Efficient Generation of Knockout and Knockin Rats Using RNA TALENs and Rat Stem C

Information

• Research Project
• 8464506

• ApplicationId

  8464506

• Core Project Number

  R43OD016687

• Full Project Number

  1R43OD016687-01

• Serial Number

  016687

• FOA Number

  RFA-OD-12-003

• Sub Project Id

• Project Start Date

  9/17/2012 - 12 years ago

• Project End Date

  2/28/2014 - 10 years ago

• Program Officer Name

  CONTRERAS, MIGUEL A.

• Budget Start Date

  9/17/2012 - 12 years ago

• Budget End Date

  2/28/2014 - 10 years ago

• Fiscal Year

  2012

• Support Year

  01

• Suffix

• Award Notice Date

  9/17/2012 - 12 years ago

Organizations

• FACTOR BIOSCIENCE INC.

DESCRIPTION (provided by applicant): The annual cost of care for Alzheimer's disease (AD) in the US is currently estimated at $200 billion, and is expected to rise to $1.1 trillion by 2050. Despite these costs and the prevalence of the disease (1 in 8 older Americans has AD), the etiology of AD remains elusive. A major limitation to the study and treatment of AD and other neurodegenerative diseases is the lack of suitable in vivo models. This application aims to solve this problem, using our proprietary RNA TALENs technology to generate knockout and knockin rats to better screen drugs to treat AD and to better model AD progression. In addition to providing products to enhance AD research (the rat models), this application will demonstrate the feasibility of our technology to generate rat models for screening other diseases, especially neurodegenerative diseases. PUBLIC HEALTH RELEVANCE: This project will use our RNA TALENs technology to generate rat stem cells with inactivation/modifications of genes associated with Alzheimer's disease. The results of this project will be a method for rapid generation of knockout and knockin rats for modeling and drug screening, and rats containing specific modification to genes associated with Alzheimer's disease.!

IC Name

• Activity

  R43

• Administering IC

  OD

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

  150000

• Sub Project Total Cost

• ARRA Funded

  False

• CFDA Code

  837

• Ed Inst. Type

• Funding ICs

  NHGRI:31500\NHLBI:2218\NIAAA:31200\NIAID:2700\NIDA:62500\NINR:782\OD:19100\

• Funding Mechanism

  SBIR-STTR RPGs

• Study Section

  ZRG1

• Study Section Name

  Special Emphasis Panel

• Organization Name

  FACTOR BIOSCIENCE, INC.

• Organization Department

• Organization DUNS

  078319523

• Organization City

  CAMBRIDGE

• Organization State

  MA

• Organization Country

  UNITED STATES

• Organization Zip Code

  021411891

• Organization District

  UNITED STATES