Claims
- 1. A method for manufacturing a drug delivery device having more than one layer containing a concentration of drug in excess of saturation which method comprises:
- forming a device comprising a first layer initially containing drug in excess of saturation and a second layer initially free of drug;
- subjecting the device to an elevated temperature for a predetermined period of time sufficient to cause a predetermined amount of a drug to migrate from said first layer into said second layer; and
- rapidly cooling the device to ambient conditions, wherein said first and second layers contain an amount of drug in excess of saturation after said cooling step.
- 2. The method of claim 1 wherein the drug loading is selected such that the first layer comprises drug in excess of saturation after the rapid cooling step.
- 3. A method according to claim 1 wherein the device is a transdermal drug delivery device.
- 4. A method according to claim 1 wherein said first layer comprises a drug reservoir.
- 5. A method according to claim 4 wherein said second layer comprises a contact adhesive.
- 6. A method for manufacturing transdermal drug delivery devices comprising:
- (a) forming a drug reservoir, the drug reservoir comprising a drug loading comprising drug in excess of saturation;
- (b) forming a contact adhesive layer, said contact adhesive being free of drug;
- (c) placing the drug reservoir in drug transferring relation to said adhesive layer to form the device;
- (d) subjecting the device to an elevated temperature for a predetermined period of time in order to cause enhanced migration of the drug from the drug reservoir into the contact adhesive; and
- (e) rapidly cooling the device to ambient conditions.
- 7. A method according to claim 6 further comprising selecting the drug loading in order to provide the adhesive with an amount of drug in excess of saturation after the rapid cooling step.
- 8. A method according to claim 7 further comprising selecting the drug loading in order to provide the drug reservoir with an amount of drug in excess of saturation after the rapid cooling step.
- 9. A method according to claim 6 further comprising selecting the temperature and time in order to provide that the adhesive comprises an amount of drug in excess of saturation after the rapid cooling step.
- 10. A method according to claim 9 wherein the temperature selected is between 30 and 60.degree. C. and the time selected is between 12 hours and 20 days.
- 11. A method according to claim 10 wherein the temperature selected is between 35 and 45.degree. C. and the time selected is between 1-10 days.
- 12. A method according to claim 6 wherein a rate control membrane is provided in between the contact adhesive and the drug reservoir.
- 13. A method according to claim 6 wherein the drug reservoir comprises ethanol.
- 14. A method according to claim 6 wherein the contact adhesive comprises polyisobutylene and mineral oil.
- 15. A method according to claim 6 wherein the contact adhesive comprises an acrylate adhesive.
- 16. A method according to claim 12 wherein the rate control membrane comprises an ethylene vinyl acetate copolymer having a vinyl acetate content of 6-60%.
RELATED APPLICATIONS
This application is a division of application Ser. No. 08/886,960, filed Jul. 1, 1997, which claims priority from U.S. Provisional Application Ser. No. 60/021,124 filed on Jul. 3, 1996.
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Divisions (1)
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Number |
Date |
Country |
Parent |
886960 |
Jul 1997 |
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