Patent Application
20160010225
The invention which follows relates to an electrochemical process for coupling two phenols of different oxidation potential. The invention further relates to novel biphenols which can be prepared, for example, by electrochemical coupling.
The term “phenols” is used as a generic term in this application and therefore also encompasses substituted phenols. Two phenols having a different oxidation potential must therefore also have different substitution.
Direct coupling of two different phenols has to date been described only by an electrochemical route: Sartori et al. J. Org. Chem. 1993, 58, 7271-7273. The coupling is effected here using an oxidizing agent such as FeCl3, VOCl3, p-benzoquinone, CuBr2 or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), and with addition of AlCl3.
Disadvantages of the methods described by Sartori et al. are need for the dry solvents and for exclusion of air. Furthermore, large amounts of oxidizing agents, some of which are toxic (e.g. DDQ), are used. During the reaction, toxic by-products occur, which have to be separated in a complex manner from the desired product and disposed of in an expensive manner.
To date, the coupling only of identical phenols by an electrochemical route has been successfully conducted and described: Kirste et al. Chem. Eur. J. 2011, 17, 14164-14169; Kirste et al. Org. Lett., Vol. 13, No. 12, 2011; Kirste et al. Chem. Eur. J. 2009, 15, 2273-2277.
A problem which occurs in the electrochemical coupling of different molecules is that the co-reactants generally have different oxidation potentials EOx. The result of this is that the molecule having the lower oxidation potential has a higher propensity to release an electron (e−) to the anode and an H+ ion to, for example, the solvent than the molecule having the higher oxidation potential. The oxidation potential EOx can be calculated via the Nernst equation:
E
Ox
=E°+(0.059/n)*Ig([Ox]/[Red])
EOx: electrode potential for the oxidation reaction (=oxidation potential)
E°: standard electrode potential
n: number of electrons transferred
[Ox]: concentration of the oxidized form
[Red]: concentration of the reduced form
If the processes cited in the literature above were to be applied to two different phenols, the result of this would be to form predominantly free radicals of the molecule having a lower oxidation potential, which would then react with themselves. By far the predominant main product obtained would thus be a biphenol which has formed from two identical phenols. This problem does not occur in the coupling of identical molecules.
The problem addressed by the invention which follows was to provide an electrochemical process in which phenols having different oxidation potentials can be coupled to one another, and the yield of the biphenol formed from two different phenols is above that as achievable by the electrochemical methods known from the literature, i.e. above that of the biphenol formed from two different phenols.
In addition, novel biphenols were to be synthesized.
The problem is solved by a process according to Claim 8.
Compound of one of the general formulae (I) to (III):
where R2, R3, R4, R5, R6, R7, R10, R11, R12, R13, R14, R16, R18, R19, R20, R21, R24 are selected from:
—H, -alkyl, —O-alkyl, —O-aryl, —S-alkyl, —S-aryl;
R8, R15, R17 are -alkyl;
R1, R9, R22, R23 are selected from: —H, -alkyl;
and, if R3 is -Me, R1 and R2 are not both —H.
Alkyl is an unbranched or branched aliphatic carbon chain having 1 to 10 carbon atoms. The carbon chain preferably has 1 to 6 carbon atoms, more preferably 1 to 4 carbon atoms.
Aryl for aromatic (hydrocarbyl) radicals, preferably having up to 14 carbon atoms, e.g. phenyl-(C6H5—), naphthyl- (C10H7—), anthryl- (C14H9—), preferably phenyl.
In one embodiment of the invention, R2, R3, R4, R5, R6, R7, R10, R11, R12, R13, R14, R16, R18, R19, R20, R21, R24 are selected from: —H, -alkyl, —O-alkyl, —O-aryl.
In one embodiment of the invention, R2, R3, R4, R5, R6, R7, R10, R11, R12, R13, R14, R16, R18, R19, R20, R21, R24 are selected from: —H, -alkyl.
In one embodiment of the invention, R4 and R5 are —H.
In one embodiment of the invention, R3 and R6 are -alkyl.
In one embodiment of the invention, R1 is —O-alkyl.
In one embodiment of the invention, R13 is -alkyl.
In one embodiment of the invention, R19 is -alkyl.
As well as the compounds, also claimed is a process by which, for example, the abovementioned compounds can be prepared.
Electrochemical process for preparing biphenols, comprising the process steps of:
a) introducing a solvent or solvent mixture and a conductive salt into a reaction vessel,
b) adding a first phenol having an oxidation potential IEOx1I to the reaction vessel,
c) adding a second phenol having an oxidation potential IEOx2I to the reaction vessel, where:
IE
Ox2>IEOx1I and IEOx2I−IEOx1I=IΔEI,
the second phenol being added in excess relative to the first phenol,
and the solvent or solvent mixture being selected such that ΔE is in the range from 10 mV to 450 mV,
d) introducing two electrodes into the reaction solution,
e) applying a voltage to the electrodes,
f) coupling the first phenol to the second phenol to give a biphenol.
Process steps a) to d) can be effected here in any sequence.
One aspect of the invention is that the yield of the reaction can be controlled via the difference in the oxidation potentials (IΔEI) of the two phenols.
The process according to the invention solves the problem mentioned at the start.
For efficient conduct of the reaction, two reaction conditions are necessary:
If the first condition is not met, the main product formed is the biphenol which forms through the coupling of two molecules of the first phenol.
If IΔEI is too small, too much biphenol which forms through the coupling of two molecules of the second phenol is by-produced.
If, in contrast, IΔEI is too large, an excessively high excess of the second phenol would be required, which would make the reaction uneconomic.
For the process according to the invention, knowledge of the absolute oxidation potentials of the two phenols is not absolutely necessary. It is sufficient when the difference in the two oxidation potentials from one another is known.
A further aspect of the invention is that the difference in the two oxidation potentials (IΔEI) can be influenced via the solvents or solvent mixtures used.
For instance, the difference in the two oxidation potentials (IΔEI) can be moved into the desired range by suitable selection of the solvent/solvent mixture.
Proceeding from 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as the base solvent, a IΔEI which is too small can be increased, for example, by addition of alcohol. A IΔEI which is too large can be lowered, in contrast, by addition of water.
The reaction sequence which proceeds is shown in the following scheme:
First of all, the compound A having the lower oxidation potential releases an electron to the anode. Because of the positive charge, the compound A becomes a very strong acid and spontaneously releases a proton. The radical thus formed then reacts with the compound B which is present in the solution in excess relative to the compound A. The biphenol AB radical formed by the coupling releases an electron to the anode and a proton to the solvent.
If the phenol B had not been added in excess, the phenol A radical would react with a second phenol A radical to give the corresponding biphenol AA.
With the aid of the process according to the invention, it has been possible for the first time to electrochemically couple phenols having different oxidation potentials in good yields.
In one variant of the process, the conductive salt is selected from the group of alkali metal, alkaline earth metal, tetra(C1-C6-alkyl)ammonium, 1,3-di(C1-C6-alkyl)imidazolium and tetra(C1-C6-alkyl)phosphonium salts.
In one variant of the process, the counter ions of the conductive salts are selected from the group of sulphate, hydrogensulphate, alkylsulphates, arylsulphates, alkylsulphonates, arylsulphonates, halides, phosphates, carbonates, alkylphosphates, alkylcarbonates, nitrate, tetrafluoroborate, hexafluorophosphate, hexafluorosilicate, fluoride and perchlorate.
In one variant of the process, the conductive salt is selected from tetra(C1-C6-alkyl)ammonium salts, and the counterion is selected from sulphate, alkylsulphate, arylsulphate.
In one variant of the process, the second phenol is used at least in twice the amount relative to the first phenol.
In one variant of the process, the ratio of the first phenol to the second phenol is in the range from 1:2 to 1:4.
In one variant of the process, either the first phenol the second phenol has an —O-alkyl group.
In one variant of the process, the solvent or solvent mixture is selected such that IΔEI is in the range from 20 mV to 400 mV, preferably in the range from 30 mV to 350 mV.
In one variant of the process, the reaction solution is free of fluorinated compounds.
In one variant of the process, the reaction is free of transition metals.
In one variant of the process, the reaction solution is free of substrates having departing functionalities other than hydrogen atoms.
In the process claimed, it is possible to dispense with leaving groups at the coupling sites apart from hydrogen atoms.
In one variant of the process, the reaction solution is free of organic oxidizing agents.
In one variant of the process, the first phenol and the second phenol are selected from: Ia, Ib, IIa, IIb, IIIa, IIIb:
where R2, R3, R4, R5, R6, R7, R10, R11, R12, R13, R14, R16 , R18, R19, R20, R21, R24 are selected from:
—H, -alkyl, —O-alkyl;
R8, R15, R17 are -alkyl;
R1, R9, R22, R23 are selected from: —H, -alkyl,
and the following combinations are possible here:
Alkyl is an unbranched or branched aliphatic carbon chain having 1 to 10 carbon atoms. The carbon chain preferably has 1 to 6 carbon atoms, more preferably 1 to 4 carbon atoms.
Aryl for aromatic (hydrocarbyl) radicals, preferably having up to 14 carbon atoms, e.g. phenyl-(C6H5—), naphthyl- (C10H7—), anthryl- (C14H9—), preferably phenyl.
In one variant of the process, if R3 is -Me, R1 and R2 are not both —H.
The invention is illustrated in detail hereinafter by working examples and a figure.
In
In
In
In
The preparative liquid chromatography separations via “flash chromatography” were conducted with a maximum pressure of 1.6 bar on 60 M silica gel (0.040-0.063 mm) from Macherey-Nagel GmbH & Co, Düren. The unpressurized separations were conducted on Geduran Si 60 silica gel (0.063-0.200 mm) from Merck KGaA, Darmstadt. The solvents used as eluents (ethyl acetate (technical grade), cyclohexane (technical grade)) were purified beforehand by distillation on a rotary evaporator.
For thin-layer chromatography (TLC), ready-to-use PSC plates, silica gel 60 F254 from Merck KGaA, Darmstadt, were used. The Rf values are reported according to the eluent mixture used. The TLC plates were stained using a cerium-molybdatophosphoric acid solution as a dipping reagent: 5.6 g of molybdatophosphoric acid, 2.2 g of cerium(IV) sulphate tetrahydrate and 13.3 g of concentrated sulphuric acid in 200 ml of water.
The gas chromatography analyses (GC) of product mixtures and pure substances were effected with the aid of the GC-2010 gas chromatograph from Shimadzu, Japan. Measurement is effected on an HP-5 quartz capillary column from Agilent Technologies, USA (length: 30 m; internal diameter: 0.25 mm; film thickness of the covalently bound stationary phase: 0.25 μm; carrier gas: hydrogen; injector temperature: 250° C.; detector temperature: 310° C.; programme: “hard” method: start temperature 50° C. for 1 min, heating rate: 15° C./min, final temperature 290° C. for 8 min). Gas chromatography mass spectra (GCMS) of product mixtures and pure substances were recorded with the aid of the GC-2010 gas chromatograph combined with the GCMS-QP2010 mass detector from Shimadzu, Japan. Measurement is effected on an HP-1 quartz capillary column from Agilent Technologies, USA (length: 30 m; internal diameter: 0.25 mm; film thickness of the covalently bound stationary phase: 0.25 μm; carrier gas: hydrogen; injector temperature: 250° C.; detector temperature: 310° C.; programme: “hard” method: start temperature 50° C. for 1 min, heating rate: 15° C./min, final temperature 290° C. for 8 min; GCMS: ion source temperature: 200° C.).
Melting points were measured with the aid of the SG 2000 melting point measuring instrument from HW5, Mainz and are uncorrected.
The elemental analyses were conducted in the Analytical Division of the Department of Organic Chemistry at the Johannes Gutenberg University of Mainz on a Vario EL Cube from Foss-Heraeus, Hanau.
All electrospray ionization analyses (ESI+) were conducted on a QT of Ultima 3 from Waters Micromasses, Milford, Massachussetts. EI mass spectra and the high-resolution EI spectra were measured on an instrument of the MAT 95 XL sector-field instrument type from ThermoFinnigan, Bremen.
The NMR spectroscopy studies were conducted on multi-nuclear resonance spectrometers of the AC 300 or AV II 400 type from Bruker, Analytische Messtechnik, Karlsruhe. The solvent used was CDCl3. The 1H and 13C spectra were calibrated according to the residual content of undeuterated solvent according to the NMR Solvent Data Chart from Cambridge Isotopes Laboratories, USA. Some of the 1H and 13C signals were assigned with the aid of H,H COSY, H,H NOESY, H,C HSQC and H,C HMBC spectra. The chemical shifts are reported as δ values in ppm. For the multiplicities of the NMR signals, the following abbreviations were used: s (singlet), bs (broad singlet), d (doublet), t (triplet), q (quartet), m (multiplet), dd (doublet of doublets), dt (doublet of triplets), tq (triplet of quartets). All coupling constants J were reported with the number of bonds covered in Hertz (Hz). The numbers reported in the signal assignment correspond to the numbering given in the formula schemes, which need not correspond to IUPAC nomenclature.
The coupling reaction was conducted in an apparatus as shown in
Anode: boron-doped diamond (BDD) on Si
Cathode: Ni mesh
Current density [j]: 2.8 mA/cm2
Quantity of charge [Q]: 2 F/mol of deficiency component
Terminal voltage [Umax]: 3-5 V
The synthesis of the biphenols was effected according to the above-described general procedure, and in a reaction apparatus as shown in
0.69 g (5 mmol, 1.0 equiv.) of 4-methylguaiacol and 2.28 g (15 mmol, 3.0 equiv.) of 3-methyl-4-(methylethyl)phenol were dissolved in 33 ml of HFIP, 0.68 g of MTES was added and the electrolyte was transferred into the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 9:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a colourless solid.
Yield: 716 mg (50%, 2.5 mmol)
GC (hard method, HP-5): tR=14.87 min
Rf(CH:EA=4:1)=0.43
mp=126.8° C. (recrystallized from CH)
1H NMR (600 MHz, DMSO) δ=1.17-1.12 (m, 6H, 13-H), 2.24 (m, 6H, 9-H/12-H), 3.01 (dt, 1H, 11-H), 3.79 (s, 3H, 8-H), 6.55 (s, 1H, 6-H), 6.66 (d, 1H, 6′-H), 6.73 (d, 1H, 4-H), 6.96 (s, 1H, 3′-H), 8.16 (s, 1H, 7-H), 8.84 (s, 1H, 10-H);
Couplings: 4J4-H,6-H=2.2 Hz, 4J6-H,11-H=2.9 Hz, 3J11-H,13-H=6.8 Hz;
13C NMR (151 MHz, DMSO) δ=18.73, 20.80 (C-9/C-12), 23.54 (C-13), 28.10 (C-11), 55.78 (C-8), 111.23 (C-4), 117.34 (C-6′), 123.42 (C-1′), 123.49 (C-6), 126.43 (C−1), 127.36 (C-5), 127.49 (C-3′), 134.40 (C-5′), 136.62 (C-4′), 141.12 (C-2), 147.65 (C-3), 151.69 (C-2′).
HRMS for C18H22O3 (ESI+) [M+Na+]: calc.: 309.1467. found: 309.1457.
MS (EI, GCMS): m/z (%): 286 (50) [M]+, 271 (100) [M−CH3]+, 244 (22) [M−C3H6]+.
Elemental analysis for C18H22O3: calc.: C, 75.50%; H, 7.74%. found: C, 75.01%; H, 7.70%.
1.66 g (12 mmol, 1.0 equiv.) of 4-methylguaiacol and 3.91 g (36 mmol, 3.0 equiv.) of 4-methylphenol were dissolved in 65 ml of HFIP and 14 ml of MeOH, 1.63 g of MTES were added and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 4:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a colourless solid.
Yield: 440 mg (36%, 1.8 mmol)
GC (hard method, HP-5): tR=13.56 min
Rf(CH:EA=4:1)=0.38
mp=162.0° C. (recrystallized from CH)
1H NMR (400 MHz, DMSO) δ=2.18 (s, 3H, 9-H/11-H), 2.21 (s, 3H, 9-H/11-H), 3.76 (s, 3H, 8-H), 6.53 (s, 1H, 6-H), 6.71 (s, 1H, 4-H), 6.75 (d, 1H, 3′-H), 6.86-6.94 (m, 2H, 4′-H/6′-H), 8.53 (bs, 1H, 7-H/12-H);
Couplings: 3J3′-H,4′-H=8.4 Hz;
13C NMR (101 MHz, DMSO) δ=20.21, 20.77 (C-9/C-11), 55.79 (C-8), 111.36 (C-4), 115.69 (C-3′), 123.50 (C-6), 125.72 (C-1′), 126.16 (C−1), 127.20 (C-5), 127.30 (C-5′), 128.50 (C-6′), 131.83 (C-4′), 141.20 (C-2), 147.61 (C-3), 152.11 (C-2′).
HRMS for C15H16O3 (ESI+) [M+Na+]: calc.: 267.0997. found: 267.0999.
MS (EI, GCMS): m/z (%): 244 (100) [M]+, 229 (64) [M−CH3]+.
Elemental analysis for C15H16O3: calc.: C, 73.75%; H, 6.60%. found: C, 73.81%; H, 6.54%.
1.66 g (12 mmol, 1.0 equiv.) of 4-methylguaiacol and 4.49 g (36 mmol, 3.0 equiv.) of 4-methoxyphenol were dissolved in 80 ml of HFIP, 1.63 g of MTES were added and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 4:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a colourless solid.
Yield: 2.05 g (66%, 7.9 mmol)
GC (hard method, HP-5): tR=14.03 min
Rf(CH:EA=4:1)=0.33
mp=118.7° C. (recrystallized from DCM/CH)
1H NMR (600 MHz, DMSO) δ=2.01 (s, 3H, 9-H), 3.66 (s, 3H, 8-H), 3.77 (s, 3H, 10-H), 6.53 (d, 1H, 6-H), 6.55 (s, 1H, 6′-H), 6.72 (dd, 1H, 4-H), 6.77 (s, 1H, 3′-H), 6.79 (d, 1H, 3-H), 8.73 (s, 1H, 11-H), 8.75 (s, 1H, 7-H);
Couplings: 3J3-H,4-H=8.7 Hz; 4J4-H,6-H=3.0 Hz
13C NMR (151 MHz, DMSO) δ=19.33 (C-9), 55.32 (C-8), 55.73 (C-10), 113.24 (C-4), 113.75 (C-3′), 115.99 (C-3), 116.07 (C-6), 117.40 (C-6′), 126.56 (C-2′), 129.06 (C−1), 130.95 (C-1′), 143.80 (C-5′), 146.52 (C-4′), 148.29 (C-2), 151.81 (C-5).
HRMS for C15H16O4 (ESI+) [M+Na+]: calc.: 283.0946. found: 283.0942.
MS (EI, GCMS): m/z (%): 260 (100) [M]+, 245 (12) [M−CH3]+.
Elemental analysis for C15H16O4: calc.: 69.22%; H, 6.20%. found: C, 69.02%; H, 6.34%.
0.70 g (6 mmol, 1.0 equiv.) of 4-methylguaiacol and 2.08 g (17 mmol, 3.0 equiv.) of 2,4-dimethylphenol were dissolved in 27 ml of HFIP and 6 ml of MeOH, 0.68 g of MTES was added and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 9:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a pale yellow solid.
Yield: 663 mg (45%, 2.5 mmol)
GC (hard method, HP-5): tR=13.97 min
Rf(CH:EA=4:1)=0.29
mp=119.7° C. (recrystallized from DCM/CH)
1H NMR (400 MHz, CDCl3) δ=2.34 (s, 3H, 10-H), 2.35 (s, 3H, 11-H), 2.38 (s, 3H, 9-H), 3.94 (s, 3H, 8-H), 6.16 (s, 1H, 12-H), 6.20 (s, 1H, 7-H), 6.76 (d, 1H, 4-H), 6.78 (d, 1H, 6-H), 6.98 (d, 1H, 6′-H), 7.03 (d, 1H, 4′-H);
Couplings: 4J4-H,6-H=1.7 Hz, 4J4′-H,6′-H=2.1 Hz;
13C NMR (101 MHz, CDCl3) δ=16.51 (C-9), 20.54 (C-10), 21.20 (C-11), 56.12 (C-8), 110.92 (C-4), 123.95 (C-6), 124.13 (C−1), 124.64 (C-1′), 126.18 (C-3′), 128.82 (C-6′), 129.59 (C-5′), 130.40 (C-5), 131.40 (C-4′), 139.46 (C-2), 146.35 (C-3), 149.42 (C-2′).
HRMS for C18H16O3 (ESI+) [M+Na+]: calc.: 281.1154. found: 281.1152.
MS (EI, GCMS): m/z (%): 242 (100) [M]+, 227 (38) [M−CH3]+.
Elemental analysis for C16H18O3: calc.: C, 68.31%; H, 6.45%. found: C, 68.29%; H, 6.40%.
0.69 g (5 mmol, 1.0 equiv.) of 4-methylguaiacol and 2.25 g (15 mmol, 3.0 equiv.) of 3-tert-butylphenol were dissolved in 33 ml of HFIP, 0.68 g of MTES was added and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 4:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a colourless solid.
Yield: 808 mg (63%, 3.1 mmol)
GC (hard method, HP-5): tR=13.97 min
Rf(CH:EA=4:1)=0.29
mp=160.3° C. (recrystallized from DCM/CH)
1H NMR (400 MHz, CDCl3) δ=1.37 (s, 9H, 12-H), 2.36 (s, 3H, 9-H), 3.94 (s, 3H, 8-H), 6.25 (s, 1H, 7-H), 6.48 (s, 1H, 10-H), 6.75 (d, 1H, 6-H), 6.79 (d, 1H, 4-H), 7.08 (dd, 1H, 5′-H), 7.12 (d, 1H, 3′-H), 7.27 (d, 1H, 6′-H);
Couplings: 4J4-H,6-H=1.7 Hz; 3J5′-H,6′-H=8.0 Hz, 4J3′-H,5′-H=1.7 Hz;
13C NMR (101 MHz, CDCl3) δ=21.24 (C-9), 31.31 (C-12), 34.58 (C-11), 56.15 (C-8), 110.79 (C-4), 114.94 (C-3′), 118.30 (C-5′), 122.37 (C-1′), 123.88 (C−1), 123.94 (C-6), 130.45 (C-6′), 130.53 (C-4′), 139.24 (C-5), 146.32 (C-3), 152.91 (C-2′), 153.13 (C-2).
HRMS for C15H16O4 (ESI+) [M+Na+]: calc.: 309.1467. found: 309.1466.
MS (EI, GCMS): m/z (%): 242 (100) [M]+, 227 (38) [M−CH3]+.
Elemental analysis for C18H22O3: calc.: 75.50%; H, 7.74%. found: C, 75.41%; H, 7.72%.
0.70 g (5 mmol, 1.0 equiv.) of 4-methylguaiacol and 1.65 g (15 mmol, 3.0 equiv.) of 3-methylphenol were dissolved in 33 ml of HFIP, 0.68 g of MTES was added and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 4:1 eluent (cyclohexane:ethyl acetate) and two cross-coupling products are obtained as colourless solids.
Yield: 266 mg (21%, 1.1 mmol)
GC (hard method, HP-5): tR=13.72 min
Rf(CH:EA=4:1)=0.25
mp=136.2° C. (recrystallized from DCM/CH)
1H NMR (400 MHz, CDCl3) δ=2.35 (s, 3H, 9-H/11-H), 2.37 (s, 3H, 9-H/11-H), 3.94 (s, 3H, 8-H), 6.17 (s, 1H, 10-H), 6.35 (s, 1H, 2-H), 6.74 (d, 1H, 4-H), 6.76 (s, 1H, 6-H), 6.88-6.83 (m, 1H, 5′-H), 6.90 (d, 1H, 3′-H), 7.21 (d, 1H, 6′-H);
Couplings: 4J4-H,6-H=1.8 Hz, 3J5′-H,6′-H=7.7 Hz, 4J3′-H,5′-H=1.5 Hz;
13C NMR (101 MHz, CDCl3) δ=21.11, 21.20 (C-9/C-11), 56.13 (C-8), 110.81 (C-4), 118.25 (C-3′), 121.97 (C-5′), 122.39 (C−1), 123.77 (C-1′), 123.85 (C-6), 130.50 (C-5), 130.68 (C-6′), 139.30 (C-4′), 139.54 (C-2), 146.31 (C-3), 153.33 (C-2′).
HRMS for C15H16O3 (ESI+) [M+Na+]: calc.: 267.0997. found: 267.1006.
MS (EI, GCMS): m/z (%): 244 (100) [M]+, 229 (18) [M−CH3]+.
Elemental analysis for C15H16O3: calc.: C, 73.75%; H, 6.60%. found: C, 73.70%; H, 6.68%.
Yield: 285 mg (23%, 1.2 mmol)
GC (hard method, HP-5): tR=13.81 min
Rf(CH:EA=4:1)=0.19
mp=61.9° C. (recrystallized from DCM/CH)
1H NMR (400 MHz, CDCl3) δ=2.17 (s, 3H, 10-H), 2.32 (s, 3H, 9-H), 3.92 (s, 3H, 8-H), 4.77 (s, 1H, 11-H), 5.45 (s, 1H, 7-H), 6.59-6.53 (m, 1H, 6-H), 6.74-6.68 (m, 2H, 4-H/5′-H), 6.76 (d, 1H, 3′-H), 7.09 (d, 1H, 6′-H);
Couplings: 3J5′-H,6′-H=8.2 Hz, 4J3′-H,5′-H=2.7 Hz;
13C NMR (101 MHz, CDCl3) δ=20.04 (C-10), 21.09 (C-9), 55.97 (C-8), 110.51 (C-4), 112.53 (C-5′), 116.62 (C-3′), 123.47 (C-6), 127.28 (C−1), 128.74 (C-5), 130.02 (C-1′), 131.17 (C-6′), 138.56 (C-2′), 140.49 (C-2), 146.24 (C-3), 154.84 (C-4′).
HRMS for C15H16O3 (ESI+) [M+Na+]: calc.: 267.0997. found: 267.0995.
MS (EI, GCMS): m/z (%): 244 (100) [M]+, 229 (18) [M−CH3]+.
Elemental analysis for C15H16O3: calc.: C, 73.75%; H, 6.60%. found: C, 73.70%; H, 6.70%.
0.69 g (5 mmol, 1.0 equiv.) of 4-methylguaiacol and 1.83 g (15 mmol, 3.0 equiv.) of 3,4-dimethylphenol were dissolved in 27 ml of HFIP and 6 ml of MeOH, 0.68 g of MTES was added and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 9:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a colourless solid.
Yield: 688 mg (52%, 2.6 mmol)
GC (hard method, HP-5): tR=14.52 min
Rf(CH:EA=4:1)=0.29
mp=152.3° C. (recrystallized from DCM/CH)
1H NMR (400 MHz, CDCl3) δ=12.25 (s, 3H, 11-H), 2.28 (s, 3H, 12-H), 2.36 (s, 3H, 9-H), 3.93 (s, 3H, 8-H), 6.19 (s, 1H, 7-H), 6.25 (s, 1H, 10-H), 6.73 (d, 1H, 4-H), 6.76 (s, 1H, 6-H), 6.88 (s, 1H, 3′-H), 7.08 (s, 1H, 6′-H);
Couplings: 4J4-H,6-H=1.7 Hz;
13C NMR (101 MHz, CDCl3) δ=18.89 (C-11), 19.60 (C-12), 21.24 (C-9), 56.14 (C-8), 110.74 (C-4), 118.93 (C-3′), 122.54 (C−1), 123.82 (C-6), 123.97 (C-1′), 129.03 (C-5), 130.46 (C-4′), 131.69 (C-6′), 137.94 (C-5′), 139.26 (C-2), 146.31 (C-3), 151.36 (C-2′).
HRMS for C16H18O3 (ESI+) [M+Na+]: calc.: 281.1154. found: 281.1157.
MS (EI, GCMS): m/z (%): 258 (100) [M]+, 243 (10) [M−CH3]+.
Elemental analysis for C16H18O3: calc.: 74.39%; H, 7.02%. found: C, 74.32%; H, 7.20%.
0.69 g (5 mmol, 1.0 equiv.) of 4-methylguaiacol and 2.05 g (15 mmol, 3.0 equiv.) of 4-isopropylphenol were dissolved in 27 ml of HFIP and 6 ml of MeOH, 0.68 g of MTES was added and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 4:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a brownish oil.
Yield: 0.53 g (39%, 1.9 mmol)
GC (hard method, HP-5): tR=14.23 min
Rf(CH:EA=4:1)=0.30
1H NMR (400 MHz, CDCl3) δ=1.27 (m, 6H), 2.36 (s, 3H), 2.91 (dt, J=13.8, 6.9, 6.9 Hz, 1H), 3.94 (s, 3H), 6.13-6.27 (m, 2H), 6.82-6.65 (m, 1H), 6.25 (m, 2H), 6.75 (s, 1H), 6.77 (s, 1H), 6.99 (d, J=8.1 Hz, 1H), 7.19-7.12 (m, 2H);
13C NMR (101 MHz, CDCl3) δ=21.25, 24.27, 33.40, 56.18, 110.92, 117.60, 123.91, 124.23, 125.07, 127.29, 128.80, 130.57, 139.29, 141.42, 146.31, 151.51.
HRMS for C17H20O3 (ESI+) [M+Na+]: calc.: 295.1310. found: 295.1297.
MS (EI, GCMS): m/z (%): 272 (80) [M]+, 257 (100) [M−CH3]+.
0.69 g (5 mmol, 1.0 equiv.) of 4-methylguaiacol and 2.26 g (15 mmol, 3.0 equiv.) of 4-tert-butylphenol were dissolved in 27 ml of HFIP and 6 ml of MeOH, 0.68 g of MTES was added and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 4:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a yellowish oil.
Yield: 0.48 g (34%, 1.7 mmol)
GC (hard method, HP-5): tR=14.52 min
Rf(CH:EA=4:1)=0.24
1H NMR (400 MHz, CDCl3) δ=1.34 (s, 9H), 2.37 (s, 3H), 3.94 (s, 3H), 6.17 (s, 1H), 6.24 (s, 1H), 6.75 (s, 1H), 6.77 (s, 1H), 6.99 (d, J=8.4 Hz, 1H), 7.31-7.29 (m, 1H), 7.33 (dd, J=8.4, 2.5 Hz, 1H).
13C NMR (101 MHz, CDCl3) δ=21.28, 31.61, 34.20, 56.18, 110.91, 117.25, 123.92, 124.41, 124.63, 126.38, 127.78, 130.58, 139.32, 143.70, 146.32, 151.22.
HRMS for C18H22O3 (ESI+) [M+Na+]: calc.: 309.1467. found: 309.1476.
MS (EI, GCMS): m/z (%): 286 (28) [M]+, 271 (100) [M−CH3]+.
0.69 g (5 mmol, 1.0 equiv.) of 4-methylguaiacol and 3.12 g (15 mmol, 3.0 equiv.) of 2,4-di-tert-butylphenol were dissolved in 27 ml of HFIP and 6 ml of MeOH, 0.68 g of MTES was added and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 9:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a colourless solid.
Yield: 0.41 g (24%, 1.2 mmol)
GC (hard method, HP-5): tR=15.15 min
Rf(CH:EA=9:1)=0.35
mp=120.2° C. (recrystallized in n-pentane)
1H NMR (400 MHz, CDCl3) δ=1.36 (s, 9H), 1.50 (s, 9H), 2.38 (s, 3H), 3.96 (s, 3H), 6.00 (s, 1H), 6.05 (s, 1H), 6.77 (s, 1H), 7.16 (d, J=2.5 Hz, 1H), 7.39 (d, J=2.5 Hz, 1H).
13C NMR (101 MHz, CDCl3) δ=21.23, 29.88, 31.69, 34.40, 35.23, 56.17, 111.03, 123.96, 124.17, 125.09, 125.50, 130.42, 136.73, 139.72, 142.36, 146.45, 149.82.
MS (EI, GCMS): m/z (%): 342 (22) [M]+, 327 (100) [M−CH3]+.
0.69 g (5 mmol, 1.0 equiv.) of 4-methylguaiacol and 2.47 g (15 mol, 3.0 equiv.) of 2-methyl-4-tert-butylphenol were dissolved in 27 ml of HFIP and 6 ml of MeOH, 0.68 g of MTES was added and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 4:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a yellowish oil.
Yield: 0.69 g (46%, 2.3 mmol)
GC (hard method, HP-5): tR=14.79 min
Rf(CH:EA=4:1)=0.33
1H NMR (400 MHz, CDCl3) δ=1.37 (s, 9H), 2.39 (d, J=2.4 Hz, 6H), 3.94 (s, 3H), 6.15 (s, 1H), 6.17 (s, 1H), 6.77 (s, 1H), 6.79 (s, 1H), 7.17 (d, J=2.5 Hz, 1H), 7.24 (d, J=2.4 Hz, 1H);
13C NMR (101 MHz, CDCl3) δ=16.90, 21.28, 31.67, 34.12, 56.16, 110.94, 124.02, 124.17, 124.59, 125.41, 125.65, 127.86, 130.47, 139.50, 143.07, 146.40, 149.41.
MS (EI, GCMS): m/z (%): 300 (18) [M]+, 285 (100) [M−CH3]+.
MTES was added to 0.69 g (5 mmol, 1.0 eq.) of 4-methylguaiacol and 2.05 g (15 mmol, 3.0 eq.) of 4-isopropylphenol and 0.68 g of MTES in 27 ml of HFIP+6 ml of MeOH and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 4:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a brownish oil.
Yield: 39%, 527 mg, 1.9 mmol.
Rf (cyclohexane:ethyl acetate=4:1)=0.30; 1H NMR (400 MHz, CDCl3) δ=1.27 (m, 6H), 2.36 (s, 3H), 2.91 (sept, J=6.9 Hz, 1H), 3.94 (s, 3H), 6.13-6.27 (m, 2H), 6.65-6.82 (m, 2H), 6.99 (d, J=8.1 Hz, 1H), 7.12-7.19 (m, 2H); 13C NMR (101 MHz, CDCl3) 5=21.37, 24.39, 33.53, 56.31, 111.04, 117.73, 124.04, 124.36, 125.20, 127.42, 128.93, 130.70, 139.42, 141.55, 146.44, 151.64. HRMS for C17H20O3 (ESI+) [M+Na+]: calc.: 295.1310. found: 295.1297. MS (EI, GCMS): m/z (%): 272 (80) [M]+, 257 (100) [M−CH3]+.
0.69 g (5 mmol, 1.0 eq.) of 4-methylguaiacol and 2.065 g (15 mmol, 3.0 eq.) of 3-isopropylphenol and 0.68 g of MTES were dissolved in 33 ml of HFIP and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 4:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a brownish oil (yield: 52%, 705 mg, 2.6 mmol).
Rf (cyclohexane:ethyl acetate=4:1)=0.29; 1H NMR (400 MHz, CDCl3) δ=1H NMR (400 MHz, CDCl3) δ 1.27 (s, 3H), 1.29 (s, 3H), 2.34 (s, 3H), 2.91 (sept, J=7.0 Hz, 1H), 3.94 (s, 3H), 6.15 (s, 1H), 6.35 (s, 1H), 6.73 (d, J=1.8 Hz, 1H), 6.75-6.77 (m, 1H), 6.90 (dd, J=7.9 Hz, 1.8 Hz, 1H), 6.94 (d, J=1.7 Hz, 1H), 7.23 (d, J=7.8 Hz, 1H). 13C NMR (101 MHz, CDCl3) δ=13C NMR (101 MHz, CDCl3) δ 21.36, 24.02, 33.92, 56.30, 77.16, 110.91, 115.77, 119.56, 122.81, 124.00, 124.08, 130.65, 130.84, 139.38, 146.43, 150.72, 153.54. HRMS for C17H20O3 (ESI+) [M+Na+]: calc.: 295.1310. found: 295.1305. MS (EI, GCMS): m/z (%): 272 (100) [M]+, 257 (50) [M−CH3]+.
Elemental anal. for C17H20O3: calc.: 74.97%; H, 7.40%. found: C, 75.05%; H, 7.36%.
0.28 g (2 mmol, 1.0 eq.) of 4-methylguaiacol, 1.22 g (6 mmol, 3.0 eq.) of 3-methylphenyl and 0.77 g of MTBS were dissolved 25 ml of HFIP and the electrolyte was transferred to the beaker-type electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 4:1 eluent (cyclohexane:ethyl acetate) and led to the two cross-coupling products as a colourless and viscous oil.
Yield: 21%, 266 mg, 1.1 mmol; Rf (cyclohexane:ethyl acetate=4:1)=0.25; mp=136.2° C. (crystallized from dichloromethane/cyclohexane); 1H NMR (400 MHz, CDCl3) δ=2.35 (s, 3H), 2.37 (s, 3H), 3.94 (s, 3H), 6.17 (s, 1H), 6.35 (s, 1H), 6.74 (d, J=1.8 Hz, 1H), 6.76 (s, 1H), 6.88-6.83 (m, 1H), 6.90 (d, 1H, J=1.5 Hz), 7.21 (d, 1H, J=7.7 Hz); 3C NMR (101 MHz, CDCl3) δ=21.11, 21.20 56.13, 110.81, 118.25, 121.97, 122.39, 123.77, 123.85, 130.50, 130.68, 139.30, 139.54, 146.31, 153.33. HRMS for C15H16O3 (ESI+) [M+Na+]: calc.: 267.0997. found: 267.1006. MS (EI, GCMS): m/z (%): 244 (100) [M], 229 (18) [M−CH3]+. Elemental anal. for C15H16O3: calc.: C, 73.75%; H, 6.60%. found: C, 73.70%; H, 6.68%.
Yield: 23%, 285 mg, 1.2 mmol; Rf (cyclohexane:ethyl acetate=4:1)=0.19 mp=61.9° C. (crystallized from dichloromethane/cyclohexane); 1H NMR (400 MHz, CDCl3) δ=2.17 (s, 3H), 2.32 (s, 3H), 3.92 (s, 3H), 4.77 (s, 1H), 5.45 (s, 1H), 6.59-6.53 (m, 1H), 6.74-6.68 (m, 2H), 6.76 (d, 1H, J=2.7 Hz), 7.09 (d, 1H, J=8.2 Hz); 13C NMR (101 MHz, CDCl3) δ=20.04, 21.09, 55.97, 110.51, 112.53, 116.62, 123.47, 127.28, 128.74, 130.02, 131.17, 138.56, 140.49, 146.24, 154.84. HRMS for C15H16O3 (ESI+) [M+Na+]: calc.: 267.0997. found: 267.0995. MS (EI, GCMS): m/z (%): 244 (100) [M]+, 229 (18) [M−CH3]+. Elemental anal. for C15H16O3: calc.: C, 73.75%; H, 6.60%. found: C, 73.70%; H, 6.70%.
0.69 g (5 mmol, 1.0 eq.) of 4-methylguaiacol, 2.47 g (15 mmol, 3.0 eq.) of 4-methyl-2-tert-butylphenol and 0.68 g of MTES were dissolved dissolved in 27 ml of HFIP+6 ml of MeOH and the electrolyte was transferred to the electrolysis cell. The solvent and unconverted amounts of reactant are removed under reduced pressure after the electrolysis, the crude product is purified by flash chromatography on silica gel 60 in a 4:1 eluent (cyclohexane:ethyl acetate) and the product is obtained as a yellow oil (yield: 36%, 545 mg, 1.8 mmol).
Rf (cyclohexane:ethyl acetate=9:1)=0.36; 1H NMR (400 MHz, CDCl3) δ=1.46 (s, 9H), 2.34 (m, 6H), 3.93 (s, 3H), 5.99 (s, 1H), 6.01 (s, 1H), 6.74 (s, 2H), 6.96 (d, J=1.9 Hz, 1H), 7.14 (d, J=1.9 Hz, 1H); 13C NMR (101 MHz, CDCl3) δ=21.05, 21.32, 29.96, 35.05, 56.30, 77.16, 111.21, 124.18, 124.24, 125.92, 127.67, 129.15, 129.22, 130.51, 137.57, 139.87, 146.57, 150.10.
HRMS for C22H30O3 (ESI+) [M+Na+]: calc.: 323.1623. found: 323.1618. MS (EI, GCMS): m/z (%): 300 (100) [M]+, 285 (100) [M−CH3]+.
Table 1 lists the yields and selectivities:
aisolated yield based on n(first phenol);
bdetermined via GC. AB: cross-coupling product, BB: homo-coupling product.
Table 1 shows that a large spectrum of structurally different phenols can be directly cross-coupled by the method described above.
In a first experimental series (ES1) which was effected under inventive conditions, the general procedure was modified in that 0.757 mmol of the first phenol having an oxidation potential EOx1 and 2.271 mmol of the second phenol having an oxidation potential EOx2 were dissolved.
As comparative experiments, a second experimental series (ES2) was conducted. Here, the general procedure was modified in that 0.757 mmol of the first phenol having an oxidation potential EOx1 and 0.757 mmol of the second phenol having an oxidation potential EOx2 were dissolved. In the comparative experiment, the two phenols were thus present in equal portions.
aisolated yield based on n(phenol1);
bdetermined via GC. AB: cross-coupling product, BB: homo-coupling product.
It can be clearly inferred from Table 2 that, under non-inventive conditions, i.e. in the second experimental series (ES2), much poorer yields are achieved than in the first experimental series (ES1) under inventive experimental conditions.
2nd phenol:
The oxidation potential of each of the two phenols shown was determined in a measurement series. The determination was effected here in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) and methanol (MeOH), with variation in the amount of methanol (MeOH) (the figures are % by volume).
Working electrode: glassy carbon, counterelectrode: glassy carbon,
Reference electrode: Ag/AgCl, v=10 mV/s,
Oxidation criterion: I=0.1 mA/cm2, c(phenol)=0.152 M,
Conductive salt: MTES, c(MTES)=0.09 M.
Solvents: HFIP and MeOH
The experimental series show clearly that the addition of methanol can noticeably increase the difference in the two oxidation potentials (ΔE).
Influence of the oxidation potential differences (ΔEOx) on yields and selectivities
Cyclic voltammetry measurements on substrates used show that differences between individual oxidation potential differences (ΔEOx) correlate with selectivities and yields of the electrochemical cross-coupling phenols. A greater potential difference results in better yields and improved selectivities.
In
Table 4 shows that the greatest possible ΔEOx are advantageous here. Entry 1 shows a ΔEOx greater by 10 mV in the HFIP/MeOH system than in pure HFIP, which results in an excellent selectivity for formation of the cross-coupling product. By-products such as homo-coupling products are also the consequence in Entry 2: here, ΔEOx=−0.22 V appears to be much too small to avoid homo-coupling. Side reactions can also severely reduce the yield, as shown by Entry 3. Here, a ΔEOx in HFIP/MeOH of only −0.05 V causes a collapse in the amount of cross-coupling product formed.
In
Table 5 shows, in Entry 1, that the optimal ΔEOx window has not been found, either in pure HFIP or with an 18% MeOH content. In both cases, by-products occur, and the GC product integrals suggest only relatively small amounts of the cross-coupling product. Entry 2 shows, with a rising ΔEOx (here IΔEI=0.25 V), a loss in yield. The optimum here appears to be at 0.13 V<IΔEoptimal<0.25 V. The limit of IΔEI=0.13 V is confirmed in Entry 3. No cross-coupling product formation occurs here, whereas, with slightly greater ΔEOx in pure HFIP, traces of the desired biphenol are isolable here.
Table 6 reflects the dependence on the respective substrate classes of the ΔEOx window sizes. The importance of the size of ΔEOx on the selectivity of the reaction is confirmed thereby.
Table 7 reflects the complexity of the ΔEOx window sizes. According to the substitution pattern, even small ΔEOx (Entry 2, here ΔEOx=−20 mV) already cause distinct selectivity for product formation. Generally, the importance of the size of ΔEOx for the selectivity of the reaction is confirmed. Entry 1, for the coupling with 2,3-dimethylphenol, shows a high proportion of homo-coupling products in pure HFIP. This can be explained by the virtually identical oxidation potential of the two co-reactants. Only in the case of MeOH addition does a ΔEOx of −30 mV develop. Only then is the formation of the unsymmetric product actually possible. If there is a fall in the difference in the oxidation potentials of phenols used, product formation is suppressed (Entry 2, pure HFIP). In the case of 3-(1,1-dimethylethyl)-4-methoxyphenol (Entry 3), this is entirely absent, since the latter phenol derivative is oxidized first and cross-coupling is impossible.
If the difference between the two potentials becomes too great (Table 8, ΔEOx=−330 mV, HFIP pure), there is apparently electrochemical combustion of the 4-methylguaiacol used.
By the experiments conducted, it has been shown that the difference between the oxidation potentials (ΔE) of the two phenols can be influenced via the solvent or solvent mixtures. In addition, it has been shown that the difference between the oxidation potentials (ΔE) of the two phenols has a distinct effect on the coupling behaviour/outcome. It has thus been demonstrated that the coupling reaction of two phenols having different oxidation potentials can be controlled via the appropriate choice of solvent or solvent mixture.
| Number | Date | Country | Kind |
|---|---|---|---|
| 10 2013 203 865.8 | Mar 2013 | DE | national |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/EP2013/076078 | 12/10/2013 | WO | 00 |
