Drug Delivery System to Save Hearing During Pediatric Chemotherapy Regimens. POP 09/19/17 - 06/18/18.

Information

  • Research Project
  • 9773848
  • ApplicationId
    9773848
  • Core Project Number
  • Full Project Number
    261201700023C-3-0-1
  • Serial Number
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/19/2017 - 7 years ago
  • Project End Date
    8/28/2020 - 4 years ago
  • Program Officer Name
  • Budget Start Date
    -
  • Budget End Date
    -
  • Fiscal Year
    2018
  • Support Year
  • Suffix
  • Award Notice Date
    -
Organizations

Drug Delivery System to Save Hearing During Pediatric Chemotherapy Regimens. POP 09/19/17 - 06/18/18.

Otomagnetics has invented a magnetic drug delivery device that we intend to develop to enable prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin chemotherapy regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing loss in kids has a dramatic impact on their ability to communicate and learn and is associated with substantial cognitive and speech development deficits. Otomagnetics' drug delivery technology enables topical delivery of otoprotective therapy to the cochlea, and in animal studies has been shown to save hearing from cisplatin regimens. Topical and non-invasive magnetic delivery of a small dose of otoprotective steroid to the cochlea would not interrupt the systemic anti-tumor action of chemotherapy, and in some patients would remove limits on administering needed chemo doses due to induced severe hearing loss.

IC Name
NATIONAL CANCER INSTITUTE
  • Activity
    N43
  • Administering IC
    CA
  • Application Type
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    1999787
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
  • Ed Inst. Type
  • Funding ICs
    NCI:1999787\
  • Funding Mechanism
    SBIR/STTR Contracts
  • Study Section
  • Study Section Name
  • Organization Name
    OTOMAGNETICS, LLC
  • Organization Department
  • Organization DUNS
    078788097
  • Organization City
    BETHESDA
  • Organization State
    MD
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    208141450
  • Organization District
    UNITED STATES