Drug-containing capsule, and component for air treatment device

Information

  • Patent Grant
  • 11583601
  • Patent Number
    11,583,601
  • Date Filed
    Wednesday, August 26, 2020
    4 years ago
  • Date Issued
    Tuesday, February 21, 2023
    a year ago
  • Inventors
    • Donoshita; Yuka
    • Sakamoto; Masako
  • Original Assignees
  • Examiners
    • Purdy; Kyle A
    Agents
    • Birch, Stewart, Kolasch & Birch, LLP
Abstract
A drug-containing capsule (20, 30, 40) includes a capsule material (21, 31, 41) and a drug (22, 32, 42) disposed within the capsule material (21, 31, 41) and having a sterilization action for a specific microorganism. The capsule material (21, 31, 41) includes a degradable part (21a, 31a, 41a) formed of a raw material that is caused to biodegrade by the specific microorganism. This results in suppression of release of the drug while the specific microorganism does not proliferate.
Description
TECHNICAL FIELD

The present disclosure relates to a drug-containing capsule and a component for an air treatment device.


BACKGROUND ART

There is a known fin including a base member and a hydrophilic film and used for a heat exchanger (for example, Patent Literature 1). The hydrophilic film includes a plurality of types of drug particles that have a surface covered with a capsule material having controlled dissolubility in water and that are different from each other in the timing of exerting the drug action. In this way, the drug particles can exert the drug action for a long term.


CITATION LIST
Patent Literature

PTL 1: Japanese Unexamined Patent Application Publication No. 2016-125698


SUMMARY

A first embodiment of the present disclosure is directed to a drug-containing capsule (20, 30, 40) including a capsule material (21, 31, 41) and a drug (22, 32, 42) disposed within the capsule material (21, 31, 41) and having a sterilization action for a specific microorganism. The capsule material (21, 31, 41) includes a degradable part (21a, 31a, 41a) formed of a raw material that is caused to biodegrade by the specific microorganism.





BRIEF DESCRIPTION OF THE DRAWINGS


FIG. 1 is a schematic view illustrating the configuration of an air conditioning device according to an embodiment.



FIG. 2 is a sectional view schematically illustrating a near-surface region of a heat exchanger of an air conditioning device according to an embodiment.



FIG. 3 illustrates an example of a drug-containing capsule according to an embodiment.



FIG. 4 illustrates an example of a drug-containing capsule according to an embodiment.



FIG. 5 illustrates an example of a drug-containing capsule according to an embodiment.



FIG. 6 illustrates an example of a drug-containing capsule according to another embodiment.



FIG. 7 illustrates an example of a drug-containing capsule according to another embodiment.





DESCRIPTION OF EMBODIMENTS

A drug-containing capsule (20, 30, 40) according to an embodiment is used for an air treatment device (1). As illustrated in FIG. 1, the air treatment device (1) according to the embodiment is constituted by an air conditioning device (1). This air conditioning device (1) includes a casing (2), a heat exchanger (10a), a fan (10b), a drain pan (10c), a filter (10d), and a flap (not shown) that are each contained in the casing (2), and a duct (not shown). These individually constitute components (10).


Configurations of Near-Surface Regions of Components

As illustrated in FIG. 2, the components (10) of the air conditioning device (1) each include a base member (11), a corrosion resistant film (12) formed on the base member (11), and a hydrophilic film (13) formed on this corrosion resistant film (12). The base member (11) is formed of, for example, metal or resin. The corrosion resistant film (12) and the hydrophilic film (13) may be formed of, for example, different types of resins. The hydrophilic film (13) constitutes a film.


Drug-Containing Capsule

As illustrated in FIG. 2, the hydrophilic film (13) includes therein a plurality of types of drug-containing capsules (20, 30, 40). In this example, the hydrophilic film (13) includes three types of drug-containing capsules (20, 30, 40), specifically a first drug-containing capsule (20), a second drug-containing capsule (30), and a third drug-containing capsule (40).


As illustrated in FIG. 3, the first drug-containing capsule (20) includes a plurality of (in this example, two) capsule materials (21) disposed as layers and having the shapes of hollow spheres and drugs (22) disposed within the capsule materials (21). The capsule materials (21) include degradable parts (21a) formed of a raw material that is caused to biodegrade by a specific microorganism (specifically, a polymer including caprolactone or a polymer including ethylene adipate). In this example, the capsule materials (21) are wholly constituted by the degradable parts (21a). The drugs (22) have a sterilization action for a specific microorganism and include, for example, a fungicide-bactericide and a plant essential oil. Incidentally, in the drawings, the fungicide-bactericide is illustrated in a white solid color, and the plant essential oil is illustrated as densely hatched areas.


As illustrated in FIG. 4, the second drug-containing capsule (30) includes a single capsule material (31) having the shape of, for example, a hollow sphere and a drug (32) disposed within the capsule material (31). The capsule material (31) includes a degradable part (31a) formed of a raw material that is caused to biodegrade by a specific microorganism (specifically, a polymer including caprolactone or a polymer including ethylene adipate). In this example, the capsule material (31) is wholly constituted by the degradable part (31a). The drug (32) has a sterilization action for a specific microorganism and includes, for example, a fungicide-bactericide and a plant essential oil.


As illustrated in FIG. 5, the third drug-containing capsule (40) includes a single capsule material (41) having the shape of, for example, a hollow sphere and a drug (42) disposed within the capsule material (41). The capsule material (41) includes a degradable part (41a) formed of a raw material that is caused to biodegrade by a specific microorganism (specifically, a polymer including caprolactone or a polymer including ethylene adipate). In this example, the capsule material (41) is wholly constituted by the degradable part (41a). The thickness (T3) of the capsule material (41) of the third drug-containing capsule (40) is larger than the thickness (T1) of the outer capsule material (21) of the first drug-containing capsule (20) and the thickness (T2) of the capsule material (31) of the second drug-containing capsule (30) (T1<T3, T2<T3). The drug (42) has a sterilization action for a specific microorganism and includes, for example, a fungicide-bactericide and a plant essential oil.


Incidentally, in this Description, the “specific microorganism” means a microorganism to be destroyed by the drug-containing capsules (20, 30, 40). The microorganism is specifically a mold, a yeast, or a bacterium proliferating in the air treatment device (1): the mold includes at least one of Penicillium molds, Cladosporium molds, Aspergillus molds, Toxicocladosporium molds, Engyodontium molds, Aureobasidium molds, Alternaria molds, Paecilomyces molds, Tricoderma molds, Nigrospora molds, Chaetomium molds, Ulocladium molds, Fusarium molds, Eurotium molds, Curvularia molds, Rhodotorula molds, Chaetomium molds, Mucor molds, and Rhizopus molds; the yeast includes at least one of true fungi that are collectively called yeast; and the bacterium includes at least one of Arthrobacter bacteria, Baccilus bacteria, Serratia bacteria, and Staphylococcus aureus.


Exertion of Drug Action

Hereinafter, how the drug-containing capsules (20, 30, 40) exert the drug action will be described.


For example, on the surface of the heat exchanger (10a) of the air conditioning device (1), moisture in the air condenses during a cooling operation to generate drain water, which leads to proliferation of a specific microorganism.


The proliferating specific microorganism causes biodegradation of the capsule materials (21, 31, 41) of the first to third drug-containing capsules (20, 30, 40). In this case, first, the outer capsule material (21) of the first drug-containing capsule (20) and the capsule material (31) of the second drug-containing capsule (30) are perforated. This causes release of the drugs (22, 32) from within the capsule materials (21, 31) to destroy the specific microorganism.


When the specific microorganism further proliferates, the inner capsule material (21) of the first drug-containing capsule (20) is then perforated. This causes release of the drug (22) from within the capsule material (21) to destroy the specific microorganism.


When the specific microorganism further proliferates, the capsule material (41) of the third drug-containing capsule (40) is then perforated. This causes release of the drug (42) from within the capsule material (41) to destroy the specific microorganism.


In this way, the first to third drug-containing capsules (20, 30, 40) exert the drug action at the spot and timing of the proliferation of the specific microorganism. The capsule materials (21, 31, 41) are perforated at timings different from each other, so that the drug action is exerted for a relatively long term.


Advantages of Embodiments

The drug-containing capsules (20, 30, 40) according to these embodiments include capsule materials (21, 31, 41) and drugs (22, 32, 42) disposed within the capsule materials (21, 31, 41) and having a sterilization action for a specific microorganism, wherein the capsule materials (21, 31, 41) include degradable parts (21a, 31a, 41a) formed of a raw material that is caused to biodegrade by the specific microorganism.


The inventors of the present application focused on disposition of drug-containing capsules (20, 30, 40) for a specific microorganism at the spot of proliferation of the specific microorganism. They have found that, by using a raw material that is caused to biodegrade by the specific microorganism to form at least portions of the capsule materials (21, 31, 41), the specific microorganism is destroyed at the spot and timing of proliferation. The degradable parts (21a, 31a, 41a) of the capsule materials (21, 31, 41) of the embodiments are caused to biodegrade by a specific microorganism at the spot of proliferation of the microorganism. This causes release of the drugs (22, 32, 42) from within the capsule materials (21, 31, 41) to destroy the proliferating microorganism. In this way, the drug action of the drugs (22, 32, 42) is exerted at the spot and timing of proliferation of the specific microorganism.


The specific microorganism is a mold, a yeast, or a bacterium proliferating in the air treatment device (1). Therefore, the embodiments provide drug-containing capsules (20, 30, 40) that effectively act against the mold, the yeast, or the bacterium proliferating in the air treatment device (1).


The mold includes at least one of Penicillium molds, Cladosporium molds, Aspergillus molds, Toxicocladosporium molds, Engyodontium molds, Aureobasidium molds, Alternaria molds, Paecilomyces molds, Tricoderma molds, Nigrospora molds, Chaetomium molds, Ulocladium molds, Fusarium molds, Eurotium molds, Curvularia molds, Rhodotorula molds, Chaetomium molds, Mucor molds, and Rhizopus molds; the yeast includes at least one of true fungi that are collectively called yeast; and the bacterium includes at least one of Arthrobacter bacteria, Baccilus bacteria, Serratia bacteria, and Staphylococcus aureus. The inventors of the present application have newly found that such molds, yeasts, or bacteria proliferate in the air treatment device (1). In the embodiments, a raw material that is caused to biodegrade by such a mold, a yeast, or a bacterium is used to form capsule materials (21, 31, 41). Therefore, the embodiments provide drug-containing capsules (20, 30, 40) that effectively act against such a specific mold, yeast, or bacterium.


In the drug-containing capsules (20, 30, 40) according to the embodiments, the raw material that is caused to biodegrade by such a specific microorganism is a polymer including caprolactone or a polymer including ethylene adipate. Therefore, the embodiments provide drug-containing capsules (20, 30, 40) that effectively act against the microorganism that causes biodegradation of such a polymer.


In the first drug-containing capsule (20) according to the embodiment, the capsule material (21) includes two capsule materials (21) disposed as layers, and the drug (22) is disposed within each of the capsule materials (21). Thus, upon biodegradation of the outer capsule material (21), the drug (22) disposed therein is released to destroy the specific microorganism. Subsequently, upon biodegradation of the inner capsule material (21), the drug (22) disposed therein is released to destroy the specific microorganism. In this way, such first drug-containing capsules (20) each provide a drug action twice.


The component (10) for the air treatment device (1) according to the embodiment includes the film (13) including the drug-containing capsules (20, 30, 40). Thus, the embodiment, in the air treatment device (1), effectively suppresses proliferation of the specific microorganism on the component (10) including the film (13) including the drug-containing capsules (20, 30, 40).


In the component (10) for the air treatment device (1) according to the embodiment, the film (13) includes the first to third drug-containing capsules (20, 30, 40), and, in the third drug-containing capsule (40), the thickness (T3) of the degradable part (41a) of the capsule material (41) is larger than the thicknesses (T1, T2) of the degradable parts (21a, 31a) of the capsule materials (21, 31) of the first and second drug-containing capsules (20, 30). Thus, compared with the first drug-containing capsule (20) and the second drug-containing capsule (30), in the third drug-containing capsule (40), perforation of the capsule material (21, 31, 41) due to biodegradation occurs at a later timing, so that the drug action is exerted in a later period. Therefore, compared with a case where the thicknesses (T1 to T3) of the capsule materials (21, 31, 41) of all the drug-containing capsules (20, 30, 40) are substantially the same, the total period of exerting the drug action by the first to third drug-containing capsules (20, 30, 40) becomes longer.


The drug-containing capsule (20, 30, 40) according to the embodiment includes the capsule material (21, 31, 41) including the degradable part (21a, 31a, 41a) formed of a polymer including caprolactone or a polymer including ethylene adipate, and the drug (22, 32, 42) disposed within the capsule material (21, 31, 41) and having a sterilization action for a microorganism. Thus, the degradable part (21a, 31a, 41a) of the capsule material (21, 31, 41) is caused to biodegrade by a microorganism proliferating in the air treatment device (1). This causes release of the drug (22, 32, 42) from within the capsule material (21, 31, 41) to destroy the microorganism. In this way, in the air treatment device (1), the drug action of the drugs (22, 32, 42) is exerted at the spot and timing of proliferation of the microorganism.


Other Embodiments

The above-described embodiments may be provided so as to have the following configurations.


In the above-described embodiment, the air treatment device (1) is constituted by the air conditioning device (1). Alternatively, the air treatment device (1) may be constituted by, for example, an air purification device, a humidity control device, or a ventilation device. In this case, the component (10) may be constituted by, for example, a fan or filter of the air purification device, a humidifying unit, fan, or filter of the humidity control device, or a fan, filter, or duct of the ventilation device.


In the above-described embodiment, the drugs (22) disposed within the two capsule materials (21) of the first drug-containing capsule (20) are of the same type. Alternatively, as illustrated in FIG. 6, the type of a drug (23) disposed within the outer capsule material (21) and the type of a drug (24) disposed within the inner capsule material (21) may be different from each other. Incidentally, in this example, the drug (23) disposed within the outer capsule material (21) is a fungicide-bactericide, while the drug (24) disposed within the inner capsule material (21) is a plant essential oil. The number of the capsule materials (21) of the first drug-containing capsule (20) may be three or more.


In the above-described embodiment, the capsule materials (21, 31, 41) of the first to third drug-containing capsules (20, 30, 40) are wholly constituted by the degradable parts (21a, 31a, 41a). Alternatively, as illustrated in FIG. 7, for example, in the second drug-containing capsule (30), only portions of the capsule material (31) may be constituted by the degradable parts (31a). In this case, the degradable parts (31a) are caused to biodegrade by a specific microorganism to release the drug (32). The same applies to the first and third drug-containing capsules (20, 40).


The drug-containing capsules (20, 30, 40) included in the hydrophilic film (13) may be of two or less types, or four or more types.


The embodiments and modifications have been described so far, and it would be understood that the forms and details can be changed in various ways without departing from the spirit and scope of the Claims. The above-described embodiments and modifications can be appropriately combined or substituted unless the function of the subject matter of the present disclosure is degraded. industrial applicability


As has been described so far, the present disclosure is useful for drug-containing capsules and components for air treatment devices.


EXPLANATION OF REFERENCES


1 air conditioning device (air treatment device)



10 component



10
a heat exchanger (component)



10
b fan (component)



10
c drain pan (component)



10
d filter (component)



13 hydrophilic film (film)



20 first drug-containing capsule (drug-containing capsule)



21 capsule material



21
a degradable part



22 drug



30 second drug-containing capsule (drug-containing capsule)



31 capsule material



31
a degradable part



32 drug



40 third drug-containing capsule (drug-containing capsule)



41 capsule material



41
a degradable part



42 drug


T1 to T3 thicknesses (of degradable parts)

Claims
  • 1. An air treatment device having an interior portion that includes an antimicrobial film wherein: the air treatment device has an outer casing that encloses an interior portion that includes components comprising at least a fan, a heat exchanger and a filter, wherein the interior portion and components have a surface of metal or a resin,a corrosion resistant layer comprising a resin, the resin being disposed on one or more of the interior portion or component surfaces; andan antimicrobial film wherein the antimicrobial film is disposed on the corrosion resistant layer and the antimicrobial film comprises a hydrophilic layer comprising a resin, wherein thewherein the hydrophilic layer contains antimicrobial capsules that comprise,an outer layer capsule material of one or more layers of caprolactone or a polymer including ethylene adipate, wherein the capsule material that degrades upon exposure to certain microorganisms, andan active material disposed within the outer layer capsule material, wherein the active material comprises at least one of a fungicide, bactericide or plant essential oil that kills the microorganisms.
  • 2. The air treatment device according to claim 1, wherein the microorganism is a mold, a yeast, or a bacterium proliferating in the air treatment device.
  • 3. The air treatment device according to claim 2, wherein the mold includes at least one of Penicillium molds, Cladosporium molds, Aspergillus molds, Toxicocladosporium molds, Engyodontium molds, Aureobasidium molds, Alternaria molds, Paecilomyces molds, Tricoderma molds, Nigrospora molds, Chaetomium molds, Ulocladium molds, Fusarium molds, Eurotium molds, Curvularia molds, Rhodotorula molds, Chaetomium molds, Mucor molds, and Rhizopus molds,the yeast includes at least one of true fungi that are collectively called yeast, andthe bacterium includes at least one of Arthrobacter bacteria, Baccilus bacteria, Serratia bacteria, and Staphylococcus aureus.
  • 4. The air treatment device according to claim 1, wherein the capsule material comprises a plurality of encapsulating layers, andthe active material is disposed within each of the encapsulating layers.
  • 5. The air treatment device according to claim 1, wherein the hydrophilic layer of the film contains a plurality of different types of the antimicrobial capsules having capsule material layers that differ with respect to thickness from other antimicrobial capsules.
Priority Claims (1)
Number Date Country Kind
JP2018-065107 Mar 2018 JP national
US Referenced Citations (6)
Number Name Date Kind
5783561 Horwitz Jul 1998 A
20050175748 Thijssen Aug 2005 A1
20070209373 Taira et al. Sep 2007 A1
20100122379 Dieckmann et al. May 2010 A1
20130078308 Hashimoto et al. Mar 2013 A1
20150086623 Chung Mar 2015 A1
Foreign Referenced Citations (15)
Number Date Country
1319571 Jun 1993 CA
2235280 Apr 1997 CA
54-4282 Jan 1979 JP
1-123673 May 1989 JP
7-173052 Jul 1995 JP
11-514360 Dec 1999 JP
2002-11340 Jan 2002 JP
2005-527633 Sep 2005 JP
2005-326137 Nov 2005 JP
2007-107806 Apr 2007 JP
2011-83222 Apr 2011 JP
2013-81929 May 2013 JP
2016-125698 Jul 2016 JP
100707499 Apr 2005 KR
WO 2015044673 Apr 2015 WO
Non-Patent Literature Citations (7)
Entry
International Preliminary Report on Patentability and English translation of the Written Opinion of the International Searching Authority, dated Oct. 8, 2020, for International Application No. PCT/JP2019/011146.
Extended European Search Report for European Application No. 197/5429.4, dated Oct. 15, 2021.
Jignesh P. et al., “Controlled-release and antibacterial studies of doxycycline-loaded poly(ε-caprolactone) microspheres”, Journal of Saudi Chemical Society, vol. 18, No. 5, Nov. 2014, pp. 566-573.
Raffaella et al., “Cotton fabric functionalisation with menthol/PCL micro- and nano-capsules for comfort improvement”, Journal of Microencapsulation, vol. 32, No. 7, Oct. 3, 2015, pp. 650-660.
Salima et al., “Antimicrobial activity of Iavandin essential oil formulations against three pathogenic food-borne bacteria”, Industrial Crops and Products, vol. 42, Mar. 2013, pp. 243-250.
International Search Report (PCT/ISA/210) issued in PCT/JP2019/011146, dated May 21, 2019.
Written Opinion of the International Searching Authority (PCT/ISA/237) issued in PCT/JP2019/011146, dated May 21, 2019.
Related Publications (1)
Number Date Country
20200390921 A1 Dec 2020 US
Continuations (1)
Number Date Country
Parent PCT/JP2019/011146 Mar 2019 US
Child 17003413 US