Diuretic, hypotensive and antiedemic quinoline oximes

Abstract

A pharmaceutical composition having diuretic, hypotensive and antiedemic effects which contains a 6-halo-4-oximino-1,2,3,4-tetrahydroquinoline derivative or a salt thereof, and a method to use the above-described derivative or a salt thereof as a diuretic, hypotensive and antiedemic agent.

Description

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention relates to a pharmaceutical composition having diuretic, hypotensive and antiedemic effects which contains a 6-halo-4-oximino-1,2,3,4-tetrahydroquinoline derivative or a salt thereof, and a method to use the above-described derivative or a salt thereof as a diuretic, hypotensive and antiedemic agent.

2. Description of the Prior Art

For treatment of hypertension, there have heretofore been frequently employed hypotensors having a nerve blocking effect and a vasodilative effect and diuretic agents having an effect to excrete electrolytes, especially Na.sup.+ and Cl.sup.-, and water.

In addition, when an edema has been generated as the result of the localized retention of water and electrolytes due to the functional depression of the liver, the heart or the like or the disorder of metabolism, diuretic agents have also been employed to excrete the retained extracellular liquid in order to prevent the occurance of secondary diseases.

Under such circumstances, it has been thought that drugs having a combination of a diuretic effect and a hypotensive effect would be more effective for treatment of hypertension and the development of such drugs has thus been sought.

However, there has heretofore been no example of a drug which has such a combination of a diuretic effect and a hypotensive effect without causing trouble for digestive organs and therefore is effective on an edema resulting from the localized retention of water or electrolytes generated by the functional depression of the liver, he heart or the like and the metabolic disorder.

We have now discovered a certain type of 6-halo-4-oximino1,2,3,4-tetrahydroquinoline derivatives have a combination of diuretic and hypotensive effects with reduced side effects and thus achieved this invention.

SUMMARY OF THE INVENTION

According to this invention there is provided a pharmaceutical composition having diuretic, hypotensive and antiedemic effects which contains a 6-halo-4-oximino-1,2,3,4-tetrahydroquinoline derivative of the formula (I): ##STR1## or a salt thereof, wherein X represents a halogen atom, and Y represents a straight-chain or branched-chain alkyl group having 1-4 carbon atoms, a phenyl-substituted lower alkyl group, a phenylalkenyl group, a lower alkoxy group or a lower alkyl-substituted amino group, as a main ingredient.

There is also provided according to this invention a method to use a 6-halo-4-oximino-1,2,3,4-tetrahydroquinoline derivative of the formula (I) or a salt thereof as a diuretic, hypotensive and antiedemic agent.

DESCRIPTION OF THE PREFERRED EMBODIMENT

6-Halo-4-oximino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I): ##STR2## wherein X represents a halogen atom, and Y represents a straight-chain or branched-chain alkyl group having 1-4 carbon atoms, a phenyl-substituted lower alkyl group, a phenylalkenyl group, a lower alkoxy group or a lower alkyl-substituted amino group, which are the main ingredients of the pharmaceutical compositions according to this invention may be produced in general by the following steps:

A p-halogen substituted aniline is acylated with an acylating agent such as .beta.-propiolactone, and then cyclized using an oxidizing agent such as polyphosphoric acid, to obtain a 6-halo-4-oxo-1,2,3,4-tetrahydroquinoline, which is then either reacted with a chloroformate in an inert solvent in the presence of an organic tertiary amine when Y is the above formula (I) is a lower alkoxy group or reacted with an acid anhydride or an acid halide when Y has above meanings other than an alkoxy group. Thereafter, the resulting product is converted into an oxime with hydroxylamine etc., thereby the product of this invention is obtained. (See Japanese Patent application Nos. 103272/1980, 39910/1981 and 39911/1981).

Preparation of the compounds of the formula (I) is illustrated by the following Preparations, in which "parts" is given by weight unless otherwise stated.

Preparation 1

Synthesis of 6-Bromo-4-oximino-1-acetyl-1,2,3,4-tetrahydroquinone (Compound I)

22.61 Parts of 6-bromo-4-oxo-1,2,3,4-tetrahydroquinoline and 13.3 parts of acetic anhydride were mixed and reacted with stirring at 90.degree. C. for 3 hours.

The reaction mixture was poured into 500 ml of water, and the precipitated crystals were filtered out, washed with water, and dried to obtain 23.9 parts of 6-bromo-4-oxo-1-acetyl-1,2,3,4-tetrahydroquinoline.

Then, the above compound was dissolved in 350 ml of ethanol, to which were added 14.6 parts of hydroxylamine hydrochloride and 16.1 parts of pyridine, and the reaction was continued under reflux for 2 hours. The reaction mixture was then poured into 500 ml of water, and the precipitated crystals were filtered out, washed with water, and dried to obtain 24.1 parts of 6-bromo-4-oximino-1-acetyl-1,2,3,4-tetrahydroquinoline as white crystals.

The melting point of this product, when measured by the method stipulated by the Japanese Pharmacopeia, showed 200.degree.-202.5.degree. C. The results of the elemental analysis of this product were as follows:

______________________________________Elemental analysis C H Br N O______________________________________Calculated: 46.64 3.89 28.27 9.89 11.31Found: 46.67 3.84 28.24 9.92 11.33______________________________________

Preparation 2

18.16 Parts of 6-chloro-4-oxo-1,2,3,4-tetrahydroquinoline, 10.3 parts of pyridine and 100 ml of dioxane were mixed and to this stirred mixture was added dropwise 12.3 parts of methyl chloroformate while maintaining the temperature at 0.degree.-5.degree. C. After the addition, the reaction was continued at room temperature for 5 hours.

The reaction mixture was poured into one liter of water, and the precipitated crystals were filtered out, washed with water and then with n-hexane, and dried to obtain 22.0 parts of 6-chloro-4-oxo-1-methoxycarbonyl-1,2,3,4-tetrahydroquinoline.

Then, the above compound was dissolved in 330 ml of ethanol, to which were added 15.0 parts of hydrochloride and 17.0 parts of pyridine, and the reaction was continued under reflux for 2 hours.

The reaction mixture was poured into one liter of water, and the precipitated product was filtered out, washed with water, dried, and recrystallized from ethanol to obtain 19.9 parts of 6-chloro-4-oximino-1-methoxycarbonyl-1,2,3,4-tetrahydroquinoline (CompoundX) as white crystals. The melting point of this product, when measured by the method stipulated by the Japanese Pahrmacopeia, showed 162.degree.-163.degree. C., and the results of the elemental analysis thereof were as follows:

______________________________________Elemental analysis O H Cl N______________________________________Calculated: 51.87 4.32 13.95 11.00Found: 51.85 4.35 13.88 11.02______________________________________

Examples of the 6-halo-4-oximino-1,2,3,4-tetrahydrouqinoline derivatives thus produced and the properties thereof are given in Table 1 below:

TABLE 1__________________________________________________________________________Properties of Respective DerivativesComp. m.p.No. Compound X Y (.degree.C.) Properties__________________________________________________________________________I 6-Chloro-4-oximino- Cl CH.sub.3 214-215.5 White crystalline powder. 1-acetyl-1,2,3,4- Sparingly soluble in water and tetrahydroquinoline hexane; easily soluble in metha- nol, acetone and chloroform.II 6-Chloro-4-oximino- Cl C.sub.2 H.sub.5 166-169 White crystalline powder. 1-propionyl-1,2,3,4- Sparingly soluble in water and tetrahydroquinoline hexane; easily soluble in metha- nol, acetone and chloroform.III 6-Chloro-4-oximino- Cl n-C.sub.3 H.sub.7 141-142 White crystalline powder. 1-butyryl-1,2,3,4- Sparingly soluble in water and tetrahydroquinoline hexane; easily soluble in metha- nol, acetone and chloroform.IV 6-Chloro-4-oximino- Cl iso-C.sub.3 H.sub.7 185-186 White crystalline powder. 1-isobutyryl-1,2,3,4- Sparingly soluble in water and tetrahydroquinoline hexane; easily soluble in metha- nol, acetone and chloroform.V 6-Chloro-4-oximino- Cl n-C.sub.4 H.sub.9 118-120 White crystalline powder. 1-valeryl-1,2,3,4- Sparingly soluble in water and tetrahydroquinoline hexane; easily soluble in metha- nol, acetone and chloroform.VI 6-Chloro-4-oximino- Cl iso-C.sub.4 H.sub.9 142-143 White crystalline powder. 1-isovaleryl-1,2,3,4- Sparingly soluble in water and tetrahydroquinoline hexane; easily soluble in metha- nol, acetone and chloroform.VII 6-Chloro-4-oximino- Cl CH.sub.2 C.sub.6 H.sub.5 181-183 White crystalline powder. 1-phenylacetyl-1,2- Sparingly soluble in water and 3,4-tetrahydroquino- hexane; easily soluble in metha- line nol, acetone and chloroform.VIII 6-Chloro-4-oximino- Cl CH.dbd.CHC.sub.6 H.sub.5 216-217 White crystalline powder. 1-cinnamoyl-1,2,3,4- Sparingly soluble in water and tetrahydroquinoline hexane; easily soluble in metha- nol, acetone and chloroform.IX 6-Fluoro-4-oximino- F OCH.sub.3 145-148 White crystals. Sparingly soluble 1-methoxycarbonyl- in water and hexane; soluble in 1,2,3,4-tetrahydro- ethanol and dichloromethane. quinolineX 6-Chloro-4-oximino-1- Cl OCH.sub.3 162-163 White crystals. Sparingly soluble methoxycarbonyl-1,2,3,4- in water and hexane; soluble in tetrahydroquinoline ethanol and dichloromethane.XI 6-Bromo-4-oximino-1- Br OCH.sub.3 155.5-158.5 White crystals. Sparingly soluble methoxycarbonyl-1,2,3,4- in water and hexane; soluble in tetrahydroquinoline ethanol and dichloromethane.XII 6-Fluoro-4-oximino-1- F OC.sub.2 H.sub.5 122-124 White crystals. Sparingly soluble ethoxycarbonyl-1,2,3,4- in water and hexane; soluble in tetrahydroquinoline ethanol and dichloromethane.XIII 6-Chloro-4-oximino-1- Cl OC.sub.2 H.sub.5 112-113 White crystals. Sparingly soluble ethoxycarbonyl-1,2,3,4- in water and hexane; soluble in tetrahydroquinoline ethanol and dichloromethane.XIV 6-Bromo-4-oximino-1- Br CH.sub.3 200-202.5 White crystals. Sparingly soluble acetyl-1,2,3,4-tetra- in water and hexane; soluble in hydroquinoline ethanol and dichloromethane.XV 6-Fluoro-4-oximino- F C.sub.2 H.sub.5 126.5-128 White crystals. Sparingly soluble 1-propionyl-1,2,3,4- in water and hexane; soluble in tetrahydroquinoline ethanol and dichloromethane.XVI 6-Bromo-4-oximino-1- Br C.sub.2 H.sub.5 151.5-152.5 White crystals. Sparingly soluble propionyl-1,2,3,4- in water and hexane; soluble in tetrahydroquinoline ethanol and dichloromethane.XVII 6-Bromo-4-oximino-1- Br i-C.sub.3 H.sub.7 195-197 White crystals. Sparingly soluble isobutyryl-1,2,3,4- in water and hexane; soluble in tetrahydroquinoline ethanol and dichloromethane.XVIII 6-Bromo-4-oximino-1- Br CH.dbd.CHC.sub.6 H.sub.5 208.5-210.5 White crystals. Sparingly soluble cinnamoyl-1,2,3,4- in water and hexane; soluble in tetrahydroquinoline ethanol and dichloromethane.XIX 6-Chloro-4-oximino-1- Cl NHCH.sub.3 211-212 White crystals. Sparingly soluble methylcarbamoyl-1,2,3,4- in water and hexane; soluble in tetrahydroquinoline ethanol and dichloromethane.XX 6-Bromo-4-oximino-1- Br NHCH.sub.3 206.5 (dec.) White crystals. Sparingly soluble methylcarbamoyl-1,2,3,4- in water and hexane; soluble in tetrahydroquinoline ethanol and dichloromethane.XXI 6-Fluoro-4-oximino-1- F N(CH.sub.3).sub.2 147-149.5 White crystals. Sparingly soluble dimethylcarbamoyl-1,2- in water and hexane; soluble in 3,4-tetrahydroquinoline ethanol and dichloromethane.XXII 6-Chloro-4-oximino-1- Cl N(CH.sub.3).sub.2 150-152 White crystals. Sparingly soluble dimethylcarbamoyl-1,2- in water and hexane; soluble in 3,4-tetrahydroquinoline ethanol and dichloromethane,XXIII 6-Bromo-4-oximino-1- Br N(CH.sub.3).sub.2 113-115 White crystals. Sparingly soluble dimethylcarbamoyl-1,2- in water and hexane; soluble in 3,4-tetrahydroquinoline ethanol and dichloromethane.__________________________________________________________________________

The pharmacological effect, toxicity, method for use and dosage of each of the active compounds used in the compositions of this invention are illustrated by the following Experimental Examples.

Experimental Example 1

Diuretic Effect in Rats

Wister strain male rats weighing about 200 g were starved overnight and each compound of this invention suspended in 25 ml/kg of physiological saline were administered orally to the 5 animals in each group, and the diuretic effect up to 5 hours after the administration was measured. The diuretic effect is expressed as the average urine volume (%) of the treated group divided by that of the control group. The results are given in Tables 2 and 3 below.

TABLE 2______________________________________Diuretic Effect in RatsCompound to Dosage Diureticbe Tested mg/kg Effect (%)______________________________________Control 100Compound I 5 131 10 186 20 260Compound II 2.5 253 5 304 10 410Compound III 5 122 10 172 20 240Compound IV 25 119 50 211Compound V 50 209Compound VI 50 196Compound VII 50 202Compound VIII 50 228Furosemide 5 133 10 167 20 304______________________________________ TABLE 3______________________________________Compound Diuretic Compound Diureticto be Dosage Effect to be Dosage EffectTested mg/kg (%) Tested mg/kg (%)______________________________________IX 2.5 251 XV 10 425 5 309 XVI 5 243 10 408 10 380X 2.5 188 XVII 50 173 5 306 XVIII 50 203 10 371 XIX 50 180XI .5 152 XX 50 197 10 293 XXI 10 128XII 10 180 20 209 20 285 XXII 10 198XIII 10 204 20 263 20 310 XXIII 50 200XIV 20 234 Furosemide 5 116XV 2.5 209 10 215 5 347 20 277______________________________________

A diuretic effect was observed in each of Compounds I to XXIII.

Experimental Example 2

Hypotensive Effect in rats with Spontaneous Hypertension (SHR)

5 male SHR's weighing 250-300 g with blood pressure of 170-190 mm Hg were used in each group. Each compound of this invention was suspended in a 5% aqueous arabic gum solution and the blood pressure was measured before administration and 2 hours after daily administration by using a plethysmorgraph. The results are given in Tables 3 and 4 below.

TABLE 4______________________________________Hypotensive Effect in SHR's Blood Pressure (mm Hg)Compound Beforeto be Dosage Adminis- After After AfterTested mg/kg tration 2 days 4 days 8 days______________________________________Control 180 177 178 175I 50 178 170 167 164II 20 182 167 161 158III 50 179 166 165 157IV 100 182 172 169 162V 200 181 169 165 166VI 200 179 168 167 163VII 200 179 172 168 168VIII 100 181 169 164 159______________________________________ TABLE 5______________________________________ Blood Pressure (mm Hg)Compound Beforeto be Dosage Adminis- After After AfterTested mg/kg tration 2 days 4 days 8 days______________________________________Control 181 179 182 180IX 20 181 164 158 157X 20 180 169 158 155XI 20 181 176 171 165XII 50 179 174 170 160XIII 50 182 170 165 162XIV 50 180 175 169 163XV 20 181 166 159 154XVI 20 183 171 163 158XVII 100 181 176 178 176XVIII 100 182 177 175 167XIX 100 180 175 174 170XX 100 179 173 173 167XXI 50 183 175 167 166XXII 50 181 170 169 163XXIII 100 180 172 166 167______________________________________

Experiment Example 3

Inhibition for Carrageenin-Induced Foot Edema in Rats

10 Wister strain male rats weighing about 120 g were used in each group. Each compound of this invention was suspended in a 5% aqueous arabic gum solution and administered orally to the animals. One hour after the administration, 0.1 ml of a 1% solution of carrageenin in physiological saline as a phlogistic agent was subcutaneously injected into the right hind paw of the rats which had been shaven previously. The volume of the right hind paw was measured before the administration of the phlogistic agent and 3 hours after the administration. The intensity of edema expressed as percent increase in the foot volume was calculated from the aqueous (1) and the percent inhibition of edema was calculated from the equation (2). ##EQU1##

The effective dosage of each compound for inhibiting edema was expressed as ED.sub.30 (mg/kg) by calculating the dosage for 30% inhibition from the percent inhibition of edema according to the probit method. The results are given in Tables 6 and 7 below.

TABLE 6______________________________________Inhibition for Carrageenin-Induced Foot Edema in RatsCompound ED.sub.30 (mg/kg)______________________________________I 39II 8.8III 33IV 87V 140VI 105VII 140VIII 44Phenylbutazone 65______________________________________ TABLE 7______________________________________Compound to ED.sub.30 Compound to ED.sub.30be Tested (mg/kg) be Tested (mg/kg)______________________________________IX 22 XVII 102X 14 XVIII 133XI 83 XIX 62XII 86 XX 95XIII 49 XXI 141XIV 182 XXII 34XV 9.3 XXIII 51XVI 16 Phenylbutazone 63______________________________________

The inhibitory effect for carrageenin-induced foot edema in rats was observed in each of the Compounds I-XXIII.

Experimental Example 4

Acute Oral Toxicity in Mice

10 ddY Strain male mice weighing about 20 g were used in each group. Each compound of this invention was suspended in a 5% aqueous gum arabic solution and administered orally. The mortality rate (%) was determined from the number of dead animals 7 days after the administration, and the dosage corresponding to 50% mortality was calculated and expressed as LD.sub.50 (mg/kg). The results are given in Table 8 below.

TABLE 8______________________________________Acute Oral Toxicity in MiceCompound tobe Tested LD.sub.50 (mg/kg)______________________________________I >5,000II 3,488III >5,000IV >5,000V >5,000VI >5,000VII >5,000VIII >5,000IX >5,000X 4,470XI >5,000XII >5,000XIII >5,000XIV >5,000XV 3,440XVI 4,710XVII >5,000XVIII >5,000XIX >5,000XX >5,000XXI >5,000XXII >5,000XXIII >5,000______________________________________

All of the LD.sub.50 values of Compounds I-XXIII are greater than the levels which show a pharmaceutical effect and thus the compounds are of sufficient safety.

As evident from the above-described experimental examples, all of the compounds of the formula (I) according to this invention have remarkable diuretic and antiedemic effects as well as a mild hypotensitive effect. Further, these compounds are of very low toxicity and are adequately safe at the dosage at which a pharmaceutical effect is manifested. Therefore, the compounds of this invention are not only useful for the treatment of hypertension but also extremely useful for the treatment of edema resulting from the localized retention of water and electrolytes generated by the functional depression of the liver, the heart or the like or the metabolic disorder.

While the compounds of this invention are usually administered orally or intrarectally, they can also be administered as an injectable composition or as a topical composition. The dose of each compound for a human adult is given in Table 9, but this may be out of the exemplified range as appropriate depending on the severity of the disease or the administration route, and on therapeutical demand.

TABLE 9______________________________________Dose for Treating Human AdultsCompound Dose (mg/day) Compound Dose (mg/day)______________________________________I 20-2,000 V 80-6,000II 5-1,000 VI 80-6,000III 20-2,000 VII 80-6,000IV 25-2,500 VIII 40-4,000______________________________________IX 20-2,000 XVII 80-6,000X 10-2,000 XVIII 80-6,000XI 30-2,500 XIX 50-4,500XII 30-2,500 XX 50-4,500XIII 30-2,500 XXI 80-6,000XIV 40-4,000 XXII 20-2,000XV 5-1,000 XXIII 40-4,000XVI 10-2,000______________________________________ Generally speaking, peroral or intrarectal administration of 0.02-200 mg, in particular 0.1-100 mg of the compound per day per one kg of the patient's body weight would be desirable for the purpose of achieving the expected effect. In the general case of an adult a daily administration of 1 to 10 units of a composition containing 5-600 mg of the composition according to the present invention will suffice. For injection, about the same to 1/10 of the above dosage will have approximately the same effect.

The compounds of this invention may be formulated into pharmaceutical preparations in a conventional manner with conventional additives, i.e. a pharmaceutical carrier, base material or excipient.

As the pharmaceutical carrier or the base material, there may be employed lactose, mannitol, corn starch, potato starch etc. Examples of the excipient which can be used are crystalline cellulose, cellulose derivatives, gum arabic, corn starch, gelatin etec. In addition, a disintegrant such as calcium carboxymethyl cellulose and a lubricant such as talc, magnesium stearate etec. as well as polyvinylalcohol etc. may also be employed as the additive. As the liquid carrier when formulated into an injectable composition, there may be employed distilled water for injection, physiological saline, aqueous dextrose, vegetable oils for injection, glycols such as propylene glycol, polyethylene glycol etc. and so forth.

Preferred oral compositions are in the form of capsules, tablets, powders and oral liquid preparations, and preferred intrarectal compositions are rectal suppositories. The injectable composition is preferably a suspension containing a pharmaceutically acceptable dispersing agent such as Tween 80, aqueous gum arabic etc., and the topical composition is preferably presented as an ointment

The amount of the active compound of the formula (I) in the composition is 1-99.9% by weight, preferably 1-99.0% by weight and especially 5-70% by weight.

This invention is more particularly described by the following examples.

EXAMPLE 1

Capsules

______________________________________Compound I 500 gLactose 485 gMagnesium stearate 15 g 1000 g______________________________________

The above components are weighed respectively and mixed together uniformly. Each of 500 mg of the mixed powder is filled into hard gelatin capsules No. 1 to prepare capsules.

EXAMPLE 2

Tablets

______________________________________Compound XV 500 gLactose 320 gPotato starch 150 gPolyvinylalcohol 15 gMagnesium stearate 15 g 1000 g______________________________________

The above components are weighed respectively, and Compound XV, lactose and potato starch are mixed together uniformly. To this mixture is added an aqueous solution of polyvinylalcohol, and granules are prepared by a wet pelletization method. The granules are dried, magnesium stearate is added and compressed on a tabletting machine to prepare tablets weighing 200 mg each.

EXAMPLE 3

Powder

______________________________________Compound XIII 100 gLactose 890 gMagnesium stearate 10 g 1000 g______________________________________

The above components are weighed respectively, and mixed together uniformly, to prepare a 10% powder.

EXAMPLE 4

Suppository

______________________________________Compound XIII 100 gPolyethylene glycol 1500 180 gPolyethylene glycol 4000 720 g 1000 g______________________________________

Compound XIII is pulverized on a mortar to a fine powder, and made into a rectal suppository by a melting method.

Claims

1. A pharmaceutical composition containing a diuretic, hypotensive and antiedemic effective amount of a 6-halo-4-oximino-1,2,3,4-tetrahydroquinoline derivative of the formula (I): ##STR3## or a salt thereof, wherein X represents a halogen atom, and Y represents a straight-chain or branched-chain alkyl group having 1-4 carbon atoms, a phenyl-substituted lower alkyl group, a phenylalkenyl group, a lower alkoxy group or a lower alkyl-substituted amino group, as an active ingredient together with a conventional pharmaceutically acceptable additive.

2. The pharmaceutical composition according to claim 1 which contains 1.0-99.9% by weight of the active ingredient and 99.0-0.1% by weight of the additive.

3. The pharmaceutical composition according to claim 1 which contains 5-70% by weight of the active ingredient and 95-30% by weight of the additive.

4. The pharmaceutical composition according to claim 1, 2 or 3 in which the active ingredient is selected from the group consisting of

6-chloro-4-oximino-1-acetyl-1,2,3,4-tetrahydroquinoline,

6-chloro-4-oximino-1-propionyl-1,2,3,4-tetrahydroquinoline,

6-chloro-4-oximino-1-butyryl-1,2,3,4-tetrahydroquinoline,

6-chloro-4-oximino-1-isobutyryl-1,2,3,4-tetrahydroquinoline,

6-chloro-4-oximino-1-valeryl-1,2,3,4-tetrahydroquinoline,

6-chloro-4-oximino-1-isovaleryl-1,2,3,4-tetrahydroquinoline,

6-chloro-4-oximino-1-phenylacetyl-1,2,3,4-tetrahydroquinoline,

6-chloro-4-oximino-1-cinnamoyl-1,2,3,4-tetrahydroquinoline,

6-fluoro-4-oximino-1-methoxycarbonyl-1,2,3,4-tetrahydroquinoline,

6-chloro-4-oximino-1-methoxycarbonyl-1,2,3,4-tetrahydroquinoline,

6-bromo-4-oximino-1-methoxycarbonyl-1,2,3,4-tetrahydroquinoline,

6-fluoro-4-oximino-1-ethoxycarbonyl-1,2,3,4-tetrahydroquinoline,

6-chloro-4-oximino-1-ethoxycarbonyl-1,2,3,4-tetrahydroquinoline,

6-bromo-4-oximino-1-acetyl-1,2,3,4-tetrahydroquinoline,

6-fluoro-4-oximino-1-propionyl-1,2,3,4-tetrahydroquinoline,

6-bromo-4-oximino-1-propionyl-1,2,3,4-tetrahydroquinoline,

6-bromo-4-oximino-1-isobutyryl-1,2,3,4-tetrahydroquinoline,

6-bromo-4-oximino-1-cinnamoyl-1,2,3,4-tetrahydroquinoline,

6-choro-4-oximino-1-methylcarbamoyl-1,2,3,4-tetrahydroquinoline,

6-bromo-4-oximino-1-methylcarbamoyl-1,2,3,4-tetrahydroquinoline.

6-fluoro-4-oximino-1-dimethylcarbamoyl-1,2,3,4-tetrahydroquinoline,

6-chloro-4-oximino-1-dimethylcarbamoyl-1,2,3,4-tetrahydroquinoline, and

6-bromo-4-oximino-1-dimethylcarbamoyl-1,2,3,4-tetrahydroquinoline.

5. The pharmaceutical composition according to any of claims 1-4 in which the additive is selected from the group consisting of Tween 80, arabic gum, lactose, magnesium stearate, potato starch, polyvinylalcohol and polyethylene glycol.

6. The pharmaceutical composition according to any of claims 1-5 which is in the form selected from the group consisting of an oral dosage form, a rectal dosage form, an injectable form and a topical application form.

7. A method for treating a disease selected from the group consisting of hypertension and edema which comprises administering to a human body needing treatment for such a disease an effective amount of a 6-halo-4-oximino-1,2,3,4-tetrahydroquinoline derivative of the formula (I): ##STR4## or a pharmaceutically acceptable salt thereof, wherein X represents a halogen atom, and Y represents a straight-chain or branched-chain alkyl group having 1-4 carbon atoms, a phenyl-substituted lower alkyl group, a phenylalkenyl group, a lower alkoxy group or a lower alkyl-substituted amino group.

8. The method according to claim 7 in which the daily dose of the compound of the formula (I) or the salt thereof is in the range of 1 mg to 10 g.

9. The method according to claim 8 in which the daily dose of the compound of the formula (I) or a salt thereof is in the range of 5 mg to 6 g.

10. The method according to claim 7, 8 or 9 in which the compound of the formula (I) or a salt thereof is administered orally, intrarectally, by injection or topically.

11. A method for treating a disease selected from the group consisting of hypertension and edema which comprises administering to a human body needing treatment for such a disease an effective amount of a composition comprising a carrier and a compound of the formula (I) ##STR5## wherein X represents a halogen and Y represents a straight-chain or branched chain alkyl having 1-4 carbon atoms, a phenyl-substituted lower alkyl, a phenylalkenyl, a lower alkoxy or a lower alkyl-substituted amino group, or a pharmaceutically acceptable salt thereof.

12. The method according to claim 11 in which the daily dose of the compound of the formula (I) or the salt thereof is in the range of 1 mg to 10 g.

13. The method according to claim 12 in which the daily dose of the compound of the formula (I) or a salt thereof is in the range of 5 mg to 6 g.

14. The method according to claim 11, 12 or 13 in which the compound of the formula (I) or a salt thereof is administered orally, intrarectally, by injection or topically.