ELECTRICALLY ENHANCED TRANSDERMAL DELIVERY OF CALCITONIN

Information

  • Research Project
  • 2646784
  • ApplicationId
    2646784
  • Core Project Number
    R43AR044794
  • Full Project Number
    1R43AR044794-01A1
  • Serial Number
    44794
  • FOA Number
  • Sub Project Id
  • Project Start Date
    4/10/1998 - 26 years ago
  • Project End Date
    2/9/1999 - 25 years ago
  • Program Officer Name
  • Budget Start Date
    4/10/1998 - 26 years ago
  • Budget End Date
    2/9/1999 - 25 years ago
  • Fiscal Year
    1998
  • Support Year
    1
  • Suffix
    A1
  • Award Notice Date
    4/6/1998 - 26 years ago
Organizations

ELECTRICALLY ENHANCED TRANSDERMAL DELIVERY OF CALCITONIN

DESCRIPTION (Adapted from the application): Electrically enhanced transdermal delivery of calcitonin has the potential to be a superior alternative to patient injection for several clinical indications. Iontophoresis, alone or in combination with electrophoration, could deliver calcitonin for chronic treatment of post-menopausal osteoporosis and Paget's disease, possibly via a biofeedback system and under certain circumstances electroporation followed by iontophoresis could deliver calcitonin rapidly for control of hypercalcemic emergencies. The goal of this proposal is to establish the optimum combination of electrical parameters such as ionophoretic current density, electroporative voltage, pulse length, number and spacing to rapidly achieve steady state flux of therapeutically relevant concentrations of calcitonin for various indications. Formulation factors such as pH, buffer, ionic strength, and the use of excipients such as stabilizers, preservatives and/or protease inhibitors will also be optimized. After establishing the optimum formulation and electrical protocol by in vitro studies across human epidermis, results will be validated in hairless rats by measuring serum calcitonin levels as well as blood calcium levels in the rat. This proposed study will expand on the most encouraging preliminary results which have shown a 4 fold enhancement in the flux of calcitonin transported across human skin in vitro when iontophoresis was combined with electroporation over iontophoresis alone. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

IC Name
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
  • Activity
    R43
  • Administering IC
    AR
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    846
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    ZRG3
  • Study Section Name
  • Organization Name
    GENETRONICS, INC.
  • Organization Department
  • Organization DUNS
    122735749
  • Organization City
    SAN DIEGO
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    921211318
  • Organization District
    UNITED STATES