DRUG THERAPY FOR HYPERCALCEMIA/BONE RESORPTION

Information

• Research Project
• 3490267

• ApplicationId

  3490267

• Core Project Number

  R43AR037712

• Full Project Number

  1R43AR037712-01

• Serial Number

  37712

• FOA Number

• Sub Project Id

• Project Start Date

  8/15/1988 - 36 years ago

• Project End Date

  2/14/1989 - 35 years ago

• Program Officer Name

• Budget Start Date

  8/15/1988 - 36 years ago

• Budget End Date

  2/14/1989 - 35 years ago

• Fiscal Year

  1988

• Support Year

  1

• Suffix

• Award Notice Date

  8/11/1988 - 36 years ago

Organizations

• MacroChem Corporation

Current drug therapy for hypercalcemic diseases involving bone resorption is of limited effectiveness. Preliminary animal testing has shown benzo(b)thiophene-2-carboxylic acid (thionapthenecarboxylic acid, TNCA) to be of potential use in inhibiting bone resorption. Overall project goals are to develop TNCA and its derivatives as novel therapeutic entities in the treatment of hypercalcemia of malignancy, hypercalcemia of primary hyperparathyroidism, Paget's Disease, arthritis a osteoporosis. TNCA's use application potentially extends to bone calcium loss suffered in stratospheric residence. Specific Phase I activities include the testing of a novel water- soluble derivative of TNCA in a number of in vivo biological test systems, such as rats with Leydig cell tumors and Walker 256 carcinosarcomas. Animals will be evaluated for survival, bone changes, and toxic effects. Selected animals will be examined histologically for changes in bone resorption based upon the number of osteoclasts and resorption lacunae. In addition, several new and novel tetracycline and phosphonate derivatives will be synthesized and evaluated in a tissue culture test model of bone cells. The new derivatives will also be tested in tissue culture models.

IC Name

• Activity

  R43

• Administering IC

  AR

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  846

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SB

• Study Section Name

  Surgery and Bioengineering Study Section

• Organization Name

  MACROCHEM CORPORATION

• Organization Department

• Organization DUNS

• Organization City

  LEXINGTON

• Organization State

  MA

• Organization Country

  UNITED STATES

• Organization Zip Code

  02421

• Organization District

  UNITED STATES