight window or aperture 152 can have an oval shape. During operation of the dispenser device 100, as a stopper 146 travels through the vial 142 (e.g. in a distal direction), the user can view the stopper 146 through the sight window 152 and the vial 142, and the position of the stopper 146 within the vial 142 can provide a visual indication to the user of the approximate amount of material that remains in the vial 142. In some embodiments, the viewing assembly 150 depicted here may be referred to as a disposable holder for a vial 142. In some cases, dispenser device 100 can be provided as a disposable device.
In some embodiments, the configuration, location, and action the dosage knob 132, dosage window 134, and/or dispense button 136 may be dependent on which type of control assembly 130 a user may wish to use. For example, if a control assembly 130 is provided as a radio or infra-red linked electronically-controlled embodiment, then the control assembly may not include a dosage knob 132, a dosage window 134, and/or a dispense button 136. In some embodiments, a control assembly 130 may include a shaft 380. In some cases, and as explained elsewhere herein (e.g. with reference to
As depicted in
The viewing assemblies depicted in
According to some embodiments, a viewing assembly can be fabricated from a polycarbonate material. Such embodiments may be advantageous over embodiments using ethylene bis-stearamide (EBS) viewing assemblies, as EBS may tend to absorb oil, crack, or otherwise become defective during use, particularly during use with Cannabis preparations.
According to some embodiments, the dispenser tip depicted in
In some embodiments,
In this illustration, aspects of the dispenser device 1100 are shown in an unassembled state. In some embodiments, the term “cartridge and housing assembly” 940 can refer to the combination of the viewing assembly 1150 and a cartridge subassembly (e.g. vial assembly 1140 and dispenser tip 1160). In some embodiments, the viewing assembly 1150 depicted here may be referred to as a reusable holder for a vial. In some cases, dispenser device 1100 can be provided as a reusable device. As shown here, a control assembly 1130 can include a control assembly coupling mechanism 1137, such as a threaded section, where the control assembly coupling mechanism 1137 is configured to secure or couple the control assembly 1130 with the viewing assembly 1150 (e.g. via a viewing assembly coupling mechanism, such as viewing assembly coupling mechanism 159A depicted in
According to some embodiments, dispenser device 1100 is manufactured, sold, or otherwise provided to be a single-use dispenser device. In some cases, a junction between a control assembly or actuator assembly 1130 and a cartridge and housing assembly 940 can be made permanent using gluing or fusing techniques, including without limitation techniques such as ultrasonic welding, adhesives, fixtures, and the like. In some cases, the control assembly 1130 may be non-resettable.
A control assembly 1130 of the dispenser device 1100 may include or be coupled with a pocket clip 1112 that allows a user to clip the dispenser system 1100 to a pocket or a strap. Clip 1112 can include an elongate arm having one end 1112A coupled to the control assembly 1130 and an opposite free end 1112B that cantilevers away from the control assembly 1130 to create a space for receiving a material thereby clipping the control assembly 1130 to the material. By virtue of this configuration, the dispenser device 1100 can be stored in a pocket of a user's garment (e.g. shirt, jacket, pants) in a “tip down” orientation, whereby the exit port of the dispenser tip 160 is facing toward the ground.
According to some embodiments, the term “actuator assembly” may refer to the control assembly 1130. In some cases, the actuator assembly can refer to a subassembly of the complete pen assemblage 1100 that incorporates and secures the mechanism that provides the motive force for the stopper in the vial assembly. In practice, such an actuator mechanism may be fully mechanical in nature, or may be a hybrid of mechanical and electrical means. In some cases, the actuator mechanism or control assembly may include features of one or more of U.S. Pat. No. 5,456,672 (Diederich), U.S. Pat. No. 5,879,336 (Brinon), U.S. Pat. No. 6,957,752 (Py), 7,018,364 (Giambattista), U.S. Pat. No. 7,828,231 (Harms), U.S. Pat. No. 8,608,708 (Cowe), and U.S. Pat. No. 9,108,003 (Forstreuter), and U.S. Patent Publication No. 2017/0100738 (Kendziorek), the contents of each of which are incorporated herein by reference, so as to enable for the delivery of a controlled, fixed, and/or metered amount of a preparation.
The control assembly 1130 can include a fixed-amount setting selection mechanism such as a dosage knob 1132 that can be adjusted to select a fixed-amount (amount to be dispensed) of preparation. In some cases, the fixed-amount setting selection mechanism may be something other than a knob. In some cases, for example in the instance of an electronic version of a dispenser device, a radio-link or infra-red link to a smartphone or other electronic device could be used (instead of a dosage knob) to set the fixed-amount. In some cases, a control assembly may be of an electronic design in part or in full, and a dispense button or fixed-amount activation button 1136 may omitted in favor of using a radio-link or infra-red link to a smartphone or other electronic device for activation and delivery of the fixed-amount. In some cases, a dispenser device can be configured to be controlled by or in communication with a software application or other programming mechanism, whereby data can be collected for verifiable analytics.
In use, the operator can press the dispense button 1136, which may also be referred to as a fixed-amount dispense button, so as to cause the dispenser device 1100 to expel a fixed-amount in the amount as set by the fixed-amount setting. While certain embodiments disclosed herein show such fixed-amount dispensing mechanisms located at the top or proximal portion of a control assembly, such fixed-amount activation mechanisms may be located elsewhere, such as at a central portion of a control assembly or at a distal portion of a control assembly.
The main body 1120 may include a viewing assembly 1150 having a viewing window or material-level sight window 1152. A viewing window 1152 can be used by an operator to perform a visual check of the remaining amount of preparation or liquid disposed in a vial (not shown), which may be aided by a view of the position of the vial stopper (not shown), which may be colored so to assist the user visually. In some embodiments, a viewing or sight window 1152 can be a single cut-out of the viewing assembly 1150. As discussed elsewhere herein, the viewing assembly 1150 can house at least a portion of a cartridge subassembly.
As noted above, the term “cartridge and housing assembly” can refer to the combination of the viewing assembly 1150 and a cartridge subassembly. In some cases, a cartridge and housing assembly includes a vial (which may be filled with a preparation such as a liquid to be dispensed), the dispenser tip for dispersal of the preparation or liquid, a stopper or piston part that is inserted at the proximal portion or base of the vial which in turn is pressed to cause the release of the preparation or liquid, and any functional and/or decorative plastic, wood, ceramic, or metallic housing.
As shown in
According to some embodiments, the term “cap assembly” can refer to a subassembly that fits over a portion, or even a majority (e.g. greater than 50%) of a cartridge and housing assembly when the dispenser device is stored or otherwise not in use. In some cases, a cap subassembly can operate to protect the tip or distal portion of the dispenser device. In some cases, one or more aspects of a cap assembly can operate to provide a decorative function. In some cases, one or more aspects of a cap assembly can operate to provide a securement function. In some cases, a cap assembly can include a cap such as cap 110 depicted in
As depicted in
In some embodiments, dispenser tip 2000 can be configured so that surface 620 provides a surface that at least in part provides a liquid-tight or fluid-tight seal with a vial. In some cases, surface 620 can be configured for insertion into a distal aperture of a vial, as discussed elsewhere herein. In some cases, the distal aperture of the vial includes a tapered surface that is complementary (e.g. in a geometrical manner) to a taper of surface 620.
In some cases, dispenser tip may include an inside groove 630, which may be molded into a surface of the dispenser tip 2000. Inside groove 630 can be shaped or configured to mate to and against a molded rim of a vial. In some embodiments, inside groove 630 may be part of a snap-on cap 640 of dispenser tip 2000. Snap-on cap 640 may be configured or shaped to slip-over and lock onto a molded rim of a vial. When dispenser tip 2000 and a vial are joined together by the snap on mating of a molded rim of the vial, and the snap-on cap 640 of dispenser tip 2000, the resulting snap-on connection operates to hold pressure on the associated surfaces 620 of dispenser tip 2000, and an entry port or distal aperture of a vial. The pressure in turn can operate to maintain or help maintain a leak-tight seal of a cartridge subassembly, between the vial and the dispenser tip. As depicted in
According to some embodiments, when surface 620 and a corresponding surface of a vial distal aperture of entry port are mated and held together, they can form a leak-tight junction. In some embodiments, other leak-tight configurations can be provided whereby a dispenser tip and a vial are mated or otherwise engaged with one another.
According to some embodiments, during operation of a dispenser device, a fixed amount of preparation (e.g. fluid or liquid) exits out of the exit port 3112 of the dispenser tip 3000. As shown here, the exit port 3112 is provided as an aperture that is generally circular in shape. Embodiments of the present invention encompass other configurations of an exit port shape, including elliptical shapes, square shapes, rectangular shapes, and the like. As discussed elsewhere herein, a portion of the nozzle 3110 can extend distally from a vial holder when the dispenser device is in an assembled state, or when the dispenser tip 3000 is otherwise engaged or in contact with the vial holder. In some cases, the length of the nozzle 3110 section which protrudes or extends distally from and externally to the vial holder is about 100 mils (100 thousandths of an inch). According to some embodiments, dispenser tip 3000 is configured so that it does not mate with or accommodate a needle (e.g. tissue-piercing needle). In some cases, the exit port 3112 provides an opening that is of a smaller diameter than that necessary to mate with a needle. According to some embodiments, when a dispenser device is used to dispense a fluid or liquid, the fluid or liquid is expelled as a non-drip forming stream exiting the exit port 3112.
It is appreciated that dispenser tip or molded tip part 3000 can be manufactured using materials other than plastic, such as rubber, silicone, wood, metal, or even a fluoropolymer such as Teflon. It is also appreciated that the dispenser tip 3000, which may be provided as a single piece molded tip part, may be modified to consist of multiple pieces. By means of example, but not of limitation, the nozzle or dispensing end 3110 of the dispenser tip 3000 or molded tip part could be designed to be made of stainless steel or any other metal, thus increasing the durability of the nozzle 3110.
According to some embodiments, the instant application discloses an ornamental design for a dispenser as shown in
In some embodiments, the overall size of the housing 1270 allows for an electric motor drive and electronic control system, possible with a microprocessor, to be part of or incorporated into the dispenser device 1200. In some embodiments, control circuitry of the dispenser device 1200 could incorporate radio circuitry or infra-red circuitry to establish a link to a digital controller. For example, but not by means of limitation, such digital controller could be a custom device, smartphone, a tablet, or a computer; and the associated communications may be direct, or thru the internet or other digital or analogue communications medium. In some embodiments, aspects of the dispenser device 1200, such as the housing 1270, can be configured for use with a stand (e.g. to be held by a stand). Relatedly, in some cases, the dispenser device 1200 can be supported by a stand, above a glass or mug, for use in the home or office.
In some cases, any of the dispenser device embodiments disclosed herein may include a biometric security feature (e.g. iris recognition mechanism, fingerprint recognition mechanism, voice recognition mechanism, and the like). Such features can be used in combination with an application software (e.g. mobile app) that can be used to secure the dispenser device, and/or to prevent the dispenser device from dispensing a preparation (e.g. medicament) to a person other than the patient or intended user.
According to some embodiments, the viewing assembly depicted in
According to some embodiments, the instant application enables a claim for an ornamental design for a viewing assembly for a dispenser device as shown in
In some embodiments,
According to some embodiments, the viewing assembly depicted in
In some embodiments,
Any broken or dashed lines present in
Cannabis and Other Preparations
As discussed elsewhere herein, a preparation (e.g. preparation 144 as depicted in
In exemplary embodiments, preparation 144 may include one or more substances derived from a Cannabis plant (e.g. Cannabis indica, Cannabis sativa, or Cannabis ruderalis). Derived substances may include cannabinoids, terpenes, and flavonoids. According to some embodiments, these, and other derivatives or compounds obtained from a Cannabis plant, may be referred to generically as Cannabis constituents.
Cannabinoids are a unique class of compounds associated with the Cannabis plant. According to some embodiments, Cannabis cannabinoids may include cannabichromenes such as cannabichromene (CBC), cannabichromenic acid (CBCA), cannabichromevarin (CBCV), and cannabichromevarinic acid (CBCVA). According to some embodiments, cannabinoids may include cannabicyclols such as cannabicyclol (CBL), cannabicyclolic acid (CBLA), and cannabicyclovarin (CBLV). According to some embodiments, cannabinoids may include cannabidiols such as cannabidiol (CBD), cannabidiol monomethylether (CBDM), cannabidiolic acid (CBDA), cannabidiorcol (CBD-C1), cannabidivarin (CBDV), and cannabidivarinic acid (CBDVA). According to some embodiments, cannabinoids may include cannabielsoins such as cannabielsoic acid B (CBEA-B), cannabielsoin (CBE), and cannabielsoin acid A (CBEA-A). According to some embodiments, cannabinoids may include cannabigerols such as cannabigerol (CBG), cannabigerol monomethylether (CBGM), cannabigerolic acid (CBGA), cannabigerolic acid monomethylether (CBGAM), cannabigerovarin (CBGV), and cannabigerovarinic acid (CBGVA). According to some embodiments, cannabinoids may include cannabinols and cannabinodiols such as cannabinodiol (CBND), cannabinodivarin (CBVD), cannabinol (CBN), cannabinol methylether (CBNM), cannabinol-C2 (CBN-C2), cannabinol-C4 (CBN-C4), cannabinolic acid (CBNA), cannabiorcool (CBN-C1),and cannabivarin (CBV). According to some embodiments, cannabinoids may include cannabitriols such as 10-Ethoxy-9-hydroxy-delta-6a-tetrahydrocannabinol, 8,9-Dihydroxy-delta-6a-tetrahydrocannabinol, cannabitriol (CBT), and cannabitriolvarin (CBTV). According to some embodiments, cannabinoids may include delta-8-tetrahydrocannabinols such as delta-8-tetrahydrocannabinol (Δ8-THC), and delta-8-tetrahydrocannabinolic acid (Δ8-THCA). According to some embodiments, cannabinoids may include delta-9-tetrahydrocannabinols such as delta-9-tetrahydrocannabinol (THC), delta-9-tetrahydrocannabinol-C4 (THC-C4), delta-9-tetrahydrocannabinolic acid A (THCA-A), delta-9-tetrahydrocannabinolic acid B (THCA-B), delta-9-tetrahydrocannabinolic acid-C4 (THCA-C4), delta-9-tetrahydrocannabiorcol (THC-C1), delta-9-tetrahydrocannabiorcolic acid (THCA-C1), delta-9-tetrahydrocannabivarin (THCV), and delta-9-tetrahydrocannabivarinic acid (THCVA). According to some embodiments, cannabinoids may include other cannabinoids such as 10-Oxo-delta-6a-tetrahydrocannabinol (OTHC), cannabichromanon (CBCF), cannabifuran (CBF), cannabiglendol, cannabiripsol (CBR), cannabicitran (CBT), dehydrocannabifuran (DCBF), delta-9-cis-tetrahydrocannabinol (cis-THC), tryhydroxy-delta-9-tetrahydrocannabinol (triOH-THC), and 3,4,5,6-Tetrahydro-7-hydroxy-alpha-alpha-2-trimethyl-9-n-propyl-2,6-methano-2H-1-benzoxocin-5-methanol (OH-iso-HHCV). In some cases, certain cannabinoids obtained from raw or live Cannabis can be converted by a decarboxylation process to provide different cannabinoids. For example, tetrahydrocannabinolic acid (THCA) obtained from raw or live Cannabis can be converted by a decarboxylation process to provide tetrahydrocannabinol (THC). Similarly, cannabidiolic acid (CBDA) obtained from raw or live Cannabis can be converted by a decarboxylation process to provide cannabidiol (CBD).
Terpenes are aromatic compounds associated with the Cannabis plant. According to some embodiments, Cannabis terpenes may include myrcene, linalool, pinene, limonene, β-caryophyllene, α-humulene, ocimene, terpinolene, geraniol, terpineol, valencene, phellandrene, carene, fenchol, terpinene, borneol, bisabolol, camphene, phytol, camphor, sabinene, isoborneol, menthol, nerolidol, cedrane, isopulegol, cymene, pulegone, eucalyptol, geranyl acetate, and guaiol.
Flavonoids are secondary metabolites associated with the Cannabis plant. According to some embodiments, Cannabis flavonoids may include cannflavine A, cannflavine B, cannflavine C, vitexin, isovitexin, apigenin, kaempferol, quercetin, luteolin, and orientin.
THC is probably best known for being the main psychoactive ingredient in Cannabis. CBD, however, is generally considered to be non-psychoactive. In some cases, it may be desirable to provide a user or consumer with a particular combination of Cannabis constituents within a preparation. For example, it may be desirable to provide a user or consumer with a preparation having a CBD:THC ratio of 1:1. In other instances, it may be desirable to provide a user or consumer with a preparation having a CBD:THC ratio of 10:1. Embodiments of the present invention encompass preparations having any desired ratio and/or combination of Cannabis constituents.
Consumers, patients, and other individuals may prefer and/or require individual Cannabis constituents (e.g. cannabinoid, terpene, and/or flavonoid compounds) to be delivered in a specific relationship with each other in order to administer a desired dose.
In some cases, a preparation may include an active ingredient, such as a botanical active ingredient. In some cases, a preparation may include an inactive ingredient. In some cases, a preparation may include a cannabinoid. In some cases, a preparation may include one or more of: cetirizine, ibuprofen, naproxen, omeprazole, doxylamine, diphenhydramine, melatonin, or meclizine. In some cases, a preparation may include one or more of: a polyphonel, short chain fatty acids, medium chain fatty acids, long chain fatty acids, a green tea catechin, caffeine, a phenol, a glycoside, a labdane diterpenoid, yohimbine, a proanthocyanidin, terpene glycoside, an omega fatty acid, echinacoside, an alkaloid, isovaleric acid, a terpene, gamma-aminobutyric acid, a senna glycoside, cinnamaldehyde, or any vitamin such as Vitamin D.
According to some embodiments, a preparation may include a Cannabis infusion, such as an extract obtained by soaking the leaves or other parts of a Cannabis plant in a liquid. In some cases, a preparation may include a water soluble liquid compound that is a cannabinoid oil or a terpene. Typically, cannabinoids (e.g. CBD, THC, and the like) are hydrophobic substances. Cannabinoids can, however, be formulated to be water-compatible and appear water-soluble. For example, CBD, THC, and other oils can be made water-compatible if they are formulated as oil-in-water nanoemulsions, which are stable and visually homogeneous oil/water mixtures. Nanoemulsions can be prepared in concentrated forms (e.g. tens of mg/ml) that are fully miscible with water and, therefore, appear water-soluble. In addition, nanoemulsions can be made translucent and practically tasteless, which means that they can be mixed into water without compromising its optical clarity or taste. According to some embodiments, nanoemulsions can be beneficial because they can be easily mixed into beverages, translucent, low-taste, and safe for consumption. Nanoemulsions can also provide exceptionally high bioavailability, fast onset of action, stable blood levels and high CBD/THC loading capacities. Embodiments of the present invention encompass mechanical dispensing devices used in combination with nanoemulsion technology to provide a precise, high water soluble, and bioavailable product for the oral consumption of constituents such as Cannabis oils.
As discussed elsewhere herein, a preparation (e.g. preparation 144 as depicted in
Micro-Dosing
According to some embodiments, it may be desirable to precisely control the amount of one or more Cannabis constituents, or other compounds or molecules, that are being dispensed from a dispensing device. Embodiments of the present invention enable the user or individual to precisely vary or control the quantity of cannabinoids (or other compounds or molecules) that are dispensed from a dispensing device. For example, the quantity of a preparation or fluid that is dispensed from a dispensing device may be varied by changing the dose settings of the dispensing device. The user or healthcare professional may then select the most appropriate micro-dosing quantity for a particular treatment regime. The ability to control the dose of one cannabinoid (such as THC) to a custom level or mixture of cannabinoids (such as CBD) may give the healthcare professionals and users the flexibility to titrate the Cannabis constituents and/or other compounds or molecules upward or downward with more precision. In this way, for example through an iterative process, the user or individual is able to discover a minimum amount or dosage of a Cannabis preparation that provides the desired result.
According to some embodiments, the micro-dosing of Cannabis constituents involves taking a very measured micro-dose of THC, which is typically considered to be a psychoactive ingredient in Cannabis, and a measured dose of CBD, which is typically considered to be a non-psychoactive ingredient in Cannabis. Toward this end, vials containing Cannabis preparations can be provided which contain known amounts, ratios, and/or concentrations of Cannabis constituents. For example, a vial may contain 3 ml of a preparation that contains THC at a concentration of 25 mg/ml and CBD at a concentration of 100 mg/ml. When a dispensing device is used to dispense 0.20 ml (milliliter) of the preparation (e.g. 20 clicks), the user or individual will know that the dispensed amount contains 5 mg of THC and 20 mg of CBD. In some cases, vials or vial assemblies can be provided as pre-mixed or pre-prepared vial assemblies. According to some embodiments, vials can be prepared so as to contain one or more Cannabis constituents, in any desired combination, in any desired amount or ratio of amounts.
Because precise micro-dose amounts can be accurately dispensed using the dispensing devices and methods as disclosed herein, it is possible for users or individuals to obtain the desired dosage in an economical fashion while also minimizing waste and avoiding inadvertent or unwanted overdosing of the Cannabis constituents and/or other compounds or molecules.
Embodiments of the present invention are well suited for use in delivering a dose or an amount of a preparation for consumption by an individual or user. Any aspect of the preparation, including for example the concentration or amount of one or more Cannabis constituents contained therein, can be designed as desire. In some cases, the formulation and/or amount of the preparation to be consumed is based on a therapeutic relationship amongst one or more components of the preparation. In some case, a therapeutic relationship can be determined between individual cannabinoid compounds, and a dispenser device can help ensure that a patient/user receives an optimum therapeutic dose without the inherent risks associated with bottle droppers, smoking, vaping, or edibles. In some cases, a preparation may include one or more cannabinoids and/or terpenes present in water soluble fluids that make it easy to dispense, dissolve, and mix into beverage of choice.
Table 1 below illustrates the operability of exemplary dispenser device configurations, according to embodiments of the present invention.
In some cases, a control assembly can include a clicking mechanism, which is configured to provide the user with audible and/or tactile feedback, to assist the user in controlling how much preparation is dispensed with each click. In some cases, a dispenser device is configured to dispense 1/100 of milliliter of preparation per click. In some cases, a dispenser device is configured to dispense less than a drop (e.g. a droplet) of preparation per click. In some cases, a dispenser device is configured to dispense the contents of a vial upon actuation of 100 clicks. In some cases, a dosage amount of 2.5 mg or less of Cannabis constituent is considered to be a micro-dose. In some cases, a dosage amount on the order of micrograms is considered to be an ultra-micro-dose.
In some cases, a dispenser device can include or be used with a 3 ml vial filled with a Cannabis extraction oil formulated for oral and sublingual dosing. In some cases, a vial may include 90 mg of active cannabinoids, optionally infused with terpenes and/or nutraceuticals, to provide an entourage effect. Micro-dosing embodiments disclosed herein may be used by individuals having various conditions, including depression, stress, anxiety, pain, and the like. Micro-dosing embodiments disclosed herein may be used by individuals seeking improved mental focus and/or sleeping patterns. As described elsewhere herein, a vial may contain 3 ml of a preparation that contains cannabinoid content at a concentration of 25 mg/ml or 100 mg/ml, for example. In some cases, a vial may contain 3 ml of oil and 100 mg THC. In some cases, a vial may contain a cannabinoid concentration of about 100 mg per 3 ml of oil or other carrier. In some cases, a vial may contain a cannabinoid concentration of about 100 mg per ml of oil or other carrier. In some cases, a vial may contain a cannabinoid concentration having a value within a range from about 0.3 mg per ml of carrier to about 500 mg per ml of carrier. In some cases, a vial may include cannabinoid content having within a range of about 1 mg to about 1500 mg. In some cases, the cannabinoid content includes active cannabinoids. In some cases, the cannabinoid content contained within a vial may have a value of about 1.5 ml, or less. In some cases, a 3 ml vial may include 1.5 ml of cannabinoids, and 1.5 ml of carrier or blending oil, which may be olive oil or medium-chain triglyceride (MCT) oil.
In the Summary above and in this Detailed Description, and the claims below, and in the accompanying drawings, reference is made to particular features of embodiments of the present invention. It is to be understood that the disclosure of the embodiments of the invention in this specification includes all possible combinations of such particular features. For example, where a particular feature is disclosed in the context of a particular aspect or embodiment of the invention, or a particular claim, that feature can also be used, to the extent possible, in combination with and/or in the context of other particular aspects and embodiments of the invention, and in the invention generally.
The term “at least” followed by a number is used herein to denote the start of a range including that number (which may be a range having an upper limit or no upper limit, depending on the variable being defined). For example, “at least 1” means 1 or more than 1. The term “at most” followed by a number is used herein to denote the end of a range, including that number (which may be a range having 1 or 0 as its lower limit, or a range having no lower limit, depending upon the variable being defined). For example, “at most 4” means 4 or less than 4, and “at most 40%” means 40% or less than 40%. When, in this specification, a range is given as “(a first number) to (a second number)” or “(a first number)-(a second number),” this means a range whose limits include both numbers. For example, “25 to 100” means a range whose lower limit is 25 and upper limit is 100, and includes both 25 and 100.
Although the preceding description contains significant detail in relation to the preferred embodiment, it should not be construed as limiting the scope of the invention but rather as providing illustrations of the preferred embodiments.
All features of the described systems and devices are applicable to the described methods Mutatis mutandis, and vice versa. Embodiments of the present invention encompass kits having child-resistant safety container systems as disclosed herein. In some embodiments, the kit includes one or more container systems, along with instructions for using the system for example according to any of the methods disclosed herein.
Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, one of skill in the art will appreciate that certain changes, modifications, alternate constructions, and/or equivalents may be practiced or employed as desired, and within the scope of the appended claims. In addition, each reference provided herein in incorporated by reference in its entirety to the same extent as if each reference was individually incorporated by reference. Relatedly, all publications, patents, patent applications, journal articles, books, technical references, and the like mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, patent application, journal article, book, technical reference, or the like was specifically and individually indicated to be incorporated by reference.
This application is a continuation-in-part of application Ser. No. 29/690,976 filed May 13, 2019, the content of which is incorporated herein by reference.
| Number | Date | Country | |
|---|---|---|---|
| Parent | 29690976 | May 2019 | US |
| Child | 16712264 | US |
