DISSEMINATION AND IMPLEMENTATION CORE PROJECT SUMMARY Digital therapeutics have demonstrated potential to meet service needs and accelerate translation of science to practice. The charge of the Dissemination and Implementation (D&I) Core is to provide education, training, resources, and scientific guidance to advance implementation science and practice for digital therapeutics for SUDs and CODs. Over the past nine years, the D&I Core has supported activities to promote awareness about the science of digital therapeutics for SUDs and CODs through traditional and digital dissemination channels and developed resources to support application of implementation science in digital therapeutic research. Core affiliates have advanced a conceptual understanding of how implementation science can be applied to digital therapeutic research and contributed to the knowledge base of facilitators and barriers to implementation of digital therapeutics for SUDs across a range of populations and settings. In this renewal, the Core will continue to promote awareness about the science of digital therapeutics (Aim 1) through education, mentorship, and expansion of the CTBH digital platform features to promote cumulative knowledge about clinical evidence for digital therapeutics for SUDs and CODs. As new activities, D&I will work with the Center?s Stakeholder Advisory Board to identify the stakeholder information priorities to inform targeted dissemination strategies and will add a feature to the CTBH website to advance cumulative knowledge about digital therapeutic implementation research. The D&I Core will support adoption and implementation of digital therapeutics (Aim 2) through expanding and refining resources to promote application of implementation science in digital therapeutic research, including implementation case studies and a common implementation measurement framework. New in this renewal, the Core will conduct activities to systematically specify strategies that accelerate implementation of digital therapeutics and offer tutorials to foster actionable skills for digital therapeutic implementation research. To support new Center priorities, the Core will also engage affiliates with active later stage digital health projects to include common clinical and implementation metrics to inform methods for scaling of digital therapeutics, contribute training and methods for use of digital therapeutic usage data and other digital assessment in studies to elucidate implementation mechanisms of action and inform adaptive interventions, promote scientific understanding of determinants and strategies associated with implementation of transdiagnostic digital treatments, provide training and resources in digital health ethics with regard to access equity and cultural relevance of digital therapeutics, and support training and methods to increase representation of underrepresented populations in digital therapeutic research. These efforts will advance the state of implementation science and practice for digital therapeutics for SUDs and CODs.