EARLY DETECTION OF OVARIAN CARCINOMA

Information

  • Research Project
  • 3491190
  • ApplicationId
    3491190
  • Core Project Number
    R43CA040945
  • Full Project Number
    1R43CA040945-01
  • Serial Number
    40945
  • FOA Number
  • Sub Project Id
  • Project Start Date
    8/1/1985 - 39 years ago
  • Project End Date
    1/31/1986 - 38 years ago
  • Program Officer Name
  • Budget Start Date
    8/1/1985 - 39 years ago
  • Budget End Date
    1/31/1986 - 38 years ago
  • Fiscal Year
    1985
  • Support Year
    1
  • Suffix
  • Award Notice Date
    -
Organizations

EARLY DETECTION OF OVARIAN CARCINOMA

This phase I SBIR proposal will investigate the feasibility of conducting larger studies to determine whether the CA 25 immunoradiometric assay (IRMA), which measures tumor-associated antigenic determinants in serum, will be useful for early detection of ovarian cancer among asymptomatic women. The aims of the present investigation will be to: (1)\formulate a final protocol for a larger study; (2)\develop methods to standardize data, evaluation of data and subjects, followup, and study end points; (3)\make provisions for human subject committee requirements, subject registration and followup, collection and forwarding of samples and data, checking data for compliance, maintaining security of data, keeping investigators informed of study changes, developments, and outcomes, and analyzing data and reporting final results; (4)\identify an appropriate study population; (5)\assemble a group of investigators willing to enter subjects and follow the protocol; and (6)\gather preliminary performance data on the CA 125 IRMA to justify proceeding with a larger study. The principal end points of the phase I study will include final protocols, companion forms, a clear plan to proceed to tne next phase, and publications resulting from performance data collection. These results should also provide a model for future evaluation of serum assays for such purposes. (5)

IC Name
NATIONAL CANCER INSTITUTE
  • Activity
    R43
  • Administering IC
    CA
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    394
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    SSS
  • Study Section Name
  • Organization Name
    CENTOCOR, INC.
  • Organization Department
  • Organization DUNS
  • Organization City
    MALVERN
  • Organization State
    PA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    19355
  • Organization District
    UNITED STATES