Claims
- 1. A process for preparing a dispersion polymer comprising the steps of:
- (a) adding an emulsifier and a free-radical initiator to an aqueous seed dispersion of latex having a particle diameter of 0.02 .mu.m to 2 .mu.m; and
- (b) adding dropwise with stirring at a temperature in the range of 10.degree. C. to 120.degree. C. to the seed dispersion containing the emulsifier and the initiator a monomer of Formula I ##STR4## in which n denotes 1-6;
- R.sub.1 denotes H or CH.sub.3 ;
- R.sub.2 and R.sub.3 are identical or different and denote --(CH.sub.2).sub.m --CH.sub.3, and
- m denotes 0-7, or ##STR5## in which X, Y and Z denote (CH.sub.2).sub.p --CH.sub.3 and
- p denotes 1-3, where
- X, Y and Z are identical or different, and a monomer of Formula II ##STR6## in which R denotes 0 or NH;
- n denotes 1-3;
- m denotes 1-4;
- l denotes 0-4; and
- R.sub.1 denotes H or CH.sub.3
- to form a dispersion polymer comprising latex particles and a copolymer of Formula I and II formed on the surface of the particle.
- 2. The process of claim 1, wherein mono- or di-hydroxyalkylacrylic or methacrylic compounds are employed as monomers of the formula II.
- 3. The process of claim 1, wherein at least one of the compounds N-2,3-dihydroxypropylmethacrylamide, N-2-hydroxypropylmethacrylamide, 2-hydroxypropyl methacrylate, N-2,3-dihydroxypropylacrylamide, N-2-hydroxypropylacrylamide or ethyl 2-hydroxypropylacrylate are employed as monomers of the formula II.
- 4. The process of claim 1, wherein acrylamidoalkyl or methacrylamidoalkyl aldehyde di-alkyl acetal wherein alkyl denotes C.sub.2 to C.sub.8 are employed as monomers of the formula I.
- 5. The process of claim 1, in which methacrylamido acetaldehyde di-n-pentyl acetal is used as monomers of the Formula I.
- 6. The process of claim 1, wherein the mixture of monomers contains, as the compound of the formula II, N-2,3-dihydroxypropylmethacrylamide, N-2-hydroxypropylmethacrylamide, 2-hydroxypropyl methacrylate or the corresponding acrylic compounds, and acrylamidoalkyl or methacrylamidoalkyl acetaldehyde di-n-pentyl acetal is employed as compound of the formula I.
- 7. The process of claim 1, wherein the mixture of monomers additionally contains up to 30% by weight, based on the total mixture, of styrene, vinylnapthalene or vinyltoluene.
- 8. The process of claim 1, wherein the mixture of monomers additionally contains up to 30% by weight, based on the total mixture, of methacrylic acid, acrylic acid or crotonic acid.
- 9. The process of claim 1, wherein the mixture of monomers contains, in addition to monomers of the formulae I and II, compounds from the group comprising styrene, vinylnapthalene or vinyltoluene, and one of the compounds methacrylic acids, acrylic acid or crotonic acid, and in addition up to 20% by weight, based on the total mixture, of dimethylformamide.
- 10. The process as claimed in claim 1, wherein the mixture of monomers contains, as compound of the formula II, mono- or dihydroxyalkylacrylic or methacrylic compounds, and acrylamidoalkyl or methacrylamidoalkyl aldehyde dialkyl acetal where alkyl denotes C.sub.2 to C.sub.8 is employed as compound of the formula I.
- 11. A biologically active dispersion polymer, comprising a dispersion polymer obtained by the process of claim 1 and an antibody, an antigen or a hapten bonded thereon.
- 12. A method of diagnostically detecting an antigen, an antibody or a hapten comprising the step of bonding a dispersion polymer obtained by the process of claim 1 to an antigen, an antibody, or a hapten to form a biologically active dispersion polymer.
- 13. The method of claim 12, further comprising the step of detecting the biologically active dispersion polymer by nephelometric, turbidimetric or particle counting methods.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3545595 |
Dec 1985 |
DEX |
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Parent Case Info
This application is a continuation, of application Ser. No. 943,802, filed 12/19/86, now abandoned.
US Referenced Citations (4)
Continuations (1)
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Number |
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943802 |
Dec 1986 |
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