A portion of the disclosure of this patent document contains material that is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure as it appears in the Patent and Trademark Office patent file or records, but otherwise reserves all copyright rights whatsoever.
Trademarks used in the disclosure of the invention, and the applicants, make no claim to any trademarks referenced.
The invention relates to the field of e-liquid for use in electronic cigarettes.
The invention relates to the creation of an inhalable cancer treatment.
Currently the state of the art includes a number of E-cigarettes, and e-cigarette liquid which are very popular alternatives to utilizing cigarettes and other tobacco products. The present invention, and inventive system, is a new and novel electronic cigarette liquid used in conjunction with electronic cigarettes. The present invention can be used for medicinal, recreational, or alternative purposes desired by the user of the product. The present invention is designed to give an e-liquid user an alternative compound than existing nicotine based liquids.
In particular there is a need for an e-cigarette liquid that provides alternative compounds such as medicinal ingredients.
The instant invention in one form is directed to a new and easy to use compound for electronic cigarette liquid used in conjunction with electronic cigarettes. The present invention can be used to enhance effects for relaxation, medicinal, recreational, or alternative purposes desired by a user of an e-cigarette. The present invention provides the following benefits to other e-liquids on the market place by using extracts or herbal substances which are compounded with a e-liquid carrier for use in an e-liquid in an e-cigarette. The extracts come from select herbal plants and extracts used in Native American and Eastern cultures along with other chemicals which are capable of providing relaxing or medicinal effects to the user of the e-cigarette liquid.
An advantage of the present invention is the ability of the instant invention to provide the user of an e-cigarette an e-liquid synthesized using a carrier base of propylene glycol, vegetable glycerin, MCT Oil, terpenes, water, or any mixture thereof, mixed with an herbal powder extract (or synthetically derived active ingredients) which is generally at a ratio of 0.001 g-5.0 g per ml. The herbal extract/synthetically derived active ingredients can be any of the following: Kanna (Sceletium tortuosum), Salvia (Salvia divinorum), Salvia eivinorm, Kratom (Mitragyna speciosa), Celandine poppy (Stylophorum diphyllum), Mugwort (Artemisia), Coltsfoot leaf (Tussilago farfara), California poppy (Eschscholzia californica), Sinicuichi (Heimia salicifolia), St. John's Wort (Hypericum perforatum), Yerba lenna yesca (Artemisia scoparia), Calea zacatechichi (Calea ternifolia), Blue lotus (Nymphaea caerulea), Leonurus sibericus (Leonurus sibiricus), Wild dagga (Leonotis leonurus), Valarien (Valeriana officinalis), Klip dagga (Leonotis nepetifolia), Damiana (Turnera diffusa), Kava (Piper methysticum), Scotch broom tops (Cytisus scoparius), Indian warrior (Pedicularis densiflora), Wild lettuce (Lactuca virosa), Skullcap (Scutellaria lateriflora), Red Clover (Trifolium pretense), Psilocybin Mushroom (Psilocybin Cubensis), Psilocin Mushroom (Copelandia, Gymnopilus, Inocybe, Panaeolus, Pholiotina, Pluteus, and Psilocybe), Lions Mane (Hericium Erinaceus), Cordyceps (Cordyceps Sinesis), Reishi Mushroom (Ganoderma Lingzhi), Chaga Mushroom (Inonotus Obliquus), Cacao (Forastero, Criollo, Trinitario), mimosa shrub (Mimosa hostilis), (Amrita) Tinospora cordifolia, Hemp/cannabis and/or combinations therein.
The invention in another form utilizes a herbal mixture combined with a chlorotoxin as a method of treating cancer with an inhalable compound.
The instant invention overcomes the tendency for water molecules to attract each other and oil molecules to stick together by utilization of high shear mixing. That causes oil and water to form two separate layers. Water molecules pack closer together, so they sink to the bottom, leaving oil sitting on top of the water. The high shear mixing causes the oil to break up into tiny droplets and becomes distributed in the water forming a mixture.
A further understanding of the nature and advantages of particular embodiments may be realized by reference to the remaining portions of the specification and the drawings, in which like reference numerals are used to refer to similar components. When reference is made to a reference numeral without specification to an existing sub-label, it is intended to refer to all such multiple similar components.
Corresponding reference characters indicate corresponding parts throughout the several views. The exemplifications set out herein illustrate embodiments of the invention and such exemplifications are not to be construed as limiting the scope of the invention in any manner.
While various aspects and features of certain embodiments have been summarized above, the following detailed description illustrates a few exemplary embodiments in further detail to enable one skilled in the art to practice such embodiments. The described examples are provided for illustrative purposes and are not intended to limit the scope of the invention.
In the following description, for the purposes of explanation, numerous specific details are set forth in order to provide a thorough understanding of the described embodiments. It will be apparent to one skilled in the art however that other embodiments of the present invention may be practiced without some of these specific details. Several embodiments are described herein, and while various features are ascribed to different embodiments, it should be appreciated that the features described with respect to one embodiment may be incorporated with other embodiments as well. By the same token however, no single feature or features of any described embodiment should be considered essential to every embodiment of the invention, as other embodiments of the invention may omit such features.
In this application the use of the singular includes the plural unless specifically stated otherwise and use of the terms “and” and “or” is equivalent to “and/or,” also referred to as “non-exclusive or” unless otherwise indicated. Moreover, the use of the term “including,” as well as other forms, such as “includes” and “included,” should be considered non-exclusive. Also, terms such as “element” or “component” encompass both elements and components including one unit and elements and components that include more than one unit, unless specifically stated otherwise.
Lastly, the terms “or” and “and/or” as used herein are to be interpreted as inclusive or meaning any one or any combination. Therefore, “A, B or C” or “A, B and/or C” mean “any of the following: A; B; C; A and B; A and C; B and C; A, B and C.” An exception to this definition will occur only when a combination of elements, functions, steps or acts are in some way inherently mutually exclusive.
As this invention is susceptible to embodiments of many different forms, it is intended that the present disclosure be considered as an example of the principles of the invention and not intended to limit the invention to the specific embodiments shown and described.
The terms e-liquid, compound, solution and liquid are used interchangeably to mean a liquid that is formulated using the process of the instant invention and is capable of being used in an e-cigarette for the purpose of vapor production.
The terms e-cigarette and smoking device are used interchangeably to mean an e-cigarette that is capable of using a e-liquid formulated using the process of the instant invention.
The term inhalers as used in the specification can be either an e-cigarette, metered dose inhalers, pressurized metered dose inhalers (MDIs), Breath-activated inhalers or inhalers with spacer devices or nebulizers.
The term emulsification or emulsion as used in this specification is a mixture of two or more liquids that are normally immiscible owing to liquid-liquid phase separation. Emulsions are part of a more general class of two-phase systems of matter called colloids.
Prior to a discussion of the preferred embodiment of the invention, it should be understood that while the features and advantages of the invention are illustrated in terms of an e-liquid, the invention can be used with any type of device that is capable of aspirating, vaporizing or misting a liquid for human inhalation such as inhalable insulin delivery devices, nebulizer, e-cigarette or metered dose inhalers.
The instant invention vaping compound or e-liquid comprises the following components:
More specifically the instant invention is a vaping compound or e-liquid that is comprises of the following ingredients but not limited to:
The active ingredients which comprise of herbal powder extract, liquid, oleoresin or synthetically derived active ingredients are incorporated into the vaporizing base such that the ratio of herbal powder extract or synthetically derived active ingredients to vaporizing base is generally at a 0.001 g-5.0 g per mL of the final vaping compound or e-liquid.
The of herbal powder extract of the instant invention can be selected from any of or combination of the following:
The instant invention also envisions the process where a synthetic active ingredient is used in place of a natural extract.
The vaporizing base is a carrier such as vegetable glycerin, propylene glycol, or MCT oil, terpenes and flavoring.
MCT oil is an oil made from a fat called medium-chain triglycerides.
Vegetable glycerin (VG) is a sugar alcohol made from plant oils and it is sweet, odorless viscous liquid.
Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. Its chemical formula is CH3CH(OH)CH2OH. Containing two alcohol groups, it is classed as a diol which is an alcohol containing two hydroxyl groups in its molecule. It is miscible with a broad range of solvents, including water, acetone, and chloroform. In general, glycols are non-irritating and have very low volatility.
Terpenes (carrier/flavoring) are natural aromas and flavors which manufacturers extract from various plants. Scientists estimate that there are approximately 20,000 different terpenes existing with over 100 of them coming from hemp. The instant invention can utilize any food grade terpenes.
Terpenes are ideal for adding flavor to vaporizing base and the possess beneficial properties. Terpenes can bind to receptors in the brain and body to stimulate effects. This essentially is the science of aromatherapy. While nearly all plants contain terpenes, some of the more common sources people encounter them include: cannabis, aromatic herbs, like sage and thyme and citrus fruits.
When you add terpenes to a vaporizing base, they help to supply the body with the “entourage effect.” This is when the herbal extracts and terpenes work “synergistically” to achieve an effect greater than any single ingredient would provide.
Traditionally manufacturers have used terpenes to add natural flavor back into a product. Additionally, manufacturers can also substitute terpenes as the carrier in the vaporizing base instead of using vegetable glycerin, propylene glycol, or MCT oil.
The addition of flavorings makes the vaping compound more desirable for the user because the flavor stimulates the sense of taste. The flavors can be sweet or minty flavor. There are estimated to be over 7,000 different flavors that can be incorporated into the vaping compound. Some of these are natural flavors and some are artificial.
The flavorings used in vaping compound are non-oil based, food-grade flavorings. This means the FDA approved the flavor for consumption. These flavorings come from either a natural source (food or plant) or are artificially synthesized.
The following flavorings can be used with the instant invention and they include but are not limited to:
Using a Kanna extraction as an example of a typical the extraction process for the active ingredient one can form a Kanna isopropyl extract which can be incorporated into the instant invention by using the following recipe.
An anti-carcinogenic formulation can be formed from (Amrita) Tinospora cordifolia.
Using a (Amrita) Tinospora cordifolia extract as an example of a nano emulsifying process for the active ingredient one can form an (Amrita) Tinospora cordifolia methanolic extract which can be incorporated into the instant invention by using the following recipe.
In summary a vaping device solution or nebulizer inhalation device solution of the instant invention can be made from the following ingredients:
The methanolic (Amrita) Tinospora cordifolia extract of the instant invention can be formed by
Referring now to the drawings
As noted earlier the instant invention anticipates the use of synthetic active ingredients such as citric acid and other synthetic compounds.
The active ingredients can be combined to form a number of beneficial compounds such as adding hemp/cannabis and cacao together into one formulation. Another example would be combining Lions Mane, Cordyceps and hemp (CBD oil) together into one formulation. Any suitable combination of active ingredients is possible depending on the combination of properties desired by the user.
Referring to
The classical method to create a stable emulsion is to use an emulsifier such as a surfactant that stabilizes emulsions. The surfactant emulsifiers coat droplets within an emulsion and prevent them from coming together, or coalescing. A detergent is a typical surfactant that is used when processing emulsification liquids. However, the use of detergents in a vaping compound is not recommended because detergents are not normally utilized in food and drug applications and therefore a different method is required to overcome the separation tendencies of the oil and water components of the vaping compound. The instant invention utilizes a high shear mixing process which creates a stable emulsion wherein the oil droplets are forced into an emulsion and prevent them from coming together, or coalescing. The use of high shear method to produce a stable emulsion requires introduction of significant energy into the mixture to obtain the finest possible droplet size. The more shear energy introduced into the mixture, the smaller the suspended droplets will become, creating a fine stable emulsion. The high shear mixing of an ultrasonic mixing device such as the Branson Sonifier 450 is ideally suited to this application and can easily achieve emulsions with a droplet size of 2 to 5 microns. Finer emulsions down to 0.5 microns can be obtained by mixing for longer periods of time.
As noted, the amount of water added to the mixture can be from 1 to 38% by volume and depends on the amount of emulsification desired.
At step 220 add the active ingredient which is in this case is 500 mg of Kanna extract. The percentage of active ingredient added to the mixture can vary depending on the desired vaping compound from 0.1 to 95% by weight. This forms the mixture of Kanna, flavor, water, vegetable glycerin and propylene glycol. Then as described in step 225 Place the beaker on a hot plate and set the temperature to 120 to 140 degrees. Measure the temperature of the solution as shown in step 230 and once it reaches 100 degrees Fahrenheit remove the beaker from the hot plate. Using an ultrasonic device mix the solution for 20 minutes as described in step 235. A typical ultrasonic device that can be used is a Branson Sonifier 450. First place the sonicator tip of the Branson Sonifier 450 so that it extends to approximately 2 mm from the bottom of the beaker. Set the power supply for controls accordingly to 20% Duty Cycle, Output control to 6 and timer to 8. Cover the beaker with a piece of film to prevent splatter or contamination and sonicate for 20 minutes. Ensure that all the water and oil has formed an emulsion. Then using a Buchner funnel and a coarse porosity filter paper (90-130 microns) filter the solution as described in step 240. Squeeze filter paper until all the liquid has been removed from the filter paper. Discard the filter paper and any associated material remaining in the filter.
Place the filtered mixture in a storage container as described in step 245 The resulting filtered solution will have an active ingredient content in the range of 0.001 g-5.0 g per mL of solution. To increase the amount of active ingredient the user only has to increase the amount of extract used in the formulation.
Referring to
At step 315 add 3 ml blueberry flavoring to the 100 ml beaker. Then as described in step 320 add the active ingredient which is in this case is 500 mg of Kanna extract. The percentage of active ingredient can vary depending on the desired vaping compound from 0.1 to 95% by weight. This forms the mixture of Kanna, flavor, vegetable and propylene glycol. Then as described in step 325 Place the beaker on a hot plate and set the temperature to 120 to 140 degrees. Measure the temperature of the solution as shown in step 330 and once it reaches 100 degrees Fahrenheit remove the beaker from the hot plate. Using an ultrasonic device mix the solution for 20 minutes as described in step 335. A typical ultrasonic device that can be used is a Branson Sonifier 450, place the sonicator tip of the Branson Sonifier 450 so that it extends to approximately 2 mm from the bottom of the beaker. Set the power supply for controls accordingly to 20% Duty Cycle, Output control to 6 and timer to 8. Cover the beaker with a piece of film to prevent splatter or contamination and sonicate for 20 minutes. Then using a Buchner funnel and a coarse porosity filter paper (90-130 microns) filter the solution as described in step 340. Squeeze filter paper until all the liquid has been removed from the filter paper. Discard the filter paper and any associated material remaining in the filter.
Place the filtered mixture in a storage container as described in step 345 The resulting filtered solution will have an active ingredient content in the range of 0.001 g-5.0 g per mL of solution. To increase the amount of active ingredient the user only has to increase the amount of extract used in the formulation.
Referring to
The classical method to create a stable emulsion is to use an emulsifier such as a surfactant that stabilizes emulsions. The surfactant emulsifiers coat droplets within an emulsion and prevent them from coming together, or coalescing. A detergent is a surfactant that has cleaning properties in dilute solutions. However, the use of detergents in a vaping compound is not recommended because detergents are not normally utilized in food and drug applications and a different method is required to overcome the separation of the oil and water components of the vaping compound. The instant intention utilizes a high shear mixing process which creates a stable emulsion wherein the oil droplets are forced into an emulsion and prevent them from coming together, or coalescing. The use of high shear method to produce a stable emulsion requires the input of energy into the mixture to obtain the finest possible droplet size. The more shear energy introduced into the mixture, the smaller the suspended droplets will become, creating a fine stable emulsion. The high shear mixing of an ultrasonic disintegrator is ideally suited to this application and can easily achieve emulsions with a droplet size of 2 to 5 microns. Finer emulsions down to 0.5 microns can be obtained by mixing for longer periods of time.
As noted, the amount of water added to the mixture can be from 1 to 38% by volume and depends on the amount of emulsification desired.
At step 420 add the active ingredient which is in this case 500 mg of Kanna extract. The percentage of active ingredient can vary depending on the desired vaping compound from 0.1 to 95% by weight of the vaping compound or e-liquid. This forms the mixture of Kanna, flavor, vegetable and propylene glycol. Then as described in step 425 place the beaker on a hot plate and set the temperature to 120 to 140 degrees. Measure the temperature of the solution as shown in step 430 and once it reaches 100 degrees Fahrenheit remove the beaker from the hot plate. Using an ultrasonic device mix the solution for 20 minutes as described in step 435. A typical ultrasonic device that can be used is a Branson Sonifier 450, place the sonicator tip of the Branson Sonifier 450 so that it extends to approximately 2 mm from the bottom of the beaker. Set the power supply for controls accordingly to 20% Duty Cycle, Output control to 6 and timer to 8. Cover the beaker with a piece of film to prevent splatter or contamination and sonicate for 20 minutes. Then using a Buchner funnel and a coarse porosity filter paper (90-130 microns) filter the solution as described in step 440. Squeeze filter paper until all the liquid has been removed from the filter paper. Discard the filter paper and any associated material remaining in the filter.
Place the filtered mixture in a storage container as described in step 445 The resulting filtered solution will have an active ingredient content in the range of 0.001 g-5.0 g per mL of solution. To increase the amount of active ingredient the user only has to increase the amount of extract used in the formulation.
As shown in
Using a (Amrita) Tinospora cordifolia extract as an example of a nano emulsifying process for the active ingredient one can form an (Amrita) Tinospora cordifolia methanolic extract which can be incorporated into the instant invention by using the following recipe.
Referring to
This formulation maintains the correct viscosity without the need for other added ingredients, and still maintains a high purity resulting in a favorable end product. The instant invention envisions vaping compounds or e-liquid comprised of a water content of 1 to 38% by volume percent, propylene glycol content of 20-92 percent by volume, vegetable glycerin content can be from 5 to 85 percent by volume. In an alternative embodiment the user could incorporate terpenes and the terpene content can be from 1 to 50% by volume and Tetrahydrocannabinol (THC)) oleoresin active ingredient content of 0.1 to 95% depending on the vapor qualities desired by the user.
An alternate active ingredient which has use in the treatment of caner is the use of a chlorotoxin in the formulation. An effective chlorotoxin's is the venom from Scorpions that are part of the order Scorpiones and the class Arachnida. They are invertebrates that possess eight legs and a two-segmented body composed of a cephalothorax and abdomen. This is the classification of scorpions: Kingdom Animalia (Animals); Phylum: Arthropoda (Arthropods); Subphylum: Chelicerata; Class: Arachnida (Arachnids); and Order: Scorpiones (Scorpions). Current records show that there are 1,004 known species. The number of species and the potential of compounds from the more than 1000 known species combined with the knowledge base of both native American, Indian homeopathic medicine and other homeopathic literature indicate that there is a wealth of opportunity in the chlorotoxin's of scorpion species to elevate the symptoms of effective treatments to disease states such as heart disease, cancer, Alzheimer's, epilepsy, inflammation and pain management.
The example utilizes the Blue Scorpion Venom Chlorotoxin venom however the opportunity to expand the viable chlorotoxin pool of compounds by utilizing any one of the more than 1004 known species of scorpion's in the treatment of disease's such cancer is incorporate because any one of the vast number of scorpion's could be used as a donor animal and this specification includes the incorporation of any of these animals being used as an alternative sources of chlorotoxin's. For this example, the Blue Scorpion Venom Chlorotoxin venom is extracted by a mild electro-stimulation method. However, researchers have had success milking scorpions in the Buthidae family, the Scorpionidae family and the Heterometrus swammerdami scorpion.
Once the venom is extracted, it is frozen and then lyophilized into a powder form that can be added to methanol in the ratio 1-part venom 10,000 parts by weight of methanol, then mixing thoroughly to create a chlorotoxin and methanol mixture. The 1-part venom to 10,000 parts methanol is preferred. However, clinically effective compounds with ratios from 1 to 1000 parts venom and 1000 to 20000 parts by weight methanol have been made successfully.
As shown in
Using a (Amrita) Tinospora cordifolia extract as an example of a nano emulsifying process for the active ingredient one can form an (Amrita) Tinospora cordifolia methanolic extract which can be incorporated into the instant invention by using the following recipe.
Research to date shows that natural based formulations especially comprised of natural materials such as CDB and clove oil and natural chlorotoxin can be used for targeting cancer, heart disease, Alzheimer's, epilepsy, inflammation and pain management.
Since many modifications, variations, and changes in detail can be made to the described embodiments of the invention, it is intended that all matters in the foregoing description and shown in the accompanying drawings be interpreted as illustrative and not in a limiting sense. Furthermore, it is understood that any of the features presented in the embodiments may be integrated into any of the other embodiments unless explicitly stated otherwise. The scope of the invention should be determined by the appended claims and their legal equivalents.
In addition, the present invention has been described with reference to embodiments, it should be noted and understood that various modifications and variations can be crafted by those skilled in the art without departing from the scope and spirit of the invention. Accordingly, the foregoing disclosure should be interpreted as illustrative only and is not to be interpreted in a limiting sense. Further it is intended that any other embodiments of the present invention that result from any changes in application or method of use or operation, method of manufacture, shape, size, or materials which are not specified within the detailed written description or illustrations contained herein are considered within the scope of the present invention.
Insofar as the description above and the accompanying drawings disclose any additional subject matter that is not within the scope of the claims below, the inventions are not dedicated to the public and the right to file one or more applications to claim such additional inventions is reserved.
Although very narrow claims are presented herein, it should be recognized that the scope of this invention is much broader than presented by the claim. It is intended that broader claims will be submitted in an application that claims the benefit of priority from this application.
While this invention has been described with respect to at least one embodiment, the present invention can be further modified within the spirit and scope of this disclosure. This application is therefore intended to cover any variations, uses, or adaptations of the invention using its general principles. Further, this application is intended to cover such departures from the present disclosure as come within known or customary practice in the art to which this invention pertains and which fall within the limits of the appended claims.
This application is a Continuation-In-Part Utility Patent application claiming priority to U.S. patent application Ser. No. 17/471,475, filed on Sep. 10, 2022, which is incorporated by reference herein in its entirety.
Number | Date | Country | |
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Parent | 17471475 | Sep 2021 | US |
Child | 17719912 | US |