Claims
- 1. A cosmetic or pharmaceutical composition comprising a dispersion, in an aqueous medium D suitable for topical application to the skin and nails, of lipid spherules constituted by organized molecular layers encapsulating in aqueous phase E, the constituent lipid of the said layers being nonionic amphiphiles, wherein the lipidic phase itself of the said spherules is combined with at least one lipoprotein free from any sulphydryl functional group and chosen from mono- or polyacrylated derivatives of amino acids or of polypeptides in which the acyl reside R--CO contains a C.sub.13 -C.sub.19 hydrocarbon chain R, at least one of the functional groups which connects the polypeptide chain on the amino acid residue to the lipoprotein chain being amide functional group, it being possible for the carboxylic functional groups of the polypeptide chain or of the amino acid residue to be partially or completely neutralized by one or more alkali metal cations, or an ammonium ion or substituted ammonium ion derived from an amine, the said lipoprotein being present in a proportional of 1 to 15% by weight relative to the total weight of the said lipid phase itself.
- 2. Composition according to claim 1, characterized in that the acyl residue of the lipoproteins employed is chosen from the myristoyl, palmitoyl, stearoyl, oleoyl, linoleoyl and linolenoyl residues.
- 3. Composition according to claim 1, characterized in that the nonionic amphiphile lipids are taken from the group consisting of:
- linear or branched polyglycerol ethers, of formulae, ##STR19## respectively, n being a mean statistical value of between 1 and 6, R.sub.4 denoting a saturated or unsaturated, linear or branched aliphatic chain containing 12 to 30 carbon atoms, the hydrocarbon radicals of lanoline alcohols or the 2-hydroxyalkyl residues of long-chain .alpha.-diols;
- linear or branched polyglycerol ethers containing two fatty chains;
- polyoxyethylenated fatty alcohols or polyoxyethylenated sterols;
- polyol ethers;
- esters of polyols, oxyethylenated or otherwise;
- glycolipids of natural or synthetic origin;
- the hydroxyamides denoted by the formula: ##STR20## in which formula: R.sub.1 denotes a C.sub.7 -C.sub.21 alkyl or alkenyl radical;
- R.sub.2 denotes a C.sub.7 -C.sub.31 saturated or unsaturated hydrocarbon radical;
- COA denotes a group chosen from the following two groups:
- a residue ##STR21## B being a radical derived from mono- or polyhydroxylated primary or secondary amines and R.sub.3 denoting a hydrogen atom or a methyl, ethyl or hydroxyethyl radical;
- COOZ, Z denoting the residue of a C.sub.3 -C.sub.7 polyol.
- 4. Composition according to claim 1, characterized in that the amphiphiles intended to form the spherules are combined with additives taken from the group consisting of long-chain alcohols and diols, of sterols, of long-chain amines, of hydroxyalkylamines, of polyoxyethylenated fatty amines, of long-chain amino alcohol esters, and their salts, of phosphoric esters of fatty alcohols, of alkyl sulphates, and of ionic sterol derivatives.
- 5. Composition according to claim 1, characterized in that it contains from 0.5 to 25% by weight of amphiphile constituting the walls of spherules, these percentages being expressed on a weight basis relative to the total weight of the composition.
- 6. Composition according to claim 1 characterized in that the walls of said spherules contain at least one liposoluble substance selected from the group consisting of a keratolytic agent, an anti-inflammatory agent and an antioxidant agent.
- 7. Composition according to claim 1, characterized in that the aqueous phase E encapsulated in the spherules is an aqueous solution of an active substance, isoosmotic relative to the phase D which surrounds the spherules.
- 8. Composition according to claim 7, characterized in that the aqueous phases D and E are identical.
- 9. Composition according to claim 7, characterized in that the aqueous phase E or the outer aqueous phase D contains at least one water-soluble cosmetic substance taken from the group consisting of humectants, artificial tanning agents, skin coloring agents, antisolar agents, sunscreens, antiperspirant agents, deodorants, astringents, freshening products, tonic products, cicatrizing products, keratolytic products, depilatory products, perfumed waters, water-soluble colorants, antidandruff agents, antiseborrhoeic agents, oxidizing agents, reducing agents and animal or plant tissue extracts.
- 10. Composition according to claim 7, characterized in that the aqueous phase E or the outer aqueous phase D contains at least one product taken from the group consisting of vitamins, hormones, enzymes, vaccines, antiinflammatories, antibiotics and bactericides.
- 11. Composition according to claim 1, characterized in that at least on water-immiscible liquid phase L is dispersed in the aqueous phase D.
- 12. Composition according to claim 11, characterized in that it contains from 2 to 70% by weight of water-immiscible liquid phase L relative to the total weight of the composition, the relative weight proportion of amphiphile lipid constituent of spherules relative to the dispersed water-immiscible liquid phase being between 0.02/1 and 10/1.
- 13. Composition according to claim 11, characterized in that the water-immiscible liquid phase L dispersed in the aqueous phase D is chosen from the group consisting of esters of fatty acids and of polyols, and esters of fatty acids and of branched alcohols of formula R.sub.5 --COOR.sub.6, in which formula R.sub.5 denotes the residue of a higher fatty acid containing from 7 to 19 carbon atoms and R.sub.6 denotes a branched hydrocarbon chain containing from 3 to 20 carbon atoms, hexadecane, liquid paraffin or perhydrosqualene, perfluorodecahydronaphthalene, perfluorotributylamine, polysiloxanes, organic acid esters, ethers and polyethers.
- 14. Composition according to claim 11, characterized in that the phase L contains at least one of a perfume or a liposoluble active substance.
- 15. Composition according to claim 14, characterized in that the liposoluble substance consists of a sunscreen, a substance intended to improve the condition of dry or senile skins or an antioxidant.
- 16. Composition according to claim 1, characterized in that the aqueous phase D contains at least one adjuvant taken from the group consisting of opacifiers, gelling agents, flavors, perfumes, sunscreens, and colorants.
- 17. The composition of claim 1 wherein said nonionic amphiphiles are of natural or synthetic origin, containing, per molecule, one or more hydrophilic groups selected from hydroxyl, ether, carboxyl, phosphate and amine groups.
- 18. A cosmetic or pharmaceutical composition comprising a dispersion, in an aqueous medium D, suitable for topical application to the skin and nails, of lipidic spherules constituted by organized molecular layers encapsulating an aqueous phase E, the constituent lipid of said layers being nonionic amphiphiles wherein the lipid phase itself of said spherules is combined with at least one lipoprotein free from any sulphydryl functional group, said lipoprotein being selected from a mono- or polyacylated derivative of collegen or hydroxyproline wherein the acyl residue R--CO contains a C.sub.13 -C.sub.19 hydrocarbon chain, at least one of the functional groups which connects the collagen chain or hydroxyproline residue to the lipophile chain being an amide functional group, it being possible for the carboxylic functional groups of the collagen chain or hydroxyproline residue to be partially or completely neutralized by one or more alkali metal cations, or an ammonium ion or substituted ammonium ion derived from an amine, the said lipoprotein being present in an amount ranging from 1 to 15 percent by weight relative to the total weight of the said lipidic phase itself.
- 19. A cosmetic or pharmaceutical composition comprising a dispersion, in an aqueous medium D suitable for topical application to the skin and nails, of lipidic spherules constituted by organized molecular layers encapsulating an aqueous phase E, the constituent lipid of said layer being nonionic amphiphiles wherein the lipidic phase itself of said spherules is combined with at least one lipoprotein free from any sulphydryl functional group, said lipoprotein being selected from the group consisting of collagenic palmitoyl lipoamino acid, the O,N-dipalmitoyl derivative of hydroxyproline, hydroxyproline linoleate, sodium steroylglutamate, collagen stearoyl tripeptide, collagen oleoyl tetrapeptide and collagen oleoyl pentapeptide, it being possible for the carboxylic residue functional groups of the collegan chain or hydroxyproline residue of said lipoprotein to be partially or completely neutralized by one or more alkali metal cations, or an ammonium ion or substituted ammonium ion derived from an amine, the said lipoprotein being present in an amount ranging from 1 to 15 percent by weight relative to the total weight of the said lipidic phase itself.
Priority Claims (1)
Number |
Date |
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Kind |
86 05776 |
Apr 1986 |
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Parent Case Info
This is a continuation of application Ser. No. 07/146,133 filed as PCT/FR87/00128 on Apr. 17, 1987, now abandoned.
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Continuations (1)
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Number |
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Parent |
146133 |
Dec 1987 |
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