Claims
- 1. In a method of NMR imaging comprising imaging a patient to whom a contrast agent has been administered, the improvement wherein said contrast agent is a physiologically acceptable chelate compound of formula I ##STR6## wherein Z.sup.1 and Z.sup.2 are each, independently, H or
- --(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R,
- m and n are each independently 0-20,
- k, l, q and r are each independently 0 or 1, and
- R is H, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyl substituted by OR.sup.1, or CH.sub.2 COOR.sup.1,
- R.sup.1 is H, C.sub.1 -C.sub.6 -alkyl, or benzyl,
- R.sup.2 is a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C-atoms which is substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- an aryl group of up to 10 C-atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or
- an aralkyl group of up to 16 C-atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- R.sup.3 is H or a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C-atoms, which is optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- an aryl group of up to 10 C-atoms which is optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or
- an aralkyl group of up to 16 C-atoms optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- X is H and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83,
- wherein acid groups are, in each case, optionally present as an ester with C.sub.1 -C.sub.6 -alkyl, benzyl or 4-methoxybenzyl, or as an amide wherein the nitrogen atom of said amide is substituted by at least one saturated or unsaturated straight-chain, branched-chain or cyclic hydrocarbon radical with up to 5 C atoms, wherein said at least one hydrocarbon radical is optionally substituted by 1-3 hydroxy groups and/or 1-3 C.sub.1 -C.sub.4 -hydroxy groups, or said amide is in the form of a 5- or 6-membered heterocyclic ring with inclusion of the amide nitrogen atom; or
- a salt thereof with an inorganic and/or organic base, an amino acid or an amino acid amide,
- wherein at least two of substituents X are metal ion equivalents of at least one element of atomic numbers 21-29, 42, 44 or 58-70, at least one of substituents Z.sup.1 and Z.sup.2 is H, and, if n and l are each 0, then k and r are not both 1.
- 2. A method according to claim 1, wherein Z.sup.1 and Z.sup.2 each stand for a hydrogen.
- 3. A method according to claim 1, wherein Z.sup.1 stands for a hydrogen atom and Z.sup.2 stands for the radical --(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R.
- 4. A method according to claim 1, wherein Z.sup.2 stands for a hydrogen atom and Z.sup.1 stands for the radical --(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R.
- 5. A method according to claim 1, wherein Z.sup.1 or Z.sup.2 stand for the radicals --CH.sub.2 --C.sub.6 H.sub.4 --OH, --CH.sub.2 --C.sub.6 H.sub.4 --OCH.sub.3, --CH.sub.2 C.sub.6 H.sub.5, --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.2 --C.sub.6 H.sub.4 --OCH.sub.3, --CH.sub.2 --O--CH.sub.2 --C.sub.6 H.sub.5, --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.2 --COOH, --CH.sub.2 --C.sub.6 H.sub.4 --OC.sub.2 H.sub.5, --CH.sub.2 --C.sub.6 H.sub.4 --OC.sub.4 H.sub.9, --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.2 --C.sub.6 H.sub.5.
- 6. A method according to claim 1, wherein R.sup.3 stands for the methyl, ethyl, propyl, isopropyl, butyl, pentyl, hexyl, phenyl, benzyl, 4-carboxy-phenylene, 1-cyclohexyl-1-carboxylic acid, 1-cyclopentyl-1-carboxylic acid, 2-carboxy-phenylene, 11-carboxy-1-undecyl, 10-carboxy-1-decyl, 7-carboxy-1-heptyl, 6-carboxy-1-hexyl, 5-carboxy-1-pentyl, 4-carboxy-benzyl, 4-carboxy-1-cyclohexylmethyl, 4-carboxymethyl-phenylene, 4-(1,1-dimethylcarboxymethylene)-phenylene, 4-sulfophenylene, 10-sulfo-1-decyl, 8-sulfo-1-octyl, 17-carboxy-7-heptadecyl, 7-carboxy-2-heptyl, 1-carboxy-4-phenyl-2-propyl, 2-carboxyethyl, 4-carboxy-4-but-1-enyl radical.
- 7. A method according to claim 1, wherein the patient's gastrointestinal tract, renal system and/or hepatobiliary system is imaged.
- 8. A compound according to claim 1, wherein one COOX group is present as an amide.
- 9. A method according to claim 1, wherein said compound is a gadolinium complex of 3,6-bis(carboxymethyl)-9-(10-carboxydecylcarbamoylmethyl)-3,6,9-triazaundecanedioic acid.
- 10. A method according to claim 9, wherein a portion of the patient's hepatobiliary system is imaged.
- 11. A method of X-ray imaging comprising imaging a patient to whom a contrast agent has been administered, the improvement wherein said contrast agent is a physiologically acceptable chelate compound of formula I ##STR7## wherein Z.sup.1 and Z.sup.2 are each independently H or --(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R,
- m and n are each independently 0-20,
- k, l, q and r are each independently 0 or 1, and
- R is H, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyl substituted by OR.sup.1, or CH.sub.2 COOR.sup.1,
- R.sup.1 is H, C.sub.1 -C.sub.6 -alkyl, or benzyl,
- R.sup.2 is a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C-atoms which is substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- an aryl group of up to 10 C-atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or
- an aralkyl group of up to 16 C-atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- R.sup.3 is H or a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C-atoms, which is optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- an aryl group of up to 10 C-atoms which is optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or
- an aralkyl group of up to 16 C-atoms optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- X is H and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, wherein acid groups are, in each case, optionally present as an ester with C.sub.1 -C.sub.6 -alkyl, benzyl or 4-methoxybenzyl, or as an amide wherein the nitrogen atom of said amide is substituted by at least one saturated or unsaturated straight-chain, branched-chain or cyclic hydrocarbon radical with up to 5 C atoms, wherein said at least one hydrocarbon radical is optionally substituted by 1-3 hydroxy groups and/or 1-3 C.sub.1 -C.sub.4 -hydroxy groups, or said amide is in the form of a 5- or 6-membered heterocyclic ring with inclusion of the amide nitrogen atom; or
- a salt thereof with an inorganic and/or organic base, an amino acid or an amino acid amide,
- wherein at least two of substituents X are metal ion equivalents of at least one element of atomic numbers 21-29, 42, 44 or 57-83, at least one of substituents Z.sup.1 and Z.sup.2 is H, and, if n and l are each 0, then k and r are not both 1.
- 12. A method of radiodiagnostic imaging comprising imaging a patient to whom a contrast agent has been administered, the improvement wherein said contrast agent is a physiologically acceptable chelate compound of formula I ##STR8## wherein Z.sup.1 and Z.sup.2 are each, independently, H or --(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R,
- m and n are each independently 0-20,
- k, l, q and r are each independently 0 or 1, and
- R is H, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyl substituted by OR.sup.1, or CH.sub.2 COOR.sup.1,
- R.sup.1 is H, C.sub.1 -C.sub.6 -allyl, or benzyl,
- R.sup.2 is a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C-atoms which is substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- an aryl group of up to 10 C-atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or
- an aralkyl group of up to 16 C-atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- R.sup.3 is H or a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C-ators, which is optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- an aryl group of up to 10 C-atoms which is optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or
- an aralkyl group of up to 16 C-atoms optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- X is H and/or a metal ion equivalent of a radionuclide of atomic numbers 27, 29, 31, 32, 37-39, 43, 49, 62, 64, 70 or 77 wherein acid groups are, in each case, optionally present as an ester with C.sub.1 -C.sub.6 -alkyl, benzyl or 4-methoxybenzyl, or as an amide wherein the nitrogen atom of said amide is substituted by at least one saturated or unsaturated straight-chain, branched-chain or cyclic hydrocarbon radical with up to 5 C atoms, wherein said at least one hydrocarbon radical is optionally substituted by 1-3 hydroxy groups and/or 1-3 C.sub.1 -C.sub.4 -hydroxy groups, or said amide is in the form of a 5- or 6-membered heterocyclic ring with inclusion of the amide nitrogen atom; or
- a salt thereof with an inorganic and/or organic base, an amino acid or an amino acid amide,
- wherein at least one of substituents Z.sup.1 and Z.sup.2 is H, and, if n and l are each 0, then k and r are not both 1.
- 13. In a method of radiation therapy comprising administering a radiotherapeutic agent to a patient, the improvement wherein said agent is a physiologically acceptable chelate compound of formula I ##STR9## wherein Z.sup.1 and Z.sup.2 are each independently H or --(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R,
- m and n are each independently 0-20,
- k, l, q and r are each independently 0 or 1, and
- R is H, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyl substituted by OR.sup.1, or CH.sub.2 COOR.sup.1,
- R.sup.1 is H, C.sub.1 -C.sub.6 -alkyl, or benzyl,
- R.sup.2 is a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C-atoms which is substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- an aryl group of up to 10 C-atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or
- an aralkyl group of up to 16 C-atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- R.sup.3 is H or a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C-atoms, which is optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- an aryl group of up to 10 C-atoms which is optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or
- an aralkyl group of up to 16 C-atoms optionally substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- X is H and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, wherein acid groups are, in each case, optionally present as an ester with C.sub.1 -C.sub.6 -alkyl, benzyl or 4-methoxybenzyl, or as an amide wherein the nitrogen atom of said amide is substituted by at least one saturated or unsaturated straight-chain, branched-chain or cyclic hydrocarbon radical with up to 5 C atoms, wherein said at least one hydrocarbon radical is optionally substituted by 1-3 hydroxy groups and/or 1-3 C.sub.1 -C.sub.4 -hydroxy groups, or said amide is in the form of a 5- or 6-membered heterocyclic ring with inclusion of the amide nitrogen atom; or
- a salt thereof with an inorganic and/or organic base, an amino acid or an amino acid amide,
- wherein at least one radionuclide is an element of atomic numbers 27, 29, 31, 32, 37-39, 43, 49, 62, 64, 70 or 77, at least one of substituents Z.sup.1 and Z.sup.2 is H, and, if n and l are each 0, then k and r are not both 1.
- 14. A method according to claim 1, wherein R.sup.2 is 4-carboxy-phenylene, 1-cyclohexyl-1-carboxylic acid, 1-cyclopentyl-1-carboxylic acid, 2-carboxy-phenylene, 11-carboxy-1-undecyl, 10-carboxy-1-decyl, 7-carboxy-1-heptyl, 6-carboxy-1-hexyl, 5-carboxy-1-pentyl, 4-carboxy-benzyl, 4-carboxy-1-cyclohexylmethyl, 4-carboxymethyl-phenylene, 4-(1,1-dimethylcarboxymethylene)-phenylene, 4-sulfophenylene, 10-sulfo-1-decyl, 8-sulfo-1-octyl, 17-carboxy-7-heptadecyl, 7-carboxy-2-heptyl, 1-carboxy-4-phenyl-2-propyl, 2-carboxyethyl, or 4-carboxy-4-but-1-enyl.
- 15. A method according to claim 6, wherein R.sup.2 is 4-carboxy-phenylene, 1-cyclohexyl-1-carboxylic acid, 1-cyclopentyl-1-carboxylic acid, 2-carboxy-phenylene, 11-carboxy-1-undecyl, 10-carboxy-1decyl, 7-carboxy-1-heptyl, 6-carboxy-1-hexyl, 5-carboxy-1-pentyl, 4-carboxy-benzyl, 4-carboxy-1-cyclohexylmethyl, 4-carboxymethyl-phenylene, 4-(1,1-dimethylcarboxymethylene)-phenylene, 4-sulfophenylene, 10-sulfo-1-decyl, 8-sulfo-1-octyl, 17-carboxy-7-heptadecyl, 7-carboxy-2-heptyl, 1-carboxy-4-phenyl-2-propyl, 2-carboxyethyl, or 4-carboxy-4-but-1-enyl.
- 16. In a method of NMR imaging comprising imaging a patient to whom a contrast agent has been administered, the improvement wherein:
- the patient's gastrointestinal tract, renal system, and/or hepatobiliary system is imaged, and
- said contrast agent is a physiologically acceptable chelate compound of formula ##STR10## wherein Z.sup.1 and Z.sup.2 are each, independently, H or --(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R,
- m and n are each independently 0-20,
- k, l, q and r are each independently 0 or 1, and
- R is H, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyl substituted by OR.sup.1, or CH.sub.2 COOR.sup.1,
- R.sup.1 is H, C.sub.1 -C.sub.6 -alkyl, or benzyl,
- R.sup.2 is a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C atoms which is substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- an aryl group of up to 10 C atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or
- an aralkyl group of up to 16 C atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- R.sup.3 is H or a saturated, unsaturated, straight-chain or branched-chain or cyclic non-aromatic hydrocarbyl group with up to 20 C atoms, which is substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- an aryl group of up to 10 C atoms which is substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or
- an aralkyl group of up to 16 C atoms substituted by a carboxyl group, a sulfone group, a carboxyl group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl, or a sulfone group esterified with C.sub.1 -C.sub.6 -alkyl or benzyl,
- X is H and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, wherein acid groups are, in each case, optionally present as an ester, or as an amide;
- a salt thereof with an inorganic and/or organic base, an amino acid or an amino acid amide,
- wherein at least two of substituents X are metal ion equivalents of at least one element of atomic numbers 21-29, 42, 44 or 58-70, at least one of substituents Z.sup.1 and Z.sup.2 is H, and, if n and l are each 0, then k and r are not both 1.
- 17. A method according to claim 16, wherein one of Z.sup.1 and Z.sup.2 is H and the other is --CH.sub.2 --C.sub.6 H.sub.4 --OH, --CH.sub.2 --C.sub.6 H.sub.4 --OCH.sub.3, --CH.sub.2 C.sub.6 H.sub.5, --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.2 --C.sub.6 H.sub.4 --OCH.sub.3, --CH.sub.2 --O--CH.sub.2 --C.sub.6 H.sub.5, --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.2 --COOH, --CH.sub.2 --C.sub.6 H.sub.4 --OC.sub.2 H.sub.5, --CH.sub.2 --C.sub.6 H.sub.4 --OC.sub.4 H.sub.9, --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.2 --C.sub.6 H.sub.5.
- 18. A method according to claim 16, wherein R.sup.3 stands for the methyl, ethyl, propyl, isopropyl, butyl, pentyl, hexyl, phenyl, benzyl, 4-carboxy-phenylene, 1-cyclohexyl-1-carboxylic acid, 1-cyclopentyl-1-carboxylicacid, 2-carboxy-phenylene, 11-carboxy-1-undecyl, 10-carboxy-1-decyl, 7-carboxy-1-heptyl, 6-carboxy-1-hexyl, 5-carboxy-1-pentyl, 4-carboxybenzyl, 4-carboxy-1-cyclohexylmethyl, 4-carboxymethyl-phenylene, 4-(1,1-dimethylcarboxymethylene)-phenylene, 4-sulfophenylene, 10-sulfo-1-decyl, 8-sulfo-1-octyl, 17-carboxy-7-heptadecyl, 7-carboxy-2-heptyl, 1-carboxy-4-phenyl-2-propyl, 2-carboxyethyl, 4-carboxy-4-but-1-enyl radical.
Priority Claims (1)
Number |
Date |
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Kind |
40 11 684.0 |
Apr 1990 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 08/228,524 filed Apr. 15, 1994, which is a continuation of Ser. No. 07/681,682, filed Apr. 8, 1991 (abandoned).
US Referenced Citations (22)
Foreign Referenced Citations (6)
Number |
Date |
Country |
0 243 929 |
Nov 1987 |
EPX |
0 258 616 |
Mar 1988 |
EPX |
0 263 059 |
Apr 1988 |
EPX |
0 299 795 |
Jan 1989 |
EPX |
9001024 |
Feb 1990 |
WOX |
9008138 |
Jul 1990 |
WOX |
Divisions (1)
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228524 |
Apr 1994 |
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Continuations (1)
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Date |
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Parent |
681682 |
Apr 1991 |
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