Claims
- 1. Drug delivery composition comprising:a polymeric material; a complexing agent; and a bioactive agent complexed with the complexing agent, the polymeric material, complexing agent and bioactive agent formed into a chip.
- 2. The drug delivery composition of claim 1 wherein the complexing agent has a hydrophobic core and hydrophilic exterior.
- 3. The drug delivery composition of claim 2 wherein the complexing agent is β-cyclodextrin.
- 4. The drug delivery composition of claim 2 wherein the complexing agent is methylated β-cyclodextrin.
- 5. The drug delivery composition of claim 2 wherein the complexing agent is hydroxy-propyl β-cyclodextrin.
- 6. The drug delivery composition of claim 2 wherein the bioactive agent is hydrophobic.
- 7. The drug delivery composition of claim 1 wherein the polymeric material is polyglycolic-co-lactic acid (PLGA) co-polymer.
- 8. The drug delivery composition of claim 1 wherein the bioactive agent is an anti-microbial.
- 9. The drug delivery composition of claim 8 wherein the anti-microbial is chlorhexidine.
- 10. The drug delivery composition of claim 8 wherein the anti-microbial is chlorhexidine digluconate.
- 11. The drug delivery composition of claim 1 further including a water-soluble additive.
- 12. The drug delivery composition of claim 11 wherein the additive is a salt.
- 13. The drug delivery composition of claim 11 wherein the additive is poly (ethylene oxide).
- 14. The drug delivery composition of claim 1 wherein the bioactive agent is approximately 20% by weight of the polymer weight.
- 15. The drug delivery composition of claim 1 wherein the polymer weight is approximately 20 KDa.
- 16. The drug delivery composition of claim 1, wherein the polymer weight is approximately 30 KDa.
- 17. The drug delivery composition of claim 11 wherein the additive is in the range of 10-60% by weight of the polymer weight.
- 18. The drug delivery composition of claim 1 adapted for insertion into a periodontal cavity.
Government Interests
The government has rights in this invention pursuant to NSF Grant No. 9525913.
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Entry |
Nagaraju, et al. “Biodegradable Dental Implants Containing Inclusion Complexes of Ciprofloxacin and Norfloxacin With β-Cyclodextrin” Indian Drugs 35(10):662-664, 1998. |
Nagaraju, et al. “Biodegradable Dental Implants of Ciprofloxacin β-Cyclodextrin Inclusion Complex in the Treatment of Periodontitis” Indian Journal of Experimental Biology 37:305-307, 1999. |