Patent Application
20200363486
The invention relates to magnetic resonance imaging, in particular to Dixon magnetic resonance imaging
A large static magnetic field is used by Magnetic Resonance Imaging (MRI) scanners to align the nuclear spins of atoms as part of the procedure for producing images within the body of a patient. This large static magnetic field is referred to as the B0 field.
During an MRI scan, Radio Frequency (RF) pulses generated by a transmitter coil cause perturbations to the local magnetic field, and RF signals emitted by the nuclear spins are detected by a receiver coil. These RF signals are used to construct the MRI images. These coils can also be referred to as antennas. Further, the transmitter and receiver coils can also be integrated into a single transceiver coil that performs both functions. It is understood that the use of the term transceiver coil also refers to systems where separate transmitter and receiver coils are used. The transmitted RF field is referred to as the B1 field.
MRI scanners are able to construct images of either slices or volumes. A slice is a thin volume that is only one voxel thick. A voxel is a small volume over which the MRI signal is averaged, and represents the resolution of the MRI image. A voxel may also be referred to as a pixel herein.
Dixon methods of magnetic resonance imaging include a family of techniques for producing separate water and lipid (fat) images. The various Dixon techniques such as, but not limited to, two-point Dixon methods, three-point Dixon methods, and six-point Dixon methods are collectively referred to herein as Dixon techniques or methods. The reconstruction of the water and fat images relies on the accurate determination of the phase error, largely due to B0 inhomogeneity, to prevent swapping of water and fat signals.
The journal article Yu et. al. “Single Acquisition Water-Fat Separation: Feasibility Study for Dynamic Imaging,” Magnetic Resonance in Medicine 55:413-422 (2006) discloses a single echo Dixon method that assumes prior knowledge of B0 inhomogeneity.
The invention provides for a magnetic resonance imaging system, a computer program product, and a method in the independent claims. Embodiments are given in the dependent claims.
Gradient echo Dixon imaging is commonly associated with high sound pressure levels because of scan time, spatial resolution, echo time, and receiver bandwidth constraints.
Embodiments may reduce the amount of acoustic noise generated by merging a lower resolution (first resolution) two point Dixon magnetic resonance imaging protocol with a higher resolution (second resolution) single point Dixon magnetic resonance imaging protocol. The two point Dixon magnetic resonance imaging protocol is used to determine a first resolution magnetic field inhomogeneity map. The first resolution magnetic field inhomogeneity map is then interpolated to the second resolution to create a second resolution magnetic field inhomogeneity map. The second resolution magnetic field inhomogeneity map then enables the use of a single point Dixon magnetic resonance imaging protocol.
In one aspect, the invention provides for a magnetic resonance imaging system comprising a memory for storing machine-executable instructions and pulse sequence commands. Pulse sequence commands as used herein encompass commands or data which can be converted into such commands which may be used to control a magnetic resonance imaging system to acquire magnetic resonance imaging data. For example pulse sequence commands may take the form of a timing chart which illustrates when the various actions are performed by various components of the magnetic resonance imaging system. The pulse sequence commands are configured to acquire two point Dixon magnetic resonance data according to a two point Dixon magnetic resonance imaging protocol from a region of interest. The pulse sequence commands are configured to acquire single point Dixon magnetic resonance data according to a single point Dixon magnetic resonance imaging protocol from the region of interest. The two point Dixon magnetic resonance imaging protocol is configured to sample the two point Dixon magnetic resonance data from a central k-space region.
The single point Dixon magnetic resonance imaging protocol is configuration to sample the single point Dixon magnetic resonance data from an expanded k-space region and the central k-space region. In some instances specific data points may belong to both the single point Dixon magnetic resonance data and the two point Dixon magnetic resonance data.
The expanded k-space region is larger than the central k-space region. The combination of the expanded k-space region and the central k-space region may be considered to be the complete k-space that is sampled. The expanded k-space region at least partially surrounds the central k-space region. The two point Dixon magnetic resonance imaging protocol is configured for generating images of the region of interest with a first resolution. The single point Dixon magnetic resonance imaging protocol is configured for generating images of the region of interest with a second resolution. The second resolution is higher than the first resolution.
The magnetic resonance imaging system further comprises a processor for controlling the magnetic resonance imaging system. Execution of the machine-executable instructions causes the processor to control the magnetic resonance imaging system with the pulse sequence commands to acquire the two point Dixon magnetic resonance data and the single point Dixon magnetic resonance data. Execution of the machine-executable instructions further causes the processor to calculate a first magnetic field inhomogeneity map using the two point Dixon magnetic resonance data. Execution of the machine-executable instructions further cause the processor to calculate a second magnetic field inhomogeneity map by interpolating the first resolution magnetic inhomogeneity map to the second resolution. Execution of the machine-executable instructions further cause the processor to calculate a second resolution water image and a second resolution fat image using the single point Dixon magnetic resonance data and the second resolution magnetic field inhomogeneity map.
This embodiment may be beneficial because acquiring the two point Dixon magnetic resonance data at a lower resolution may have the effect of reducing the amount of acoustic noise that occurs when the two point Dixon magnetic resonance data is acquired in comparison to acquiring the two point Dixon magnetic resonance data at the second resolution. An advantage of performing the two point Dixon magnetic resonance imaging protocol is that the magnetic field inhomogeneity map can be determined more reliably. So in this embodiment the two point Dixon magnetic resonance imaging protocol is performed at a lower resolution to lower the noise and to obtain a magnetic field inhomogeneity map at the first resolution. This is then interpolated and used as input for processing the single point Dixon magnetic resonance data. The use of the second magnetic field inhomogeneity map reduces the likelihood of voxels being incorrectly identified as containing predominantly water or fat.
In another embodiment, the pulse sequence commands are configured to sample the two point Dixon magnetic resonance data from a central k-space region using a bipolar dual-echo pulse sequence. The first echo is generated with a first readout gradient lobe with a first polarity and the second echo is generated with a second readout gradient lobe with a second polarity.
In another embodiment, the first readout gradient lobe has a first amplitude and a first duration. The second readout gradient lobe has a second amplitude and a second duration. The first duration times the first amplitude is less than the second duration times the second amplitude. This embodiment has the effect of making the first resolution less than the second resolution. This for example may be beneficial because it may reduce the amount of noise generated when the magnetic resonance data is acquired.
The terms “first readout gradient lobe” and “second readout gradient lobe” as used herein are labels for particular readout gradient lobes. The “first readout gradient lobe” may be performed before or after the “second readout gradient lobe” depending upon the implementation.
In another embodiment, the first amplitude and the second amplitude are the same, this may be beneficial because it may enable the minimization of the gradient amplitudes which may reduce the generation of acoustic noise.
In another embodiment, for example the first amplitude and the second amplitude are equal.
In another embodiment, the first amplitude is less than the second amplitude. This may be beneficial because it may reduce the amount of acoustic noise generated during the acquisition of the two point Dixon magnetic resonance data.
In another embodiment the first duration times the first amplitude times X is less than or equal to the second duration times the second amplitude, wherein X is number having any one of the values: 1.5, 2, 2.5, 3, 4, and 5.
In another embodiment, the first readout gradient lobe has a first amplitude and a first duration. The second readout gradient lobe has a second amplitude and a second duration. The first duration times the first amplitude times 2 equals the second duration times the second amplitude. The advantages of this embodiment have been discussed previously.
In another embodiment, the pulse sequence commands are further configured to sample the second echo asymmetrically. This again may have the benefit of reducing the amount of acoustic noise.
In another embodiment, the second resolution is twice as high as the first resolution in a readout direction and/or a phase encoding direction. This embodiment may be beneficial because it may reduce the amount of acoustic noise generated during the acquisition of the magnetic resonance data.
In another embodiment, the pulse sequence commands are further configured to sample the single point Dixon magnetic resonance data from the central k-space region and the expanded k-space region using the bipolar dual-echo pulse sequence. In this embodiment the bipolar dual-echo pulse sequence is used to acquire all of the magnetic resonance data. Again, this may have the benefit of reducing the amount of acoustic noise generated.
In another embodiment, the pulse sequence commands are configured to obtain the single point Dixon magnetic resonance data from the second echo of the bipolar dual-echo pulse sequence. For example the data acquired from both the first and second echo may be used for the two point Dixon magnetic resonance protocol and the data acquired from just the second echo may be used as input for the single point Dixon magnetic resonance imaging protocol.
In another embodiment, the pulse sequence commands are configured to partially sample the single point Dixon magnetic resonance data from the expanded k-space region using a unipolar single echo pulse sequence. The pulse sequence commands are further configured to sample the single point Dixon magnetic resonance data from the central k-space region and partially sample the expanded k-space region using the bipolar dual-echo pulse sequence. In this example a combination of a unipolar single echo pulse sequence and a dual-echo pulse sequence are used to acquire the magnetic resonance data. This may provide for more complete sampling of the k-space than using the bipolar dual-echo pulse sequence alone. This may provide for better image quality.
In another embodiment, the first readout gradient lobe has a first amplitude and a first duration. The second readout gradient lobe has a second amplitude and a second duration. The first duration times the first amplitude is less than the second duration times the second amplitude. This embodiment has the effect of making the first resolution less than the second resolution. This for example may be beneficial because it may reduce the amount of noise generated when the magnetic resonance data is acquired.
In another embodiment, the first amplitude and the second amplitude are the same, this may be beneficial because it may enable the minimization of the gradient amplitudes which may reduce the generation of acoustic noise.
In another embodiment, for example the first amplitude and the second amplitude could be the same. The value of the first amplitude can then be chosen to reduce noise.
In another embodiment, the first amplitude is less than the second amplitude. This may be beneficial because it may reduce the amount of acoustic noise generated during the acquisition of the two point Dixon magnetic resonance data.
In another embodiment the first duration times the first amplitude times X is less than or equal to the second duration times the second amplitude. Wherein X is number having any one of the values: 1.5, 2, 2.5, 3, 4, and 5.
In another embodiment, the first readout gradient lobe has a first amplitude and a first duration. The second readout gradient lobe has a second amplitude and a second duration. 2 times the first duration times the first amplitude equals the second duration x the second amplitude. The advantages of this embodiment have been discussed previously.
In another embodiment, the unipolar single echo pulse sequence has a third readout gradient lobe with a third amplitude and a third duration. The third duration times the third amplitude is greater than the second duration times the second amplitude. In this case the unipolar single echo pulse sequence is used to sample regions of k-space that have not been sampled by the bipolar dual-echo pulse sequence. When the bipolar dual-echo pulse sequence is used a portion of the expanded k-space region adjacent to the central k-space region is not sampled. This embodiment may be used to sample lines of k-space which are completely outside of the central k-space region. It provides for sampling the k-space at the same resolution for the single point Dixon protocol.
In another embodiment, the third amplitude is equal to or less than the second amplitude.
In another embodiment, the unipolar single echo pulse sequence has a third readout gradient lobe with a third amplitude and a third duration. The third duration times the third amplitude is equal to the second duration times the second amplitude times 1.5. In this case the unipolar single echo pulse sequence is used to sample regions of k-space that have not been sampled by the bipolar dual-echo pulse sequence. When the bipolar dual-echo pulse sequence is used a portion of the expanded k-space region adjacent to the central k-space region is not sampled. This embodiment may be used to sample lines of k-space which are completely outside of the central k-space region. It provides for sampling the k-space at the same resolution for the single point Dixon protocol.
In another embodiment, the third amplitude and the second amplitude are the same. This may be beneficial because the amplitude of the gradient pulses may be minimized which may reduce acoustic noise generation.
In another embodiment the bipolar dual-echo pulse sequences and the unipolar single echo pulse sequence have identical repetition times and flip angles. This embodiment may be beneficial because the use of the identical repetition times and flip angles means that the data acquired from the two pulse sequences can be combined and the contrast and other qualities of the image will be the same.
In another embodiment, the pulse sequence commands are configured to acquire the two point Dixon magnetic resonance imaging data and the single point Dixon magnetic resonance imaging data interleaved in time. For example a bipolar dual-echo pulse sequence could be used to sample only the central k-space region, and a unipolar single echo pulse sequence could be used to sample the complete k-space which includes both the expanded k-space region and the central k-space region. These two sequences could then be interleaved. In this case the bipolar dual-echo pulse sequence and the unipolar single echo pulse sequence may have identical repetition times and flip angles, however it is not strictly necessary.
In another embodiment, the calculation of the second resolution water image and the second resolution fat image is calculated at least partially using the two point Dixon magnetic resonance imaging data. In this way, the two point Dixon magnetic resonance imaging data is used not only to calculate the magnetic field inhomogeneity map, but also to improve the signal-to-noise ratio in the resulting water and fat images, for example.
In another aspect, the invention provides for a method of operating a magnetic resonance imaging system. The method comprises controlling the magnetic resonance imaging system with pulse sequence commands to acquire two point Dixon magnetic resonance data and single point Dixon magnetic resonance data. The pulse sequence commands are configured to acquire the two point Dixon magnetic resonance data according to a two point Dixon magnetic resonance imaging protocol from a region of interest. The pulse sequence commands are configured to acquire the single point Dixon magnetic resonance data according to a single point Dixon magnetic resonance imaging protocol from the region of interest. The two point Dixon magnetic resonance imaging protocol is configured to sample the two point Dixon magnetic resonance data from a central k-space region.
The single point Dixon magnetic resonance imaging protocol is configured to sample the single point Dixon magnetic resonance data from an expanded k-space region. The expanded k-space region is larger than the central k-space region. The expanded k-space region is at least partially surrounding the central k-space region. The two point Dixon magnetic resonance imaging protocol is configured for generating images of the region of interest with a first resolution. The single point Dixon magnetic resonance imaging protocol is configured for generating images of the region of interest with a second resolution. The second resolution is higher than the first resolution. The method further comprises calculating a first magnetic field inhomogeneity map using the two point Dixon magnetic resonance data. The method further comprises calculating a second magnetic field inhomogeneity map by interpolating the first resolution magnetic field inhomogeneity map to the second resolution. The method further comprises calculating a second resolution water image and a second resolution fat image using the single point Dixon magnetic resonance imaging data and the second resolution magnetic field inhomogeneity map. The advantages of this embodiment have been previously discussed.
In another aspect, the invention provides for a computer program product comprising machine-executable instructions for execution by a processor controlling the magnetic resonance imaging system. Execution of the machine-executable instructions causes the processor to control the magnetic resonance imaging system with pulse sequence commands to acquire the two point Dixon magnetic resonance data and single point Dixon magnetic resonance data. The pulse sequence commands are configured to acquire the two point Dixon magnetic resonance data according to a two point Dixon magnetic resonance imaging protocol from a region of interest. The pulse sequence commands are configured to acquire the single point Dixon magnetic resonance data according to a single point Dixon magnetic resonance imaging protocol from the region of interest.
The two point Dixon magnetic resonance imaging protocol is configured to sample the two point Dixon magnetic resonance data from a central k-space region. The single point Dixon magnetic resonance imaging protocol is configured to sample the single point Dixon magnetic resonance data from an expanded k-space region. The expanded k-space region is larger than the central k-space region. The expanded k-space region at least partially surrounds the central k-space region. The two point Dixon magnetic resonance imaging protocol is configured for generating images of the region of interest with a first resolution. The single point Dixon magnetic resonance imaging protocol is configured for generating images of the region of interest with a second resolution. The second resolution is higher than the first resolution.
Execution of the machine-executable instructions further causes the processor to calculate a first resolution magnetic field inhomogeneity map using the two point Dixon magnetic resonance data. Execution of the machine-executable instructions further causes the processor to calculate a second resolution magnetic field inhomogeneity map by interpolating the first resolution magnetic field inhomogeneity map to the second resolution. Execution of the machine-executable instructions further causes the processor to calculate a second resolution water image and a second resolution fat image using the single point Dixon magnetic resonance data and the second resolution magnetic field inhomogeneity map. The advantages of this embodiment have been previously discussed.
It is understood that one or more of the aforementioned embodiments of the invention may be combined as long as the combined embodiments are not mutually exclusive.
As will be appreciated by one skilled in the art, aspects of the present invention may be embodied as an apparatus, method or computer program product. Accordingly, aspects of the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment (including firmware, resident software, micro-code, etc.) or an embodiment combining software and hardware aspects that may all generally be referred to herein as a “circuit,” “module” or “system.” Furthermore, aspects of the present invention may take the form of a computer program product embodied in one or more computer readable medium(s) having computer executable code embodied thereon.
Any combination of one or more computer readable medium(s) may be utilized. The computer readable medium may be a computer readable signal medium or a computer readable storage medium. A ‘computer-readable storage medium’ as used herein encompasses any tangible storage medium which may store instructions which are executable by a processor of a computing device. The computer-readable storage medium may be referred to as a computer-readable non-transitory storage medium. The computer-readable storage medium may also be referred to as a tangible computer readable medium. In some embodiments, a computer-readable storage medium may also be able to store data which is able to be accessed by the processor of the computing device. Examples of computer-readable storage media include, but are not limited to: a floppy disk, a magnetic hard disk drive, a solid state hard disk, flash memory, a USB thumb drive, Random Access Memory (RAM), Read Only Memory (ROM), an optical disk, a magneto-optical disk, and the register file of the processor. Examples of optical disks include Compact Disks (CD) and Digital Versatile Disks (DVD), for example CD-ROM, CD-RW, CD-R, DVD-ROM, DVD-RW, or DVD-R disks. The term computer readable-storage medium also refers to various types of recording media capable of being accessed by the computer device via a network or communication link. For example a data may be retrieved over a modem, over the internet, or over a local area network. Computer executable code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to wireless, wire line, optical fiber cable, RF, etc., or any suitable combination of the foregoing.
A computer readable signal medium may include a propagated data signal with computer executable code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated signal may take any of a variety of forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A computer readable signal medium may be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device.
‘Computer memory’ or ‘memory’ is an example of a computer-readable storage medium. Computer memory is any memory which is directly accessible to a processor. ‘Computer storage’ or ‘storage’ is a further example of a computer-readable storage medium. Computer storage is any non-volatile computer-readable storage medium. In some embodiments computer storage may also be computer memory or vice versa.
A ‘processor’ as used herein encompasses an electronic component which is able to execute a program or machine executable instruction or computer executable code. References to the computing device comprising “a processor” should be interpreted as possibly containing more than one processor or processing core. The processor may for instance be a multi-core processor. A processor may also refer to a collection of processors within a single computer system or distributed amongst multiple computer systems. The term computing device should also be interpreted to possibly refer to a collection or network of computing devices each comprising a processor or processors. The computer executable code may be executed by multiple processors that may be within the same computing device or which may even be distributed across multiple computing devices.
Computer executable code may comprise machine executable instructions or a program which causes a processor to perform an aspect of the present invention. Computer executable code for carrying out operations for aspects of the present invention may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, Smalltalk, C++ or the like and conventional procedural programming languages, such as the “C” programming language or similar programming languages and compiled into machine executable instructions. In some instances the computer executable code may be in the form of a high level language or in a pre-compiled form and be used in conjunction with an interpreter which generates the machine executable instructions on the fly.
The computer executable code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the latter scenario, the remote computer may be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet Service Provider).
Aspects of the present invention are described with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems) and computer program products according to embodiments of the invention. It is understood that each block or a portion of the blocks of the flowchart, illustrations, and/or block diagrams, can be implemented by computer program instructions in form of computer executable code when applicable. It is further under stood that, when not mutually exclusive, combinations of blocks in different flowcharts, illustrations, and/or block diagrams may be combined. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks.
These computer program instructions may also be stored in a computer readable medium that can direct a computer, other programmable data processing apparatus, or other devices to function in a particular manner, such that the instructions stored in the computer readable medium produce an article of manufacture including instructions which implement the function/act specified in the flowchart and/or block diagram block or blocks.
The computer program instructions may also be loaded onto a computer, other programmable data processing apparatus, or other devices to cause a series of operational steps to be performed on the computer, other programmable apparatus or other devices to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide processes for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks.
A ‘user interface’ as used herein is an interface which allows a user or operator to interact with a computer or computer system. A ‘user interface’ may also be referred to as a ‘human interface device.’ A user interface may provide information or data to the operator and/or receive information or data from the operator. A user interface may enable input from an operator to be received by the computer and may provide output to the user from the computer. In other words, the user interface may allow an operator to control or manipulate a computer and the interface may allow the computer indicate the effects of the operator's control or manipulation. The display of data or information on a display or a graphical user interface is an example of providing information to an operator. The receiving of data through a keyboard, mouse, trackball, touchpad, pointing stick, graphics tablet, joystick, gamepad, webcam, headset, pedals, wired glove, remote control, and accelerometer are all examples of user interface components which enable the receiving of information or data from an operator.
A ‘hardware interface’ as used herein encompasses an interface which enables the processor of a computer system to interact with and/or control an external computing device and/or apparatus. A hardware interface may allow a processor to send control signals or instructions to an external computing device and/or apparatus. A hardware interface may also enable a processor to exchange data with an external computing device and/or apparatus. Examples of a hardware interface include, but are not limited to: a universal serial bus, IEEE 1394 port, parallel port, IEEE 1284 port, serial port, RS-232 port, IEEE-488 port, Bluetooth connection, Wireless local area network connection, TCP/IP connection, Ethernet connection, control voltage interface, MIDI interface, analog input interface, and digital input interface.
A ‘display’ or ‘display device’ as used herein encompasses an output device or a user interface adapted for displaying images or data. A display may output visual, audio, and or tactile data. Examples of a display include, but are not limited to: a computer monitor, a television screen, a touch screen, tactile electronic display, Braille screen, Cathode ray tube (CRT), Storage tube, Bi-stable display, Electronic paper, Vector display, Flat panel display, Vacuum fluorescent display (VF), Light-emitting diode (LED) displays, Electroluminescent display (ELD), Plasma display panels (PDP), Liquid crystal display (LCD), Organic light-emitting diode displays (OLED), a projector, and Head-mounted display.
Magnetic Resonance (MR) data is defined herein as being the recorded measurements of radio frequency signals emitted by atomic spins using the antenna of a Magnetic resonance apparatus during a magnetic resonance imaging scan. A Magnetic Resonance Imaging (MRI) image or MR image is defined herein as being the reconstructed two or three dimensional visualization of anatomic data contained within the magnetic resonance imaging data. This visualization can be performed using a computer.
In the following preferred embodiments of the invention will be described, by way of example only, and with reference to the drawings in which:
Like numbered elements in these figures are either equivalent elements or perform the same function. Elements which have been discussed previously will not necessarily be discussed in later figures if the function is equivalent.
Within the bore 106 of the magnet there is also a set of magnetic field gradient coils 110 which is used for acquisition of magnetic resonance data to spatially encode magnetic spins within the imaging zone 108 of the magnet 104. The magnetic field gradient coils 110 are connected to a magnetic field gradient coil power supply 112. The magnetic field gradient coils 110 are intended to be representative. Typically magnetic field gradient coils 110 contain three separate sets of coils for spatially encoding in three orthogonal spatial directions. A magnetic field gradient power supply supplies current to the magnetic field gradient coils. The current supplied to the magnetic field gradient coils 110 is controlled as a function of time and may be ramped or pulsed.
Adjacent to the imaging zone 108 is a radio-frequency coil 114 for manipulating the orientations of magnetic spins within the imaging zone 108 and for receiving radio transmissions from spins also within the imaging zone 108. The radio frequency antenna may contain multiple coil elements. The radio frequency antenna may also be referred to as a channel or antenna. The radio-frequency coil 114 is connected to a radio frequency transceiver 116. The radio-frequency coil 114 and radio frequency transceiver 116 may be replaced by separate transmit and receive coils and a separate transmitter and receiver. It is understood that the radio-frequency coil 114 and the radio frequency transceiver 116 are representative. The radio-frequency coil 114 is intended to also represent a dedicated transmit antenna and a dedicated receive antenna. Likewise the transceiver 116 may also represent a separate transmitter and separate receivers. The radio-frequency coil 114 may also have multiple receive/transmit elements and the radio frequency transceiver 116 may have multiple receive/transmit channels. For example if a parallel imaging technique such as SENSE is performed, the radio-frequency could 114 will have multiple coil elements.
The transceiver 116 and the gradient controller 112 are shown as being connected to a hardware interface 128 of a computer system 126. The computer system further comprises a processor 130 that is in communication with the hardware system 128, a memory 134, and a user interface 132. The memory 134 may be any combination of memory which is accessible to the processor 130. This may include such things as main memory, cached memory, and also non-volatile memory such as flash RAM, hard drives, or other storage devices. In some examples the memory 134 may be considered to be a non-transitory computer-readable medium.
The memory 134 is shown as containing machine-executable instructions 140. The machine-executable instructions 140 enable the processor 130 to control the operation and function of the magnetic resonance imaging system 100. The machine-executable instructions 140 may also enable the processor 130 to perform various data analysis and calculation functions. The computer memory 134 is further shown as containing pulse sequence commands 142. The pulse sequence commands are configured for controlling the magnetic resonance imaging system 100 to acquire magnetic resonance data from the subject.
The computer memory 134 is further shown as containing two point Dixon magnetic resonance data 144 and single point Dixon magnetic resonance data 146 that was acquired from the region of interest 109 when the pulse sequence commands 142 were executed. The memory 134 is further shown as containing a first resolution magnetic field inhomogeneity map 148 that was calculated from the two point Dixon magnetic resonance data 144. The memory 134 is also shown as optionally containing a first resolution water image 150 and a first resolution fat image 152 that may also be calculated from the first resolution magnetic field inhomogeneity map 148.
The memory 134 is further shown as containing a second resolution magnetic field inhomogeneity map 154 that was created or calculated by interpolating the first resolution magnetic field inhomogeneity map 148 to the second resolution. The memory 134 is further shown as containing a second resolution water image 156 and a second resolution fat image 158 that were calculated using the single point Dixon magnetic resonance data 146 and the second resolution magnetic field inhomogeneity map 154. If the first resolution water image 150 and the first resolution fat image 152 are available they may also be used. For example the first resolution water image and the first resolution fat image could also be interpolated to the second resolution and used for a consistency check.
In some instances, there is some overlap or redundancy between the single point Dixon magnetic resonance data and the two point Dixon magnetic resonance data 144. For example, some of the two point Dixon magnetic resonance data 144 could be used as single point Dixon magnetic resonance data 146.
Next in step 204 the second resolution magnetic field inhomogeneity map 154 is calculated by interpolating the first resolution magnetic field inhomogeneity map 148 to the second resolution. Finally in step 206 the second resolution water image 156 and the second resolution fat image 158 are calculated using the single point Dixon magnetic resonance imaging data 146 and the second resolution magnetic field inhomogeneity map 154. The method in
Compared to standard gradient echo imaging, gradient echo Dixon imaging provides superior fat suppression and multiple contrasts simultaneously. It is commonly implemented with a dual-echo sequence, which generates two echoes after each excitation with a bipolar readout gradient.
The readout gradient 302 has a first readout gradient lobe 310 which has a first amplitude 312 and a first duration 314. It also has a second readout gradient lobe 316 which has a second amplitude 318 and a second duration 320. The second amplitude has an opposite polarity to the first amplitude. There is also an RF pulse 322 and then a first sampling 324 which corresponds to the first readout gradient lobe 310 and a second sampling 326 which corresponds to the second readout gradient lobe 316. The pulse sequence 300 depicted in
Alternatively, a single echo sequence may be used, which acquires only one echo after each excitation, as shown in
Gradient echo Dixon imaging is usually associated with high sound pressure levels because of
Dual-echo sequences require an additional inversion of the readout gradient, which contributes to acoustic noise. Single-echo sequences complicate an accurate water-fat separation, because of fundamental difficulties in estimating the spatial variation of the main field reliably.
Examples may merge low-resolution dual-echo and high-resolution single-echo sequences to reduce acoustic noise in gradient echo Dixon imaging while meeting the mentioned constraints.
Two examples are described in more detail below. The first embodiment, illustrated in
One way of reducing acoustic noise would be to first sample the central k-space region 402 using the pulse sequence 700. The first magnetic field inhomogeneity map could then be calculated. The single point Dixon magnetic resonance data could then be acquired using the pulse sequence 500 and trajectories in k-space similar to the one in
The scan time for the hybrid dual-/single-echo sequence of
If the dual-echo and single-echo sequences are interleaved in time, the repetition time and the flip angle may also be varied between the two sequences to decrease the sound pressure level further at the expense of contrast.
The second embodiment, illustrated in
In general, low-resolution or partial echo acquisitions facilitate obtaining favorable echo times in gradient echo Dixon imaging, especially when lower readout gradient strengths are employed to reduce acoustic noise.
In
The pulse sequence 900 of
While the invention has been illustrated and described in detail in the drawings and foregoing description, such illustration and description are to be considered illustrative or exemplary and not restrictive; the invention is not limited to the disclosed embodiments.
Other variations to the disclosed embodiments can be understood and effected by those skilled in the art in practicing the claimed invention, from a study of the drawings, the disclosure, and the appended claims. In the claims, the word “comprising” does not exclude other elements or steps, and the indefinite article “a” or “an” does not exclude a plurality. A single processor or other unit may fulfill the functions of several items recited in the claims. The mere fact that certain measures are recited in mutually different dependent claims does not indicate that a combination of these measured cannot be used to advantage. A computer program may be stored/distributed on a suitable medium, such as an optical storage medium or a solid-state medium supplied together with or as part of other hardware, but may also be distributed in other forms, such as via the Internet or other wired or wireless telecommunication systems. Any reference signs in the claims should not be construed as limiting the scope.
| Number | Date | Country | Kind |
|---|---|---|---|
| 18151141.1 | Jan 2018 | EP | regional |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/EP2019/050385 | 1/9/2019 | WO | 00 |
