Claims
- 1. A compound selected from the group consisting of:
- A. Disubstituted azabicycloalkanes of the general formula I: ##STR12## wherein: n is 1;
- R is selected from the group consisting of saturated and unsaturated aliphatic hydrocarbon having from 1 to 5 carbon atoms inclusive in straight and branched chain, and,
- X.sub.1, x.sub.2, x.sub.3, x.sub.4 and X.sub.5 are each selected from the group consisting of hydrogen, halogen, hydroxy, alkyl and alkoxy each having from 1 to 5 carbon atoms inclusive, trifluoromethyl, nitro, amino, and sulfamoyl, and,
- B. Physiologically tolerable acid addition salts thereof.
- 2. A compound of claim 1, which is N-ethyl-2-(2-methoxy-5-sulfamoyl benzamido methyl)-3-azabicyclo (3,3,0) octane.
- 3. A compound of claim 1 which is N-allyl-2-(2-methoxy-5-sulfamoyl benzamido methyl)-3-azabicyclo (3,3,0) octane.
- 4. A compound of claim 1 which is N-ethyl-2-(2-methoxy-4-amino-5-chloro benzamido methyl)-3-azabicyclo (3,3,0) octane.
- 5. A compound of claim 1, which is N-(2-methyl-2-propenyl)-2-(2-methoxy-5-sulfamoyl benzamido methyl)-3-azabicyclo (3,3,0) octane.
- 6. A compound of claim 1, which is N-ethyl-2-(2-methyl benzamido methyl)-3-azabicyclo (3,3,0) octane.
- 7. A compound of claim 1, which is N-ethyl-2-(2-amino benzamido methyl)-3-azabicyclo (3,3,0) octane.
- 8. A compound of claim 1, which is N-allyl-2-(2-methoxy-4-amino-5-chloro benzamido methyl)-3-azabicyclo (3,3,0) octane.
- 9. A pharmaceutical composition containing as active principle a compound of claim 1 in an amount of 10 to 200 mg, together with a suitable pharmaceutical carrier.
- 10. A pharmaceutical composition of claim 9, wherein the amount of the active principle is 20 to 100 mg.
- 11. A method for treatiang a living animal body afflicted with a nauseous syndrome of central origin, comprising the step of administering an amount of a compound of claim 1, which is effective for the alleviation of the said condition.
Priority Claims (1)
Number |
Date |
Country |
Kind |
58034/73 |
Dec 1973 |
UK |
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Parent Case Info
This is a division of application Ser. No. 525,623, filed Nov. 20, 1974, now U.S. Pat. No. 3,972,994, issued Aug. 3, 1976.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3972994 |
Beregi |
Aug 1976 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
525623 |
Nov 1974 |
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